Homology modeling and structure-based design improve hydrophobic interaction chromatography behavior of integrin binding antibodies

Rapid assessment of oxidation via middle-down LCMS correlates with methionine side-chain solvent-accessible surface area for 121 clinical stage monoclonal antibodies

(2017) Rong Yang et al.   mAbs

In-silico prediction of concentration-dependent viscosity curves for monoclonal antibody solutions

(2017) Dheeraj S. Tomar et al.   mAbs

Biophysical properties of the clinical-stage antibody landscape

(2017) Tushar Jain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ensemble Modeling and Intracellular Aggregation of an Engineered Immunoglobulin-Like Domain

(2016) Kyle Trainor et al.   JOURNAL OF MOLECULAR BIOLOGY

Investigation of protein selectivity in multimodal chromatography usingin silicodesigned Fab fragment variants

(2015) Hanne Sophie Karkov et al.   BIOTECHNOLOGY AND BIOENGINEERING

Rational Design of Biobetters with Enhanced Stability

(2015) Fabienne Courtois et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Separation of mAbs molecular variants by analytical hydrophobic interaction chromatography HPLC: overview and applications

(2014) Mark Haverick et al.   mAbs

Structure-Based Prediction of Asparagine and Aspartate Degradation Sites in Antibody Variable Regions

(2014) Jasmin F. Sydow et al.   PLoS One

Combining Structural Modeling with Ensemble Machine Learning to Accurately Predict Protein Fold Stability and Binding Affinity Effects upon Mutation

(2014) Niklas Berliner et al.   PLoS One

In silico selection of therapeutic antibodies for development: Viscosity, clearance, and chemical stability

(2014) Vikas K. Sharma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assessment of fully automated antibody homology modeling protocols in molecular operating environment

(2014) Johannes K. X. Maier et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Second antibody modeling assessment (AMA-II)

(2014) Juan C. Almagro et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

CDR-H3 Diversity Is Not Required for Antigen Recognition by Synthetic Antibodies

(2012) Helena Persson et al.   JOURNAL OF MOLECULAR BIOLOGY

General strategy for the generation of human antibody variable domains with increased aggregation resistance

(2012) K. Dudgeon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aggregation-resistant domain antibodies engineered with charged mutations near the edges of the complementarity-determining regions

(2012) J. M. Perchiacca et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Developability Index: A Rapid In Silico Tool for the Screening of Antibody Aggregation Propensity

(2011) Timothy M. Lauer et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Prognostic gene-expression signature of carcinoma-associated fibroblasts in non-small cell lung cancer

(2011) R. Navab et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibody modeling assessment

(2011) Juan C. Almagro et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

LowModeMD—Implicit Low-Mode Velocity Filtering Applied to Conformational Search of Macrocycles and Protein Loops

(2010) Paul Labute   Journal of Chemical Information and Modeling

Calibrative approaches to protein solubility modeling of a mutant series using physicochemical descriptors

(2010) William F. Long et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Structure-based engineering of a monoclonal antibody for improved solubility

(2010) S.-J. Wu et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Aggregation-Prone Motifs in Human Immunoglobulin G

(2009) Naresh Chennamsetty et al.   JOURNAL OF MOLECULAR BIOLOGY

Design of therapeutic proteins with enhanced stability

(2009) N. Chennamsetty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA