Review
Pharmacology & Pharmacy
Ruixue Shi, Yu Fu, Dongyi Zhao, Tomasz Boczek, Wuyang Wang, Feng Guo
Summary: TRPM channels, important members of the TRP family, play crucial roles in cell physiology and cell death. Studies have shown their involvement in various cell death modalities, suggesting their potential as therapeutic targets in cell death-related diseases.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jin Hee Kim, In Gyoung Ju, Namkwon Kim, Eugene Huh, So-Ri Son, Joon Pyo Hong, Yujin Choi, Dae Sik Jang, Myung Sook Oh
Summary: This study aimed to investigate the anti-neuroinflammatory effects of yomogin, isolated from Artemisia iwayomogi. The results showed that yomogin suppressed neuroinflammatory factors and regulated the MAPK pathway, suggesting its potential as a therapeutic candidate for inflammation-mediated neurological diseases.
Article
Biochemistry & Molecular Biology
Minwoo Lee, Song Hee Lee, Seunghyuk Choi, Bo Young Choi, Sang Won Suh
Summary: Carvacrol inhibits TRPM7 expression, alleviates zinc neurotoxicity induced by TBI, reduces oxidative stress, mitigates dendritic damage and neuronal degeneration, delays neuronal death, and improves neurological outcomes after TBI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Ruoyu Wang, Dong Zhang, Dan Tang, Kewei Sun, Jianping Peng, Wenfang Zhu, Sihan Yin, Yunan Wu
Summary: Amygdalin effectively suppressed the activation of hepatic stellate cells induced by TGF-beta 1 by modulating proliferation, fibrogenesis, and inflammation signaling pathways in vitro, leading to improvement in liver fibrosis and damage in a CCl4-stimulated rat model in vivo.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Matias Estaras, Manuel R. Gonzalez-Portillo, Miguel Fernandez-Bermejo, Jose M. Mateos, Daniel Vara, Gerardo Blanco-Fernandez, Diego Lopez-Guerra, Vicente Roncero, Gines M. Salido, Antonio Gonzalez
Summary: The study demonstrates that melatonin at pharmacological concentrations can diminish the proliferation of pancreatic stellate cells subjected to hypoxia by modulating the cell cycle, apoptosis, and the activation of crucial MAPKs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yuanyuan Wang, Rong Lu, Pu Chen, Rongrong Cui, Meiju Ji, Xiaozhi Zhang, Peng Hou, Yiping Qu
Summary: This study found that methylation of TRPM7 is significantly associated with better clinical outcomes in breast cancer patients, especially in the Luminal A subtype.
Article
Microbiology
Wenli Jiao, Weichen Ding, Jeffrey A. Rollins, Jinliang Liu, Yanhua Zhang, Xianghui Zhang, Hongyu Pan
Summary: In this study, SsTOR was identified as a critical component of the TOR signaling pathway in S. sclerotiorum. Gene silencing of SsTOR resulted in decreased mycelial growth, disrupted sclerotia and compound appressoria formation, and reduced virulence. Additionally, SsTOR was found to regulate cell wall integrity through the phosphorylation of SsSmk3 and induce autophagy potentially through SsAtg1 and SsAtg13. Overall, this study highlights the importance of SsTOR as a global regulator of growth, stress responses, cell wall integrity, autophagy, and virulence in S. sclerotiorum.
MICROBIOLOGY SPECTRUM
(2023)
Review
Pharmacology & Pharmacy
Nathalia Grave, Thamiris Becker Scheffel, Fernanda Fernandes Cruz, Liliana Rockenbach, Marcia Ines Goettert, Stefan Laufer, Fernanda Bueno Morrone
Summary: Gliomas are debilitating malignant brain tumors with limited response to therapies, driven by molecular abnormalities like mutations in regulatory networks. The MAPK pathway, particularly p38 MAPK activation, plays a crucial role in glioma cell invasion and metastasis, and is associated with tumor grade and chemotherapy resistance, underlining its potential as a therapeutic target.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Quiara L. Alves, Paola V. da Silva Santos, William A. Santos, Suiane C. Dantas Damasceno, Rafael L. C. de Jesus, Thamires Q. Froes, Marcelo S. Castilho, Andrezza M. Barbosa, Eneas R. de Moraes Gomes, Jader dos Santos Cruz, Darizy F. Silva
Summary: The study demonstrates the direct cardiac effects of carvacrol, including reduced contractility of cardiomyocytes and negative chronotropic effect. The study also highlights the involvement of TRPM channels in mediating these effects.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2022)
Article
Critical Care Medicine
Chan Sol Park, Jee Youn Lee, Hae Young Choi, Tae Young Yune
Summary: After spinal cord injury, TRPM7 plays a critical role in the regulation of blood-spinal cord barrier (BSCB) homeostasis. The TRPM7 inhibitor CAR can suppress BSCB disruption and improve functional recovery by inhibiting the loss of tight junction proteins and reducing apoptotic cell death.
JOURNAL OF NEUROTRAUMA
(2022)
Article
Plant Sciences
Hui Xiong, Miao Luo, Yankun Ju, Zhongqiu Zhao, Man Zhang, Ran Xu, Yongshen Ren, Guangzhong Yang, Zhinan Mei
Summary: The triterpene saponins from Entada phaseoloides have been found to have therapeutic effects on collagen-induced arthritis in rats, reducing symptoms, decreasing the production of inflammatory cytokines, and inhibiting the MAPK signaling pathway, which ultimately prevents the progression of rheumatoid arthritis.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Cell & Tissue Engineering
Zhang Hongyu, Wang Zhuo, Liu Changjiang, Wei Pingjie, Sun Fang, Zhao Lanlan, Xiao Peng
Summary: This study found that static pressure can upregulate the expression of TRPM7 in chondrocytes, leading to an increase in intracellular Ca2+ concentration and induction of cell apoptosis through a signaling pathway.
JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Mengyao Li, Binghua Li, Min Yang, Liangxin Wang, Guoyan Hou, Yuanxiu Lin, Yunting Zhang, Yong Zhang, Qing Chen, Yan Wang, Wen He, Xiaorong Wang, Haoru Tang, Guichuan Yang, Ya Luo
Summary: Studies have shown that mitogen-activated protein kinases (MAPKs) play a key role in regulating plant responses to various stresses. However, their involvement in cultivated strawberry development and ripening has not been well understood. This study identified 43 FaMAPK genes in cultivated strawberry and found that they could be classified into four groups. Analysis of their structural features and promoter regions indicated their potential involvement in phytohormone response and stress regulation. Transcriptional analysis revealed that all FaMAPK genes were expressed throughout strawberry development. The study also demonstrated the role of ABA and sucrose in regulating FaMAPK gene expression and strawberry fruit ripening. This research provides a theoretical basis and support for further understanding of the ripening process in strawberries.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Defu Lin, Huakang Du, Sen Zhao, Bowen Liu, Hongcheng Song, Guannan Wang, Weiping Zhang, Haiyan Liang, Pei Liu, Chao Liu, Wenwen Han, Zhenwu Li, Yang Yang, Shuofan Chen, Lina Zhao, Xiaoxin Li, Zhihong Wu, Ning Sun, Nan Wu
Summary: A novel BRAF variant was found to be associated with hypospadias phenotype, leading to abnormal p38 MAPK signaling. Two additional variants in p38 MAPK signaling-related genes were also identified potentially associated with hypospadias.
ORPHANET JOURNAL OF RARE DISEASES
(2022)
Article
Limnology
Xiaoyan Zhang, Yuan Tian, Haohui Yu, Min Cao, Chao Li
Summary: This study identified, characterized, and analyzed the expression profiles of mapk genes in black rockfish, revealing their crucial roles in preventing bacterial infection and providing insights into the function of mapk genes in teleost immune responses.
JOURNAL OF OCEANOLOGY AND LIMNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Can Wei, Junfeng Jing, Yanbin Zhang, Ling Fang
Article
Biochemistry & Molecular Biology
Lingling Li, Can Wei, Shiyi Cai, Ling Fang
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Cell Biology
Yiyun Deng, Zhe Zhang, Hui Yang, Jing Wang, Lijuan Feng, Yong Su, Dujuan Xu
Summary: This study found that Mycophenolic acid (MPA) induces intestinal barrier dysfunction through regulation of mitochondrial reactive oxygen species (ROS). MPA increases intracellular and mitochondrial ROS production, promoting oxidative stress and causing abnormalities in intestinal barrier function. Mitochondrial protectants can reduce ROS production, upregulate tight junction (TJ) protein expression, and reduce apoptosis.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Chemistry, Medicinal
Guofang Liu, Can Wei, Siyu Yuan, Zhe Zhang, Jiahao Li, Lijun Zhang, Guokai Wang, Ling Fang
Summary: This study found that Wogonoside (WG) alleviates liver fibrosis by inducing ferroptosis in hepatic stellate cells (HSCs), providing a new clue for the treatment of liver fibrosis.
PHYTOTHERAPY RESEARCH
(2022)