Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19
Authors
Keywords
-
Journal
NATURE MEDICINE
Volume 27, Issue 4, Pages 668-676
Publisher
Springer Science and Business Media LLC
Online
2021-04-09
DOI
10.1038/s41591-021-01310-z
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Neuroinvasion of SARS-CoV-2 in human and mouse brain
- (2021) Eric Song et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Evidence for gastrointestinal infection of SARS-CoV-2
- (2020) Fei Xiao et al. GASTROENTEROLOGY
- Genotyping Array Design and Data Quality Control in the Million Veteran Program
- (2020) Haley Hunter-Zinck et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19
- (2020) Daniel Blanco-Melo et al. CELL
- Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2
- (2020) Vanessa Monteil et al. CELL
- Comparative replication and immune activation profiles of SARS-CoV-2 and SARS-CoV in human lungs: an ex vivo study with implications for the pathogenesis of COVID-19
- (2020) Hin Chu et al. CLINICAL INFECTIOUS DISEASES
- The COVID-19 Host Genetics Initiative, a global initiative to elucidate the role of host genetic factors in susceptibility and severity of the SARS-CoV-2 virus pandemic
- (2020) EUROPEAN JOURNAL OF HUMAN GENETICS
- Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial
- (2020) Ivan Fan-Ngai Hung et al. LANCET
- Remdesivir for the Treatment of Covid-19 — Preliminary Report
- (2020) John H. Beigel et al. NEW ENGLAND JOURNAL OF MEDICINE
- Multiorgan and Renal Tropism of SARS-CoV-2
- (2020) Victor G. Puelles et al. NEW ENGLAND JOURNAL OF MEDICINE
- Eliciting priors and relaxing the single causal variant assumption in colocalisation analyses
- (2020) Chris Wallace PLoS Genetics
- Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China
- (2020) Ling Mao et al. JAMA Neurology
- Antiviral activities of type I interferons to SARS-CoV-2 infection
- (2020) Emily Mantlo et al. ANTIVIRAL RESEARCH
- Genetic Associations with Plasma ACE2 Concentration: Potential Relevance to COVID-19 Risk
- (2020) Christopher P. Nelson et al. CIRCULATION
- Presence of Genetic Variants Among Young Men With Severe COVID-19
- (2020) Caspar I. van der Made et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Interferon-β-1a Inhibition of Severe Acute Respiratory Syndrome–Coronavirus 2 In Vitro When Administered After Virus Infection
- (2020) Nicola Clementi et al. JOURNAL OF INFECTIOUS DISEASES
- Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report
- (2020) NEW ENGLAND JOURNAL OF MEDICINE
- Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients
- (2020) Jérôme Hadjadj et al. SCIENCE
- Type I interferon susceptibility distinguishes SARS-CoV-2 from SARS-CoV.
- (2020) Kumari G. Lokugamage et al. JOURNAL OF VIROLOGY
- A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures
- (2020) Kenneth H. Dinnon et al. NATURE
- Interferons and viruses induce a novel truncated ACE2 isoform and not the full-length SARS-CoV-2 receptor
- (2020) Olusegun O. Onabajo et al. NATURE GENETICS
- Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
- (2020) Qian Zhang et al. SCIENCE
- Autoantibodies against type I IFNs in patients with life-threatening COVID-19
- (2020) Paul Bastard et al. SCIENCE
- Human recombinant soluble ACE2 in severe COVID-19
- (2020) Alexander Zoufaly et al. Lancet Respiratory Medicine
- Mendelian randomization analysis identified genes pleiotropically associated with the risk and prognosis of COVID-19
- (2020) Di Liu et al. JOURNAL OF INFECTION
- Genetic mechanisms of critical illness in Covid-19
- (2020) Erola Pairo-Castineira et al. NATURE
- Repurposed Antiviral Drugs for Covid-19 — Interim WHO Solidarity Trial Results
- (2020) NEW ENGLAND JOURNAL OF MEDICINE
- Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19
- (2020) Andre C. Kalil et al. NEW ENGLAND JOURNAL OF MEDICINE
- Genetic architecture of host proteins involved in SARS-CoV-2 infection
- (2020) Maik Pietzner et al. Nature Communications
- A Bayesian framework for multiple trait colocalization from summary association statistics
- (2018) Claudia Giambartolomei et al. BIOINFORMATICS
- A potential therapeutic role for angiotensin-converting enzyme 2 in human pulmonary arterial hypertension
- (2018) Anna R. Hemnes et al. EUROPEAN RESPIRATORY JOURNAL
- Endothelial cell functions impaired by interferon in vitro: Insights into the molecular mechanism of thrombotic microangiopathy associated with interferon therapy
- (2018) Haiyan Jia et al. THROMBOSIS RESEARCH
- Genomic atlas of the human plasma proteome
- (2018) Benjamin B. Sun et al. NATURE
- Co-regulatory networks of human serum proteins link genetics to disease
- (2018) Valur Emilsson et al. SCIENCE
- ChEMBL: towards direct deposition of bioassay data
- (2018) David Mendez et al. NUCLEIC ACIDS RESEARCH
- Nature as a Trialist?
- (2017) Sonja A. Swanson et al. EPIDEMIOLOGY
- The druggable genome and support for target identification and validation in drug development
- (2017) Chris Finan et al. Science Translational Medicine
- PhenoScanner: a database of human genotype–phenotype associations
- (2016) James R. Staley et al. BIOINFORMATICS
- Million Veteran Program: A mega-biobank to study genetic influences on health and disease
- (2016) John Michael Gaziano et al. JOURNAL OF CLINICAL EPIDEMIOLOGY
- The support of human genetic evidence for approved drug indications
- (2015) Matthew R Nelson et al. NATURE GENETICS
- Nucleic Acid Ligands With Protein-like Side Chains: Modified Aptamers and Their Use as Diagnostic and Therapeutic Agents
- (2014) John C Rohloff et al. Molecular Therapy-Nucleic Acids
- The Genotype-Tissue Expression (GTEx) project
- (2013) John Lonsdale et al. NATURE GENETICS
- Matrix eQTL: ultra fast eQTL analysis via large matrix operations
- (2012) A. A. Shabalin BIOINFORMATICS
- The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis
- (2012) LANCET
- clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters
- (2012) Guangchuang Yu et al. OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
- Homogeneous antibody-based proximity extension assays provide sensitive and specific detection of low-abundant proteins in human blood
- (2011) Martin Lundberg et al. NUCLEIC ACIDS RESEARCH
- Aptamer-Based Multiplexed Proteomic Technology for Biomarker Discovery
- (2011) Larry Gold et al. PLoS One
- METAL: fast and efficient meta-analysis of genomewide association scans
- (2010) C. J. Willer et al. BIOINFORMATICS
- CCR5: From Natural Resistance to a New Anti-HIV Strategy
- (2010) Lucia Lopalco Viruses-Basel
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started