Ingested engineered nanomaterials: state of science in nanotoxicity testing and future research needs

Criteria to define a more relevant reference sample of titanium dioxide in the context of food: a multiscale approach

(2017) William Dudefoi et al.   Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment

Short-term oral exposure to low doses of nano-sized TiO 2 and potential modulatory effects on intestinal cells

(2017) Maria Grazia Ammendolia et al.   FOOD AND CHEMICAL TOXICOLOGY

Impact of food grade and nano-TiO 2 particles on a human intestinal community

(2017) William Dudefoi et al.   FOOD AND CHEMICAL TOXICOLOGY

Gastric toxicity involving alterations of gastritis-related protein expression in mice following long-term exposure to nano TiO 2

(2017) Fashui Hong et al.   FOOD RESEARCH INTERNATIONAL

Quantitative biokinetics of titanium dioxide nanoparticles after intratracheal instillation in rats: Part 3

(2017) Wolfgang G. Kreyling et al.   Nanotoxicology

Biokinetics of engineered nano-TiO2 in rats administered by different exposure routes: implications for human health

(2017) Dhimiter Bello et al.   Nanotoxicology

Quantitative biokinetics of titanium dioxide nanoparticles after oral application in rats: Part 2

(2017) Wolfgang G. Kreyling et al.   Nanotoxicology

Preparation, characterization, and in vitro dosimetry of dispersed, engineered nanomaterials

(2017) Glen M DeLoid et al.   Nature Protocols

The unrecognized occupational relevance of the interaction between engineered nanomaterials and the gastro-intestinal tract: a consensus paper from a multidisciplinary working group

(2017) Antonio Pietroiusti et al.   Particle and Fibre Toxicology

An integrated methodology for assessing the impact of food matrix and gastrointestinal effects on the biokinetics and cellular toxicity of ingested engineered nanomaterials

(2017) Glen M. DeLoid et al.   Particle and Fibre Toxicology

Food-grade TiO2 impairs intestinal and systemic immune homeostasis, initiates preneoplastic lesions and promotes aberrant crypt development in the rat colon

(2017) Sarah Bettini et al.   Scientific Reports

Consideration of interaction between nanoparticles and food components for the safety assessment of nanoparticles following oral exposure: A review

(2016) Yi Cao et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Food-grade titanium dioxide exposure exacerbates tumor formation in colitis associated cancer model

(2016) Ismael M. Urrutia-Ortega et al.   FOOD AND CHEMICAL TOXICOLOGY

Oral intake of added titanium dioxide and its nanofraction from food products, food supplements and toothpaste by the Dutch population

(2016) Cathy Rompelberg et al.   Nanotoxicology

Survey of food-grade silica dioxide nanomaterial occurrence, characterization, human gut impacts and fate across its lifecycle

(2016) Yu Yang et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Buoyant Nanoparticles: Implications for Nano-Biointeractions in Cellular Studies

(2016) C. Y. Watson et al.   Small

Critical assessment of toxicological effects of ingested nanoparticles

(2016) Christie McCracken et al.   Environmental Science-Nano

Effects of pH and phosphate on CeO 2 nanoparticle dissolution

(2015) Jessica T. Dahle et al.   CHEMOSPHERE

Metal Oxide Nanoparticles Induce Minimal Phenotypic Changes in a Model Colon Gut Microbiota

(2015) Alicia A. Taylor et al.   ENVIRONMENTAL ENGINEERING SCIENCE

Silica nanoparticles induce oxidative stress, inflammation, and endothelial dysfunction in vitro via activation of the MAPK/Nrf2 pathway and nuclear factor-κB signaling

(2015) Caixia Guo et al.   International Journal of Nanomedicine

TiO2 Nanoparticle Exposure Decreases Spermatogenesis via Biochemical Dysfunctions in the Testis of Male Mice

(2015) Fashui Hong et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Interactions between nano-TiO2 and the oral cavity: Impact of nanomaterial surface hydrophilicity/hydrophobicity

(2015) Birgit J. Teubl et al.   JOURNAL OF HAZARDOUS MATERIALS

A study of the uptake and biodistribution of nano-titanium dioxide using in vitro and in vivo models of oral intake

(2015) Alan MacNicoll et al.   JOURNAL OF NANOPARTICLE RESEARCH

Interaction of titanium dioxide nanoparticles with glucose on young rats after oral administration

(2015) Zhangjian Chen et al.   Nanomedicine-Nanotechnology Biology and Medicine

Surface modification of zinc oxide nanoparticles with amorphous silica alters their fate in the circulation

(2015) Nagarjun V. Konduru et al.   Nanotoxicology

Implications ofin vitrodosimetry on toxicological ranking of low aspect ratio engineered nanomaterials

(2015) Anoop K. Pal et al.   Nanotoxicology

Dissolution and biodurability: Important parameters needed for risk assessment of nanomaterials

(2015) Wells Utembe et al.   Particle and Fibre Toxicology

Advanced computational modeling for in vitro nanomaterial dosimetry

(2015) Glen M. DeLoid et al.   Particle and Fibre Toxicology

Mechanistic Investigation of the Biological Effects of SiO2, TiO2, and ZnO Nanoparticles on Intestinal Cells

(2015) Magdiel I. Setyawati et al.   Small

Effect of titanium dioxide nanoparticles on the cardiovascular system after oral administration

(2015) Zhangjian Chen et al.   TOXICOLOGY LETTERS

Untangling the biological effects of cerium oxide nanoparticles: the role of surface valence states

(2015) Gerardo Pulido-Reyes et al.   Scientific Reports

Bridging the gap between in vitro and in vivo: Dose and schedule predictions for the ATR inhibitor AZD6738

(2015) Stephen Checkley et al.   Scientific Reports

High Resolution Characterization of Engineered Nanomaterial Dispersions in Complex Media Using Tunable Resistive Pulse Sensing Technology

(2014) Anoop K. Pal et al.   ACS Nano

NIOSH outlines guidance on handling titanium dioxide (TiO2)

(2014)   ANTI-CORROSION METHODS AND MATERIALS

Food grade titanium dioxide disrupts intestinal brush border microvilli in vitro independent of sedimentation

(2014) James J. Faust et al.   CELL BIOLOGY AND TOXICOLOGY

Characterization of Food-Grade Titanium Dioxide: The Presence of Nanosized Particles

(2014) Yu Yang et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Antimicrobial Activity of TiO2Nanoparticle-Coated Film for Potential Food Packaging Applications

(2014) Siti Hajar Othman et al.   INTERNATIONAL JOURNAL OF PHOTOENERGY

A combined toxicity study of zinc oxide nanoparticles and vitamin C in food additives

(2014) Yanli Wang et al.   Nanoscale

The buccal mucosa as a route for TiO2nanoparticle uptake

(2014) Birgit Johanna Teubl et al.   Nanotoxicology

Utility of models of the gastrointestinal tract for assessment of the digestion and absorption of engineered nanomaterials released from food matrices

(2014) David E. Lefebvre et al.   Nanotoxicology

Old materials, new challenges?

(2014) Andrew D. Maynard   Nature Nanotechnology

Equivalent titanium dioxide nanoparticle deposition by intratracheal instillation and whole body inhalation: the effect of dose rate on acute respiratory tract inflammation

(2014) Brittany L Baisch et al.   Particle and Fibre Toxicology

An integrated approach for the in vitro dosimetry of engineered nanomaterials

(2014) Joel M Cohen et al.   Particle and Fibre Toxicology

Titanium dioxide nanoparticle impact and translocation through ex vivo, in vivo and in vitro gut epithelia

(2014) Emilie Brun et al.   Particle and Fibre Toxicology

Uptake of different crystal structures of TiO2 nanoparticles by Caco-2 intestinal cells

(2014) Constantinos Gitrowski et al.   TOXICOLOGY LETTERS

Genotoxic evaluation of titanium dioxide nanoparticles in vivo and in vitro

(2014) Zhangjian Chen et al.   TOXICOLOGY LETTERS

Estimating the effective density of engineered nanomaterials for in vitro dosimetry

(2014) Glen DeLoid et al.   Nature Communications

Engineering safer-by-design silica-coated ZnO nanorods with reduced DNA damage potential

(2014) Georgios A. Sotiriou et al.   Environmental Science-Nano

Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders

(2013) Elaine Y. Hsiao et al.   CELL

Minimal Intestinal Epithelial Cell Toxicity in Response to Short- and Long-Term Food-Relevant Inorganic Nanoparticle Exposure

(2013) Christie McCracken et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Assessing nanoparticle toxicity in cell-based assays: influence of cell culture parameters and optimized models for bridging the in vitro–in vivo gap

(2013) Freya Joris et al.   CHEMICAL SOCIETY REVIEWS

Dispersion Method for Safety Research on Manufactured Nanomaterials

(2013) Wenting WU et al.   INDUSTRIAL HEALTH

Evaluation of the toxicity of food additive silica nanoparticles on gastrointestinal cells

(2013) Yi-Xin Yang et al.   JOURNAL OF APPLIED TOXICOLOGY

Iron oxide nanoparticle agglomeration influences dose rates and modulates oxidative stress-mediated dose–response profilesin vitro

(2013) Gaurav Sharma et al.   Nanotoxicology

Oral, short-term exposure to titanium dioxide nanoparticles in Sprague-Dawley rat: focus on reproductive and endocrine systems and spleen

(2013) Roberta Tassinari et al.   Nanotoxicology

Diet rapidly and reproducibly alters the human gut microbiome

(2013) Lawrence A. David et al.   NATURE

The Effect of Nanoparticle Size, Shape, and Surface Chemistry on Biological Systems

(2012) Alexandre Albanese et al.   Annual Review of Biomedical Engineering

Human intestinal epithelial cells exhibit a cellular response indicating a potential toxicity upon exposure to hematite nanoparticles

(2012) Madhavi Kalive et al.   CELL BIOLOGY AND TOXICOLOGY

Distinctive Toxicity of TiO2 Rutile/Anatase Mixed Phase Nanoparticles on Caco-2 Cells

(2012) Kirsten Gerloff et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Titanium Dioxide Nanoparticles in Food and Personal Care Products

(2012) Alex Weir et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Pharmacokinetics, tissue distribution, and excretion of zinc oxide nanoparticles

(2012) Soo-Jin Choi et al.   International Journal of Nanomedicine

Comparative study of ZnO and TiO2nanoparticles: physicochemical characterisation and toxicological effects on human colon carcinoma cells

(2012) Isabella De Angelis et al.   Nanotoxicology

Behaviour of silver nanoparticles and silver ions in anin vitrohuman gastrointestinal digestion model

(2012) Agata P. Walczak et al.   Nanotoxicology

Influence of simulated gastrointestinal conditions on particle-induced cytotoxicity and interleukin-8 regulation in differentiated and undifferentiated Caco-2 cells

(2012) Kirsten Gerloff et al.   Nanotoxicology

Interactions of engineered nanomaterials in physiological media and implications forin vitrodosimetry

(2012) Joel Cohen et al.   Nanotoxicology

In vitrotoxicity of amorphous silica nanoparticles in human colon carcinoma cells

(2012) Helge Gehrke et al.   Nanotoxicology

Oral exposure to polystyrene nanoparticles affects iron absorption

(2012) Gretchen J. Mahler et al.   Nature Nanotechnology

Intestinal toxicity evaluation of TiO2 degraded surface-treated nanoparticles: a combined physico-chemical and toxicogenomics approach in caco-2 cells

(2012) Matthieu Fisichella et al.   Particle and Fibre Toxicology

The complexity of nanoparticle dissolution and its importance in nanotoxicological studies

(2012) Superb K. Misra et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Exposure to Titanium Dioxide Nanoparticles Induces Autophagy in Primary Human Keratinocytes

(2012) Yun Zhao et al.   Small

Characterization and Preliminary Toxicity Assay of Nano-Titanium Dioxide Additive in Sugar-Coated Chewing Gum

(2012) Xin-Xin Chen et al.   Small

Susceptibility of Young and Adult Rats to the Oral Toxicity of Titanium Dioxide Nanoparticles

(2012) Yun Wang et al.   Small

Comparative study of genotoxicity and tissue distribution of nano and micron sized iron oxide in rats after acute oral treatment

(2012) Shailendra Pratap Singh et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Good Caco-2 cell culture practices

(2012) Manuela Natoli et al.   TOXICOLOGY IN VITRO

Titanium dioxide induced inflammation in the small intestine

(2012) Carolina Maciel Nogueira   WORLD JOURNAL OF GASTROENTEROLOGY

Decreased Dissolution of ZnO by Iron Doping Yields Nanoparticles with Reduced Toxicity in the Rodent Lung and Zebrafish Embryos

(2011) Tian Xia et al.   ACS Nano

Oral drug delivery with polymeric nanoparticles: The gastrointestinal mucus barriers

(2011) Laura M. Ensign et al.   ADVANCED DRUG DELIVERY REVIEWS

Twin Study Indicates Loss of Interaction Between Microbiota and Mucosa of Patients With Ulcerative Colitis

(2011) Patricia Lepage et al.   GASTROENTEROLOGY

TSQ (6-Methoxy-8-p-Toluenesulfonamido-Quinoline), a Common Fluorescent Sensor for Cellular Zinc, Images Zinc Proteins

(2011) Jeffrey W. Meeusen et al.   INORGANIC CHEMISTRY

Molecular mechanism of hippocampal apoptosis of mice following exposure to titanium dioxide nanoparticles

(2011) Renping Hu et al.   JOURNAL OF HAZARDOUS MATERIALS

Induction of oxidative stress, DNA damage and apoptosis in mouse liver after sub-acute oral exposure to zinc oxide nanoparticles

(2011) Vyom Sharma et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Toxicity of zinc oxide nanoparticles through oral route

(2011) Surekha Pasupuleti et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Emerging roles of engineered nanomaterials in the food industry

(2011) V.J. Morris   TRENDS IN BIOTECHNOLOGY

Use of a Rapid Cytotoxicity Screening Approach To Engineer a Safer Zinc Oxide Nanoparticle through Iron Doping

(2010) Saji George et al.   ACS Nano

Correlating Physico-Chemical with Toxicological Properties of Nanoparticles: The Present and the Future

(2010) Pilar Rivera Gil et al.   ACS Nano

Highlighting new phylogenetic specificities of Crohnʼs disease microbiota

(2010) S. Mondot et al.   INFLAMMATORY BOWEL DISEASES

Cell growing density affects the structural and functional properties of Caco-2 differentiated monolayer

(2010) Manuela Natoli et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Concept of Assessing Nanoparticle Hazards Considering Nanoparticle Dosemetric and Chemical/Biological Response Metrics

(2010) Erik K. Rushton et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Adsorption of hematite nanoparticles onto Caco-2 cells and the cellular impairments: effect of particle size

(2010) Wen Zhang et al.   NANOTECHNOLOGY

Minimal analytical characterization of engineered nanomaterials needed for hazard assessment in biological matrices

(2010) Hans Bouwmeester et al.   Nanotoxicology

Presence and risks of nanosilica in food products

(2010) Susan Dekkers et al.   Nanotoxicology

Toxicological characteristics of nanoparticulate anatase titanium dioxide in mice

(2009) Yanmei Duan et al.   BIOMATERIALS

Toxicity and cellular responses of intestinal cells exposed to titanium dioxide

(2009) Brian A. Koeneman et al.   CELL BIOLOGY AND TOXICOLOGY

Cytotoxicity and oxidative DNA damage by nanoparticles in human intestinal Caco-2 cells

(2009) Kirsten Gerloff et al.   Nanotoxicology

Comparison of the Mechanism of Toxicity of Zinc Oxide and Cerium Oxide Nanoparticles Based on Dissolution and Oxidative Stress Properties

(2008) Tian Xia et al.   ACS Nano

Bioavailability of nanoparticles in nutrient and nutraceutical delivery

(2008) Edgar Acosta   CURRENT OPINION IN COLLOID & INTERFACE SCIENCE

Characterization of size, surface charge, and agglomeration state of nanoparticle dispersions for toxicological studies

(2008) Jingkun Jiang et al.   JOURNAL OF NANOPARTICLE RESEARCH

Does nanoparticle activity depend upon size and crystal phase?

(2008) Jingkun Jiang et al.   Nanotoxicology

Photocatalytic titania based surfaces: Environmental benefits

(2008) Norman S. Allen et al.   POLYMER DEGRADATION AND STABILITY

Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts

(2008) M. Lundqvist et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA