Article
Pharmacology & Pharmacy
Beatriz Lasa-Saracibar, Souhaila H. El Moukhtari, Theodoros Tsotakos, Stavros Xanthopoulos, George Loudos, Penelope Bouziotis, Maria J. Blanco-Prieto
Summary: Nanoencapsulated Edelfosine is effective in various types of tumors, and biodistribution studies revealed that the intraperitoneal route is optimal for sustaining consistent blood levels and avoiding accumulation in RES organs.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Biophysics
Xueling Yin, Siyi Ran, Haoyan Cheng, Meng Zhang, Wei Sun, Ying Wan, Chunsheng Shao, Zhihong Zhu
Summary: This study develops a novel drug delivery system based on polydopamine-modified ZIF-8 nanoparticles loaded with methotrexate, and combines it with photothermal therapy, aiming to achieve synergistic treatment of osteosarcoma and enhance the therapeutic efficacy of anticancer drugs.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Biotechnology & Applied Microbiology
Chaitali Surve, Ananya Banerjee, S. Anupriya, Rajasree Chakraborty, Dhiraj Kumar, Ramesh Butti, Mahadeo Gorain, Sabyasachi Parida, Gopal C. Kundu, Supriya Shidhaye, Srinivas Patnaik
Summary: The efficacy of novel methotrexate-loaded nanoparticles (MTX-NPs) in the treatment of breast cancer was evaluated in vitro and in vivo. The results showed that MTX-NPs have improved cellular uptake and in vivo efficacy, making them a promising candidate for breast cancer treatment.
Review
Pharmacology & Pharmacy
Masomeh Maleki, Asal Golchin, Forough Alemi, Simin Younesi, Zatollah Asemi, Samira Javadi, Payam Ali Khiavi, Jafar Soleinmapour, Bahman Yousefi
Summary: This study systematically reviewed the cytotoxic effects and apoptosis of nanoparticles (NPs) on cellular viability in vitro. It found that 43.47% of synthesized NPs showed no toxicity to osteosarcoma cells, while 39.13% showed time and/or concentration-related cytotoxicity. There was a significant difference in the half-maximal inhibitory concentration (IC50) between drug and drug/NP in all studies, indicating the potential for using NPs as drug delivery systems.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Oncology
Stefan S. Bielack, Beate Kempf-Bielack, Guenter Delling, G. Ulrich Exner, Silke Flege, Knut Helmke, Rainer Kotz, Mechthild Salzer-Kuntschik, Matthias Werner, Winfried Winkelmann, Andreas Zoubek, Heribert Juergens, Kurt Winkler
Summary: The study aims to identify prognostic factors for a wide range of osteosarcomas, beyond those typically seen in young patients with localized extremity disease. The analysis of demographic, tumor-related, and treatment-related variables, response, and survival of 1,702 newly diagnosed patients revealed that tumor location and size, primary metastases, response to chemotherapy, and surgical remission are important independent prognostic factors for osteosarcoma.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Medicine, General & Internal
Jun-Ping Yan, Rong-Mei Xiang
Summary: This study investigates the clinical therapeutic effects of combining methotrexate with other chemotherapeutic agents for treating osteosarcoma in children, providing substantial quality evidence for this treatment approach.
Article
Chemistry, Physical
Sheeba Malik, Smarajit Karmakar, Ananya Debnath
Summary: All-atom molecular dynamics simulations reveal a significant growth in the heterogeneity length scales of interface water (IW) in 1,2-dimyristoyl-sn-glycero-3-phosphocholine lipid membranes across fluid to ripple to gel phase transitions. IW acts as an alternate probe to capture the ripple size of the membrane and follows an activated dynamical scaling within the gel phase. These results quantify the mostly unknown correlations between the spatiotemporal scales of IW and membranes at various phases under physiological and supercooled conditions.
JOURNAL OF CHEMICAL PHYSICS
(2023)
Article
Materials Science, Biomaterials
Yong-Chao Wang, Hong-Lian Dai, Ze-Hao Li, Zhi-Yuan Meng, Yao Xiao, Zheng Zhao
Summary: In this study, a novel nanocomposite system AI-MPHA NCs for photothermal therapy was developed, demonstrating the ability to induce NO gas therapy under NIR irradiation and effectively ablate osteosarcoma.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Review
Medicine, General & Internal
Cheng Peng, Zhinan Ren, Jian Zhu, Panke Zhang, Shuyan Cao, Yingjie Hao
Summary: The study aims to examine the clinical therapeutic impacts of combined methotrexate along with other chemotherapeutic agents for treating osteosarcoma in children and young adults. The research will analyze literature from English and Chinese databases, assess bias risks, and evaluate heterogeneity among studies. The results are expected to provide significant evidence and clinical recommendations for the treatment of osteosarcoma.
Article
Cell Biology
Trang Le, Sumeyye Su, Leili Shahriyari
Summary: This study developed a mathematical model for osteosarcoma, analyzing three clusters of tumors with unique immune profiles to suggest optimal drug dosages. The effects of chemotherapy regimens and treatment start times on immune and cancer cell behaviors were investigated. The results showed that the MAP regimen was effective in killing cancer cells, and consideration of the tumor's growth rate is crucial when determining treatment details.
Article
Chemistry, Multidisciplinary
Yucheng Fu, Guoyu He, Zhuochao Liu, Jun Wang, Meng Li, Zhusheng Zhang, Qiyuan Bao, Junxiang Wen, Xinyuan Zhu, Chuan Zhang, Weibin Zhang
Summary: Inspired by the Watson-Crick base pairing in nucleic acids, hydrophobic and hydrophilic chemo-drugs are self-assembled into nanoparticles and coated with cancer cell membranes. These cancer-cell membrane-coated nanoparticles exhibit excellent stability, tumor-targeting capability, and inhibit the PI3K/AKT/mTOR pathway, promoting cancer cell apoptosis and cell cycle arrest. The cell membrane camouflage significantly prolongs the circulation half-life of nanoparticles, enhances drug accumulation at tumor sites, and improves anti-tumor efficacy.
Article
Cell Biology
Richa Rathore, Katharine E. Caldwell, Charles Schutt, Caitlyn B. Brashears, Bethany C. Prudner, William R. Ehrhardt, Cheuk Hong Leung, Heather Lin, Najat C. Daw, Hannah C. Beird, Abigail Giles, Wei-Lien Wang, Alexander J. Lazar, John S. A. Chrisinger, J. Andrew Livingston, Brian A. Van Tine
Summary: Inhibition of PHGDH in osteosarcoma cells leads to metabolic changes, activating pro-survival mTORC1 signaling. This increased mTORC1 activation sensitizes cells to mTORC1 pathway inhibition, resulting in significant cell death. This study offers a potential dual metabolism-based combination therapy for osteosarcoma with preclinical justification.
Article
Oncology
Nicole Bodmer, Stefanie Hecker-Nolting, Godehard Friedel, Claudia Blattmann, Leo Kager, Torsten Kessler, Matthias Kevric Dok, Thomas Kuhne, Vanessa Mettmann, Peter Mueller-Abt, Benjamin Sorg, Matthias Theobald, Stefan S. Bielack
Summary: This study analyzed the clinical characteristics and optimal therapeutic strategies for primary rib osteosarcoma. The results showed that surgery and chemotherapy played a key role in treatment, but negative prognostic factors included incomplete tumor surgery, osteoblastic histology, and poor response to chemotherapy. Early diagnosis and effective local control are crucial for better outcomes.
Article
Biochemistry & Molecular Biology
Catia Santos-Pereira, Joana P. Guedes, Debora Ferreira, Ligia R. Rodrigues, Manuela Corte-Real
Summary: The milk-derived bovine lactoferrin (bLf) has selective anticancer activity against highly metastatic cancer cells with V-ATPase at the plasma membrane. It co-localizes with V-ATPase and cholesterol-rich lipid rafts, perturbs cellular trafficking, induces cholesterol accumulation and disrupts lipid rafts, downregulates PI3K and AKT/p-AKT, and inhibits glycolysis of cancer cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Multidisciplinary
Yoshimi Oka
Summary: Membrane-anchored proteins and their mimics, such as PNAs, show selective partitioning into lipid raft or non-raft domains based on their lipophilic anchors. In this study, anchor-matched PNA was found to be excluded from the lipid raft domains of giant unilamellar vesicles when hybridized with complementary flavin-labeled DNA. The distribution of PNA was not only dependent on the lipophilic anchor, but also on the structure of the hybridized DNA or PNA pair.
Article
Instruments & Instrumentation
Edurne Luque-Michel, Laurent Lemaire, Maria J. Blanco-Prieto
Summary: Researchers developed polymeric nanoparticles loaded with SPION and DOX, successfully achieving targeted accumulation in tumor tissue in experimental mice, leading to a reduction in tumor growth rate.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Review
Chemistry, Multidisciplinary
Laura Saludas, Claudia C. Oliveira, Carmen Roncal, Adrian Ruiz-Villalba, Felipe Prosper, Elisa Garbayo, Maria J. Blanco-Prieto
Summary: Extracellular vesicles (EVs) are heterogeneous membrane vesicles secreted by most cell types that play a crucial role in cell-cell communication. Recent studies have suggested that EVs may serve as a novel therapeutic option for cardiovascular diseases, showing desirable features for cardiac repair. Additionally, EVs as drug delivery vehicles may overcome limitations associated with current drug delivery systems.
Editorial Material
Instruments & Instrumentation
Maria J. Blanco-Prieto, Helena F. Florindo
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Article
Oncology
Stefano Gambera, Ana Patino-Garcia, Arantzazu Alfranca, Javier Garcia-Castro
Summary: There is a renewed interest in cancer heterogeneity and clonal dynamics governing tumor growth, progression, and therapy resistance. Sequencing data suggest different cancer development models related to patients' prognosis and therapeutic response. Some studies have reconstructed the evolution of osteosarcoma, showing evidence of linear and branched clonal development patterns.
Review
Pharmacology & Pharmacy
Souhaila H. El Moukhtari, Carlos Rodriguez-Nogales, Maria J. Blanco-Prieto
Summary: Oral anticancer drugs play a crucial role in cancer treatment, and lipid nanoparticles are proposed to overcome the main obstacle in oral chemotherapy delivery. Lipid nanoparticles have unique characteristics that allow efficient drug absorption and protection from early degradation.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Chemistry, Medicinal
Carlos Rodriguez-Nogales, Didier Desmaele, Victor Sebastian, Patrick Couvreur, Maria J. Blanco-Prieto
Summary: A novel bone-affine squalene-based nanomedicine was developed by conjugating a hydroxybisphosphonate moiety to the squalene chain and inserting it into squalenoyl-gemcitabine nanoparticles. The presence of squalenyl-hydroxybisphosphonate enhanced nanoparticles' binding affinity for hydroxyapatite in bones and preserved their anticancer activity in vitro. Further in vivo studies are needed to explore the potential of these nanomedicines for treating bone sarcomas.
Article
Pharmacology & Pharmacy
Laura Saludas, Elisa Garbayo, Adrian Ruiz-Villalba, Silvia Hernandez, Pieter Vader, Felipe Prosper, Maria J. Blanco-Prieto
Summary: Extracellular vesicles (EVs), as the next-generation therapies, have attracted great interest. This study investigated the effects of different cell culture conditions and purification methods on EV isolation using cardiac progenitor cells (CPCs). The findings contribute to the establishment of the basis for the use of EVs as therapeutic platforms.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Beatriz Lasa-Saracibar, Souhaila H. El Moukhtari, Theodoros Tsotakos, Stavros Xanthopoulos, George Loudos, Penelope Bouziotis, Maria J. Blanco-Prieto
Summary: Nanoencapsulated Edelfosine is effective in various types of tumors, and biodistribution studies revealed that the intraperitoneal route is optimal for sustaining consistent blood levels and avoiding accumulation in RES organs.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Review
Oncology
Luisa Sanchez-Lorenzo, Diego Salas-Benito, Julia Villamayor, Ana Patino-Garcia, Antonio Gonzalez-Martin
Summary: Epithelial ovarian cancer is the most lethal gynecological cancer, and germline and somatic mutations in breast cancer genes play important roles in genetic counseling and treatment. The use of PARP inhibitors has revolutionized the treatment of ovarian cancer.
Article
Chemistry, Multidisciplinary
Souhaila H. El Moukhtari, Elisa Garbayo, Ana Fernandez-Teijeiro, Carlos Rodriguez-Nogales, Patrick Couvreur, Maria J. Blanco-Prieto
Summary: Embryonal tumors of the nervous system, such as neuroblastoma (NB) and medulloblastoma (MB), mainly affect children and pose significant treatment challenges. Nanomedicine and cell therapy have emerged as potential solutions to improve the prognosis and quality of life for pediatric patients with these tumors. However, there are various obstacles hindering pediatric drug research and translation into clinical practice.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biochemistry & Molecular Biology
Pablo Vicente Torres-Ortega, Ruben Del Campo-Montoya, Daniel Plano, Jacobo Paredes, Javier Aldazabal, Maria-Rosario Luquin, Enrique Santamaria, Carmen Sanmartin, Maria J. Blanco-Prieto, Elisa Garbayo
Summary: The co-administration of GDNF and MSCs in nanoparticle-modified supramolecular HGs provides a promising drug delivery system for brain repair. The multifunctional HG is mechanically compatible with brain tissue, easily injectable, and protects GDNF from degradation. The inclusion of MSCs in the nanoreinforced HG enhances their anti-inflammatory effect and promotes their differentiation into neuron-like cells.
Review
Pharmacology & Pharmacy
Ruben Del Campo-Montoya, Maria-Rosario Luquin, Elena Puerta, Elisa Garbayo, Maria J. Blanco-Prieto
Summary: This article discusses the potential application of hydrogel-based therapies for Parkinson's disease. It addresses the desirable composition and mechanical properties of these therapies for brain application, as well as the preclinical research available with hydrogels in Parkinson's disease. Lastly, translational and manufacturing challenges are presented.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Article
Pharmacology & Pharmacy
Paula Gil-Cabrerizo, Ilaria Scacchetti, Elisa Garbayo, Maria J. Blanco-Prieto
Summary: Myocardial infarction is a major cause of illness and death worldwide. Current treatments for myocardial ischemia can relieve symptoms but cannot repair necrotic heart tissue. New therapeutic strategies involving cellular and acellular therapies, as well as biomaterial-based delivery systems, show promise in restoring cardiac function and preventing complications. This review explores recent advancements in these approaches and discusses the challenges that need to be addressed for the clinical translation of cardiac tissue engineering.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Cell Biology
Aurora Gomez-Vecino, Roberto Corchado-Cobos, Adrian Blanco-Gomez, Natalia Garcia-Sancha, Sonia Castillo-Lluva, Ana Martin-Garcia, Marina Mendiburu-Elicabe, Carlos Prieto, Sara Ruiz-Pinto, Guillermo Pita, Alejandro Velasco-Ruiz, Carmen Patino-Alonso, Purificacion Galindo-Villardon, Maria Linarejos Vera-Pedrosa, Jose Jalife, Jian-Hua Mao, Guillermo Macias de Plasencia, Andres Castellanos-Martin, Maria del Mar Saez-Freire, Susana Fraile-Martin, Telmo Rodrigues-Teixeira, Carmen Garcia-Macias, Julie Milena Galvis-Jimenez, Asuncion Garcia-Sanchez, Maria Isidoro-Garcia, Manuel Fuentes, Maria Begona Garcia-Cenador, Francisco Javier Garcia-Criado, Juan Luis Garcia-Hernandez, Maria Angeles Hernandez-Garcia, Juan Jesus Cruz-Hernandez, Cesar Augusto Rodriguez-Sanchez, Alejandro Martin Garcia-Sancho, Estefania Perez-Lopez, Antonio Perez-Martinez, Federico Gutierrez-Larraya, Antonio J. Carton, Jose Angel Garcia-Saenz, Ana Patino-Garcia, Miguel Martin, Teresa Alonso-Gordoa, Christof Vulsteke, Lieselot Croes, Sigrid Hatse, Thomas Van Brussel, Diether Lambrechts, Hans Wildiers, Hang Chang, Marina Holgado-Madruga, Anna Gonzalez-Neira, Pedro L. Sanchez, Jesu Perez Losada
Summary: Cardiotoxicity due to anthracyclines (CDA) affects cancer patients, and identifying individuals at risk is challenging. In this study, the authors investigated intermediate molecular phenotypes (IMPs) associated with myocardial damage to determine CDA susceptibility. By analyzing a mouse cohort treated with doxorubicin and docetaxel, they identified genetic markers linked to IMPs and CDA. These markers were also found to be associated with CDA in cancer patients, highlighting their potential as predictive factors. Additionally, genetic risk scores were generated using machine-learning regression to personalize patient management.
Article
Materials Science, Biomaterials
Adria Botet-Carreras, Cristina Tamames-Tabar, Fabrice Salles, Sara Rojas, Edurne Imbuluzqueta, Hugo Lana, Maria Jose Blanco-Prieto, Patricia Horcajada
Summary: This study successfully encapsulated genistein in mesoporous MIL-100 nanoparticles, demonstrating sustained release and higher bioavailability in a mouse model, suggesting potential for efficient oral delivery of nontoxic antitumor drugs.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Pharmacology & Pharmacy
Xueliang Xiu, Shichao Ma, Zhiyong Li, Zhipeng Li, Xuemei Li, Yangtao Ruan, Dezhao Li, Jianwei Wang, Fengsen Ma
Summary: Liposomes are promising delivery vehicles for drugs and vaccines. The use of microfluidic chips for liposome preparation is an effective method. However, traditional liposome preparation technologies hinder their industrial production and clinical application. This study presents a novel three-dimensional integrated microfluidic device for continuous liposome preparation and purification, which shows potential for industrial production of nano-pharmaceutical applications.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2024)