Article
Multidisciplinary Sciences
Baotong Zhang, Yixiang Li, Qiao Wu, Lin Xie, Benjamin Barwick, Changying Fu, Xin Li, Daqing Wu, Siyuan Xia, Jing Chen, Wei Ping Qian, Lily Yang, Adeboye O. Osunkoya, Lawrence Boise, Paula M. Vertino, Yichao Zhao, Menglin Li, Hsiao-Rong Chen, Jeanne Kowalski, Omer Kucuk, Wei Zhou, Jin-Tang Dong
Summary: Therapies for bone metastatic prostate cancer are limited and the underlying mechanisms are unclear. Research shows that bone-derived TGF-beta induces acetylation of KLF5, which promotes prostate cancer bone metastasis and resistance to docetaxel.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Jackson R. Richards, Donghan Shin, Rob Pryor, Lise K. Sorensen, Zhonglou Sun, Won Mi So, Garam Park, Roger Wolff, Amanda Truong, Martin McMahon, Allie H. Grossmann, J. William Harbour, Weiquan Zhu, Shannon J. Odelberg, Jae Hyuk Yoo
Summary: Preventing or effectively treating metastatic uveal melanoma (UM) is critical due to its high occurrence rate and poor prognosis. The study identified a signaling pathway involving HGF, IGF-1, ARF6, ASAP1, and NFAT1 that promotes UM liver metastasis. Inhibiting this pathway could potentially be a targeted therapy for metastatic uveal melanoma.
Article
Cell Biology
Ke-Fan Pan, Yu-Cheng Liu, Michael Hsiao, Tsu-Yao Cheng, Kuo-Tai Hua
Summary: Naa10p plays an oncogenic role in promoting esophageal cancer metastasis, with higher expression correlating with poorer patient survival. Transcription of NAA10 is regulated by the critical oncogene c-Myc. The enzymatic activity of Naa10p, along with Naa15p, inhibits the secretion of the protease inhibitor PAI1. These findings establish the significance of Naa10p in driving metastasis in esophageal cancer, suggesting its potential use as a prognostic biomarker and therapeutic target.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Birgit Lohberger, Susanne Scheipl, Ellen Heitzer, Franz Quehenberger, Danielle de Jong, Karoly Szuhai, Bernadette Liegl-Atzwanger, Beate Rinner
Summary: Chordomas are rare malignant bone tumors with no approved medical treatment. Research has shown that cMET and HGF are expressed in Chordomas, and cMET inhibitors may benefit patients with sacral Chordomas.
SCIENTIFIC REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Yuxiao Zheng, Feng Qi, Lu Li, Bin Yu, Yifei Cheng, Minghui Ge, Chao Qin, Xiao Li
Summary: This study identified lncNAP1L6 as an oncogene in prostate cancer (PCa) and suggested it as a potential therapeutic target. Functional assays revealed that lncNAP1L6 promotes cell migration, invasion, and epithelial-mesenchymal transition (EMT) in PCa. Mechanism assays showed that lncNAP1L6 regulates NAP1L2 mRNA stability through METTL14/METTL3 complex-mediated m6A methylation and interacts with YY1 to activate MMP signaling pathway.
CANCER GENE THERAPY
(2023)
Article
Oncology
Yara Rodriguez, Kenji Unno, Mihai I. Truica, Zachary R. Chalmers, Young A. Yoo, Rajita Vatapalli, Vinay Sagar, Jindan Yu, Barbara Lysy, Maha Hussain, Huiying Han, Sarki A. Abdulkadir
Summary: This study identifies PRRX2 as a driver of enzalutamide resistance in prostate cancer. PRRX2 expression is highest in double-negative prostate cancer cases and its associated gene signature can serve as a biomarker for enzalutamide resistance, which can be reversed with CDK4/6 and BCL2 inhibitors.
Article
Cell Biology
Chenchen Pan, Frank Winkler
Summary: This article reviews recent advances in understanding the interactions between cancer and the nervous system, and how this knowledge can be applied to improve cancer therapies. It highlights the importance of cancer neuroscience research and provides a roadmap for future studies.
NATURE CELL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Haixiang Qin, Yang Yang, Bo Jiang, Chun Pan, Wei Chen, Wenli Diao, Meng Ding, Wenmin Cao, Zhenxing Zhang, Mengxia Chen, Jie Gao, Xiaozhi Zhao, Xuefeng Qiu, Hongqian Guo
Summary: The study revealed a novel insight into the molecular mechanism where cancer-associated fibroblasts promote SOX9 expression in prostate cancer cells through the HGF/c-Met-ERK1/2-FRA1 axis. SOX9 may serve as an alternative marker for the activated HGF/c-Met signaling in selecting optimal patients for treatment.
Review
Biochemistry & Molecular Biology
Marzia Di Donato, Pia Giovannelli, Antimo Migliaccio, Gabriella Castoria
Summary: Prostate cancer is the most diagnosed and second most lethal cancer in men worldwide, and its development and progression are influenced by alterations in the tumor microenvironment and neurotrophins like nerve growth factor (NGF). Aberrations in NGF signaling are implicated in neurological disorders as well as the pathogenesis of proliferative diseases, including prostate cancer, by promoting a metastatic phenotype. Nerve outgrowth and perineural invasion also play important roles in cancer progression. Understanding the interactions between the tumor microenvironment, nerves, and prostate cancer cells can potentially lead to new therapeutic strategies.
CELL AND BIOSCIENCE
(2023)
Article
Oncology
Jian-Hua Hong, Sung-Tzu Liang, Alexander Sheng-Shin Wang, Chia-Ming Yeh, Hsiang-Po Huang, Chia-Dong Sun, Zong-Han Zhang, Shih-Yu Lu, Yen-Hsiang Chao, Chung-Hsin Chen, Yeong-Shiau Pu
Summary: Prostate cancer is common among men in the Western world, but there are currently no reliable biomarkers to differentiate between aggressive and indolent cancer. Studies have shown that LMNB1 may play a role in the progression of prostate cancer, but the results have been inconsistent.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
Jian-Hua Hong, Sung-Tzu Liang, Alexander Sheng-Shin Wang, Chia-Ming Yeh, Hsiang-Po Huang, Chia-Dong Sun, Zong-Han Zhang, Shih-Yu Lu, Yen-Hsiang Chao, Chung-Hsin Chen, Yeong-Shiau Pu
Summary: LMNB1 may play a role in early prostate cancer progression, but additional molecular alterations may be needed to confer full malignancy potential to initiated cells.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jiadi Lv, Yaoping Liu, Feiran Cheng, Jiping Li, Yabo Zhou, Tianzhen Zhang, Nannan Zhou, Cong Li, Zhenfeng Wang, Longfei Ma, Mengyu Liu, Qiang Zhu, Xiaohan Liu, Ke Tang, Jingwei Ma, Huafeng Zhang, Jing Xie, Yi Fang, Haizeng Zhang, Ning Wang, Yuying Liu, Bo Huang
Summary: Microfluidic devices can sort cancer stem cells into mechanically stiff and soft subpopulations, with soft tumor cells showing higher tumorigenicity. The upregulation of Wnt signaling protein BCL9L in soft tumor cells is associated with their stemness and tumorigenicity. These findings suggest that intrinsic softness can serve as a unique marker for highly tumorigenic and metastatic tumor cells.
Review
Oncology
Xu Zhang, Peng Jiang, Chaojun Wang
Summary: Prostate cancer is unique in its ability to predominantly generate osteoblastic bone metastases, which account for over 90% of prostate cancer bone metastases. Prostate-specific antigen (PSA) plays a crucial role in this process by promoting osteomimicry of cancer cells, inhibiting osteoclast differentiation, and facilitating osteoblast proliferation and activation at metastatic sites. Furthermore, PSA activates osteogenic factors while suppressing osteolytic factors, contributing to the predominance of osteoblastic bone metastasis and bone remodeling in prostate cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Lucia Janacova, Michaela Stenckova, Petr Lapcik, Sarka Hrachovinova, Pavla Bouchalova, David Potesil, Roman Hrstka, Petr Muller, Pavel Bouchal
Summary: Catechol-O-methyl transferase (COMT) is involved in the detoxification of catechol estrogens and suppresses migration potential of breast cancer cells. In this study, the role of COMT in estrogen receptor-dependent breast cancer metastasis was investigated. Overexpression of COMT was found to decrease cell invasion and affect the transcriptome, proteome, and interactome of MCF7 cells. The study also revealed that COMT interacts with proteins involved in the MET signaling pathway, suggesting its involvement in tumor suppression.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Chong Fu, Yan Chen, Wei Xu, Yanping Zhang
Summary: Using genetic data, a Mendelian randomization analysis was conducted to explore the causal relationships between inflammatory cytokines and migraine. The results showed a positive association between hepatocyte growth factor (HGF) and migraine risk, while interleukin-2 (IL-2) was considered a downstream consequence of migraine.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Chun-Che Tseng, Bailing Jia, Robert B. Barndt, Yang-Hong Dai, Yu Hsin Chen, Po-Wen A. Du, Jehng-Kang Wang, Hung-Jen Tang, Chen-Yong Lin, Michael D. Johnson
Article
Immunology
Xiaoping Xie, Lele Zhu, Zuliang Jie, Yanchuan Li, Meidi Gu, Xiaofei Zhou, Hui Wang, Jae-Hoon Chang, Chun-Jung Ko, Xuhong Cheng, Shao-Cong Sun
Summary: TRAF2 maintains a survival signaling axis in effector and memory CD8 T cells, required for immune responses against infections, by controlling the activation of Tpl2 and its downstream kinase ERK through NIK and degradation of the proapoptotic factor Bim. Uncontrolled NIK activation due to loss of TRAF2 leads to severe defects in ERK activation and CD8 T cell survival, affecting protective immunity.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chun-Jung Ko, Lingyun Zhang, Zuliang Jie, Lele Zhu, Xiaofei Zhou, Xiaoping Xie, Tianxiao Gao, Jin-Young Yang, Xuhong Cheng, Shao-Cong Sun
Summary: The E3 ubiquitin ligase Peli1 is identified as a critical regulator of T cell metabolism and antitumor immunity. Peli1 deficiency promotes tumor rejection by enhancing metabolic activities, particularly glycolysis, in T cells. Peli1 controls mTORC1 activation through regulation of TSC1 and TSC2 proteins, establishing it as a novel regulator of mTORC1-mediated actions on T cell metabolism and antitumor immunity.
Article
Oncology
Hsin-Fang Tu, Chun-Jung Ko, Ching-Tai Lee, Cheng-Fan Lee, Shao-Wei Lan, Hsin-Hsien Lin, Hsin-Ying Lin, Chia-Chi Ku, Der-Yen Lee, I-Chun Chen, Ya-Hui Chuang, Francisco Del Cano-Ochoa, Santiago Ramon-Maiques, Chao-Chi Ho, Ming-Shyue Lee, Geen-Dong Chang
Summary: Afatinib can suppress CD8(+)T lymphocyte proliferation by targeting CAD, and its transient immunomodulatory effect may enhance therapeutic efficacy when combined with anti-PD1 immunotherapy. Furthermore, the timing window for combined therapy with afatinib and immunotherapy may prevent the dampening of ICB efficacy by EGFR-TKIs.
Article
Multidisciplinary Sciences
Chia-Lin Chen, Sheng-Chieh Hsu, Tan-Ya Chung, Cheng-Ying Chu, Hung-Jung Wang, Pei-Wen Hsiao, Shauh-Der Yeh, David K. Ann, Yun Yen, Hsing-Jien Kung
Summary: Arginine globally upregulates nuclear-encoded oxidative phosphorylation genes in prostate cancer cells by altering histone acetylation and retaining TEAD4 in the nucleus, which may provide potential therapeutic targets for enhancing arginine-deprivation therapy and prostate cancer treatment. Silencing TEAD4 suppresses OXPHOS functions and prostate cancer cell growth.
NATURE COMMUNICATIONS
(2021)
Article
Hematology
Yanchuan Li, Xiaoping Xie, Zuliang Jie, Lele Zhu, Jin-Young Yang, Chun-Jung Ko, Tianxiao Gao, Antrix Jain, Sung Yun Jung, Natalia Baran, Marina Y. Konopleva, Xuhong Cheng, Shao-Cong Sun
Summary: DYRK1a is identified as a critical mediator in the BAFF signaling pathway, playing a key role in B-cell survival and contributing to the pathogenesis of B-cell acute lymphoblastic leukemia (B-ALL).
Article
Multidisciplinary Sciences
Zuliang Jie, Chun-Jung Ko, Hui Wang, Xiaoping Xie, Yanchuan Li, Meidi Gu, Lele Zhu, Jin-Young Yang, Tianxiao Gao, Wenjuan Ru, Shao-Jun Tang, Xuhong Cheng, Shao-Cong Sun
Summary: Microglia play a critical role in the progression of EAE by mediating noncanonical NF-κB signaling pathway, with NIK being essential for the recruitment of inflammatory T cells and monocytes in the CNS. The activation of T cell-derived cytokines and chemokines is important for the second-wave of T cell recruitment and disease progression in EAE.
Article
Multidisciplinary Sciences
Tianxiao Gao, Ting Liu, Chun-Jung Ko, Lingyun Zhang, Donghyun Joo, Xiaoping Xie, Lele Zhu, Yanchuan Li, Xuhong Cheng, Shao-Cong Sun
Summary: The study demonstrates that TBK1 plays a crucial role in regulating proinflammatory macrophage function and protecting against tissue inflammation. It suppresses the induction of proinflammatory cytokines, particularly IL-1 beta, by inhibiting the NF-kappa B and MAP kinase signaling pathways in macrophages. This finding is important for further understanding the pathogenesis of inflammatory diseases and identifying new therapeutic approaches.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Lingyun Zhang, Chun-Jung Ko, Yanchuan Li, Zuliang Jie, Lele Zhu, Xiaofei Zhou, Xiaoping Xie, Tianxiao Gao, Ting Liu, Xuhong Cheng, Shao-Cong Sun
Summary: Inflammasomes are important for innate immunity against infections but can also contribute to inflammatory diseases when deregulated. Peli1, as an E3 ubiquitin ligase, plays a critical role in regulating the activation of NLRP3 inflammasome by promoting ASC ubiquitination and facilitating inflammasome assembly. Deficiency in Peli1 impairs NLRP3-induced caspase-1 activation and IL-1 beta maturation, highlighting its significance as an inflammasome regulator.
Article
Biochemistry & Molecular Biology
Hsin-Ying Lin, Chun-Jung Ko, Tzu-Yu Lo, Shang-Ru Wu, Shao-Wei Lan, Chen-An Huang, Yi-Chin Lin, Hsin-Hsien Lin, Hsin-Fang Tu, Cheng-Fan Lee, Pei-Wen Hsiao, Hsiang-Po Huang, Mei-Jou Chen, Kai-Hsiung Chang, Ming-Shyue Lee
Summary: This study demonstrates that Matriptase-2 (MT-2) can suppress prostate cancer cell invasion, tumor growth, and metastasis by altering the action of TGF-beta and upregulating the expression of p21 and PAI-1 through the NR4A3/Smad2 pathway.
Article
Oncology
Chia-Lun Hong, I-Shing Yu, Chen-Hsueh Pai, Jin-Shing Chen, Min-Shu Hsieh, Hua-Lin Wu, Shu-Wha Lin, Hsiang-Po Huang
Summary: CD248 maintains pericyte function in lung cancer through the Wnt signaling pathway and upregulates angiogenic factors, suggesting it as a potential therapeutic target.
Article
Cell Biology
Lele Zhu, Xiaofei Zhou, Meidi Gu, Jiseong Kim, Yanchuan Li, Chun-Jung Ko, Xiaoping Xie, Tianxiao Gao, Xuhong Cheng, Shao-Cong Sun
Summary: This study identified Dapl1 as a crucial regulator of CD8(+) T cell immunity, showing that Dapl1 deficiency can lead to functional exhaustion of CD8(+) T cells in chronic infection and cancer.
NATURE CELL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
De-Fong Huang, Chih-Yu Lee, Ming-Yi Chou, Tzu-Yin Yang, Xuhui Cao, Yu-Hsuan Hsiao, Rui-Ni Wu, Cheng-Chang Lien, Yi-Shuian Huang, Hsiang-Po Huang, Susan Shur-Fen Gau, Hsien-Sung Huang
Summary: This study reveals the critical role of RBFOX3 in the regulation of epilepsy and provides new potential targets and pathways for epilepsy treatment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Neng-Wei Tsai, Cheng-Chen Lin, Ti -Yen Yeh, Yu-An Chiu, Hsin-Hui Chiu, Hsiang -Po Huang, Sung -Tsang Hsieh
Summary: In this study, we established a cell system of iPSC-derived sensory neurons to model peripheral nerve degeneration and investigate the molecular mechanisms of neurodegeneration. We found that vincristine, a drug that causes chemotherapy-induced peripheral neuropathy, led to faster degeneration of neurites compared to somata, consistent with length-dependent neuropathy. Additionally, we discovered that JNK phosphorylation was upregulated, while p38 and ERK1/2 phosphorylation remained unchanged. Furthermore, vincristine treatment impaired autophagy and reduced autophagic flux, which could be reversed by rapamycin treatment. These findings not only provide insights into the molecular mechanisms of neurodegeneration but also offer potential therapeutic targets.
DISEASE MODELS & MECHANISMS
(2022)
Article
Immunology
Yanchuan Li, Lele Zhu, Chun-Jung Ko, Jin-Young Yang, Hongjiao Wang, Ganiraju Manyam, Jing Wang, Xuhong Cheng, Shuli Zhao, Zuliang Jie
Summary: Li et al. demonstrate that the TRAF3-EWSR1 signaling axis functions as a critical checkpoint in regulating induced germinal center (GC) responses and immunoglobulin production. This signaling axis acts as a negative regulator of Bcl6 upregulation, thus negatively impacting GC B cell generation and IgG production.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)