Nanomaterials toward the treatment of Alzheimer’s disease: Recent advances and future trends

Nanotechnology-based Targeting of Neurodegenerative Disorders: A Promising Tool for Efficient Delivery of Neuromedicines

(2020) Kuldeep Rajpoot   CURRENT DRUG TARGETS

Intelligently thermoresponsive flower-like hollow nano-ruthenium system for sustained release of nerve growth factor to inhibit hyperphosphorylation of tau and neuronal damage for the treatment of Alzheimer's disease

(2020) Hui Zhou et al.   BIOMATERIALS

Quercetin-loaded selenium nanoparticles inhibit amyloid-β aggregation and exhibit antioxidant activity

(2020) Yujie Qi et al.   COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS

Transferrin-Modified Osthole PEGylated Liposomes Travel the Blood-Brain Barrier and Mitigate Alzheimer’s Disease-Related Pathology in APP/PS-1 Mice

(2020) Liang Kong et al.   International Journal of Nanomedicine

Neuron tau-targeting biomimetic nanoparticles for curcumin delivery to delay progression of Alzheimer’s disease

(2020) Chunhong Gao et al.   JOURNAL OF NANOBIOTECHNOLOGY

Nanotheranostic Applications for Detection and Targeting Neurodegenerative Diseases

(2020) Ajay Kumar et al.   Frontiers in Neuroscience

Role of tau protein in Alzheimer's disease: The prime pathological player

(2020) Shibi Muralidar et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Chiral gold nanoparticles enantioselectively rescue memory deficits in a mouse model of Alzheimer’s disease

(2020) Ke Hou et al.   Nature Communications

Biomedical Application of Reactive Oxygen Species–Responsive Nanocarriers in Cancer, Inflammation, and Neurodegenerative Diseases

(2020) Jinggong Liu et al.   Frontiers in Chemistry

Macrophage membrane-coated nanocarriers Co-Modified by RVG29 and TPP improve brain neuronal mitochondria-targeting and therapeutic efficacy in Alzheimer's disease mice

(2020) Yang Han et al.   Bioactive Materials

Review of Current Strategies for Delivering Alzheimer’s Disease Drugs across the Blood-Brain Barrier

(2019) Ka Wong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Antineuroinflammatory Activities and Neurotoxicological Assessment of Curcumin Loaded Solid Lipid Nanoparticles on LPS-Stimulated BV-2 Microglia Cell Models

(2019) Palanivel Ganesan et al.   MOLECULES

Microtubule network as a potential candidate for targeting by gold nanoparticle-assisted photothermal therapy

(2019) Behafarid Ghalandari et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Drug Development for Alzheimer’s Disease: Microglia Induced Neuroinflammation as a Target?

(2019) Yuan Dong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Calixarene/pillararene-based supramolecular selective binding and molecular assembly

(2019) Pei-yu Li et al.   CHINESE CHEMICAL LETTERS

Autophagy dysfunction in Alzheimer’s disease: mechanistic insights and new therapeutic opportunities

(2019) Antonio Di Meco et al.   BIOLOGICAL PSYCHIATRY

Vitamin D-binding protein-loaded PLGA nanoparticles suppress Alzheimer's disease-related pathology in 5XFAD mice

(2019) Seong Gak Jeon et al.   Nanomedicine-Nanotechnology Biology and Medicine

Alzheimer’s disease: pathogenesis, diagnostics, and therapeutics

(2019) Sneham Tiwari et al.   International Journal of Nanomedicine

Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation

(2019) Jun Zheng et al.   Nature Communications

Protein-Capped Metal Nanoparticles Inhibit Tau Aggregation in Alzheimer’s Disease

(2019) Shweta Kishor Sonawane et al.   ACS Omega

Real time rheological study of first network effects on the in situ polymerized semi-interpenetrating hydrogels

(2019) Huiqiong Wu et al.   COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS

Neuroinflammation in Alzheimer’s Disease: Microglia, Molecular Participants and Therapeutic Choices

(2019) Haijun Wang et al.   Current Alzheimer Research

Nanomedicine for the Treatment of Alzheimer's Disease

(2019) Beatrice Formicola et al.   Journal of Biomedical Nanotechnology

Reactive oxygen species-responsive drug delivery systems for the treatment of neurodegenerative diseases

(2019) William C. Ballance et al.   BIOMATERIALS

Nanoparticle-mediated approaches for Alzheimer’s disease pathogenesis, diagnosis, and therapeutics

(2019) Sajini D. Hettiarachchi et al.   JOURNAL OF CONTROLLED RELEASE

Mitochondria-targeted TPP-MoS2 with dual enzyme activity provides efficient neuroprotection through M1/M2 microglial polarization in an Alzheimer's disease model

(2019) Chaoxiu Ren et al.   BIOMATERIALS

Nanomaterial-based blood-brain-barrier (BBB) crossing strategies

(2019) Jinbing Xie et al.   BIOMATERIALS

β-amyloid and Oxidative Stress: Perspectives in Drug Development

(2019) Giuseppe Caruso et al.   CURRENT PHARMACEUTICAL DESIGN

Au23(CR)14 Nanocluster restores fibril Aβ’s Unfolded state with abolished cytotoxicity and dissolves endogenous Aβ Plaques

(2019) Wenkang Zhang et al.   National Science Review

Tau-Targeted Multifunctional Nanocomposite for Combinational Therapy of Alzheimer’s Disease

(2018) Qing Chen et al.   ACS Nano

Memory and Brain Amyloid and Tau Effects of a Bioavailable Form of Curcumin in Non-Demented Adults: A Double-Blind, Placebo-Controlled 18-Month Trial

(2018) Gary W. Small et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Custom-Made Ceria Nanoparticles Show a Neuroprotective Effect by Modulating Phenotypic Polarization of the Microglia

(2018) Feng Zeng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The cholinergic system in the pathophysiology and treatment of Alzheimer’s disease

(2018) Harald Hampel et al.   BRAIN

Charge effects of self-assembled chitosan-hyaluronic acid nanoparticles on inhibiting amyloid β-protein aggregation

(2018) Zhiqiang Jiang et al.   CARBOHYDRATE RESEARCH

Fabrication and biomedical potential of nanogels: An overview

(2018) Maninderjeet Kaur et al.   International Journal of Polymeric Materials and Polymeric Biomaterials

Mitochondria and Mitochondrial Cascades in Alzheimer’s Disease

(2018) Russell H. Swerdlow   JOURNAL OF ALZHEIMERS DISEASE

Nanotherapeutics for Gene Modulation that Prevents Apoptosis in the Brain and Fatal Neuroinflammation

(2018) Sang-Soo Kim et al.   MOLECULAR THERAPY

Dendrimers for Drug Delivery

(2018) Abhay Chauhan   MOLECULES

The inflammatory response to silver and titanium dioxide nanoparticles in the central nervous system

(2018) Tianshu Wu et al.   Nanomedicine

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   Nature Reviews Neurology

A self-destructive nanosweeper that captures and clears amyloid β-peptides

(2018) Qiang Luo et al.   Nature Communications

Autophagy and Alzheimer’s Disease: From Molecular Mechanisms to Therapeutic Implications

(2018) Md. Sahab Uddin et al.   Frontiers in Aging Neuroscience

Fabrication and biomedical potential of nanogels: An overview

(2018) Maninderjeet Kaur et al.   International Journal of Polymeric Materials and Polymeric Biomaterials

ROS responsive resveratrol delivery from LDLR peptide conjugated PLA-coated mesoporous silica nanoparticles across the blood–brain barrier

(2018) Yang Shen et al.   JOURNAL OF NANOBIOTECHNOLOGY

Oxidative stress and the amyloid beta peptide in Alzheimer’s disease

(2018) C. Cheignon et al.   Redox Biology

Mitochondria-targeting drug conjugates for cytotoxic, anti-oxidizing and sensing purposes: current strategies and future perspectives

(2018) Gantumur Battogtokh et al.   Acta Pharmaceutica Sinica B

Alzheimer’s disease hypothesis and related therapies

(2018) Xiaoguang Du et al.   Translational Neurodegeneration

Ultrasound-Excited Protoporphyrin IX-Modified Multifunctional Nanoparticles as a Strong Inhibitor of Tau Phosphorylation and β-Amyloid Aggregation

(2018) Mengmeng Xu et al.   ACS Applied Materials & Interfaces

Overcoming the Blood-Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases

(2018) Denzil Furtado et al.   ADVANCED MATERIALS

Curcumin-loaded PLGA-PEG nanoparticles conjugated with B6 peptide for potential use in Alzheimer’s disease

(2018) Shengnuo Fan et al.   DRUG DELIVERY

Mitochondrial therapeutic interventions in Alzheimer’s disease

(2018) Vo Van Giau et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Treatment of neurodegenerative disorders through the blood–brain barrier using nanocarriers

(2018) N. Poovaiah et al.   Nanoscale

The identity and function of microglia in neurodegeneration

(2018) Wilbur M. Song et al.   NATURE IMMUNOLOGY

Nanogels of dual inhibitor-modified hyaluronic acid function as a potent inhibitor of amyloid β-protein aggregation and cytotoxicity

(2018) Zhiqiang Jiang et al.   Scientific Reports

KLVFF peptide functionalized nanoparticles capture Aβ42 by co-assembly for decreasing cytotoxicity

(2018) Peipei Yang et al.   CHINESE CHEMICAL LETTERS

Liposome delivery systems for the treatment of Alzheimer’s disease

(2018) Callum Ross et al.   International Journal of Nanomedicine

Nanocomposites Inhibit the Formation, Mitigate the Neurotoxicity, and Facilitate the Removal of β-Amyloid Aggregates in Alzheimer’s Disease Mice

(2018) Yu Zhao et al.   NANO LETTERS

The Mechanisms of Action of Curcumin in Alzheimer’s Disease

(2017) Mengxi Tang et al.   JOURNAL OF ALZHEIMERS DISEASE

Multifunctional liposomes delay phenotype progression and prevent memory impairment in a presymptomatic stage mouse model of Alzheimer disease

(2017) Simona Mancini et al.   JOURNAL OF CONTROLLED RELEASE

Gold nanoparticles prevent cognitive deficits, oxidative stress and inflammation in a rat model of sporadic dementia of Alzheimer's type

(2017) Alexandre Pastoris Muller et al.   Materials Science & Engineering C-Materials for Biological Applications

Osmotin-loaded magnetic nanoparticles with electromagnetic guidance for the treatment of Alzheimer's disease

(2017) Faiz Ul Amin et al.   Nanoscale

Modulators of microglial activation and polarization after intracerebral haemorrhage

(2017) Xi Lan et al.   Nature Reviews Neurology

Drug Delivery to the Brain across the Blood-Brain Barrier Using Nanomaterials

(2017) Yung-Hao Tsou et al.   Small

Advances in Alzheimer’s Diagnosis and Therapy: The Implications of Nanotechnology

(2017) Mohammad Javad Hajipour et al.   TRENDS IN BIOTECHNOLOGY

Nanopreparations for mitochondria targeting drug delivery system: Current strategies and future prospective

(2017) Zhenjie Wang et al.   Asian Journal of Pharmaceutical Sciences

Rethinking Alzheimer's Disease Therapy: Are Mitochondria the Key?

(2017) Maria Ankarcrona et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondria-Targeting Ceria Nanoparticles as Antioxidants for Alzheimer’s Disease

(2016) Hyek Jin Kwon et al.   ACS Nano

Gold coated magnetic nanoparticles: from preparation to surface modification for analytical and biomedical applications

(2016) Saimon Moraes Silva et al.   CHEMICAL COMMUNICATIONS

Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release

(2016) Nazila Kamaly et al.   CHEMICAL REVIEWS

Current Treatment Options for Alzheimer's Disease and Parkinson's Disease Dementia

(2016) Jennifer Y.Y. Szeto et al.   Current Neuropharmacology

Inflammatory Process in Alzheimer's and Parkinson's Diseases: Central Role of Cytokines

(2016) Qamre Alam et al.   CURRENT PHARMACEUTICAL DESIGN

Current investigations into magnetic nanoparticles for biomedical applications

(2016) Xiaoming Li et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease

(2016) H. Lian et al.   JOURNAL OF NEUROSCIENCE

Role of neuroinflammation in neurodegenerative diseases (Review)

(2016) WEI-WEI CHEN et al.   Molecular Medicine Reports

Highly energetic compositions based on functionalized carbon nanomaterials

(2016) Qi-Long Yan et al.   Nanoscale

Curcumin, a Compound from Natural Sources, a True Scientific Challenge – A Review

(2016) Zorka Stanić   PLANT FOODS FOR HUMAN NUTRITION

Multifunctionality of self-assembled nanogels of curcumin-hyaluronic acid conjugates on inhibiting amyloid β-protein fibrillation and cytotoxicity

(2016) Zhiqiang Jiang et al.   REACTIVE & FUNCTIONAL POLYMERS

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

The Nanopharmacology and Nanotoxicology of Nanomaterials: New Opportunities and Challenges

(2016) Anna Radomska et al.   Advances in Clinical and Experimental Medicine

Protein aggregation in Alzheimer’s disease: Aβ and τ and their potential roles in the pathogenesis of AD

(2015) Dietmar Rudolf Thal et al.   ACTA NEUROPATHOLOGICA

Therapeutic approaches of magnetic nanoparticles for the central nervous system

(2015) Fahima Dilnawaz et al.   DRUG DISCOVERY TODAY

Chitosan as a suitable nanocarrier material for anti-Alzheimer drug delivery

(2015) Jayrajsinh Sarvaiya et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Graphene quantum dots for the inhibition of β amyloid aggregation

(2015) Yibiao Liu et al.   Nanoscale

Amyloid cascade hypothesis: Pathogenesis and therapeutic strategies in Alzheimer's disease

(2015) Sagar H. Barage et al.   NEUROPEPTIDES

Gold-Nanoparticle-Based Multifunctional Amyloid-β Inhibitor against Alzheimer’s Disease

(2014) Nan Gao et al.   CHEMISTRY-A EUROPEAN JOURNAL

Potential of nanoliposomes for the therapy and/or diagnosis of Alzheimer's disease: recent progress

(2014) Sophia G Antimisiaris   Clinical Lipidology

Multifunctional nanoliposomes with curcumin–lipid derivative and brain targeting functionality with potential applications for Alzheimer disease

(2014) Spyridon Mourtas et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

(2014) Jeffrey L Cummings et al.   Alzheimers Research & Therapy

Curcumin-Loaded Nanoparticles Potently Induce Adult Neurogenesis and Reverse Cognitive Deficits in Alzheimer’s Disease Model via Canonical Wnt/β-Catenin Pathway

(2013) Shashi Kant Tiwari et al.   ACS Nano

The effect of lipid nanoparticle PEGylation on neuroinflammatory response in mouse brain

(2013) Ji-yun Huang et al.   BIOMATERIALS

Systemic Oxidative Stress in Older Patients with Mild Cognitive Impairment or Late Onset Alzheimer's Disease

(2013) Carlo Cervellati et al.   Current Alzheimer Research

Mitochondrial Diseases of the Brain

(2013) Rajnish K. Chaturvedi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Stimuli-responsive nanocarriers for drug delivery

(2013) Simona Mura et al.   NATURE MATERIALS

Alzheimer’s disease: Pathogenesis and prevention

(2012) Heiko Braak et al.   Alzheimers & Dementia

Pharmacokinetics of curcumin-loaded PLGA and PLGA–PEG blend nanoparticles after oral administration in rats

(2012) Najeh Maissar Khalil et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

PLGA-based nanoparticles: An overview of biomedical applications

(2012) Fabienne Danhier et al.   JOURNAL OF CONTROLLED RELEASE

Curcumin-conjugated nanoliposomes with high affinity for Aβ deposits: Possible applications to Alzheimer disease

(2012) Adina N. Lazar et al.   Nanomedicine-Nanotechnology Biology and Medicine

Graphene oxide strongly inhibits amyloid beta fibrillation

(2012) Morteza Mahmoudi et al.   Nanoscale

Negatively Charged Gold Nanoparticles Inhibit Alzheimer's Amyloid-β Fibrillization, Induce Fibril Dissociation, and Mitigate Neurotoxicity

(2012) Yi-Hung Liao et al.   Small

Mitochondrial dysfunction and cellular metabolic deficiency in Alzheimer’s disease

(2012) Xue-Mei Gu et al.   Neuroscience Bulletin

Pulsed ultrasound associated with gold nanoparticle gel reduces oxidative stress parameters and expression of pro-inflammatory molecules in an animal model of muscle injury

(2012) Eduardo G Victor et al.   JOURNAL OF NANOBIOTECHNOLOGY

Metal ions, Alzheimer's disease and chelation therapy

(2011) Ana Budimir   ACTA PHARMACEUTICA

Brain aging, Alzheimer's disease, and mitochondria

(2011) Russell H. Swerdlow   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Carbon Nanotube Inhibits the Formation of β-Sheet-Rich Oligomers of the Alzheimer's Amyloid-β(16-22) Peptide

(2011) Huiyu Li et al.   BIOPHYSICAL JOURNAL

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes

(2011) Ying Liu et al.   JOURNAL OF PATHOLOGY

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Curcumin-decorated nanoliposomes with very high affinity for amyloid-β1-42 peptide

(2010) Spyridon Mourtas et al.   BIOMATERIALS

Relationship Between Tau Pathology and Neuroinflammation in Alzheimer's Disease

(2010) Maria Jose Metcalfe et al.   MOUNT SINAI JOURNAL OF MEDICINE

Nanogels as Pharmaceutical Carriers: Finite Networks of Infinite Capabilities

(2009) Alexander V. Kabanov et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Alzheimer's Disease: From Pathology to Therapeutic Approaches

(2009) Roland Jakob-Roetne et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dementia incidence continues to increase with age in the oldest old: The 90+ study

(2009) María M. Corrada et al.   ANNALS OF NEUROLOGY

Characteristics of compounds that cross the blood-brain barrier

(2009) William A Banks   BMC Neurology

Progress in the preparation of magnetic nanoparticles for applications in biomedicine

(2009) A G Roca et al.   JOURNAL OF PHYSICS D-APPLIED PHYSICS

Small mitochondria-targeting molecules as anti-cancer agents

(2009) Feng Wang et al.   MOLECULAR ASPECTS OF MEDICINE

Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies

(2009) Kurt R. Brunden et al.   NATURE REVIEWS DRUG DISCOVERY

TiO2 nanoparticles promote β-amyloid fibrillation in vitro

(2008) Wei-hui Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS