The role of type II transmembrane serine protease-mediated signaling in cancer

Type II transmembrane serine proteases as potential targets for cancer therapy

(2016) Andrew S. Murray et al.   BIOLOGICAL CHEMISTRY

α-Ketobenzothiazole Serine Protease Inhibitors of Aberrant HGF/c-MET and MSP/RON Kinase Pathway Signaling in Cancer

(2016) Zhenfu Han et al.   ChemMedChem

Inhibition of pro-HGF activation by SRI31215, a novel approach to block oncogenic HGF/MET signaling

(2016) Benjamin Y. Owusu et al.   Oncotarget

TMPRSS4 induces invasion and proliferation of prostate cancer cells through induction of Slug and cyclin D1

(2016) Yunhee Lee et al.   Oncotarget

Matriptase regulates c-Met mediated proliferation and invasion in inflammatory breast cancer

(2016) Gina L. Zoratti et al.   Oncotarget

Clinical and Biological Significance of Hepsin Overexpression in Breast Cancer

(2016) Peng Xing et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Structure-based discovery of small molecule hepsin and HGFA protease inhibitors: Evaluation of potency and selectivity derived from distinct binding pockets

(2015) Francisco M. Franco et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Androgen-Induced TMPRSS2 Activates Matriptase and Promotes Extracellular Matrix Degradation, Prostate Cancer Cell Invasion, Tumor Growth, and Metastasis

(2015) C.-J. Ko et al.   CANCER RESEARCH

Molecular landscape of prostate cancer: Implications for current clinical trials

(2015) Galina Khemlina et al.   CANCER TREATMENT REVIEWS

Influenza virus activating host proteases: Identification, localization and inhibitors as potential therapeutics

(2015) Wolfgang Garten et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesion

(2015) T A Tervonen et al.   ONCOGENE

Epithelial Sodium Channel-Mediated Sodium Transport Is Not Dependent on the Membrane-Bound Serine Protease CAP2/Tmprss4

(2015) Anna Keppner et al.   PLoS One

Transmembrane Protease Serine 4 Promotes Thyroid Cancer Proliferation via CREB Phosphorylation

(2015) Hongyu Guan et al.   THYROID

Targeting matriptase in breast cancer abrogates tumour progression via impairment of stromal-epithelial growth factor signalling

(2015) Gina L. Zoratti et al.   Nature Communications

Targeted inhibition of cell-surface serine protease Hepsin blocks prostate cancer bone metastasis

(2015) Xi Tang et al.   Oncotarget

TMPRSS4 regulates levels of integrin α5 in NSCLC through miR-205 activity to promote metastasis

(2014) L Larzabal et al.   BRITISH JOURNAL OF CANCER

TMPRSS4: an emerging potential therapeutic target in cancer

(2014) A L de Aberasturi et al.   BRITISH JOURNAL OF CANCER

Matriptase promotes inflammatory cell accumulation and progression of established epidermal tumors

(2014) K U Sales et al.   ONCOGENE

Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis

(2014) K U Sales et al.   ONCOGENE

Potent and specific inhibition of the biological activity of the type-II transmembrane serine protease matriptase by the cyclic microprotein MCoTI-II

(2014) Kelly Gray et al.   THROMBOSIS AND HAEMOSTASIS

Inhibitors of HGFA, Matriptase, and Hepsin Serine Proteases: A Nonkinase Strategy to Block Cell Signaling in Cancer

(2014) Zhenfu Han et al.   ACS Medicinal Chemistry Letters

The Androgen-Regulated Protease TMPRSS2 Activates a Proteolytic Cascade Involving Components of the Tumor Microenvironment and Promotes Prostate Cancer Metastasis

(2014) J. M. Lucas et al.   Cancer Discovery

Identification of the first synthetic inhibitors of the type II transmembrane serine protease TMPRSS2 suitable for inhibition of influenza virus activation

(2013) Daniela Meyer et al.   BIOCHEMICAL JOURNAL

Discovery of novel 2-hydroxydiarylamide derivatives as TMPRSS4 inhibitors

(2013) Sunghyun Kang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Phase II randomised proof-of-concept study of the urokinase inhibitor upamostat (WX-671) in combination with gemcitabine compared with gemcitabine alone in patients with non-resectable, locally advanced pancreatic cancer

(2013) V Heinemann et al.   BRITISH JOURNAL OF CANCER

A Matriptase-Prostasin Reciprocal Zymogen Activation Complex with Unique Features

(2013) Stine Friis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-affinity Cyclic Peptide Matriptase Inhibitors

(2013) Pedro Quimbar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammatory breast cancer: New factors contribute to disease etiology: A review

(2013) Mona M. Mohamed et al.   Journal of Advanced Research

Hepatocyte Growth Factor Activation Inhibitors – Therapeutic Potential in Cancer

(2012) Christian Parr et al.   Anti-Cancer Agents in Medicinal Chemistry

TMPRSS4 is a type II transmembrane serine protease involved in cancer and viral infections

(2012) Anke Ohler et al.   BIOLOGICAL CHEMISTRY

Serine protease hepsin regulates hepatocyte size and hemodynamic retention of tumor cells by hepatocyte growth factor signaling in mice

(2012) Yu-Chen Hsu et al.   HEPATOLOGY

Imaging a functional tumorigenic biomarker in the transformed epithelium

(2012) A. M. LeBeau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity

(2012) J. I. Partanen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Variants in the HEPSIN gene are associated with susceptibility to prostate cancer

(2012) H J Kim et al.   PROSTATE CANCER AND PROSTATIC DISEASES

Design and Synthesis of Potent, Selective Inhibitors of Matriptase

(2012) Éloïc Colombo et al.   ACS Medicinal Chemistry Letters

Membrane-Anchored Serine Proteases in Vertebrate Cell and Developmental Biology

(2011) Roman Szabo et al.   Annual Review of Cell and Developmental Biology

Allosteric antibody inhibition of human hepsin protease

(2011) Tobias Koschubs et al.   BIOCHEMICAL JOURNAL

Overexpression of TMPRSS4 in non-small cell lung cancer is associated with poor prognosis in patients with squamous histology

(2011) L Larzabal et al.   BRITISH JOURNAL OF CANCER

Strong expression association between matriptase and its substrate prostasin in breast cancer

(2011) Christopher Bergum et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Proteolytic Activation of Pro-Macrophage-Stimulating Protein by Hepsin

(2011) R. Ganesan et al.   MOLECULAR CANCER RESEARCH

c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptase

(2011) R Szabo et al.   ONCOGENE

The role of the microenvironment in tumor growth and invasion

(2011) Yangjin Kim et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Protease-activated receptor 2 signaling in inflammation

(2011) Andrea S. Rothmeier et al.   Seminars in Immunopathology

The cutting edge: membrane-anchored serine protease activities in the pericellular microenvironment

(2010) Toni M. Antalis et al.   BIOCHEMICAL JOURNAL

A Novel Signaling Axis of Matriptase/PDGF-D/ -PDGFR in Human Prostate Cancer

(2010) C. V. Ustach et al.   CANCER RESEARCH

TMPRSS4 induces invasion and epithelial-mesenchymal transition through upregulation of integrin  5 and its signaling pathways

(2010) S. Kim et al.   CARCINOGENESIS

Local Protease Signaling Contributes to Neural Tube Closure in the Mouse Embryo

(2010) Eric Camerer et al.   DEVELOPMENTAL CELL

Type II Transmembrane Serine Protease (TTSP) deregulation in cancer

(2010) Siobhan et al.   Frontiers in Bioscience-Landmark

Proteolysis-induced N-terminal Ectodomain Shedding of the Integral Membrane Glycoprotein CUB Domain-containing Protein 1 (CDCP1) Is Accompanied by Tyrosine Phosphorylation of Its C-terminal Domain and Recruitment of Src and PKCδ

(2010) Yaowu He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane-anchored serine protease matriptase regulates epithelial barrier formation and permeability in the intestine

(2010) M. S. Buzza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epithelial Integrity Is Maintained by a Matriptase-Dependent Proteolytic Pathway

(2009) Karin List et al.   AMERICAN JOURNAL OF PATHOLOGY

Pegylated Kunitz Domain Inhibitor Suppresses Hepsin-Mediated Invasive Tumor Growth and Metastasis

(2009) W. Li et al.   CANCER RESEARCH

Type II Transmembrane Serine Proteases

(2009) Thomas H. Bugge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Matriptase and Proteinase-Activated Receptor-2 in Nonmelanoma Skin Cancer

(2009) Georgeta Bocheva et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Hepsin activates prostasin and cleaves the extracellular domain of the epidermal growth factor receptor

(2009) Mengqian Chen et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Common variants in 8q24 are associated with risk for prostate cancer and tumor aggressiveness in men of European ancestry

(2009) Prodipto Pal et al.   PROSTATE

Emerging Biomarkers for the Diagnosis and Prognosis of Prostate Cancer

(2008) G. Sardana et al.   CLINICAL CHEMISTRY

Role of platelet-derived growth factors in physiology and medicine

(2008) J. Andrae et al.   GENES & DEVELOPMENT

Hepsin colocalizes with desmosomes and induces progression of ovarian cancer in a mouse model

(2008) Jiangyong Miao et al.   INTERNATIONAL JOURNAL OF CANCER

Molecular Basis of Metastasis

(2008) Anne C. Chiang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tissue Factor and Protease-Activated Receptor Signaling in Cancer

(2008) Florence Schaffner et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Type II transmembrane serine proteases in development and disease

(2007) R SZABO et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY