Journal
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
Volume 14, Issue 2, Pages 353-364Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.nano.2017.11.012
Keywords
Diabetes; Oral delivery system; Nanoparticles; Hydroxyapatite
Funding
- National Natural Science Foundation of China [31370967, 31170919]
- Guangdong Province Universities and Colleges Pearl River Scholar Fund Scheme, China
- Science and Technology Planning Project of Guangdong Province, China [2015A020212033]
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Although nanoparticles carriers for oral delivery of insulin have been researched for many years, this method still fails to solve issues with toxicity, biocompatibility, and degradability in the organism. We therefore developed an innovative conjugation system to solve this problem. Nano hydroxyapatite (HAP) particles were used as the core, then polyethylene glycol (PEG) was wrapped onto the surface of hydroxyapatite, and, finally, insulin (INS) and gallic acid (GA) were conjugated with PEG. PEG functionalized HAP was increased the hydrophilicity of the nanoparticles, also protected them from degradation in the gastrointestinal (GI) tract. Most importantly, the in vivo absorption of nanoparticles in rat small intestines revealed that HAP-PEG-GA-INS was absorbed by the small intestine epithelium. The blood glucose of the type 1 diabetes (T1D) rats that were given intragastrically HAP-PEG-GA-INS showed an obvious downward trend. Overall, we synthesized a safe, non-toxic, and effective oral insulin delivery system. (C) 2017 Elsevier Inc. All rights reserved.
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