Structure and activity of human TMPRSS2 protease implicated in SARS-CoV-2 activation

SARS-CoV-2 variants with mutations at the S1/S2 cleavage site are generated in vitro during propagation in TMPRSS2-deficient cells

(2021) Michihito Sasaki et al.   PLoS Pathogens

Proteolytic Activation of SARS-CoV-2 Spike at the S1/S2 Boundary: Potential Role of Proteases beyond Furin

(2021) Tiffany Tang et al.   ACS Infectious Diseases

SARS-CoV-2 and SARS-CoV spike-mediated cell-cell fusion differ in the requirements for receptor expression and proteolytic activation

(2021) Bojan F. Hörnich et al.   JOURNAL OF VIROLOGY

TMPRSS11D and TMPRSS13 Activate the SARS-CoV-2 Spike Protein

(2021) Mai Kishimoto et al.   Viruses-Basel

Crystal structure of inhibitor-bound human MSPL that can activate high pathogenic avian influenza

(2021) Ayako Ohno et al.   Life Science Alliance

A high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entry

(2021) Yanwen Chen et al.   Nature Communications

Nafamostat Mesylate Blocks Activation of SARS-CoV-2: New Treatment Option for COVID-19

(2020) Markus Hoffmann et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells

(2020) Markus Hoffmann et al.   MOLECULAR CELL

TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes

(2020) Ruochen Zang et al.   Science Immunology

Intracellular autoactivation of TMPRSS11A, an airway epithelial transmembrane serine protease

(2020) Ce Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of TMPRSS2 by HAI-2 reduces prostate cancer cell invasion and metastasis

(2020) Chun-Jung Ko et al.   ONCOGENE

Structure-based design of prefusion-stabilized SARS-CoV-2 spikes

(2020) Ching-Lin Hsieh et al.   SCIENCE

TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells

(2020) Dorothea Bestle et al.   Life Science Alliance

Bromhexine Hydrochloride Tablets for the Treatment of Moderate COVID‐19: An Open‐Label Randomized Controlled Pilot Study

(2020) Ting Li et al.   CTS-Clinical and Translational Science

Targeting enteropeptidase with reversible covalent inhibitors to achieve metabolic benefits

(2020) Weimei Sun et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

SARS-CoV-2 receptor ACE2 is co-expressed with genes related to transmembrane serine proteases, viral entry, immunity and cellular stress

(2020) Wasco Wruck et al.   Scientific Reports

D614G Mutation Alters SARS-CoV-2 Spike Conformation and Enhances Protease Cleavage at the S1/S2 Junction

(2020) Sophie M.-C. Gobeil et al.   Cell Reports

The EMBL-EBI search and sequence analysis tools APIs in 2019

(2019) Fábio Madeira et al.   NUCLEIC ACIDS RESEARCH

TMPRSS2 is the major activating protease of influenza A virus in primary human airway cells and influenza B virus in human type II pneumocytes

(2019) Hannah Limburg et al.   JOURNAL OF VIROLOGY

N-glycosylation in the protease domain of trypsin-like serine proteases mediates calnexin-assisted protein folding

(2018) Hao Wang et al.   eLife

Homology modeling and structure-based design improve hydrophobic interaction chromatography behavior of integrin binding antibodies

(2018) Arif Jetha et al.   mAbs

Different residues in the SARS-CoV spike protein determine cleavage and activation by the host cell protease TMPRSS2

(2017) Lennart Michel Reinke et al.   PLoS One

MolProbity: More and better reference data for improved all-atom structure validation

(2017) Christopher J. Williams et al.   PROTEIN SCIENCE

Matriptase shedding is closely coupled with matriptase zymogen activation and requires de novo proteolytic cleavage likely involving its own activity

(2017) Chun-Che Tseng et al.   PLoS One

The role of type II transmembrane serine protease-mediated signaling in cancer

(2016) Lauren M. Tanabe et al.   FEBS Journal

Androgen-Induced TMPRSS2 Activates Matriptase and Promotes Extracellular Matrix Degradation, Prostate Cancer Cell Invasion, Tumor Growth, and Metastasis

(2015) C.-J. Ko et al.   CANCER RESEARCH

Divergent Inhibitor Susceptibility among Airway Lumen-Accessible Tryptic Proteases

(2015) Shilpa Nimishakavi et al.   PLoS One

A neutron-diffraction study of the low-cycle fatigue behaviour of an austenitic stainless steel 316

(2015) Adelaide Dubreuil et al.   ACTA CRYSTALLOGRAPHICA SECTION A

Distinct Roles ofN-Glycosylation at Different Sites of Corin in Cell Membrane Targeting and Ectodomain Shedding

(2014) Hao Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deciphering key features in protein structures with the new ENDscript server

(2014) Xavier Robert et al.   NUCLEIC ACIDS RESEARCH

The Androgen-Regulated Protease TMPRSS2 Activates a Proteolytic Cascade Involving Components of the Tumor Microenvironment and Promotes Prostate Cancer Metastasis

(2014) J. M. Lucas et al.   Cancer Discovery

Matriptase and MET are prominently expressed at the site of bone metastasis in renal cell carcinoma: immunohistochemical analysis

(2014) Shoichiro Mukai et al.   Human Cell

Identification of the first synthetic inhibitors of the type II transmembrane serine protease TMPRSS2 suitable for inhibition of influenza virus activation

(2013) Daniela Meyer et al.   BIOCHEMICAL JOURNAL

TMPRSS2 and ADAM17 Cleave ACE2 Differentially and Only Proteolysis by TMPRSS2 Augments Entry Driven by the Severe Acute Respiratory Syndrome Coronavirus Spike Protein

(2013) A. Heurich et al.   JOURNAL OF VIROLOGY

HAI-2 suppresses the invasive growth and metastasis of prostate cancer through regulation of matriptase

(2013) C-H Tsai et al.   ONCOGENE

Overexpression of TMPRSS4 in non-small cell lung cancer is associated with poor prognosis in patients with squamous histology

(2011) L Larzabal et al.   BRITISH JOURNAL OF CANCER

Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response

(2011) I. Glowacka et al.   JOURNAL OF VIROLOGY

TMPRSS2, a Serine Protease Expressed in the Prostate on the Apical Surface of Luminal Epithelial Cells and Released into Semen in Prostasomes, Is Misregulated in Prostate Cancer Cells

(2010) Ya-Wen Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

Efficient Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by the Transmembrane Protease TMPRSS2

(2010) S. Matsuyama et al.   JOURNAL OF VIROLOGY

Epithelial Integrity Is Maintained by a Matriptase-Dependent Proteolytic Pathway

(2009) Karin List et al.   AMERICAN JOURNAL OF PATHOLOGY