Isorhamnetin Inhibits Liver Fibrosis by Reducing Autophagy and Inhibiting Extracellular Matrix Formation via the TGF-β1/Smad3 and TGF-β1/p38 MAPK Pathways

Isorhamnetin: A hepatoprotective flavonoid inhibits apoptosis and autophagy via P38/PPAR-α pathway in mice

(2018) Xiya Lu et al.   BIOMEDICINE & PHARMACOTHERAPY

GDF‑15 prevents LPS and D‑galactosamine‑induced inflammation and acute liver injury in mice

(2018) Min Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

TGF-β and the Tissue Microenvironment: Relevance in Fibrosis and Cancer

(2018) Laia Caja et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Alleviation of hepatic fibrosis and autophagy via inhibition of transforming growth factor-β 1/Smads pathway through shikonin

(2018) Tong Liu et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Matrix metalloproteinases and liver fibrosis (translational aspects)

(2018) Elke Roeb   MATRIX BIOLOGY

Assessment of liver disease in cystic fibrosis

(2018) Suzanne Davison   Paediatric Respiratory Reviews

Liver fibrosis

(2018) M. Merve Aydin et al.   Turkish Journal of Gastroenterology

Salidroside ameliorates autophagy and activation of hepatic stellate cells in mice via NF-κB and TGF-β1/Smad3 pathways

(2018) Jiao Feng et al.   Drug Design Development and Therapy

Emodin suppresses activation of hepatic stellate cells through p38 mitogen-activated protein kinase and Smad signaling pathways in vitro

(2018) Xiaoli Wang et al.   PHYTOTHERAPY RESEARCH

Isorhamnetin protects against bleomycin-induced pulmonary fibrosis by inhibiting endoplasmic reticulum stress and epithelial-mesenchymal transition

(2018) Qing Zheng et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Starvation-induced autophagy promotes the invasion and migration of human bladder cancer cells via TGF-β1/Smad3-mediated epithelial-mesenchymal transition activation

(2018) Hang Tong et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The Protective Effects of Levo-Tetrahydropalmatine on ConA-Induced Liver Injury Are via TRAF6/JNK Signaling

(2018) Qiang Yu et al.   MEDIATORS OF INFLAMMATION

Preclinical Evaluation of AZ12601011 and AZ12799734, Inhibitors of Transforming Growth Factor β Superfamily Type 1 Receptors

(2018) Lindsay C. Spender et al.   MOLECULAR PHARMACOLOGY

Capsaicin Inhibits Dimethylnitrosamine-Induced Hepatic Fibrosis by Inhibiting the TGF-β1/Smad Pathway via Peroxisome Proliferator-Activated Receptor Gamma Activation

(2017) Jae Ho Choi et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Isorhamnetin protects against cardiac hypertrophy through blocking PI3K–AKT pathway

(2017) Lu Gao et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Mechanisms of hepatic stellate cell activation

(2017) Takuma Tsuchida et al.   Nature Reviews Gastroenterology & Hepatology

3-Methyladenine ameliorates liver fibrosis through autophagy regulated by the NF-κB signaling pathways on hepatic stellate cell

(2017) Bingying Wang et al.   Oncotarget

AMP-activated protein kinase regulates lipid metabolism and the fibrotic phenotype of hepatic stellate cells through inhibition of autophagy

(2017) Ming Chen et al.   FEBS Open Bio

Anti-fibrotic Effects of Synthetic Oligodeoxynucleotide for TGF-β1 and Smad in an Animal Model of Liver Cirrhosis

(2017) Jung-Yeon Kim et al.   Molecular Therapy-Nucleic Acids

Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-β1/Smads and PI3K/Akt pathways

(2017) Liwei Wu et al.   Scientific Reports

Isorhamnetin attenuates liver fibrosis by inhibiting TGF-β/Smad signaling and relieving oxidative stress

(2016) Ji Hye Yang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Vitamin A and insulin are required for the maintenance of hepatic stellate cell quiescence

(2016) Akihiro Yoneda et al.   EXPERIMENTAL CELL RESEARCH

TGF-β signalling and liver disease

(2016) Isabel Fabregat et al.   FEBS Journal

TGF-β/SMAD Pathway and Its Regulation in Hepatic Fibrosis

(2016) Fengyun Xu et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Protective effect of fucoidan from Fucus vesiculosus on liver fibrosis via the TGF-β1/Smad pathway-mediated inhibition of extracellular matrix and autophagy

(2016) Chuanyong Guo et al.   Drug Design Development and Therapy

Novel TGF-β inhibitors ready for prime time in onco-immunology

(2016) Armand de Gramont et al.   OncoImmunology

Hepatic inflammation and fibrosis: Functional links and key pathways

(2015) Ekihiro Seki et al.   HEPATOLOGY

Isorhamnetin protects mice from lipopolysaccharide-induced acute lung injury via the inhibition of inflammatory responses

(2015) Gefu Chi et al.   INFLAMMATION RESEARCH

Ghrelin Attenuates Liver Fibrosis through Regulation of TGF-β1 Expression and Autophagy

(2015) Yuqing Mao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Matrix metalloproteinases in liver injury, repair and fibrosis

(2015) Sergio Duarte et al.   MATRIX BIOLOGY

SKI2162, an inhibitor of the TGF-β type I receptor (ALK5), inhibits radiation-induced fibrosis in mice

(2015) Jin-hong Park et al.   Oncotarget

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

(2015) Carmen G. Tag et al.   Jove-Journal of Visualized Experiments

Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis

(2014) Ali A Mokdad et al.   BMC Medicine

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy in Hepatic Fibrosis

(2014) Yang Song et al.   Biomed Research International

Autophagy: A Multifaceted Partner in Liver Fibrosis

(2014) Ariane Mallat et al.   Biomed Research International

Astragaloside IV suppresses collagen production of activated hepatic stellate cells via oxidative stress-mediated p38 MAPK pathway

(2013) Xiaoming Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Isorhamnetin Protects against Doxorubicin-Induced Cardiotoxicity In Vivo and In Vitro

(2013) Jing Sun et al.   PLoS One

Autophagy fuels tissue fibrogenesis

(2012) Virginia Hernández-Gea et al.   Autophagy

Peroxisome proliferator-activated receptor-γ as a therapeutic target for hepatic fibrosis: from bench to bedside

(2012) Feng Zhang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Autophagy Releases Lipid That Promotes Fibrogenesis by Activated Hepatic Stellate Cells in Mice and in Human Tissues

(2012) Virginia Hernández–Gea et al.   GASTROENTEROLOGY

Isorhamnetin Inhibits Proliferation and Invasion and Induces Apoptosis through the Modulation of Peroxisome Proliferator-activated Receptor γ Activation Pathway in Gastric Cancer

(2012) Lalitha Ramachandran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Establishment of a Standardized Liver Fibrosis Model with Different Pathological Stages in Rats

(2012) Li Li et al.   Gastroenterology Research and Practice

Mechanisms of hepatic fibrogenesis

(2011) Ursula E. Lee et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

TGF-β in progression of liver disease

(2011) Steven Dooley et al.   CELL AND TISSUE RESEARCH

Peroxisome proliferator-activated receptor gamma inhibits hepatic fibrosis in rats

(2011) Zheng Wang et al.   Hepatobiliary & Pancreatic Diseases International

A role for autophagy during hepatic stellate cell activation

(2011) Lien F.R. Thoen et al.   JOURNAL OF HEPATOLOGY

Induction of Heart Valve Lesions by Small-Molecule ALK5 Inhibitors

(2011) Mark J. Anderton et al.   TOXICOLOGIC PATHOLOGY

Smaddening Complexity: The Role of Smad3 in Epithelial-Myofibroblast Transition

(2010) András Masszi et al.   CELLS TISSUES ORGANS

Loss of Matrix Metalloproteinase-2 Amplifies Murine Toxin-Induced Liver Fibrosis by Upregulating Collagen I Expression

(2010) Brian D. Radbill et al.   DIGESTIVE DISEASES AND SCIENCES

Targeted disruption of Smad3 confers resistance to the development of dimethylnitrosamine-induced hepatic fibrosis in mice

(2009) Giovanni Latella et al.   LIVER INTERNATIONAL

Mechanisms of Hepatic Fibrogenesis

(2008) Scott L. Friedman   GASTROENTEROLOGY

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

(2008) Scott L. Friedman   PHYSIOLOGICAL REVIEWS