Two Naturally Occurring Terpenes, Dehydrocostuslactone and Costunolide, Decrease Intracellular GSH Content and Inhibit STAT3 Activation

STAT3 is constitutively phosphorylated on serine 727 residues, binds DNA, and activates transcription in CLL cells

(2010) I. Hazan-Halevy et al.   BLOOD

Inflammatory bowel disease and intestinal cancer: a paradigm of the Yin–Yang interplay between inflammation and cancer

(2010) S Danese et al.   ONCOGENE

Glutathione dysregulation and the etiology and progression of human diseases

(2009) Nazzareno Ballatori et al.   BIOLOGICAL CHEMISTRY

Dehydrocostuslactone, a Medicinal Plant-Derived Sesquiterpene Lactone, Induces Apoptosis Coupled to Endoplasmic Reticulum Stress in Liver Cancer Cells

(2009) Y.-L. Hsu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Oxidative and endoplasmic reticulum stress signaling are involved in dehydrocostuslactone-mediated apoptosis in human non-small cell lung cancer cells

(2009) Jen-Yu Hung et al.   LUNG CANCER

Signaling Molecules: The Pathogenic Role of the IL-6/STAT-3 Trans Signaling Pathway in Intestinal Inflammation and in Colonic Cancer

(2008) R. Atreya et al.   CURRENT DRUG TARGETS

S-Glutathionylation Impairs Signal Transducer and Activator of Transcription 3 Activation and Signaling

(2008) Yi Xie et al.   ENDOCRINOLOGY

Molecular Mechanisms and Potential Clinical Significance of S-Glutathionylation

(2007) Isabella Dalle–Donne et al.   ANTIOXIDANTS & REDOX SIGNALING

Protective effects of St. John's wort extract and its component hyperforin against cytokine-induced cytotoxicity in a pancreatic β-cell line

(2007) Marta Menegazzi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Protective effect of Arbutus unedo aqueous extract in carrageenan-induced lung inflammation in mice

(2007) Sofia Mariotto et al.   PHARMACOLOGICAL RESEARCH