A Biopharmaceutical Perspective on Higher-Order Structure and Thermal Stability of mRNA Vaccines

Nanomaterial Delivery Systems for mRNA Vaccines

(2021) Michael D. Buschmann et al.   Vaccines

RNA secondary structure prediction using deep learning with thermodynamic integration

(2021) Kengo Sato et al.   Nature Communications

Engineered ionizable lipid nanoparticles for targeted delivery of RNA therapeutics into different types of cells in the liver

(2021) M. Kim et al.   Science Advances

Encapsulation state of messenger RNA inside lipid nanoparticles

(2021) Mark L. Brader et al.   BIOPHYSICAL JOURNAL

From influenza to COVID-19: Lipid nanoparticle mRNA vaccines at the frontiers of infectious diseases

(2021) Emily H. Pilkington et al.   Acta Biomaterialia

Scalable mRNA and siRNA Lipid Nanoparticle Production Using a Parallelized Microfluidic Device

(2021) Sarah J. Shepherd et al.   NANO LETTERS

Theoretical basis for stabilizing messenger RNA through secondary structure design

(2021) Hannah K Wayment-Steele et al.   NUCLEIC ACIDS RESEARCH

Lipid nanoparticles for mRNA delivery

(2021) Xucheng Hou et al.   Nature Reviews Materials

Intracellular Routing and Recognition of Lipid-Based mRNA Nanoparticles

(2021) Christophe Delehedde et al.   Pharmaceutics

Chemistry of Lipid Nanoparticles for RNA Delivery

(2021) Yulia Eygeris et al.   ACCOUNTS OF CHEMICAL RESEARCH

Angle-dependent effects in DLS measurements of polydisperse particles

(2021) Lin Jin et al.   MEASUREMENT SCIENCE and TECHNOLOGY

A novel mechanism for the loss of mRNA activity in lipid nanoparticle delivery systems

(2021) Meredith Packer et al.   Nature Communications

Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA

(2020) Siddharth Patel et al.   Nature Communications

Deconvoluting Lipid Nanoparticle Structure for Messenger RNA Delivery

(2020) Yulia Eygeris et al.   NANO LETTERS

Making ends meet: New functions of mRNA secondary structure

(2020) Dmitri N. Ermolenko et al.   Wiley Interdisciplinary Reviews-RNA

Impact of mRNA chemistry and manufacturing process on innate immune activation

(2020) Jennifer Nelson et al.   Science Advances

Addressing the Cold Reality of mRNA Vaccine Stability

(2020) Daan J.A. Crommelin et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Stability of Vaccines

(2019) N. Dumpa et al.   AAPS PHARMSCITECH

Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery

(2019) Piotr S. Kowalski et al.   MOLECULAR THERAPY

Interfacial Stress in the Development of Biologics: Fundamental Understanding, Current Practice, and Future Perspective

(2019) Jinjiang Li et al.   AAPS Journal

Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines

(2019) Kimberly J. Hassett et al.   Molecular Therapy-Nucleic Acids

Lipid nanoparticles for delivery of messenger RNA to the back of the eye

(2019) Siddharth Patel et al.   JOURNAL OF CONTROLLED RELEASE

mRNA structure regulates protein expression through changes in functional half-life

(2019) David M. Mauger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pervasive Regulatory Functions of mRNA Structure Revealed by High-Resolution SHAPE Probing

(2018) Anthony M. Mustoe et al.   CELL

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

Patisiran: First Global Approval

(2018) Sheridan M. Hoy   DRUGS

Using X-Ray Crystallography to Simplify and Accelerate Biologics Drug Development

(2017) Mark L. Brader et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Melting temperature highlights functionally important RNA structure and sequence elements in yeast mRNA coding regions

(2017) Fei Qi et al.   NUCLEIC ACIDS RESEARCH

Temperature stability of proteins: Analysis of irreversible denaturation using isothermal calorimetry

(2017) Arne Schön et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Differential Scanning Calorimetry — A Method for Assessing the Thermal Stability and Conformation of Protein Antigen

(2017) Ibrahim B. Durowoju et al.   Jove-Journal of Visualized Experiments

Computational modeling of RNA 3D structures and interactions

(2016) Wayne K Dawson et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Similarities and Differences between RNA and DNA Double-Helical Structures in Circular Dichroism Spectroscopy: A SAC–CI Study

(2016) Tomoo Miyahara et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy

(2016) Matthias A. Oberli et al.   NANO LETTERS

Role of mRNA structure in the control of protein folding

(2016) Guilhem Faure et al.   NUCLEIC ACIDS RESEARCH

Concise Review: Application of In Vitro Transcribed Messenger RNA for Cellular Engineering and Reprogramming: Progress and Challenges

(2016) Heidrun Steinle et al.   STEM CELLS

Protein Engineering: A New Frontier for Biological Therapeutics

(2015) Peter Tobin et al.   CURRENT DRUG METABOLISM

Microfluidic Mixing: A General Method for Encapsulating Macromolecules in Lipid Nanoparticle Systems

(2015) Alex K. K. Leung et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Examination of Thermal Unfolding and Aggregation Profiles of a Series of Developable Therapeutic Monoclonal Antibodies

(2015) Mark L. Brader et al.   MOLECULAR PHARMACEUTICS

Twenty years of RNA crystallography

(2015) Eric Westhof   RNA

Vaccine instability in the cold chain: Mechanisms, analysis and formulation strategies

(2014) Ozan S. Kumru et al.   BIOLOGICALS

mRNA-based therapeutics — developing a new class of drugs

(2014) Ugur Sahin et al.   NATURE REVIEWS DRUG DISCOVERY

Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity

(2014) Kathryn A. Whitehead et al.   Nature Communications

The imperative for stronger vaccine supply and logistics systems

(2013) Michel Zaffran et al.   VACCINE

Weak Interactions Govern the Viscosity of Concentrated Antibody Solutions: High-Throughput Analysis Using the Diffusion Interaction Parameter

(2012) Brian D. Connolly et al.   BIOPHYSICAL JOURNAL

Proximity energies: a framework for understanding concentrated solutions

(2012) Tom Laue   JOURNAL OF MOLECULAR RECOGNITION

Analytical tools for characterizing biopharmaceuticals and the implications for biosimilars

(2012) Steven A. Berkowitz et al.   NATURE REVIEWS DRUG DISCOVERY

The Molecular Interactions That Stabilize RNA Tertiary Structure: RNA Motifs, Patterns, and Networks

(2011) Samuel E. Butcher et al.   ACCOUNTS OF CHEMICAL RESEARCH

Conformational change of single-stranded RNAs induced by liposome binding

(2011) Keishi Suga et al.   NUCLEIC ACIDS RESEARCH

Visualizing large RNA molecules in solution

(2011) A. Gopal et al.   RNA

Direct observation of the temperature-induced melting process of the Salmonella fourU RNA thermometer at base-pair resolution

(2010) Jörg Rinnenthal et al.   NUCLEIC ACIDS RESEARCH

Stability of Protein Pharmaceuticals: An Update

(2010) Mark Cornell Manning et al.   PHARMACEUTICAL RESEARCH

The Many Pathways of RNA Degradation

(2009) Jonathan Houseley et al.   CELL

Circular dichroism and conformational polymorphism of DNA

(2009) J. Kypr et al.   NUCLEIC ACIDS RESEARCH

Principles, approaches, and challenges for predicting protein aggregation rates and shelf life

(2008) William F. Weiss et al.   JOURNAL OF PHARMACEUTICAL SCIENCES