Article
Dentistry, Oral Surgery & Medicine
E. A. C. Song, K. Smalley, A. Oyelakin, E. Horeth, M. Che, T. Wrynn, J. Osinski, R. A. Romano, S. Sinha
Summary: This study investigates the expression and function of ETS genes in salivary gland development using genomic and epigenomic data. The results show that Elf5 is dispensable for maintaining the homeostatic state of the adult salivary gland epithelium, while Ehf plays a nonredundant role in directing ductal cell differentiation.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Immunology
Julita Szulimowska, Anna Zalewska, Katarzyna Taranta-Janusz, Grazyna Marczuk-Kolada, Malgorzata Zendzian-Piotrowska, Mateusz Maciejczyk
Summary: Chronic kidney disease (CKD) is a systemic inflammatory disease that affects multiple organs, including the kidneys, cardiovascular system, and oral cavity. Children with CKD experience reduced saliva secretion (hyposalivation), leading to increased dental caries and impaired quality of life. This study evaluated the inflammatory and anti-inflammatory profile in the saliva of CKD children at different stages of renal failure. The results showed significant changes in salivary cytokines, chemokines, and growth factors in CKD children compared to healthy controls.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Agriculture, Dairy & Animal Science
Caroline Grisoni Sanchez, Marxa Leao Figueiredo, Laiza de Sartori Camargo, Luiz Guilherme Dercore Benevenuto, Zara Alves Lacerda, Carlos Eduardo Fonseca-Alves
Summary: Osteopontin (OPN) expression was investigated in canine mammary gland tumors (MGTs) and prostate cancer (PC) samples, and its association with bone metastasis was explored. Higher OPN expression was detected in primary tumor samples from animals with bone metastasis. In MGT samples, patients with higher OPN expression had significantly lower survival rates. Although not statistically significant, animals with positive OPN expression in PC samples showed a trend toward lower survival. These findings suggest that OPN may be a promising target for future studies on MGTs and PC due to its role in enhancing cell invasion and metastasis.
Review
Endocrinology & Metabolism
Yu Feng Shang, Yi Yang Shen, Meng Chen Zhang, Min Chao Lv, Tong Ying Wang, Xue Qun Chen, Jun Lin
Summary: Saliva production and secretion are essential functions of the salivary glands, with multiple functions including moistening, digestion, mineralization, lubrication, and mucosal protection. Saliva undergoes dynamic changes in its chemical and physical properties during physiological and pathophysiological processes. The central nervous system regulates salivary secretion and function through various neurotransmitters and neuroreceptors. Salivary glands play a crucial role in innate and adaptive immunity and protection, and saliva contains potential biomarkers for monitoring and predicting health and disease in clinical practice and precision medicine.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Gian Enrico Magi, Francesca Mariotti, Lorenzo Pallotta, Alessandro Di Cerbo, Franco Maria Venanzi
Summary: The expression of p62 protein is significantly higher in feline mammary carcinoma compared to non-neoplastic mammary glands, similar to human breast cancer. This study suggests that p62 may have oncogenic potential in feline mammary carcinoma.
Review
Cell Biology
Christine J. Watson
Summary: Research on mammary stem cells is currently facing controversies, but with innovative experimental approaches and technologies, there is a reevaluation of the concept of stem and progenitor cell hierarchy in progress.
TRENDS IN CELL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Swarajit Kumar Biswas, Saswati Banerjee, Ginger Wendolyn Baker, Chieh-Yin Kuo, Indrajit Chowdhury
Summary: The mammary gland, a compound and branched structure, plays a crucial role in mammalian reproduction by producing milk. Its development involves hormonal regulation and different stages of morphogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Jooyoung Kim, Min Rye Eom, Eun Ji Jeong, Ji Suk Choi, Seong Keun Kwon
Summary: In this study, regeneration of radiation-damaged salivary glands (SGs) was enhanced by combining adult SG stem cells (SGSCs) and adipose-derived stem cells (ASCs) in spheroids. Multiple stimulations improved the viability, differentiation, and vascular endothelial growth factor (VEGF) secretion of SGSC/ASC spheroids, leading to increased in vivo regeneration and functional recovery of SG tissue in mice.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Elena Ferrari, Mariana Gallo, Alberto Spisni, Rita Antonelli, Marco Meleti, Thelma A. Pertinhez
Summary: This study aimed to investigate the relationship between the metabolomes of saliva and serum to gain a comprehensive understanding of the metabolic phenotype under physiological conditions. The results showed that serum had higher concentration and less variability for most shared metabolites compared to the three types of saliva. There were moderate to strong correlations between the concentrations of specific metabolites in serum and saliva, but saliva is not simply a filtration of blood due to the intense oral metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Lei-Lei Wu, Jia-Yi Qian, Chong-Wu Li, Yu Zhang, Wei-Kang Lin, Kun Li, Zhi-Xin Li, Dong Xie
Summary: This study explores the clinical and prognostic characteristics of primary salivary gland-type carcinoma (SGC). The findings show that SGC has the best prognosis among different histological types of lung cancer, and lobectomy can further improve the survival of SGC patients. The study provides important insights into the understanding and management of SGC.
Article
Cell Biology
Amritha Varshini Hanasoge Somasundara, Matthew A. Moss, Mary J. Feigman, Chen Chen, Samantha L. Cyrill, Michael F. Ciccone, Marygrace C. Trousdell, Macy Vollbrecht, Siran Li, Jude Kendall, Semir Beyaz, John E. Wilkinson, Camila O. dos Santos
Summary: Pregnancy induces expansion of NKT-like immune cells and upregulation of immune signaling molecules in mammary epithelial cells. Lack of CD1d expression or activated NKT cells may lead to mammary oncogenesis.
Article
Rheumatology
Hong Ki Min, Se Hee Kim, Kyung-Ann Lee, Joon-Hyung Jo, Young So, Hyun Woo Chung, Sang-Heon Lee, Hae-Rim Kim
Summary: This study compared the findings of salivary gland ultrasonography (SGUS) and salivary gland scintigraphy (SGS) in patients with primary SS. The study found that patients with a higher SGUS score had lower salivary gland function, and there was a significant correlation between SGUS score and SGS results. These findings suggest a possible predictive role of SGUS in diagnosing salivary gland dysfunction.
Article
Otorhinolaryngology
Muhammet Bekir Hacioglu, Bulent Erdogan, Murat Bardakci, Efnan Algin, Burcu Gulbagci, Ilhan Hacibekiroglu, Jamshid Hamdard, Omer Fatih Olmez, Hadi Akkus, Berna Oksuzoglu, Sema Sezgin Goksu, Shute Ailia Dae, Ahmet Taner Sumbul, Muzaffer Ugrakli, Mustafa Karaagac, Elif Sahin, Devrim Cabuk, Ozden Ozer, Tugba Yavuzsen, Rukiye Arikan, Osman Kostek, Muhammed Mustafa Atci, Abdullah Sakin, Adem Deligonul, Duygu Bayir, Murat Dincer, Oktay Unsal, Ozan Yazici, Esra Zeynelgil, Ahmet Gulmez, Hakan Harputluoglu, Cihan Erol, Mehmet Ali Nahit Sendur, Aydin Aytekin, Baran Akagunduz, Irem Oner, Ozlem Er, Bugra Oztosun, Mahmut Gumus, Fatih Selcuk Biricik, Musa Baris Aykan, Nuri Karadurmus, Ezgi Degerli, Nebi Serkan Demirci, Esma Turkmen, Teoman Sakalar, Saban Secmeler, Ozgur Tanriverdi, Ali Alkan, Yasemin Kemal, Ibrahim Cil, Caglar Unal, Yakup Iriagac, Ozkan Alan, Sevinc Balli, Yuksel Urun, Erkan Ozcan, Nazim Serdar Turhal, Irfan Cicin
Summary: This retrospective-multicenter study includes data from 37 medical oncology clinics from different regions of Turkey, and a total of 443 salivary gland cancers were analyzed. The study shows that distant metastasis is more common in major salivary gland cancers, while locoregional recurrence is more common in minor salivary gland cancers. Epidemiological information, metastasis and recurrence patterns, treatment modalities, and survival analysis of the patients over 20 years of follow-up are presented in this study.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Cell Biology
Jessica Elswood, Scott J. Pearson, H. Ross Payne, Rola Barhoumi, Monique Rijnkels, Weston W. Porter
Summary: Through studying the differentiation and metabolism of mammary epithelial cells, it was found that mitophagy occurs selectively during the differentiation process. Inhibiting autophagy impairs cell differentiation, while the PRKN protein is necessary for cell differentiation.
Article
Medicine, Research & Experimental
Wan Seok Kang, Woo Kwon Jung, Su-Bin Park, Hyung Rae Kim, Junghyun Kim
Summary: The DPP4 inhibitor gemigliptin demonstrates protective effects against salivary dysfunction in diabetes by mediating antioxidant, anti-apoptotic, and salivary secretion mechanisms.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Urology & Nephrology
Malini Mukherjee, Jennifer deRiso, Karla Otterpohl, Ishara Ratnayake, Divya Kota, Phil Ahrenkiel, Indra Chandrasekar, Kameswaran Surendran
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2019)
Article
Immunology
Li-Yin Hung, Debasish Sen, Taylor K. Oniskey, Jeremey Katzen, Noam A. Cohen, Andrew E. Vaughan, Wildaliz Nieves, Anatoly Urisman, Michael F. Beers, Matthew F. Krummel, De'Broski R. Herbert
MUCOSAL IMMUNOLOGY
(2019)
Review
Biochemistry & Molecular Biology
Malini Mukherjee, Eric Fogarty, Madhusudhana Janga, Kameswaran Surendran
Letter
Critical Care Medicine
Nilam S. Mangalmurti, John P. Reilly, Douglas B. Cines, Nuala J. Meyer, Christopher A. Hunter, Andrew E. Vaughan
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Article
Developmental Biology
Malini Mukherjee, Jennifer DeRiso, Madhusudhana Janga, Eric Fogarty, Kameswaran Surendran
DEVELOPMENTAL BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Malini Mukherjeel, Ishara Ratnayake, Madhusudhana Janga, Eric Fogarty, Shania Scheidt, Justin Grassmeyer, Jennifer DeRiso, Indra Chandrasekar, S. Phil Ahrenkiel, Raphael Kopan, Kameswaran Surendran
Review
Cell & Tissue Engineering
Maria Fernanda de Mello Costa, Aaron Weiner, Andrew E. Vaughan
Article
Medicine, Research & Experimental
Karla L. Otterpohl, Brook W. Busselman, Ishara Ratnayake, Ryan G. Hart, Kimberly R. Hart, Claire M. Evans, Carrie L. Phillips, Jordan R. Beach, Phil Ahrenkiel, Bruce A. Molitoris, Kameswaran Surendran, Indra Chandrasekar
Review
Biochemistry & Molecular Biology
Heather L. Rossi, Jorge F. Ortiz-Carpena, Devon Tucker, Andrew E. Vaughan, Nilam S. Mangalmurti, Noam A. Cohen, De'Broski R. Herbert
Summary: This review discusses the important role of TFF family members in healthy and diseased airways. TFF peptides maintain and restore homeostasis in the airways through their regulation of the mucous layer, cell motility, cell differentiation, and immune function. Differences in TFF member tracks between humans and mice pose a challenge for research. New evidence suggests that TFF proteins interact with receptor binding partners in mediating biological effects in mouse models of repair and infection. TFF peptides may be reasonable therapeutic targets in the treatment of airway diseases.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Sara Kass-Gergi, Andrew E. Vaughan
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Cell & Tissue Engineering
Isabel Sierra, Sarah Pyfrom, Aaron Weiner, Gan Zhao, Amanda Driscoll, Xiang Yu, Brian D. Gregory, Andrew E. Vaughan, Montserrat C. Anguera
Summary: Sex differences in lung diseases, including COVID-19 and pulmonary fibrosis, may be influenced by the gene expression of the X-linked Ace2 gene in alveolar type 2 cells (AT2s), as well as the maintenance of X chromosome inactivation (XCI) in AT2s. A significant proportion of X-linked genes, including Ace2, escape XCI in AT2s, leading to genome-wide expression differences between male and female AT2s and potentially affecting lung physiology and pathological responses.
Article
Oncology
Snahlata Singh, Rumela Chakrabarti
Summary: Cytokines in the tumor microenvironment play a crucial role in tumor growth, progression, and treatment response, making them potential therapeutic agents and targets. IFNy, a pleiotropic cytokine mostly secreted by immune cells, interacts with IFNGR1 and IFNGR2 receptors on target cells. Clinical trials investigating the effectiveness of IFNy in combination with other therapies for cancer treatment have shown diverse outcomes. In this review, we summarize the effects of IFNy signaling on tumor cells and discuss its potential clinical application.
Article
Multidisciplinary Sciences
Gan Zhao, Aaron Weiner, Katherine M. Neupauer, Maria Fernanda de Mello Costa, Gargi Palashikar, Stephanie Adams-Tzivelekidis, Nilam S. Mangalmurti, Andrew E. Vaughan
Article
Cell & Tissue Engineering
Aaron Weiner, Sergio R. Jackson, Gan Zhao, Kwaku K. Quansah, Joseph N. Farshchian, Katherine M. Neupauer, Elizabeth Q. Littauer, Andrew J. Paris, Derek C. Liberti, G. Scott Worthen, Edward E. Morrisey, Andrew E. Vaughan
NPJ REGENERATIVE MEDICINE
(2019)
