Identification of the first synthetic inhibitors of the type II transmembrane serine protease TMPRSS2 suitable for inhibition of influenza virus activation

Ligand Binding Stepwise Disrupts Water Network in Thrombin: Enthalpic and Entropic Changes Reveal Classical Hydrophobic Effect

(2012) Adam Biela et al.   JOURNAL OF MEDICINAL CHEMISTRY

A New Strategy for the Development of Highly Potent and Selective Plasmin Inhibitors

(2012) Sebastian M. Saupe et al.   JOURNAL OF MEDICINAL CHEMISTRY

Simultaneous Treatment of Human Bronchial Epithelial Cells with Serine and Cysteine Protease Inhibitors Prevents Severe Acute Respiratory Syndrome Coronavirus Entry

(2012) M. Kawase et al.   JOURNAL OF VIROLOGY

New 3-amidinophenylalanine-derived inhibitors of matriptase

(2012) Maya Hammami et al.   MedChemComm

Aprotinin and similar protease inhibitors as drugs against influenza

(2011) O.P. Zhirnov et al.   ANTIVIRAL RESEARCH

Development of substrate analogue inhibitors for the human airway trypsin-like protease HAT

(2011) Frank Sielaff et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Protease-activated receptors and myocardial infarction

(2011) Silvio Antoniak et al.   IUBMB LIFE

Cleavage and Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by Human Airway Trypsin-Like Protease

(2011) S. Bertram et al.   JOURNAL OF VIROLOGY

Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response

(2011) I. Glowacka et al.   JOURNAL OF VIROLOGY

TMPRSS2, a Serine Protease Expressed in the Prostate on the Apical Surface of Luminal Epithelial Cells and Released into Semen in Prostasomes, Is Misregulated in Prostate Cancer Cells

(2010) Ya-Wen Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

Identification of the First Low-Molecular-Weight Inhibitors of Matriptase-2

(2010) Mihiret Tekeste Sisay et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Transmembrane Serine Protease Is Linked to the Severe Acute Respiratory Syndrome Coronavirus Receptor and Activates Virus Entry

(2010) A. Shulla et al.   JOURNAL OF VIROLOGY

Efficient Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by the Transmembrane Protease TMPRSS2

(2010) S. Matsuyama et al.   JOURNAL OF VIROLOGY

Cleavage of Influenza Virus Hemagglutinin by Airway Proteases TMPRSS2 and HAT Differs in Subcellular Localization and Susceptibility to Protease Inhibitors

(2010) E. Bottcher-Friebertshauser et al.   JOURNAL OF VIROLOGY

Inhibition of Influenza Virus Infection in Human Airway Cell Cultures by an Antisense Peptide-Conjugated Morpholino Oligomer Targeting the Hemagglutinin-Activating Protease TMPRSS2

(2010) E. Bottcher-Friebertshauser et al.   JOURNAL OF VIROLOGY

Evidence for CCl/CBr⋅⋅⋅π Interactions as an Important Contribution to Protein-Ligand Binding Affinity

(2009) Hans Matter et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Potent Inhibitors of Furin and Furin-like Proprotein Convertases Containing Decarboxylated P1 Arginine Mimetics

(2009) Gero L. Becker et al.   JOURNAL OF MEDICINAL CHEMISTRY

MDCK cells that express proteases TMPRSS2 and HAT provide a cell system to propagate influenza viruses in the absence of trypsin and to study cleavage of HA and its inhibition

(2009) Eva Böttcher et al.   VACCINE

Factor VIIa inhibitors: Target hopping in the serine protease family using X-ray structure determination

(2008) Takuya Shiraishi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Modification of the N-terminal sulfonyl residue in 3-amidinophenylalanine-based matriptase inhibitors

(2008) Torsten Steinmetzer et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Efficient Multiplication of Human Metapneumovirus in Vero Cells Expressing the Transmembrane Serine Protease TMPRSS2

(2008) Y. Shirogane et al.   JOURNAL OF VIROLOGY

Type II transmembrane serine proteases in development and disease

(2007) R SZABO et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY