Pinus mugo Essential Oil Impairs STAT3 Activation through Oxidative Stress and Induces Apoptosis in Prostate Cancer Cells

Thyme Oil and Thymol Counter Doxorubicin-Induced Hepatotoxicity via Modulation of Inflammation, Apoptosis, and Oxidative Stress

(2022) Osama M. Ahmed et al.   Oxidative Medicine and Cellular Longevity

In vivo Antiphytoviral Activity of Essential Oils and Hydrosols From Origanum vulgare, Thymus vulgaris, and Rosmarinus officinalis to Control Zucchini Yellow Mosaic Virus and Tomato Leaf Curl New Delhi Virus in Cucurbita pepo L.

(2022) Anna Taglienti et al.   Frontiers in Microbiology

Essential Oils Biofilm Modulation Activity and Machine Learning Analysis on Pseudomonas aeruginosa Isolates from Cystic Fibrosis Patients

(2022) Marco Artini et al.   Microorganisms

Sorafenib Chemosensitization by Caryophyllane Sesquiterpenes in Liver, Biliary, and Pancreatic Cancer Cells: The Role of STAT3/ABC Transporter Axis

(2022) Silvia Di Giacomo et al.   Pharmaceutics

Liquid and Vapor Phase of Four Conifer-Derived Essential Oils: Comparison of Chemical Compositions and Antimicrobial and Antioxidant Properties

(2021) Stefania Garzoli et al.   Pharmaceuticals

Essential Oils, Pituranthos chloranthus and Teucrium ramosissimum, Chemosensitize Resistant Human Uterine Sarcoma MES-SA/Dx5 Cells to Doxorubicin by Inducing Apoptosis and Targeting P-Glycoprotein

(2021) Aida Lahmar et al.   Nutrients

Dietary Polyphenols: Promising Adjuvants for Colorectal Cancer Therapies

(2021) Laura Bracci et al.   Cancers

Antitumor effect of Melaleuca alternifolia essential oil and its main component terpinen-4-ol in combination with target therapy in melanoma models

(2021) Marta Di Martile et al.   Cell Death Discovery

Thymoquinone induces oxidative stress-mediated apoptosis through downregulation of Jak2/STAT3 signaling pathway in human melanoma cells

(2021) Pawan Kumar Raut et al.   FOOD AND CHEMICAL TOXICOLOGY

Chemotherapeutic and chemopreventive potentials of ρ-coumaric acid – Squid chitosan nanogel loaded with Syzygium aromaticum essential oil

(2021) Islam Kamal et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Essential Oil Phytocomplex Activity, a Review with a Focus on Multivariate Analysis for a Network Pharmacology-Informed Phytogenomic Approach

(2020) Alessandro Buriani et al.   MOLECULES

Experimental Data Based Machine Learning Classification Models with Predictive Ability to Select in Vitro Active Antiviral and Non-Toxic Essential Oils

(2020) Manuela Sabatino et al.   MOLECULES

Potent In Vitro Activity of Citrus aurantium Essential Oil and Vitis vinifera Hydrolate Against Gut Yeast Isolates from Irritable Bowel Syndrome Patients—The Right Mix for Potential Therapeutic Use

(2020) Maura Di Vito et al.   Nutrients

Modulation of STAT3 Signaling, Cell Redox Defenses and Cell Cycle Checkpoints by β-Caryophyllene in Cholangiocarcinoma Cells: Possible Mechanisms Accounting for Doxorubicin Chemosensitization and Chemoprevention

(2020) Antonella Di Sotto et al.   Cells

An image J plugin for the high throughput image analysis of in vitro scratch wound healing assays

(2020) Alejandra Suarez-Arnedo et al.   PLoS One

Melissa officinalis Extract Induces Apoptosis and Inhibits Migration in Human Colorectal Cancer Cells

(2020) Tzu-Ting Kuo et al.   ACS Omega

Machine Learning Analyses on Data including Essential Oil Chemical Composition and In Vitro Experimental Antibiofilm Activities against Staphylococcus Species

(2019) Alexandros Patsilinakos et al.   MOLECULES

STAT3 Post-Translational Modifications Drive Cellular Signaling Pathways in Prostate Cancer Cells

(2019) Rossana Cocchiola et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

STAT1 drives M1 microglia activation and neuroinflammation under hypoxia

(2019) Elena Butturini et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Extraction, Chemical Composition, and Anticancer Potential of Origanum onites L. Essential Oil

(2019) Katerina Spyridopoulou et al.   MOLECULES

Curcumin Combination Chemotherapy: The Implication and Efficacy in Cancer

(2019) Bee Ling Tan et al.   MOLECULES

Natural compounds as potential adjuvants to cancer therapy: preclinical evidence

(2019) Shian‐Ren Lin et al.   BRITISH JOURNAL OF PHARMACOLOGY

Essential Oil from Pinus Koraiensis Pinecones Inhibits Gastric Cancer Cells via the HIPPO/YAP Signaling Pathway

(2019) Yandong Zhang et al.   MOLECULES

Natural Sesquiterpene Lactones Enhance Chemosensitivity of Tumor Cells through Redox Regulation of STAT3 Signaling

(2019) Elena Butturini et al.   Oxidative Medicine and Cellular Longevity

S-glutathionylation exerts opposing roles in the regulation of STAT1 and STAT3 signaling in reactive microglia

(2018) Elena Butturini et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lemongrass essential oil and citral inhibit Src/Stat3 activity and suppress the proliferation/survival of small-cell lung cancer cells, alone or in combination with chemotherapeutic agents

(2018) Takayuki Maruoka et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Two decades of research in discovery of anticancer drugs targeting STAT3, how close are we?

(2018) Jenny D. Beebe et al.   PHARMACOLOGY & THERAPEUTICS

Essential Oil Derived From Eupatorium adenophorum Spreng. Mediates Anticancer Effect by Inhibiting STAT3 and AKT Activation to Induce Apoptosis in Hepatocellular Carcinoma

(2018) Hao Chen et al.   Frontiers in Pharmacology

Esential oils extraction: a 24-hour steam distillation systematic methodology

(2017) Mijat Božović et al.   NATURAL PRODUCT RESEARCH

Frankincense, pine needle and geranium essential oils suppress tumor progression through the regulation of the AMPK/mTOR pathway in breast cancer

(2017) Peng Ren et al.   ONCOLOGY REPORTS

Constitutive activated STAT3 is an essential regulator and therapeutic target in esophageal squamous cell carcinoma

(2017) Fang Tian et al.   Oncotarget

Strategies and Approaches of Targeting STAT3 for Cancer Treatment

(2016) Steffanie L. Furtek et al.   ACS Chemical Biology

Melissa officinalis extract induces apoptosis and inhibits proliferation in colon cancer cells through formation of reactive oxygen species

(2015) C. Weidner et al.   PHYTOMEDICINE

Curcuma zedoaria (Berg.) Rosc. essential oil and paclitaxel synergistically enhance the apoptosis of SKOV3 cells

(2015) YUNXIAO ZHOU et al.   Molecular Medicine Reports

S-Glutathionylation at Cys328 and Cys542 Impairs STAT3 Phosphorylation

(2014) Elena Butturini et al.   ACS Chemical Biology

Thymoquinone induces apoptosis in human colon cancer HCT116 cells through inactivation of STAT3 by blocking JAK2- and Src-mediated phosphorylation of EGF receptor tyrosine kinase

(2014) JUTHIKA KUNDU et al.   ONCOLOGY REPORTS

Inhibition of Inflammatory and Proliferative Responses of Human Keratinocytes Exposed to the Sesquiterpene Lactones Dehydrocostuslactone and Costunolide

(2014) Claudia Scarponi et al.   PLoS One

Essential Oils and Their Constituents as Anticancer Agents: A Mechanistic View

(2014) Nandini Gautam et al.   Biomed Research International

STAT3 Target Genes Relevant to Human Cancers

(2014) Richard Carpenter et al.   Cancers

STAT3 Regulation by S-Nitrosylation: Implication for Inflammatory Disease

(2013) Jinsu Kim et al.   ANTIOXIDANTS & REDOX SIGNALING

Generation of Prostate Tumor-Initiating Cells Is Associated with Elevation of Reactive Oxygen Species and IL-6/STAT3 Signaling

(2013) Y. Qu et al.   CANCER RESEARCH

Mild oxidative stress induces S-glutathionylation of STAT3 and enhances chemosensitivity of tumoural cells to chemotherapeutic drugs

(2013) Elena Butturini et al.   FREE RADICAL BIOLOGY AND MEDICINE

New Role of JAK2/STAT3 Signaling in Endothelial Cell Oxidative Stress Injury and Protective Effect of Melatonin

(2013) Weixun Duan et al.   PLoS One

Constitutive Activation of STAT3 Signaling Regulates hTERT and Promotes Stem Cell-Like Traits in Human Breast Cancer Cells

(2013) Seyung S. Chung et al.   PLoS One

STAT3 activation in response to IL-6 is prolonged by the binding of IL-6 receptor to EGF receptor

(2013) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The TORC1/TORC2 inhibitor, Palomid 529, reduces tumor growth and sensitizes to docetaxel and cisplatin in aggressive and hormone-refractory prostate cancer cells

(2011) G. L. Gravina et al.   ENDOCRINE-RELATED CANCER

Two Naturally Occurring Terpenes, Dehydrocostuslactone and Costunolide, Decrease Intracellular GSH Content and Inhibit STAT3 Activation

(2011) Elena Butturini et al.   PLoS One

Modulation of Gene Expression and Tumor Cell Growth by Redox Modification of STAT3

(2010) L. Li et al.   CANCER RESEARCH

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

Constitutively Active Stat3 Enhances Neu-Mediated Migration and Metastasis in Mammary Tumors via Upregulation of Cten

(2010) I. Barbieri et al.   CANCER RESEARCH

Antiproliferative effects of essential oils and their major constituents in human renal adenocarcinoma and amelanotic melanoma cells

(2008) M. R. Loizzo et al.   CELL PROLIFERATION