Natural essential oils efficacious in internal organs fibrosis treatment: Mechanisms of action and application perspectives

Downregulation of hepatic fat accumulation, inflammation and fibrosis by nerolidol in purpose built western-diet-induced multiple-hit pathogenesis of NASH animal model

(2022) Usman Sabir et al.   BIOMEDICINE & PHARMACOTHERAPY

Extracts of Dracocephalum tanguticum Maxim Ameliorate Acute Alcoholic Liver Disease via Regulating Transcription Factors in Mice

(2022) Min Guo et al.   Frontiers in Pharmacology

Exploring the Potential Effects and Mechanisms of Asarum sieboldii Radix Essential Oil for Treatment of Asthma

(2022) Jae Min Han et al.   Pharmaceutics

D-Carvone Attenuates CCl4-Induced Liver Fibrosis in Rats by Inhibiting Oxidative Stress and TGF-ß 1/SMAD3 Signaling Pathway

(2022) Hanan A. Ogaly et al.   Biology-Basel

Prediction and verification of target of helenalin against hepatic stellate cell activation based on miR-200a-mediated PI3K/Akt and NF-κB pathways

(2021) Bin Fang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Maternal Reproductive Toxicity of Some Essential Oils and Their Constituents

(2021) Noura S. Dosoky et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Germacrone improves liver fibrosis by regulating the PI3K/AKT/mTOR signalling pathway

(2021) De Ji et al.   CELL BIOLOGY INTERNATIONAL

Carvacrol alleviates liver fibrosis by inhibiting TRPM7 and modulating the MAPK signaling pathway

(2021) Shiyi Cai et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Chemical Composition, Antioxidant Potential, and Blood Glucose Lowering Effect of Aqueous Extract and Essential Oil of Thymus Serrulatus Hochst. Ex Benth

(2021) Tesfay Haile et al.   Frontiers in Pharmacology

Cymbopogon winterianus Essential Oil Attenuates Bleomycin-Induced Pulmonary Fibrosis in a Murine Model

(2021) Lívia A. Tavares et al.   Pharmaceutics

Dehydrocostus lactone inhibits BLM-induced pulmonary fibrosis and inflammation in mice via the JNK and p38 MAPK-mediated NF-κB signaling pathways

(2021) Yue Xiong et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Nerolidol, a Sesquiterpene from the Essential Oils of Aromatic Plants, Attenuates Doxorubicin-Induced Chronic Cardiotoxicity in Rats

(2021) M. F. Nagoor Meeran et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Chronic kidney disease

(2021) Kamyar Kalantar-Zadeh et al.   LANCET

Nerolidol Attenuates Oxidative Stress, Inflammation, and Apoptosis by Modulating Nrf2/MAPK Signaling Pathways in Doxorubicin-Induced Acute Cardiotoxicity in Rats

(2021) Seenipandi Arunachalam et al.   Antioxidants

Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction

(2021) Vaibhao Janbandhu et al.   Cell Stem Cell

Nootkatone confers antifibrotic effect by regulating the TGF-β/Smad signaling pathway in mouse model of unilateral ureteral obstruction

(2021) Shobhit Gairola et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Curcumol attenuates liver sinusoidal endothelial cell angiogenesis via regulating Glis‐PROX1‐HIF‐1α in liver fibrosis

(2020) Xiang Yang et al.   CELL PROLIFERATION

Alantolactone mitigates renal injury induced by diabetes via inhibition of high glucose-mediated inflammatory response and macrophage infiltration

(2020) Yu Zhu et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Selonsertib for Patients with Bridging Fibrosis or Compensated Cirrhosis Due to NASH: Results from Randomized Ph III STELLAR Trials

(2020) Stephen A. Harrison et al.   JOURNAL OF HEPATOLOGY

Reducing mortality from 2019-nCoV: host-directed therapies should be an option

(2020) Alimuddin Zumla et al.   LANCET

Chemical Composition and Antioxidant, Antimicrobial, and Antiproliferative Activities of Cinnamomum zeylanicum Bark Essential Oil

(2020) Behrooz Alizadeh Behbahani et al.   Evidence-based Complementary and Alternative Medicine

Cymbopogon Proximus Essential Oil Protects Rats against Isoproterenol-Induced Cardiac Hypertrophy and Fibrosis

(2020) Hassan N. Althurwi et al.   MOLECULES

Nose to brain drug delivery - a promising strategy for active components from herbal medicine for treating cerebral ischemia reperfusion

(2020) Yu Long et al.   PHARMACOLOGICAL RESEARCH

Pulmonary fibrosis and COVID-19: the potential role for antifibrotic therapy

(2020) Peter M George et al.   Lancet Respiratory Medicine

Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives

(2020) Natascha Roehlen et al.   Cells

NF-κB and tPA Signaling in Kidney and Other Diseases

(2020) Samantha White et al.   Cells

Atractylenolide III attenuates Bleomycin-induced experimental pulmonary fibrosis and oxidative stress in rat model via Nrf2/NQO1/HO-1 pathway activation

(2020) Bin Huai et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Antiviral Effects of Plant-Derived Essential Oils and Their Components: An Updated Review

(2020) Li Ma et al.   MOLECULES

Study on Lavender Essential Oil Chemical Compositions by GC-MS and Improved pGC

(2020) Guangyao Dong et al.   MOLECULES

Inhibition of proliferation-linked signaling cascades with atractylenolide I reduces myofibroblastic phenotype and renal fibrosis

(2020) Yangyang Guo et al.   BIOCHEMICAL PHARMACOLOGY

Fibrosis: from mechanisms to medicines

(2020) Neil C. Henderson et al.   NATURE

Natural volatile oils derived from herbal medicines: A promising therapy way for treating depressive disorder

(2020) Yulu Zhang et al.   PHARMACOLOGICAL RESEARCH

Antioxidant, hepatoprotective and antifungal activities of black pepper (Piper nigrum L.) essential oil

(2020) Chi Zhang et al.   FOOD CHEMISTRY

Dietary zerumbone, a sesquiterpene, ameliorates hepatotoxin-mediated acute and chronic liver injury in mice

(2019) Jong-Won Kim et al.   PHYTOTHERAPY RESEARCH

Carvacrol ameliorates the progression of liver fibrosis through targeting of Hippo and TGF-β signaling pathways in carbon tetrachloride (CCl4)-induced liver fibrosis in rats

(2019) Roohollah Mohseni et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

The protective effect of Zataria multiflora Boiss essential oil on CCl4 induced liver fibrosis in rats

(2019) Maryam Barghi et al.   DRUG AND CHEMICAL TOXICOLOGY

Costunolide inhibits pulmonary fibrosis via regulating NF-kB and TGF-β1/Smad2/Nrf2-NOX4 signaling pathways

(2019) Bin Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Micheliolide ameliorates renal fibrosis by suppressing the Mtdh/BMP/MAPK pathway

(2019) Fenfen Peng et al.   LABORATORY INVESTIGATION

Gas Chromatography-Mass Spectrometry (GC-MS) Analysis of the Volatile Oil of Cichorium Glandulosum Boiss et Huet and its Effects on Carbon Tetrachloride-Induced Liver Fibrosis in Rats

(2019) Dong-Mei Qin et al.   MEDICAL SCIENCE MONITOR

Neuropharmacology of the Neuropsychiatric Symptoms of Dementia and Role of Pain: Essential Oil of Bergamot as a Novel Therapeutic Approach

(2019) Damiana Scuteri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of Metabolic Activation in Elemicin-Induced Cellular Toxicity

(2019) Yi-Kun Wang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Isorhamnetin Inhibits Liver Fibrosis by Reducing Autophagy and Inhibiting Extracellular Matrix Formation via the TGF-β1/Smad3 and TGF-β1/p38 MAPK Pathways

(2019) Ning Liu et al.   MEDIATORS OF INFLAMMATION

Thymoquinone alleviates renal interstitial fibrosis and kidney dysfunction in rats with unilateral ureteral obstruction

(2019) Sara Hosseinian et al.   PHYTOTHERAPY RESEARCH

PLGA nanoparticles optimized by Box-Behnken for efficient encapsulation of therapeutic Cymbopogon citratus essential oil

(2019) Kessiane B. Almeida et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Beneficial effects of Silexan on sleep are mediated by its anxiolytic effect

(2019) Erich Seifritz et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Nerolidol attenuates cyclophosphamide-induced cardiac inflammation, apoptosis and fibrosis in Swiss Albino mice

(2019) Ashif Iqubal et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Microencapsulation of sweet orange essential oil (Citrus aurantium var. dulcis) by liophylization using maltodextrin and maltodextrin/gelatin mixtures: Preparation, characterization, antimicrobial and antioxidant activities

(2019) Jayuri Susy Fernandes de Araújo et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Costunolide represses hepatic fibrosis through WW domain‐containing protein 2‐mediated Notch3 degradation

(2019) Mao‐xu Ge et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hemistepsin A alleviates liver fibrosis by inducing apoptosis of activated hepatic stellate cells via inhibition of nuclear factor-κB and Akt

(2019) Jae Kwang Kim et al.   FOOD AND CHEMICAL TOXICOLOGY

New Insights for Cellular and Molecular Mechanisms of Aging and Aging-Related Diseases: Herbal Medicine as Potential Therapeutic Approach

(2019) Yanfei Liu et al.   Oxidative Medicine and Cellular Longevity

Targeting renal fibrosis: Mechanisms and drug delivery systems

(2018) Madalina V. Nastase et al.   ADVANCED DRUG DELIVERY REVIEWS

Liver diseases: A major, neglected global public health problem requiring urgent actions and large-scale screening

(2018) Patrick Marcellin et al.   LIVER INTERNATIONAL

Evaluation of the effect of topical chamomile (Matricaria chamomilla L.) oleogel as pain relief in migraine without aura: a randomized, double-blind, placebo-controlled, crossover study

(2018) Arman Zargaran et al.   NEUROLOGICAL SCIENCES

Black Seed Thymoquinone Improved Insulin Secretion, Hepatic Glycogen Storage, and Oxidative Stress in Streptozotocin-Induced Diabetic Male Wistar Rats

(2018) Heba M. A. Abdelrazek et al.   Oxidative Medicine and Cellular Longevity

Antifibrogenic Influence of Mentha piperita L. Essential Oil against CCl4-Induced Liver Fibrosis in Rats

(2018) Hanan A. Ogaly et al.   Oxidative Medicine and Cellular Longevity

Cardiac fibrosis: Cell biological mechanisms, molecular pathways and therapeutic opportunities

(2018) Nikolaos G. Frangogiannis   MOLECULAR ASPECTS OF MEDICINE

Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues

(2018) Maurizio Parola et al.   MOLECULAR ASPECTS OF MEDICINE

Curcumol induces RIPK1/RIPK3 complex-dependent necroptosis via JNK1/2-ROS signaling in hepatic stellate cells

(2018) Yan Jia et al.   Redox Biology

Aloysia citriodora Palau (lemon verbena) for insomnia patients: A randomized, double-blind, placebo-controlled clinical trial of efficacy and safety

(2018) Farshid Afrasiabian et al.   PHYTOTHERAPY RESEARCH

(+)-Isobicyclogermacrenal and spathulenol from Aristolochia yunnanensis alleviate cardiac fibrosis by inhibiting transforming growth factor β /small mother against decapentaplegic signaling pathway

(2018) Lan-Lan Lou et al.   PHYTOTHERAPY RESEARCH

Antifibrotic effects of D-limonene (5(1-methyl-4-[1-methylethenyl]) cyclohexane) in CCl4 induced liver toxicity in Wistar rats

(2017) Sheikh Bilal Ahmad et al.   ENVIRONMENTAL TOXICOLOGY

The Antidiabetic Activity ofNigella sativaand Propolis on Streptozotocin-Induced Diabetes and Diabetic Nephropathy in Male Rats

(2017) Haddad A. El Rabey et al.   Evidence-based Complementary and Alternative Medicine

Toxic essential oils. Part V: Behaviour modulating and toxic properties of thujones and thujone-containing essential oils of Salvia officinalis L., Artemisia absinthium L., Thuja occidentalis L. and Tanacetum vulgare L.

(2017) Niko S. Radulović et al.   FOOD AND CHEMICAL TOXICOLOGY

Nootkatone confers hepatoprotective and anti-fibrotic actions in a murine model of liver fibrosis by suppressing oxidative stress, inflammation, and apoptosis

(2017) Amani Kurdi et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

TNF-α-induced NF-κB activation promotes myofibroblast differentiation of LR-MSCs and exacerbates bleomycin-induced pulmonary fibrosis

(2017) Jiwei Hou et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Transforming Growth Factor-β: Master Regulator of the Respiratory System in Health and Disease

(2016) Yael Aschner et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Protective Effects of Myrtol Standardized Against Radiation-Induced Lung Injury

(2016) De-yun Zhao et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Allergic contact cheilitis caused by menthol in toothpaste and throat medication: a case report

(2016) Pieter Bourgeois et al.   CONTACT DERMATITIS

Essential Oils, Part V

(2016) Anton de Groot et al.   Dermatitis

Development of Novel Agents for Idiopathic Pulmonary Fibrosis

(2015) Thomas G. O'Riordan et al.   CHEST

Comorbidities in idiopathic pulmonary fibrosis patients: a systematic literature review

(2015) Ganesh Raghu et al.   EUROPEAN RESPIRATORY JOURNAL

Hepatocyte Growth Factor Mediates the Antifibrogenic Action of Ocimum bacilicum Essential Oil against CCl4-Induced Liver Fibrosis in Rats

(2015) Hanan Ogaly et al.   MOLECULES

Therapeutic targets for treating fibrotic kidney diseases

(2015) So-Young Lee et al.   Translational Research

Essential Oils: Extraction, Bioactivities, and Their Uses for Food Preservation

(2014) Phakawat Tongnuanchan et al.   JOURNAL OF FOOD SCIENCE

A Phase 3 Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis

(2014) Talmadge E. King et al.   NEW ENGLAND JOURNAL OF MEDICINE

Comorbidity in cirrhosis

(2014) Peter Jepsen   WORLD JOURNAL OF GASTROENTEROLOGY

Development and Validation of a Comorbidity Scoring System for Patients With Cirrhosis

(2013) Peter Jepsen et al.   GASTROENTEROLOGY

A Novel Paradigm for Heart Failure With Preserved Ejection Fraction

(2013) Walter J. Paulus et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Anti-fibrotic effect of thymoquinone on hepatic stellate cells

(2013) Mohammed Ghazwani et al.   PHYTOMEDICINE

The antioxidant effect of β-caryophyllene protects rat liver from carbon tetrachloride-induced fibrosis by inhibiting hepatic stellate cell activation

(2012) Miguel Angel Calleja et al.   BRITISH JOURNAL OF NUTRITION

Role of Oxidative Stress and Molecular Changes in Liver Fibrosis: A Review

(2012) V. Sanchez-Valle et al.   CURRENT MEDICINAL CHEMISTRY

Parthenolide-induced apoptosis of hepatic stellate cells and anti-fibrotic effects in anin vivorat model

(2012) In Hee Kim et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Houttuynia cordata inhibits lipopolysaccharide-induced rapid pulmonary fibrosis by up-regulating IFN-γ and inhibiting the TGF-β1/Smad pathway

(2012) Shaohui Du et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

Thymoquinone blocks lung injury and fibrosis by attenuating bleomycin-induced oxidative stress and activation of nuclear factor Kappa-B in rats

(2012) Dalia El-Khouly et al.   TOXICOLOGY

NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma

(2011) Tom Luedde et al.   Nature Reviews Gastroenterology & Hepatology

Downregulation effects of beta-elemene on the levels of plasma endotoxin, serum TNF-alpha, and hepatic CD14 expression in rats with liver fibrosis

(2011) Jianguo Liu et al.   Frontiers of Medicine

Antiatherogenic Potential ofNigella sativaSeeds and Oil in Diet-Induced Hypercholesterolemia in Rabbits

(2010) Ghanya Al-Naqeep et al.   Evidence-based Complementary and Alternative Medicine

Chemical composition of essential oils in Zataria multiflora Boiss. from different parts of Iran and their radical scavenging and antimicrobial activity

(2010) Seyyed Siavash Saei-Dehkordi et al.   FOOD AND CHEMICAL TOXICOLOGY

Wormwood (Artemisia absinthium L.)—A curious plant with both neurotoxic and neuroprotective properties?

(2010) Dirk W. Lachenmeier   JOURNAL OF ETHNOPHARMACOLOGY

Treatment of Idiopathic Pulmonary Fibrosis with Etanercept

(2008) Ganesh Raghu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Farnesol ameliorates massive inflammation, oxidative stress and lung injury induced by intratracheal instillation of cigarette smoke extract in rats: An initial step in lung chemoprevention

(2008) Wajhul Qamar et al.   CHEMICO-BIOLOGICAL INTERACTIONS

TNF-α deficiency accelerates renal tubular interstitial fibrosis in the late stage of ureteral obstruction

(2008) Yoshifumi Morimoto et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY