The neuroinvasiveness, neurotropism, and neurovirulence of SARS-CoV-2
Published 2022 View Full Article
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Title
The neuroinvasiveness, neurotropism, and neurovirulence of SARS-CoV-2
Authors
Keywords
coronavirus, nervous system, brain, viral infection, neuroinflammation, pathogenesis
Journal
TRENDS IN NEUROSCIENCES
Volume 45, Issue 5, Pages 358-368
Publisher
Elsevier BV
Online
2022-03-03
DOI
10.1016/j.tins.2022.02.006
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Note: Only part of the references are listed.- The omicron (B.1.1.529) SARS-CoV-2 variant of concern does not readily infect Syrian hamsters
- (2022) Rana Abdelnabi et al. ANTIVIRAL RESEARCH
- Non-cell-autonomous disruption of nuclear architecture as a potential cause of COVID-19-induced anosmia
- (2022) Marianna Zazhytska et al. CELL
- SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters
- (2022) Peter J. Halfmann et al. NATURE
- Hamsters Expressing Human Angiotensin-Converting Enzyme 2 Develop Severe Disease following Exposure to SARS-CoV-2
- (2022) Joseph W. Golden et al. mBio
- Advances and gaps in SARS-CoV-2 infection models
- (2022) César Muñoz-Fontela et al. PLoS Pathogens
- The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2
- (2022) Susanne Krasemann et al. Stem Cell Reports
- Administration of aerosolized SARS-CoV-2 to K18-hACE2 mice uncouples respiratory infection from fatal neuroinvasion
- (2022) Valeria Fumagalli et al. Science Immunology
- ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response
- (2021) Cheng Wang et al. Cell Stem Cell
- Neuroinvasion of SARS-CoV-2 in human and mouse brain
- (2021) Eric Song et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Intranasal Infection of Ferrets with SARS-CoV-2 as a Model for Asymptomatic Human Infection
- (2021) Helen E. Everett et al. Viruses-Basel
- The Spatial and Cell-Type Distribution of SARS-CoV-2 Receptor ACE2 in the Human and Mouse Brains
- (2021) Rongrong Chen et al. Frontiers in Neurology
- Neurotropic Effects of SARS-CoV-2 Modeled by the Human Brain Organoids
- (2021) Anand Ramani et al. Stem Cell Reports
- Trigeminal neuralgia as the sole neurological manifestation of COVID‐19: A case report
- (2021) Javier Molina‐Gil et al. HEADACHE
- Intracerebral hemorrhage in COVID-19: A narrative review
- (2021) Nikolaos Panagiotis Margos et al. JOURNAL OF CLINICAL NEUROSCIENCE
- Brainstem neuropathology in two cases of COVID-19: SARS-CoV-2 trafficking between brain and lung
- (2021) Gaetano Bulfamante et al. JOURNAL OF NEUROLOGY
- Long COVID: understanding the neurological effects
- (2021) The Lancet Neurology LANCET NEUROLOGY
- COVID-19-related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters
- (2021) Guilherme Dias de Melo et al. Science Translational Medicine
- SARS-CoV-2 infection, neuropathogenesis and transmission among deer mice: Implications for spillback to New World rodents
- (2021) Anna Fagre et al. PLoS Pathogens
- SARS-CoV-2 targets glial cells in human cortical organoids
- (2021) Courtney L. McMahon et al. Stem Cell Reports
- Global Incidence of Neurological Manifestations Among Patients Hospitalized With COVID-19—A Report for the GCS-NeuroCOVID Consortium and the ENERGY Consortium
- (2021) Sherry H.-Y. Chou et al. JAMA Network Open
- Activation of the trigeminal system as a likely target of SARS-CoV-2 may contribute to anosmia in COVID-19
- (2021) Karl Messlinger et al. CEPHALALGIA
- SARS-CoV-2 Viremia is Associated with COVID-19 Severity and Predicts Clinical Outcomes
- (2021) Jana L Jacobs et al. CLINICAL INFECTIOUS DISEASES
- Neuropathological findings from COVID‐19 patients with neurological symptoms argue against a direct brain invasion of SARS‐CoV‐2: A critical systematic review
- (2021) Giuseppe Cosentino et al. EUROPEAN JOURNAL OF NEUROLOGY
- Long COVID in a prospective cohort of home-isolated patients
- (2021) Bjørn Blomberg et al. NATURE MEDICINE
- Comprehensive Review on Neuro-COVID-19 Pathophysiology and Clinical Consequences
- (2021) Helia Jafari Khaljiri et al. NEUROTOXICITY RESEARCH
- Intracerebral Hemorrhage in Patients With COVID-19
- (2021) Audrey C. Leasure et al. STROKE
- Incidence of Bell Palsy in Patients With COVID-19
- (2021) Akina Tamaki et al. JAMA Otolaryngology-Head & Neck Surgery
- Replication Kinetics, Cell Tropism, and Associated Immune Responses in SARS-CoV-2- and H5N1 Virus-Infected Human Induced Pluripotent Stem Cell-Derived Neural Models
- (2021) Lisa Bauer et al. mSphere
- Temporal Kinetics of RNAemia and Associated Systemic Cytokines in Hospitalized COVID-19 Patients
- (2021) Debby van Riel et al. mSphere
- Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb
- (2021) Mona Khan et al. CELL
- Infection of Brain Pericytes Underlying Neuropathology of COVID-19 Patients
- (2021) Matteo Bocci et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells
- (2021) Jan Wenzel et al. NATURE NEUROSCIENCE
- Autoimmune Encephalitis After SARS-CoV-2 Infection
- (2021) Cristina Valencia Sanchez et al. NEUROLOGY
- Frequency of Neurologic Manifestations in COVID-19
- (2021) Shubham Misra et al. NEUROLOGY
- Chronological brain lesions after SARS-CoV-2 infection in hACE2-transgenic mice
- (2021) Enric Vidal et al. VETERINARY PATHOLOGY
- Hamster organotypic modeling of SARS-CoV-2 lung and brainstem infection
- (2021) Marion Ferren et al. Nature Communications
- Neuropsychiatric manifestations of COVID-19, potential neurotropic mechanisms, and therapeutic interventions
- (2021) Ying Han et al. Translational Psychiatry
- Host genetic factors determining COVID-19 susceptibility and severity
- (2021) Thirumalaisamy P. Velavan et al. EBioMedicine
- Pathogenesis and transmission of SARS-CoV-2 in golden hamsters
- (2020) Sin Fun Sia et al. NATURE
- Respiratory disease in rhesus macaques inoculated with SARS-CoV-2
- (2020) Vincent J. Munster et al. NATURE
- Bilateral transient olfactory bulbs edema during COVID-19-related anosmia
- (2020) Thomas Laurendon et al. NEUROLOGY
- Neurologic manifestations in hospitalized patients with COVID-19: The ALBACOVID registry
- (2020) Carlos Manuel Romero-Sánchez et al. NEUROLOGY
- Mild or Moderate Covid-19
- (2020) Rajesh T. Gandhi et al. NEW ENGLAND JOURNAL OF MEDICINE
- Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young
- (2020) Thomas J. Oxley et al. NEW ENGLAND JOURNAL OF MEDICINE
- COVID-19 –associated Diffuse Leukoencephalopathy and Microhemorrhages
- (2020) Alireza Radmanesh et al. RADIOLOGY
- Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS–coronavirus 2
- (2020) Jianzhong Shi et al. SCIENCE
- Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model
- (2020) Barry Rockx et al. SCIENCE
- Neuropathogenesis and Neurologic Manifestations of the Coronaviruses in the Age of Coronavirus Disease 2019
- (2020) Adeel S. Zubair et al. JAMA Neurology
- Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China
- (2020) Ling Mao et al. JAMA Neurology
- Massive transient damage of the olfactory epithelium associated with infection of sustentacular cells by SARS-CoV-2 in golden Syrian hamsters
- (2020) Bertrand Bryche et al. BRAIN BEHAVIOR AND IMMUNITY
- SARS-CoV-2 infects human neural progenitor cells and brain organoids
- (2020) Bao-Zhong Zhang et al. CELL RESEARCH
- A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids
- (2020) Liuliu Yang et al. Cell Stem Cell
- SARS-CoV-2 infects and damages the mature and immature olfactory sensory neurons of hamsters
- (2020) Anna Jinxia Zhang et al. CLINICAL INFECTIOUS DISEASES
- Early evidence of pronounced brain involvement in fatal COVID-19 outcomes
- (2020) Claus Hann von Weyhern et al. LANCET
- Inflammatory olfactory neuropathy in two patients with COVID-19
- (2020) Daniel Kirschenbaum et al. LANCET
- Neuropathological Features of Covid-19
- (2020) Isaac H. Solomon et al. NEW ENGLAND JOURNAL OF MEDICINE
- Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development
- (2020) Masaki Imai et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Neuropathogenic human coronaviruses: A review
- (2020) Osama S. Abdelaziz et al. REVIEWS IN MEDICAL VIROLOGY
- Identification of required host factors for SARS-CoV-2 infection in human cells
- (2020) Zharko Daniloski et al. CELL
- Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism Predominates in Choroid Plexus Epithelium
- (2020) Fadi Jacob et al. Cell Stem Cell
- SARS-CoV-2 infects the brain choroid plexus and disrupts the blood-CSF-barrier in human brain organoids
- (2020) Laura Pellegrini et al. Cell Stem Cell
- SARS-CoV-2 Infectivity and Neurological Targets in the Brain
- (2020) Walter J. Lukiw et al. CELLULAR AND MOLECULAR NEUROBIOLOGY
- SARS ‐CoV‐2 targets neurons of 3D human brain organoids
- (2020) Anand Ramani et al. EMBO JOURNAL
- Single‐cell RNA sequencing analysis of SARS‐CoV‐2 entry receptors in human organoids
- (2020) Rajasekaran Mahalingam et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Animal models for COVID-19
- (2020) César Muñoz-Fontela et al. NATURE
- Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters
- (2020) Lisa H. Tostanoski et al. NATURE MEDICINE
- Infection of Brain Organoids and 2D Cortical Neurons with SARS-CoV-2 Pseudovirus
- (2020) Sang Ah Yi et al. Viruses-Basel
- Ultrastructural Evidence of Direct Viral Damage to the Olfactory Complex in Patients Testing Positive for SARS-CoV-2
- (2020) Patrizia Morbini et al. JAMA Otolaryngology-Head & Neck Surgery
- Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks
- (2020) William M. Schneider et al. CELL
- Olfactory epithelium histopathological findings in long-term coronavirus disease 2019 related anosmia
- (2020) L A Vaira et al. JOURNAL OF LARYNGOLOGY AND OTOLOGY
- Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19
- (2020) Jenny Meinhardt et al. NATURE NEUROSCIENCE
- Microvascular Injury in the Brains of Patients with Covid-19
- (2020) Myoung-Hwa Lee et al. NEW ENGLAND JOURNAL OF MEDICINE
- Recombinant ACE2 Expression Is Required for SARS-CoV-2 To Infect Primary Human Endothelial Cells and Induce Inflammatory and Procoagulative Responses
- (2020) Jonas Nascimento Conde et al. mBio
- The Roborovski Dwarf Hamster Is A Highly Susceptible Model for a Rapid and Fatal Course of SARS-CoV-2 Infection
- (2020) Jakob Trimpert et al. Cell Reports
- SARS-CoV-2 Receptors and Entry Genes Are Expressed in the Human Olfactory Neuroepithelium and Brain
- (2020) Leon Fodoulian et al. iScience
- Contemporary Circulating Enterovirus D68 Strains Infect and Undergo Retrograde Axonal Transport in Spinal Motor Neurons Independent of Sialic Acid
- (2019) Alison M. Hixon et al. JOURNAL OF VIROLOGY
- Understanding Enterovirus D68-Induced Neurologic Disease: A Basic Science Review
- (2019) Hixon et al. Viruses-Basel
- Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System?
- (2019) Marc Desforges et al. Viruses-Basel
- Causation of Acute Flaccid Paralysis by Myelitis and Myositis in Enterovirus-D68 Infected Mice Deficient in Interferon αβ/γ Receptor Deficient Mice
- (2018) John Morrey et al. Viruses-Basel
- Human iPSC-derived trigeminal neurons lack constitutive TLR3-dependent immunity that protects cortical neurons from HSV-1 infection
- (2018) Bastian Zimmer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Neurologic Alterations Due to Respiratory Virus Infections
- (2018) Karen Bohmwald et al. Frontiers in Cellular Neuroscience
- Neurotropic virus infections as the cause of immediate and delayed neuropathology
- (2015) Martin Ludlow et al. ACTA NEUROPATHOLOGICA
- Virus Infections in the Nervous System
- (2013) Orkide O. Koyuncu et al. Cell Host & Microbe
- Impaired learning resulting from Respiratory Syncytial Virus infection
- (2013) J. A. Espinoza et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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