Natural Sesquiterpene Lactones Enhance Chemosensitivity of Tumor Cells through Redox Regulation of STAT3 Signaling

Targeting Metabolic–Redox Circuits for Cancer Therapy

(2019) Kui Wang et al.   TRENDS IN BIOCHEMICAL SCIENCES

MTMR2 promotes invasion and metastasis of gastric cancer via inactivating IFNγ/STAT1 signaling

(2019) Lei Jiang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

STAT1 drives M1 microglia activation and neuroinflammation under hypoxia

(2019) Elena Butturini et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Sensitization to immune checkpoint blockade through activation of a STAT1/NK axis in the tumor microenvironment

(2019) Rachael M. Zemek et al.   Science Translational Medicine

Cystathionine Promotes the Proliferation of Human Astrocytoma U373 Cells

(2018) HALINA JURKOWSKA et al.   ANTICANCER RESEARCH

NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism

(2018) Wusheng Xiao et al.   ANTIOXIDANTS & REDOX SIGNALING

Activated STAT3 may participate in tumor progression through increasing CD133/survivin expression in early stage of colon cancer

(2018) Wanlu Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Natural small molecule bigelovin suppresses orthotopic colorectal tumor growth and inhibits colorectal cancer metastasis via IL6/STAT3 pathway

(2018) Mingyue Li et al.   BIOCHEMICAL PHARMACOLOGY

A new xanthatin analogue 1 β -hydroxyl-5 α -chloro-8-epi-xanthatin induces apoptosis through ROS-mediated ERK/p38 MAPK activation and JAK2/STAT3 inhibition in human hepatocellular carcinoma

(2018) Xin-Yi Fang et al.   BIOCHIMIE

α-Hederin inhibits interleukin 6-induced epithelial-to-mesenchymal transition associated with disruption of JAK2/STAT3 signaling in colon cancer cells

(2018) Dongdong Sun et al.   BIOMEDICINE & PHARMACOTHERAPY

Hispidulin suppresses cell growth and metastasis by targeting PIM1 through JAK2/STAT3 signaling in colorectal cancer

(2018) Kaili Liu et al.   CANCER SCIENCE

JAK/STAT3-Regulated Fatty Acid β-Oxidation Is Critical for Breast Cancer Stem Cell Self-Renewal and Chemoresistance

(2018) Tianyi Wang et al.   Cell Metabolism

S-glutathionylation exerts opposing roles in the regulation of STAT1 and STAT3 signaling in reactive microglia

(2018) Elena Butturini et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mutant FGFR3 associated with SADDAN disease causes cytoskeleton disorganization through PLCγ1/Src-mediated paxillin hyperphosphorylation

(2018) R. Montone et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

SOX2-mediated upregulation of CD24 promotes adaptive resistance towards targeted therapy in melanoma

(2018) Laura Hüser et al.   INTERNATIONAL JOURNAL OF CANCER

Glutathione metabolism in cancer progression and treatment resistance

(2018) Ankita Bansal et al.   JOURNAL OF CELL BIOLOGY

Disulfide bond based polymeric drug carriers for cancer chemotherapy and relevant redox environments in mammals

(2018) Pei Zhang et al.   MEDICINAL RESEARCH REVIEWS

Parthenolide Inhibits STAT3 Signaling by Covalently Targeting Janus Kinases

(2018) Man Liu et al.   MOLECULES

Parthenolide facilitates apoptosis and reverses drug-resistance of human gastric carcinoma cells by inhibiting the STAT3 signaling pathway

(2018) Hua Li et al.   Oncology Letters

STAT3 activation confers trastuzumab-emtansine (T-DM1) resistance in HER2-positive breast cancer

(2018) Lei Wang et al.   CANCER SCIENCE

Thioredoxin Confers Intrinsic Resistance to Cytostatic Drugs in Human Glioma Cells

(2018) Bodo Haas et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Alantolactone sensitizes human pancreatic cancer cells to EGFR inhibitors through the inhibition of STAT3 signaling

(2018) Hailun Zheng et al.   MOLECULAR CARCINOGENESIS

Ophiopogonin D, a Steroidal Glycoside Abrogates STAT3 Signaling Cascade and Exhibits Anti-Cancer Activity by Causing GSH/GSSG Imbalance in Lung Carcinoma

(2018) Jong Lee et al.   Cancers

Control of the NADPH supply for oxidative stress handling in cancer cells

(2017) Rafael Moreno-Sánchez et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dehydrocostus Lactone Suppresses Proliferation of Human Chronic Myeloid Leukemia Cells Through Bcr/Abl-JAK/STAT Signaling Pathways

(2017) Hong Cai et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

STAT3 signaling mediates tumour resistance to EGFR targeted therapeutics

(2017) Ahmad A. Zulkifli et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

STAT3 inhibition by WP1066 suppresses the growth and invasiveness of bladder cancer cells

(2017) Yujiro Tsujita et al.   ONCOLOGY REPORTS

Santamarine Inhibits NF-кB and STAT3 Activation and Induces Apoptosis in HepG2 Liver Cancer Cells via Oxidative Stress.

(2017) Tahir Mehmood et al.   Journal of Cancer

Phosphorylation of STAT3 at Tyr705 regulates MMP-9 production in epithelial ovarian cancer

(2017) Zan-Hui Jia et al.   PLoS One

Bigelovin triggered apoptosis in colorectal cancer in vitro and in vivo via upregulating death receptor 5 and reactive oxidative species

(2017) Mingyue Li et al.   Scientific Reports

Alantolactone induces apoptosis, promotes STAT3 glutathionylation and enhances chemosensitivity of A549 lung adenocarcinoma cells to doxorubicin via oxidative stress

(2017) Amara Maryam et al.   Scientific Reports

Intermolecular disulfide bond influences unphosphorylated STAT3 dimerization and function

(2016) E. Butturini et al.   BIOCHEMICAL JOURNAL

A Novel Plant Sesquiterpene Lactone Derivative, DETD-35, Suppresses BRAF V600E Mutant Melanoma Growth and Overcomes Acquired Vemurafenib Resistance in Mice

(2016) Jia-Hua Feng et al.   MOLECULAR CANCER THERAPEUTICS

IL-6 mediates the signal pathway of JAK-STAT3-VEGF-C promoting growth, invasion and lymphangiogenesis in gastric cancer

(2016) GUIBIN ZHAO et al.   ONCOLOGY REPORTS

Proteomic identification of the oncoprotein STAT3 as a target of a novel Skp1 inhibitor

(2016) Xin Cheng et al.   Oncotarget

A phase I trial combining carboplatin/doxorubicin with tocilizumab, an anti-IL-6R monoclonal antibody, and interferon-α2b in patients with recurrent epithelial ovarian cancer

(2015) E. M. Dijkgraaf et al.   ANNALS OF ONCOLOGY

Phase 1 study in Japan of siltuximab, an anti-IL-6 monoclonal antibody, in relapsed/refractory multiple myeloma

(2015) Kenshi Suzuki et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Targeting JAK kinase in solid tumors: emerging opportunities and challenges

(2015) M Buchert et al.   ONCOGENE

Disruption of STAT3-DNMT1 interaction by SH-I-14 induces re-expression of tumor suppressor genes and inhibits growth of triple-negative breast tumor

(2015) Hyo Jin Kang et al.   Oncotarget

S-Glutathionylation at Cys328 and Cys542 Impairs STAT3 Phosphorylation

(2014) Elena Butturini et al.   ACS Chemical Biology

A phase 2, randomized, double-blind, placebo-controlled study of siltuximab (anti-IL-6 mAb) and bortezomib versus bortezomib alone in patients with relapsed or refractory multiple myeloma

(2014) Robert Z. Orlowski et al.   AMERICAN JOURNAL OF HEMATOLOGY

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

Stat3 promotes invasion of esophageal squamous cell carcinoma through up-regulation of MMP2

(2014) Xaioyan Xuan et al.   MOLECULAR BIOLOGY REPORTS

The glutathione synthesis inhibitor buthionine sulfoximine synergistically enhanced melphalan activity against preclinical models of multiple myeloma

(2014) A Tagde et al.   Blood Cancer Journal

A phase 2 multicentre study of siltuximab, an anti-interleukin-6 monoclonal antibody, in patients with relapsed or refractory multiple myeloma

(2013) Peter M. Voorhees et al.   BRITISH JOURNAL OF HAEMATOLOGY

Generation of Prostate Tumor-Initiating Cells Is Associated with Elevation of Reactive Oxygen Species and IL-6/STAT3 Signaling

(2013) Y. Qu et al.   CANCER RESEARCH

A sesquiterpene lactone antrocin from Antrodia camphorata negatively modulates JAK2/STAT3 signaling via microRNA let-7c and induces apoptosis in lung cancer cells

(2013) Chi-Tai Yeh et al.   CARCINOGENESIS

Mild oxidative stress induces S-glutathionylation of STAT3 and enhances chemosensitivity of tumoural cells to chemotherapeutic drugs

(2013) Elena Butturini et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sesquiterpenoids Lactones: Benefits to Plants and People

(2013) Martin Chadwick et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effect of AZD1480 in an epidermal growth factor receptor-driven lung cancer model

(2013) Toshi Murakami et al.   LUNG CANCER

AZD1480: A Phase I Study of a Novel JAK2 Inhibitor in Solid Tumors

(2013) E. R. Plimack et al.   ONCOLOGIST

Role of Glutathione in Cancer Progression and Chemoresistance

(2013) Nicola Traverso et al.   Oxidative Medicine and Cellular Longevity

Interplay between microRNAs and the STAT3 signaling pathway in human cancers

(2013) Qing Cao et al.   PHYSIOLOGICAL GENOMICS

Evaluation of STAT3 Signaling in ALDH+ and ALDH+/CD44+/CD24− Subpopulations of Breast Cancer Cells

(2013) Li Lin et al.   PLoS One

Protective Role of Methionine Sulfoxide Reductase A Against Ischemia/Reperfusion Injury in Mouse Kidney and Its Involvement in the Regulation of Trans-Sulfuration Pathway

(2012) Jee In Kim et al.   ANTIOXIDANTS & REDOX SIGNALING

Stat3 induces oncogenic Skp2 expression in human cervical carcinoma cells

(2012) Hanhui Huang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Critical Role of STAT5 Transcription Factor Tetramerization for Cytokine Responses and Normal Immune Function

(2012) Jian-Xin Lin et al.   IMMUNITY

Isoalantolactone Induces Reactive Oxygen Species Mediated Apoptosis in Pancreatic Carcinoma PANC-1 Cells

(2012) Muhammad Khan et al.   International Journal of Biological Sciences

Disulfiram, an old drug with new potential therapeutic uses for human hematological malignancies

(2012) Concetta Conticello et al.   INTERNATIONAL JOURNAL OF CANCER

The SOCS box-Adapting proteins for ubiquitination and proteasomal degradation

(2012) Edmond M. Linossi et al.   IUBMB LIFE

(−)-Epigallocatechin Gallate Induces Fas/CD95-Mediated Apoptosis through Inhibiting Constitutive and IL-6-Induced JAK/STAT3 Signaling in Head and Neck Squamous Cell Carcinoma Cells

(2012) Hui-Yi Lin et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Acyloxy Nitroso Compounds Inhibit LIF Signaling in Endothelial Cells and Cardiac Myocytes: Evidence That STAT3 Signaling Is Redox-Sensitive

(2012) Carlos Zgheib et al.   PLoS One

Intestinal redox biology and oxidative stress

(2012) Magdalena L. Circu et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Alantolactone Induces Apoptosis in HepG2 Cells through GSH Depletion, Inhibition of STAT3 Activation, and Mitochondrial Dysfunction

(2012) Muhammad Khan et al.   Biomed Research International

Randomised phase II study of siltuximab (CNTO 328), an anti-IL-6 monoclonal antibody, in combination with mitoxantrone/prednisone versus mitoxantrone/prednisone alone in metastatic castration-resistant prostate cancer

(2011) K. Fizazi et al.   EUROPEAN JOURNAL OF CANCER

Potent and Selective Phosphopeptide Mimetic Prodrugs Targeted to the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 3

(2011) Pijus K. Mandal et al.   JOURNAL OF MEDICINAL CHEMISTRY

JAK2/STAT3 signaling pathway activation mediates tumor angiogenesis by upregulation of VEGF and bFGF in non-small-cell lung cancer

(2011) Mei Zhao et al.   LUNG CANCER

Regulatory Control or Oxidative Damage? Proteomic Approaches to Interrogate the Role of Cysteine Oxidation Status in Biological Processes

(2011) Jason M. Held et al.   MOLECULAR & CELLULAR PROTEOMICS

Two Naturally Occurring Terpenes, Dehydrocostuslactone and Costunolide, Decrease Intracellular GSH Content and Inhibit STAT3 Activation

(2011) Elena Butturini et al.   PLoS One

Small Compound 6-O-Angeloylplenolin Induces Mitotic Arrest and Exhibits Therapeutic Potentials in Multiple Myeloma

(2011) Ying Liu et al.   PLoS One

The anti-interleukin-6 antibody siltuximab down-regulates genes implicated in tumorigenesis in prostate cancer patients from a phase I study

(2011) Jayaprakash Karkera et al.   PROSTATE

Phase 2 study of dasatinib in the treatment of head and neck squamous cell carcinoma

(2010) Heather D. Brooks et al.   CANCER

Modulation of Gene Expression and Tumor Cell Growth by Redox Modification of STAT3

(2010) L. Li et al.   CANCER RESEARCH

Potential use of the anti-inflammatory drug, sulfasalazine, for targeted therapy of pancreatic cancer

(2010) P. W. Gout et al.   Current Oncology

What made sesquiterpene lactones reach cancer clinical trials?

(2010) Akram Ghantous et al.   DRUG DISCOVERY TODAY

Redox sensing: orthogonal control in cell cycle and apoptosis signalling

(2010) D. P. Jones   JOURNAL OF INTERNAL MEDICINE

Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes

(2010) J. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signal Transducer and Activator of Transcription-3, Inflammation, and Cancer

(2009) Bharat B. Aggarwal et al.   Annals of the New York Academy of Sciences

LLL-3 inhibits STAT3 activity, suppresses glioblastoma cell growth and prolongs survival in a mouse glioblastoma model

(2009) B Fuh et al.   BRITISH JOURNAL OF CANCER

Regulation of the IL-23 and IL-12 Balance by Stat3 Signaling in the Tumor Microenvironment

(2009) Marcin Kortylewski et al.   CANCER CELL

Disruption of Transcriptionally Active Stat3 Dimers with Non-phosphorylated, Salicylic Acid-Based Small Molecules: Potent in vitro and Tumor Cell Activities

(2009) Steven Fletcher et al.   CHEMBIOCHEM

Targeting Signal Transducer and Activator of Transcription Signaling Pathway in Leukemias

(2009) Mustafa Benekli et al.   JOURNAL OF CLINICAL ONCOLOGY

Dehydrocostuslactone disrupts signal transducers and activators of transcription 3 through up-regulation of suppressor of cytokine signaling in breast cancer cells

(2009) P.-L. Kuo et al.   MOLECULAR CANCER THERAPEUTICS

Molecular Mechanisms and Clinical Implications of Reversible Protein S-Glutathionylation

(2008) John J. Mieyal et al.   ANTIOXIDANTS & REDOX SIGNALING

Crystal structure of unphosphorylated STAT3 core fragment

(2008) Zhiyong Ren et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

S-Glutathionylation Impairs Signal Transducer and Activator of Transcription 3 Activation and Signaling

(2008) Yi Xie et al.   ENDOCRINOLOGY

Thiol chemistry and specificity in redox signaling

(2008) Christine C. Winterbourn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulation of glutathione synthesis

(2008) Shelly C. Lu   MOLECULAR ASPECTS OF MEDICINE

Molecular Mechanisms and Potential Clinical Significance of S-Glutathionylation

(2007) Isabella Dalle–Donne et al.   ANTIOXIDANTS & REDOX SIGNALING