Activation of Mechanosensitive Ion Channels by Ultrasound

Focused ultrasound excites cortical neurons via mechanosensitive calcium accumulation and ion channel amplification

(2022) Sangjin Yoo et al.   Nature Communications

Sonogenetic control of mammalian cells using exogenous Transient Receptor Potential A1 channels

(2022) Marc Duque et al.   Nature Communications

Stimulation of the hepatoportal nerve plexus with focused ultrasound restores glucose homoeostasis in diabetic mice, rats and swine

(2022) Victoria Cotero et al.   Nature Biomedical Engineering

Force From Filaments: The Role of the Cytoskeleton and Extracellular Matrix in the Gating of Mechanosensitive Channels

(2022) Yu-Chia Chuang et al.   Frontiers in Cell and Developmental Biology

Auditory independent low-intensity ultrasound stimulation of mouse brain is associated with neuronal ERK phosphorylation and an increase of Tbr2 marked neuroprogenitors

(2022) Jormay Lim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tornado-inspired acoustic vortex tweezer for trapping and manipulating microbubbles

(2021) Wei-Chen Lo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ultrasound activates mechanosensitive TRAAK K+ channels through the lipid membrane

(2021) Ben Sorum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acid-Sensing Ion Channels and Mechanosensation

(2021) Nina Ruan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sensitization of nerve cells to ultrasound stimulation through Piezo1-targeted microbubbles

(2021) Xuelian Shen et al.   ULTRASONICS SONOCHEMISTRY

Elevation of Intra-Cellular Calcium in Nucleus Pulposus Cells with Micro-Pipette-Guided Ultrasound

(2021) Ya-Cherng Chu et al.   ULTRASOUND IN MEDICINE AND BIOLOGY

Effect of Low Intensity Transcranial Ultrasound Stimulation on Neuromodulation in Animals and Humans: An Updated Systematic Review

(2021) Taewon Kim et al.   Frontiers in Neuroscience

Physiology and Pathophysiology of Mechanically Activated PIEZO Channels

(2021) Ruhma Syeda   Annual Review of Neuroscience

Sonothermogenetics for noninvasive and cell-type specific deep brain neuromodulation

(2021) Yaoheng Yang et al.   Brain Stimulation

Sonogenetic-Based Neuromodulation for the Amelioration of Parkinson’s Disease

(2021) Ching-Hsiang Fan et al.   NANO LETTERS

Advances in TRP channel drug discovery: from target validation to clinical studies

(2021) Ari-Pekka Koivisto et al.   NATURE REVIEWS DRUG DISCOVERY

A role for substance P and acid-sensing ion channel 1a in prolotherapy with dextrose-mediated analgesia in a mouse model of chronic muscle pain

(2021) Der-Sheng Han et al.   PAIN

Enhanced tumor cell killing by ultrasound after microtubule depolymerization

(2021) Aditi Singh et al.   Bioengineering & Translational Medicine

The mechanosensory and mechanotransductive processes mediated by ion channels and the impact on bone metabolism: A systematic review

(2021) Kun Zhang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Transcranial Focused Ultrasound Neuromodulation: A Review of the Excitatory and Inhibitory Effects on Brain Activity in Human and Animals

(2021) Tingting Zhang et al.   Frontiers in Human Neuroscience

Ultrasound Activation of Mechanosensory Ion Channels in Caenorhabditis Elegans

(2021) Wei Zhou et al.   IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL

Acid-sensing ion channels as potential therapeutic targets

(2021) Stephanie A. Heusser et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

ASIC1a is required for neuronal activation via low-intensity ultrasound stimulation in mouse brain

(2021) Jormay Lim et al.   eLife

Low Intensity Pulsed Ultrasound for Bone Tissue Engineering

(2021) Colleen McCarthy et al.   Micromachines

Mechanosensitive Ion Channels: Structural Features Relevant to Mechanotransduction Mechanisms

(2020) Peng Jin et al.   Annual Review of Neuroscience

Therapeutic Potentials of Localized Blood–Brain Barrier Disruption by Noninvasive Transcranial Focused Ultrasound

(2020) Amanda Cammalleri et al.   JOURNAL OF CLINICAL NEUROPHYSIOLOGY

Blood–brain barrier opening with low intensity pulsed ultrasound for immune modulation and immune therapeutic delivery to CNS tumors

(2020) Kevin Beccaria et al.   JOURNAL OF NEURO-ONCOLOGY

Low Intensity Ultrasound Induces Epithelial Cell Adhesion Responses

(2020) Jormay Lim et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

Direct activation of zebrafish neurons by ultrasonic stimulation revealed by whole CNS calcium imaging

(2020) Nicolo Meneghetti et al.   Journal of Neural Engineering

TRPV4 promotes acoustic wave-mediated BBB opening via Ca2+/PKC-δ pathway

(2020) Wei-Hao Liao et al.   Journal of Advanced Research

Focused Ultrasound Stimulates ER Localized Mechanosensitive PANNEXIN-1 to Mediate Intracellular Calcium Release in Invasive Cancer Cells

(2020) Nan Sook Lee et al.   Frontiers in Cell and Developmental Biology

Focused acoustic vortex generated by a circular array of planar sector transducers using an acoustic lens, and its application in object manipulation

(2020) Chenchen Zhou et al.   JOURNAL OF APPLIED PHYSICS

The responses of nucleus pulposus cells to pressure and ultrasound stimulation

(2020) Ya-Cherng Chu et al.   JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA

Ultrasound Technologies for Imaging and Modulating Neural Activity

(2020) Claire Rabut et al.   NEURON

Ultrasound neuromodulation depends on pulse repetition frequency and can modulate inhibitory effects of TTX

(2020) Thomas J. Manuel et al.   Scientific Reports

Targeted Neurostimulation in Mouse Brains with Non-invasive Ultrasound

(2020) Zhihai Qiu et al.   Cell Reports

Discoveries in structure and physiology of mechanically activated ion channels

(2020) J. M. Kefauver et al.   NATURE

Manipulation of Subcortical and Deep Cortical Activity in the Primate Brain Using Transcranial Focused Ultrasound Stimulation

(2019) Davide Folloni et al.   NEURON

Ultrasound Neuromodulation: A Review of Results, Mechanisms and Safety

(2019) Joseph Blackmore et al.   ULTRASOUND IN MEDICINE AND BIOLOGY

Ultrasound Stimulation Modulates Voltage-Gated Potassium Currents Associated With Action Potential Shape in Hippocampal CA1 Pyramidal Neurons

(2019) Zhengrong Lin et al.   Frontiers in Pharmacology

Design of an ultrasound chamber for cellular excitation and observation

(2019) Ya-Cherng Chu et al.   JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA

A MEMS ultrasound stimulation system for modulation of neural circuits with high spatial resolution in vitro

(2019) Jungpyo Lee et al.   Microsystems & Nanoengineering

Structure and mechanogating of the mammalian tactile channel PIEZO2

(2019) Li Wang et al.   NATURE

Activation of Piezo1 mechanosensitive ion channel in HEK293T cells by 30 MHz vertically deployed surface acoustic waves

(2019) Defei Liao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ultrasonic Neuromodulation via Astrocytic TRPA1

(2019) Soo-Jin Oh et al.   CURRENT BIOLOGY

First-in-human trial of blood–brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound

(2019) Agessandro Abrahao et al.   Nature Communications

Sonogenetic Modulation of Cellular Activities Using an Engineered Auditory-Sensing Protein

(2019) Yao-Shen Huang et al.   NANO LETTERS

Shear force sensing of epithelial Na+channel (ENaC) relies onN-glycosylated asparagines in the palm and knuckle domains of αENaC

(2019) Fenja Knoepp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential regulation of TRP channel gene and protein expression by intervertebral disc degeneration and back pain

(2019) A. Sadowska et al.   Scientific Reports

Ultrasound Elicits Behavioral Responses through Mechanical Effects on Neurons and Ion Channels in a Simple Nervous System

(2018) Jan Kubanek et al.   JOURNAL OF NEUROSCIENCE

Ultrasonic Control of Neural Activity through Activation of the Mechanosensitive Channel MscL

(2018) Jia Ye et al.   NANO LETTERS

Structure and mechanogating mechanism of the Piezo1 channel

(2018) Qiancheng Zhao et al.   NATURE

Ultrasonic Neuromodulation Causes Widespread Cortical Activation via an Indirect Auditory Mechanism

(2018) Tomokazu Sato et al.   NEURON

Mechanogenetics for the remote and noninvasive control of cancer immunotherapy

(2018) Yijia Pan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of Piezo1 but Not Na V 1.2 Channels by Ultrasound at 43 MHz

(2018) Martin Loynaz Prieto et al.   ULTRASOUND IN MEDICINE AND BIOLOGY

Mechanisms of endogenous repair failure during intervertebral disc degeneration

(2018) K. Ma et al.   OSTEOARTHRITIS AND CARTILAGE

A Review of Low-Intensity Pulsed Ultrasound for Therapeutic Applications

(2018) Xiaoxue Jiang et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Role of Piezo Channels in Ultrasound-stimulated Dental Stem Cells

(2017) Qianhua Gao et al.   JOURNAL OF ENDODONTICS

ASIC and ENaC type sodium channels: conformational states and the structures of the ion selectivity filters

(2016) Israel Hanukoglu   FEBS Journal

Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release

(2016) ShengPeng Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Evidence for the involvement of ASIC3 in sensory mechanotransduction in proprioceptors

(2016) Shing-Hong Lin et al.   Nature Communications

Ultrasound modulates ion channel currents

(2016) Jan Kubanek et al.   Scientific Reports

Sonogenetics is a non-invasive approach to activating neurons in Caenorhabditis elegans

(2015) Stuart Ibsen et al.   Nature Communications

Physiological and Pathological Functions of Mechanosensitive Ion Channels

(2014) Yuanzheng Gu et al.   MOLECULAR NEUROBIOLOGY

A NOMPC-Dependent Membrane-Microtubule Connector Is a Candidate for the Gating Spring in Fly Mechanoreceptors

(2013) Xin Liang et al.   CURRENT BIOLOGY

Targeting ASIC3 for pain, anxiety, and insulin resistance

(2012) Wei-Li Wu et al.   PHARMACOLOGY & THERAPEUTICS

Transient receptor potential channels as therapeutic targets

(2011) Magdalene M. Moran et al.   NATURE REVIEWS DRUG DISCOVERY

Analysis of Ultrasound Fields in Cell Culture Wells for In Vitro Ultrasound Therapy Experiments

(2011) Karin Hensel et al.   ULTRASOUND IN MEDICINE AND BIOLOGY

Optogenetics: controlling cell function with light

(2010) Erika Pastrana   NATURE METHODS

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

(2010) B. Coste et al.   SCIENCE

Safety and U.S. Regulatory Considerations in the Nonclinical Use of Medical Ultrasound Devices

(2010) Robert A. Phillips et al.   ULTRASOUND IN MEDICINE AND BIOLOGY

Mechanotransduction by TRP Channels: General Concepts and Specific Role in the Vasculature

(2009) Jun Yin et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Interplay between TRP channels and the cytoskeleton in health and disease

(2008) K CLARK et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Neurosensory mechanotransduction

(2008) Martin Chalfie   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Remote Excitation of Neuronal Circuits Using Low-Intensity, Low-Frequency Ultrasound

(2008) William J. Tyler et al.   PLoS One