New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

Efficacy and Safety of Atacicept in Patients With Systemic Lupus Erythematosus

(2018) Joan T. Merrill et al.   Arthritis & Rheumatology

Meta-analysis of genome-wide association studies for height and body mass index in ∼700000 individuals of European ancestry

(2018) Loic Yengo et al.   HUMAN MOLECULAR GENETICS

Genomic atlas of the human plasma proteome

(2018) Benjamin B. Sun et al.   NATURE

Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function

(2018) Annah B. Wyss et al.   Nature Communications

Mutations in KIAA0753 cause Joubert syndrome associated with growth hormone deficiency

(2017) Joshi Stephen et al.   HUMAN GENETICS

Conditional eQTL analysis reveals allelic heterogeneity of gene expression

(2017) Rick Jansen et al.   HUMAN MOLECULAR GENETICS

The daughter centriole controls ciliogenesis by regulating Neurl-4 localization at the centrosome

(2017) Abdelhalim Loukil et al.   JOURNAL OF CELL BIOLOGY

The centriolar satellite protein CCDC66 interacts with CEP290 and functions in cilium formation and trafficking

(2017) Deniz Conkar et al.   JOURNAL OF CELL SCIENCE

Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2017) Theo Vos et al.   LANCET

Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2017) Mohsen Naghavi et al.   LANCET

Genetic effects on gene expression across human tissues

(2017) François Aguet et al.   NATURE

Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis

(2017) Brian D Hobbs et al.   NATURE GENETICS

Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets

(2017) Louise V Wain et al.   NATURE GENETICS

DGIdb 3.0: a redesign and expansion of the drug–gene interaction database

(2017) Kelsy C Cotto et al.   NUCLEIC ACIDS RESEARCH

Novel KIAA0753 mutations extend the phenotype of skeletal ciliopathies

(2017) A. Hammarsjö et al.   Scientific Reports

Exome Array Analysis Identifies a Common Variant inIL27Associated with Chronic Obstructive Pulmonary Disease

(2016) Brian D. Hobbs et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Resetting the bar: Statistical significance in whole-genome sequencing-based association studies of global populations

(2016) Sara L. Pulit et al.   GENETIC EPIDEMIOLOGY

Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps

(2016) Valentina Iotchkova et al.   NATURE GENETICS

A reference panel of 64,976 haplotypes for genotype imputation

(2016)   NATURE GENETICS

The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog)

(2016) Jacqueline MacArthur et al.   NUCLEIC ACIDS RESEARCH

A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry

(2015) Sharon M. Lutz et al.   BMC GENETICS

Integrative analysis of 111 reference human epigenomes

(2015) Anshul Kundaje et al.   NATURE

The support of human genetic evidence for approved drug indications

(2015) Matthew R Nelson et al.   NATURE GENETICS

Partitioning heritability by functional annotation using genome-wide association summary statistics

(2015) Hilary K Finucane et al.   NATURE GENETICS

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

Efficient Bayesian mixed-model analysis increases association power in large cohorts

(2015) Po-Ru Loh et al.   NATURE GENETICS

Predicting effects of noncoding variants with deep learning–based sequence model

(2015) Jian Zhou et al.   NATURE METHODS

The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

(2015) et al.   SCIENCE

Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

(2015) María Soler Artigas et al.   Nature Communications

Evaluating the Performance of Fine-Mapping Strategies at Common Variant GWAS Loci

(2015) Martijn van de Bunt et al.   PLoS Genetics

Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank

(2015) Louise V Wain et al.   Lancet Respiratory Medicine

GRASP: analysis of genotype-phenotype results from 1390 genome-wide association studies and corresponding open access database

(2014) R. Leslie et al.   BIOINFORMATICS

Genome-wide association analysis identifies six new loci associated with forced vital capacity

(2014) Daan W Loth et al.   NATURE GENETICS

Whole Exome Re-Sequencing Implicates CCDC38 and Cilia Structure and Function in Resistance to Smoking Related Airflow Obstruction

(2014) Louise V. Wain et al.   PLoS Genetics

Systematic identification of trans eQTLs as putative drivers of known disease associations

(2013) Harm-Jan Westra et al.   NATURE GENETICS

GSTCD and INTS12 Regulation and Expression in the Human Lung

(2013) Ma’en Obeidat et al.   PLoS One

Refining Susceptibility Loci of Chronic Obstructive Pulmonary Disease with Lung eqtls

(2013) Maxime Lamontagne et al.   PLoS One

LRRC45 Is a Centrosome Linker Component Required for Centrosome Cohesion

(2013) Runsheng He et al.   Cell Reports

Predicting the Functional, Molecular, and Phenotypic Consequences of Amino Acid Substitutions using Hidden Markov Models

(2012) Hashem A. Shihab et al.   HUMAN MUTATION

Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits

(2012) Jian Yang et al.   NATURE GENETICS

The ConsensusPathDB interaction database: 2013 update

(2012) Atanas Kamburov et al.   NUCLEIC ACIDS RESEARCH

Lung eQTLs to Help Reveal the Molecular Underpinnings of Asthma

(2012) Ke Hao et al.   PLoS Genetics

GWAS of butyrylcholinesterase activity identifies four novel loci, independent effects within BCHE and secondary associations with metabolic risk factors

(2011) Beben Benyamin et al.   HUMAN MOLECULAR GENETICS

A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13

(2011) M. H. Cho et al.   HUMAN MOLECULAR GENETICS

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

(2011) María Soler Artigas et al.   NATURE GENETICS

GCTA: A Tool for Genome-wide Complex Trait Analysis

(2010) Jian Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A map of human genome variation from population-scale sequencing

(2010) Richard M. Durbin et al.   NATURE

ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data

(2010) K. Wang et al.   NUCLEIC ACIDS RESEARCH

Chronic obstructive pulmonary disease in non-smokers

(2009) Sundeep S Salvi et al.   LANCET

Genome-wide association study identifies five loci associated with lung function

(2009) Emmanouela Repapi et al.   NATURE GENETICS

Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function

(2009) Dana B Hancock et al.   NATURE GENETICS

A Genome-Wide Association Study of Pulmonary Function Measures in the Framingham Heart Study

(2009) Jemma B. Wilk et al.   PLoS Genetics

Changes in elastic fibres in the small airways and alveoli in COPD

(2008) P. N. Black et al.   EUROPEAN RESPIRATORY JOURNAL

Reporting and interpretation in genome-wide association studies

(2008) Jon Wakefield   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY