Journal
SMALL
Volume 17, Issue 15, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202004630
Keywords
engineered nanomaterial pre-treatment; gastro-intestinal digestion; in vitro hazard assessment; nanomaterials; physico-chemical characterisation
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Funding
- European Union [760813]
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The study shows that engineered nanomaterials may undergo identity transformation after passing through multiple physiological compartments, with pre-treatments enhancing the physiological relevance of in vitro testing. However, pre-treatments are recommended for only specific ENMs.
Would an engineered nanomaterial (ENM) still have the same identity once it reaches a secondary target tissue after a journey through several physiological compartments? Probably not. Does it matter? ENM pre-treatments may enhance the physiological relevance of in vitro testing via controlled transformation of the ENM identity. The implications of material transformation upon reactivity, cytotoxicity, inflammatory, and genotoxic potential of Ag and SiO2 ENM on advanced gastro-intestinal tract cell cultures and 3D liver spheroids are demonstrated. Pre-treatments are recommended for certain ENM only.
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