The uses of 3D human brain organoids for neurotoxicity evaluations: A review

From cohorts to molecules: Adverse impacts of endocrine disrupting mixtures

(2022) Nicolò Caporale et al.   SCIENCE

Expression of the transcription factor PU.1 induces the generation of microglia-like cells in human cortical organoids

(2022) Bilal Cakir et al.   Nature Communications

Zika-Associated Birth Defects Reported in Pregnancies with Laboratory Evidence of Confirmed or Possible Zika Virus Infection — U.S. Zika Pregnancy and Infant Registry, December 1, 2015–March 31, 2018

(2022) Nicole M. Roth et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Mechanisms of coronavirus infectious disease 2019-related neurologic diseases

(2022) Robyn S. Klein   CURRENT OPINION IN NEUROLOGY

Advanced human developmental toxicity and teratogenicity assessment using human organoid models

(2022) Minghui Li et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Toxicity of transition metal nanoparticles: A review of different experimental models in the gastrointestinal tract

(2022) Wanting Hu et al.   JOURNAL OF APPLIED TOXICOLOGY

Toxic implications of silver nanoparticles on the central nervous system: A systematic literature review

(2022) Jitendra Kumar Suthar et al.   JOURNAL OF APPLIED TOXICOLOGY

The neuroinvasiveness, neurotropism, and neurovirulence of SARS-CoV-2

(2022) Lisa Bauer et al.   TRENDS IN NEUROSCIENCES

3D Tissue-Engineered Vascular Drug Screening Platforms: Promise and Considerations

(2022) Isra Marei et al.   Frontiers in Cardiovascular Medicine

Nanomaterials toward the treatment of Alzheimer’s disease: Recent advances and future trends

(2021) Huihui Zeng et al.   CHINESE CHEMICAL LETTERS

3D Cell Culture Models: Drug Pharmacokinetics, Safety Assessment, and Regulatory Consideration

(2021) Hongbing Wang et al.   CTS-Clinical and Translational Science

Potential roles of Kruppel‐like factors in mediating adverse vascular effects of nanomaterials: A review

(2021) Yi Cao   JOURNAL OF APPLIED TOXICOLOGY

ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids

(2021) Kathryn R. Bowles et al.   CELL

Gene–Environment Interactions in Developmental Neurotoxicity: a Case Study of Synergy between Chlorpyrifos and CHD8 Knockout in Human BrainSpheres

(2021) Sergio Modafferi et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Organoids: A new approach in toxicity testing of nanotherapeutics

(2021) Showkat Ul Nabi et al.   JOURNAL OF APPLIED TOXICOLOGY

The cytotoxicity of zinc oxide nanoparticles to 3D brain organoids results from excessive intracellular zinc ions and defective autophagy

(2021) Liangliang Liu et al.   CELL BIOLOGY AND TOXICOLOGY

N-methyl-d-aspartate Receptor-mediated Preconditioning Mitigates Excitotoxicity in Human Induced Pluripotent Stem Cell-derived Brain Organoids

(2021) Hanke Gwendolyn Bauersachs et al.   NEUROSCIENCE

Exposure to cadmium induces neuroinflammation and impairs ciliogenesis in hESC-derived 3D cerebral organoids

(2021) Yan Huang et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Human Organoids for Predictive Toxicology Research and Drug Development

(2021) Toshikatsu Matsui et al.   Frontiers in Genetics

Probing prodrug metabolism and reciprocal toxicity with an integrated and humanized multi-tissue organ-on-a-chip platform

(2020) Shiny Amala Priya Rajan et al.   Acta Biomaterialia

Glial cell diversity and methamphetamine-induced neuroinflammation in human cerebral organoids

(2020) Jason Dang et al.   MOLECULAR PSYCHIATRY

A brief history of organoids

(2020) Claudia Corrò et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Brain organoids: an ensemble of bioassays to investigate human neurodevelopment and disease

(2020) Jaydeep Sidhaye et al.   CELL DEATH AND DIFFERENTIATION

The cyanobacterial saxitoxin exacerbates neural cell death and brain malformations induced by Zika virus

(2020) Carolina da S. G. Pedrosa et al.   PLoS Neglected Tropical Diseases

Acrylamide exposure represses neuronal differentiation, induces cell apoptosis and promotes tau hyperphosphorylation in hESC-derived 3D cerebral organoids

(2020) Qian Bu et al.   FOOD AND CHEMICAL TOXICOLOGY

Neurotoxicity of metal‐containing nanoparticles and implications in glial cells

(2020) Xiaoru Chang et al.   JOURNAL OF APPLIED TOXICOLOGY

Multi-walled carbon nanotubes decrease neuronal NO synthase in 3D brain organoids

(2020) Ying Jiang et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Modeling better in vitro models for the prediction of nanoparticle toxicity: a review

(2020) Yi Cao et al.   TOXICOLOGY MECHANISMS AND METHODS

Modeling alcohol-induced neurotoxicity using human induced pluripotent stem cell-derived three-dimensional cerebral organoids

(2020) Thiago Arzua et al.   Translational Psychiatry

Generation and long-term culture of advanced cerebral organoids for studying later stages of neural development

(2020) Stefano L. Giandomenico et al.   Nature Protocols

Patient-derived iPSC modeling of rare neurodevelopmental disorders: Molecular pathophysiology and prospective therapies

(2020) K.R. Sabitha et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Organoids are promising tools for species‐specific in vitro toxicological studies

(2019) Justyna Augustyniak et al.   JOURNAL OF APPLIED TOXICOLOGY

Individual brain organoids reproducibly form cell diversity of the human cerebral cortex

(2019) Silvia Velasco et al.   NATURE

CNS organoids: an innovative tool for neurological disease modeling and drug neurotoxicity screening

(2019) Tanya Chhibber et al.   DRUG DISCOVERY TODAY

Engineering of human brain organoids with a functional vascular-like system

(2019) Bilal Cakir et al.   NATURE METHODS

Outdoor Air Pollution and Brain Structure and Function From Across Childhood to Young Adulthood: A Methodological Review of Brain MRI Studies

(2019) Megan M. Herting et al.   Frontiers in Public Health

Nano- and neurotoxicology: An emerging discipline

(2018) Anna Bencsik et al.   PROGRESS IN NEUROBIOLOGY

Rotenone exerts developmental neurotoxicity in a human brain spheroid model

(2018) David Pamies et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Overcoming the Blood-Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases

(2018) Denzil Furtado et al.   ADVANCED MATERIALS

Probing impaired neurogenesis in human brain organoids exposed to alcohol

(2017) Yujuan Zhu et al.   Integrative Biology

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons

(2016) Junghyun Jo et al.   Cell Stem Cell

Human brain slices for epilepsy research: Pitfalls, solutions and future challenges

(2016) Roland S.G. Jones et al.   JOURNAL OF NEUROSCIENCE METHODS

Exposure to air pollution as a potential contributor to cognitive function, cognitive decline, brain imaging, and dementia: A systematic review of epidemiologic research

(2016) Melinda C. Power et al.   NEUROTOXICOLOGY

Organotypic brain slice cultures: A review

(2015) C. Humpel   NEUROSCIENCE

Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue

(2015) Hideya Sakaguchi et al.   Nature Communications

Self-Organization of Polarized Cerebellar Tissue in 3D Culture of Human Pluripotent Stem Cells

(2015) Keiko Muguruma et al.   Cell Reports

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals

(2008) Mototsugu Eiraku et al.   Cell Stem Cell