Changes of physico-chemical properties of nano-biomaterials by digestion fluids affect the physiological properties of epithelial intestinal cells and barrier models

Simulating Nanomaterial Transformation in Cascaded Biological Compartments to Enhance the Physiological Relevance of In Vitro Dosing Regimes: Optional or Required?

(2021) Samantha V. Llewellyn et al.   Small

The combined effect of food additive titanium dioxide and lipopolysaccharide on mouse intestinal barrier function after chronic exposure of titanium dioxide-contained feedstuffs

(2021) Yongliang Zhang et al.   Particle and Fibre Toxicology

Co-exposure to boscalid and TiO2 (E171) or SiO2 (E551) downregulates cell junction gene expression in small intestinal epithelium cellular model and increases pesticide translocation

(2021) Xiaoqiong Cao et al.   NanoImpact

Tannic acid-fortified zein-pectin nanoparticles: Stability, properties, antioxidant activity, and in vitro digestion

(2021) Xiao Liang et al.   FOOD RESEARCH INTERNATIONAL

Genotoxicity and oxidative stress induction by polystyrene nanoparticles in the colorectal cancer cell line HCT116

(2021) Giulia Vecchiotti et al.   PLoS One

Do Engineered Nanomaterials Affect Immune Responses by Interacting With Gut Microbiota?

(2021) Mingxing Tang et al.   Frontiers in Immunology

Oral nanomedicine for modulating immunity, intestinal barrier functions, and gut microbiome

(2021) Yonghyun Lee et al.   ADVANCED DRUG DELIVERY REVIEWS

Caco-2 in vitro model of human gastrointestinal tract for studying the absorption of titanium dioxide and silver nanoparticles from seafood

(2021) María Vanesa Taboada-López et al.   TALANTA

Evaluation of the Genotoxic and Oxidative Damage Potential of Silver Nanoparticles in Human NCM460 and HCT116 Cells

(2020) Mingxi Jia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Stability and Dynamic Aggregation of Bare and Stabilized Zero-Valent Iron Nanoparticles under Variable Solution Chemistry

(2020) Hesham M. Ibrahim et al.   Nanomaterials

Small silica nanoparticles transiently modulate the intestinal permeability by actin cytoskeleton disruption in both Caco-2 and Caco-2/HT29-MTX models

(2020) Raphaël Cornu et al.   ARCHIVES OF TOXICOLOGY

Rat Blood Leukocytes after Intravenous Injection of Chitosan-Modified Magnetic Nanospheres

(2020) I. V. Milto et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Functionalized Surface-Charged SiO2 Nanoparticles Induce Pro-Inflammatory Responses, but Are Not Lethal to Caco-2 Cells

(2020) Saeko Tada-Oikawa et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Synthesis and Physicochemical Transformations of Size‐Sorted Graphene Oxide during Simulated Digestion and Its Toxicological Assessment against an In Vitro Model of the Human Intestinal Epithelium

(2020) Dimitrios Bitounis et al.   Small

The impact of synthetic amorphous silica (E 551) on differentiated Caco-2 cells, a model for the human intestinal epithelium

(2020) Claudia Hempt et al.   TOXICOLOGY IN VITRO

Nanoparticle Digestion Simulator Reveals pH-dependent Aggregation in the Gastrointestinal Tract

(2020) Jia H. Shi et al.   ANALYTICAL CHEMISTRY

Analysis of cerium oxide and copper oxide nanoparticles bioaccessibility from radish using SP‐ICP‐MS

(2020) Maria Hayder et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Transformation of Nanomaterials and Its Implications in Gut Nanotoxicology

(2020) Magdiel Inggrid Setyawati et al.   Small

Ultrasonicated resveratrol loaded starch nanocapsules: Characterization, bioactivity and release behaviour under in-vitro digestion

(2020) Mudasir Ahmad et al.   CARBOHYDRATE POLYMERS

Comparing the permeability of human and porcine small intestinal mucus for particle transport studies

(2020) Lukasz Krupa et al.   Scientific Reports

Investigations of acute effects of polystyrene and polyvinyl chloride micro- and nanoplastics in an advanced in vitro triple culture model of the healthy and inflamed intestine

(2020) Mathias Busch et al.   ENVIRONMENTAL RESEARCH

Effect of food on orally-ingested titanium dioxide and zinc oxide nanoparticle behaviors in simulated digestive tract

(2020) Pengfei Zhou et al.   CHEMOSPHERE

IL-22 Preserves Gut Epithelial Integrity and Promotes Disease Remission during Chronic Salmonella Infection

(2019) Bernard C. Lo et al.   JOURNAL OF IMMUNOLOGY

Temperature- and rigidity-mediated rapid transport of lipid nanovesicles in hydrogels

(2019) Miaorong Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-31 Reduces Inflammatory Signaling and Promotes Regeneration in Colon Epithelium, and Delivery of Mimics in Microspheres Reduces Colitis in Mice

(2019) Yuhua Tian et al.   GASTROENTEROLOGY

Pro- and anti-oxidant properties of near-infrared (NIR) light responsive carbon nanoparticles

(2019) Ida Kokalari et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cytotoxic and proinflammatory responses induced by ZnO nanoparticles in in vitro intestinal barrier

(2019) Graziano Colombo et al.   JOURNAL OF APPLIED TOXICOLOGY

Formation and properties of amorphous magnesium-calcium phosphate particles in a simulated intestinal fluid

(2019) Rita Gelli et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Polymeric nanoparticles as an alternative for application of gibberellic acid in sustainable agriculture: a field study

(2019) Anderson do Espírito Santo Pereira et al.   Scientific Reports

Epithelial Cells as a Transmitter of Signals From Commensal Bacteria and Host Immune Cells

(2019) Yoshiyuki Goto   Frontiers in Immunology

In Vitro Intestinal Uptake And Permeability Of Fluorescently-Labelled Hyaluronic Acid Nanogels

(2019) Miguel Xavier et al.   International Journal of Nanomedicine

Impact of in vitro digestion on gastrointestinal fate and uptake of silver nanoparticles with different surface modifications

(2019) Ashraf Abdelkhaliq et al.   Nanotoxicology

Applicability and Limitations in the Characterization of Poly-Dispersed Engineered Nanomaterials in Cell Media by Dynamic Light Scattering (DLS)

(2019) Arianna Marucco et al.   Materials

Exosomes Derived From M2b Macrophages Attenuate DSS-Induced Colitis

(2019) Ruibing Yang et al.   Frontiers in Immunology

Anionic nanoparticles enable the oral delivery of proteins by enhancing intestinal permeability

(2019) Nicholas G. Lamson et al.   Nature Biomedical Engineering

Low-density polyethylene films incorporated with silver nanoparticles to promote antimicrobial efficiency in food packaging

(2019) Sabrina da Costa Brito et al.   FOOD SCIENCE AND TECHNOLOGY INTERNATIONAL

Improvement of Commercially Valuable Traits of Industrial Crops by Application of Carbon-based Nanomaterials

(2019) Kamal Pandey et al.   Scientific Reports

Reversibly pH-responsive gold nanoparticles and their applications for photothermal cancer therapy

(2019) Sanghak Park et al.   Scientific Reports

Dissolution Behavior And Biodurability Of Ingested Engineered Nanomaterials In The Gastrointestinal Environment

(2018) Ikjot Singh Sohal et al.   ACS Nano

Targeting Endothelial Cell Junctions with Negatively Charged Gold Nanoparticles

(2018) Jinping Wang et al.   CHEMISTRY OF MATERIALS

Titanium dioxide nanoparticle–protein interaction explained by docking approach

(2018) Shivendu Ranjan et al.   International Journal of Nanomedicine

Use of a Caco-2 permeability assay to evaluate the effects of several Kampo medicines on the drug transporter P-glycoprotein

(2018) Takashi Matsumoto et al.   Journal of Natural Medicines

Incorporation of Metallic Nanoparticles into Cosmetic Preparations and Assessment of Their Physicochemical and Utility Properties

(2018) Jolanta Pulit-Prociak et al.   JOURNAL OF SURFACTANTS AND DETERGENTS

Structure and Interaction of Nanoparticle–Protein Complexes

(2018) Sugam Kumar et al.   LANGMUIR

Preparation and characterization of hydroxyapatite nanoparticles carrying insulin and gallic acid for insulin oral delivery

(2018) Yuxiao Zhang et al.   Nanomedicine-Nanotechnology Biology and Medicine

Ingested engineered nanomaterials: state of science in nanotoxicity testing and future research needs

(2018) Ikjot Singh Sohal et al.   Particle and Fibre Toxicology

Applications of Panax ginseng leaves-mediated gold nanoparticles in cosmetics relation to antioxidant, moisture retention, and whitening effect on B16BL6 cells

(2018) Zuly Elizabeth Jiménez-Pérez et al.   Journal of Ginseng Research

Mucoadhesive chitosan-coated PLGA nanoparticles for oral delivery of ferulic acid

(2018) Isabela Angeli de Lima et al.   Artificial Cells Nanomedicine and Biotechnology

Interaction of nanoparticles with biological systems

(2018) Peter Gehr   COLLOIDS AND SURFACES B-BIOINTERFACES

Toxicological impact of acute exposure to E171 food additive and TiO2 nanoparticles on a co-culture of Caco-2 and HT29-MTX intestinal cells

(2018) Marie Dorier et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Intestinal Dendritic Cells in Health and Gut Inflammation

(2018) Andrew J. Stagg   Frontiers in Immunology

Loading of fish oil into nanocarriers prepared through gelatin-gum Arabic complexation

(2018) Rahimeh Esfahani et al.   FOOD HYDROCOLLOIDS

Effect of Protein Corona on Silver Nanoparticle Stabilization and Ion Release Kinetics in Artificial Seawater

(2017) Maja Levak et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Effects of calcium on lipid digestion in nanoemulsions stabilized by modified starch: Implications for bioaccessibility of β -carotene

(2017) Quanquan Lin et al.   FOOD HYDROCOLLOIDS

Polyarginine nanocapsules: A versatile nanocarrier with potential in transmucosal drug delivery

(2017) Ana Gonzalez-Paredes et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Polyester–Solid Lipid Mixed Nanoparticles with Improved Stability in Gastro-Intestinal Tract Facilitated Oral Delivery of Larotaxel

(2017) Jingxin Gou et al.   MOLECULAR PHARMACEUTICS

The unrecognized occupational relevance of the interaction between engineered nanomaterials and the gastro-intestinal tract: a consensus paper from a multidisciplinary working group

(2017) Antonio Pietroiusti et al.   Particle and Fibre Toxicology

An integrated methodology for assessing the impact of food matrix and gastrointestinal effects on the biokinetics and cellular toxicity of ingested engineered nanomaterials

(2017) Glen M. DeLoid et al.   Particle and Fibre Toxicology

Effects of food-borne nanomaterials on gastrointestinal tissues and microbiota

(2017) Hans Bouwmeester et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Regulation of intestinal permeability: The role of proteases

(2017) Hanne Van Spaendonk et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Induced Pluripotent Stem Cell (iPSC)–Derived Extracellular Vesicles Are Safer and More Effective for Cardiac Repair Than iPSCs

(2017) Marta Adamiak et al.   CIRCULATION RESEARCH

Mathematical Nanotoxicoproteomics: Quantitative Characterization of Effects of Multi-walled Carbon Nanotubes (MWCNT) and TiO2 Nanobelts (TiO2-NB) on Protein Expression Patterns in Human Intestinal Cells

(2016) Subhash Basak et al.   Current Computer-Aided Drug Design

Titanium dioxide nanoparticles exacerbate DSS-induced colitis: role of the NLRP3 inflammasome

(2016) Pedro A Ruiz et al.   GUT

Titanium dioxide food additive (E171) induces ROS formation and genotoxicity: contribution of micro and nano-sized fractions

(2016) Héloïse Proquin et al.   MUTAGENESIS

Mechanism of hard-nanomaterial clearance by the liver

(2016) Kim M. Tsoi et al.   NATURE MATERIALS

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

The MaxQuant computational platform for mass spectrometry-based shotgun proteomics

(2016) Stefka Tyanova et al.   Nature Protocols

Protein corona-induced modification of silver nanoparticle aggregation in simulated gastric fluid

(2016) Andrew P. Ault et al.   Environmental Science-Nano

Biocorona Bound Gold Nanoparticles Augment Their Hematocompatibility Irrespective of Size or Surface Charge

(2016) Abhilash Sasidharan et al.   ACS Biomaterials-Science & Engineering

Biocorona Bound Gold Nanoparticles Augment Their Hematocompatibility Irrespective of Size or Surface Charge

(2016) Abhilash Sasidharan et al.   ACS Biomaterials Science & Engineering

Lipid nanoparticles enhance the efficacy of chemotherapy in primary and metastatic human osteosarcoma cells

(2015) Yolanda González-Fernández et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Cellulose nanocrystals with tunable surface charge for nanomedicine

(2015) Zeinab Hosseinidoust et al.   Nanoscale

Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration

(2015) Caroline A. Lindemans et al.   NATURE

Comprehensive In Vitro Toxicity Testing of a Panel of Representative Oxide Nanomaterials: First Steps towards an Intelligent Testing Strategy

(2015) Lucian Farcal et al.   PLoS One

Interactions between mammalian cells and nano- or micro-sized wear particles: Physico-chemical views against biological approaches

(2014) Polina Prokopovich   ADVANCES IN COLLOID AND INTERFACE SCIENCE

Optimized ferrozine-based assay for dissolved iron

(2014) Thomas M. Jeitner   ANALYTICAL BIOCHEMISTRY

In vitrolipolysis tests on lipid nanoparticles: comparison between lipase/co-lipase and pancreatic extract

(2014) Vincent Jannin et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Dermal exposure potential from textiles that contain silver nanoparticles

(2014) Aleksandr B. Stefaniak et al.   INTERNATIONAL JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH

‘Stealth’ lipid-based formulations: Poly(ethylene glycol)-mediated digestion inhibition improves oral bioavailability of a model poorly water soluble drug

(2014) Orlagh M. Feeney et al.   JOURNAL OF CONTROLLED RELEASE

Dissolution, Agglomerate Morphology, and Stability Limits of Protein-Coated Silver Nanoparticles

(2014) Matthew N. Martin et al.   LANGMUIR

Development and evaluation of lipid nanocarriers for quercetin delivery: A comparative study of solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), and lipid nanoemulsions (LNE)

(2014) N.P. Aditya et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Titanium dioxide nanoparticle impact and translocation through ex vivo, in vivo and in vitro gut epithelia

(2014) Emilie Brun et al.   Particle and Fibre Toxicology

Screening of budesonide nanoformulations for treatment of inflammatory bowel disease in an inflamed 3D cell-culture model

(2014) Fransisca Leonard   ALTEX-Alternatives to Animal Experimentation

Fabrication of coated bovine serum albumin (BSA)–epigallocatechin gallate (EGCG) nanoparticles and their transport across monolayers of human intestinal epithelial Caco-2 cells

(2014) Zheng Li et al.   Food & Function

Physicochemical properties and in vitro intestinal permeability properties and intestinal cell toxicity of silica particles, performed in simulated gastrointestinal fluids

(2013) Kumiko Sakai-Kato et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Specificity of Infant Digestive Conditions: Some Clues for Developing Relevant In Vitro Models

(2013) Claire Bourlieu et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

A novel preservation technique applied to fiordilatte cheese

(2013) A. Conte et al.   Innovative Food Science & Emerging Technologies

Bridge over troubled waters: understanding the synthetic and biological identities of engineered nanomaterials

(2013) Bengt Fadeel et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Cyproterone Synthesis, Recognition and Controlled Release by Molecularly Imprinted Nanoparticle

(2012) Ebadullah Asadi et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Systematic investigation on the interaction of bovine serum albumin with ZnO nanoparticles using fluorescence spectroscopy

(2012) A. Bhogale et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Behaviour of silver nanoparticles and silver ions in anin vitrohuman gastrointestinal digestion model

(2012) Agata P. Walczak et al.   Nanotoxicology

Influence of simulated gastrointestinal conditions on particle-induced cytotoxicity and interleukin-8 regulation in differentiated and undifferentiated Caco-2 cells

(2012) Kirsten Gerloff et al.   Nanotoxicology

The Evolution of the Protein Corona around Nanoparticles: A Test Study

(2011) Martin Lundqvist et al.   ACS Nano

Size and surface charge of gold nanoparticles determine absorption across intestinal barriers and accumulation in secondary target organs after oral administration

(2011) Carsten Schleh et al.   Nanotoxicology

A protocol for in situ enzyme assays to assess the differentiation of human intestinal Caco-2 cells

(2011) Simonetta Ferruzza et al.   TOXICOLOGY IN VITRO

Effects of Cell Culture Media on the Dynamic Formation of Protein−Nanoparticle Complexes and Influence on the Cellular Response

(2010) Gabriele Maiorano et al.   ACS Nano

Epithelial Barriers in Homeostasis and Disease

(2010) Amanda M. Marchiando et al.   Annual Review of Pathology-Mechanisms of Disease

A/C magnetic hyperthermia of melanoma mediated by iron(0)/iron oxide core/shell magnetic nanoparticles: a mouse study

(2010) Sivasai Balivada et al.   BMC CANCER

What the Cell “Sees” in Bionanoscience

(2010) Dorota Walczyk et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Physico-chemical features of engineered nanoparticles relevant to their toxicity

(2010) Bice Fubini et al.   Nanotoxicology

ISDD: A computational model of particle sedimentation, diffusion and target cell dosimetry for in vitro toxicity studies

(2010) Paul M Hinderliter et al.   Particle and Fibre Toxicology

Mechanism of cytokine modulation of epithelial tight junction barrier

(2009) Rana Al-Sadi   Frontiers in Bioscience-Landmark

Microparticle transport in the human intestinal M cell model

(2008) Yin Hwa Lai et al.   JOURNAL OF DRUG TARGETING

Changes in the expression of claudins in active ulcerative colitis

(2008) Tadayuki Oshima et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Proteomic Analysis for the Assessment of Different Lots of Fetal Bovine Serum as a Raw Material for Cell Culture. Part IV. Application of Proteomics to the Manufacture of Biological Drugs

(2006) Xiaoyang Zheng et al.   BIOTECHNOLOGY PROGRESS