Irisin Stimulates the Release of CXCL1 From Differentiating Human Subcutaneous and Deep-Neck Derived Adipocytes via Upregulation of NFκB Pathway

Progress and challenges in the biology of FNDC5 and irisin

(2021) Steffen Maak et al.   ENDOCRINE REVIEWS

Brown/Beige adipose tissues and the emerging role of their secretory factors in improving metabolic health: The batokines

(2021) Bilal Ahmad et al.   BIOCHIMIE

FTO Intronic SNP Strongly Influences Human Neck Adipocyte Browning Determined by Tissue and PPARγ Specific Regulation: A Transcriptome Analysis

(2020) Beáta B. Tóth et al.   Cells

FNDC4, a novel adipokine that reduces lipogenesis and promotes fat browning in human visceral adipocytes

(2020) Gema Frühbeck et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Involvement of the p62/Nrf2/HO-1 pathway in the browning effect of irisin in 3T3-L1 adipocytes

(2020) Yung-Chieh Tsai et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Thermogenic Activation Downregulates High Mitophagy Rate in Human Masked and Mature Beige Adipocytes

(2020) Mária Szatmári-Tóth et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Irisin Protects Against Motor Dysfunction of Rats with Spinal Cord Injury via Adenosine 5'-Monophosphate (AMP)-Activated Protein Kinase-Nuclear Factor Kappa-B Pathway

(2020) Xi Jiang et al.   Frontiers in Pharmacology

Fibroblast Growth Factor 21 and Browning of White Adipose Tissue

(2019) Daniel Cuevas-Ramos et al.   Frontiers in Physiology

FNDC5/Irisin inhibits pathological cardiac hypertrophy

(2019) Qing Yu et al.   CLINICAL SCIENCE

Interleukin-6 released from differentiating human beige adipocytes improves browning

(2019) Endre Kristóf et al.   EXPERIMENTAL CELL RESEARCH

Differentiating SGBS adipocytes respond to PPARγ stimulation, irisin and BMP7 by functional browning and beige characteristics

(2019) Ágnes Klusóczki et al.   Scientific Reports

Diverse repertoire of human adipocyte subtypes develops from transcriptionally distinct mesenchymal progenitor cells

(2019) So Yun Min et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New insights into the secretory functions of brown adipose tissue

(2019) Joan Villarroya et al.   JOURNAL OF ENDOCRINOLOGY

A 2A Receptor Activation Attenuates Hypertensive Cardiac Remodeling via Promoting Brown Adipose Tissue-Derived FGF21

(2018) Cheng-Chao Ruan et al.   Cell Metabolism

An update on the role of irisin in the regulation of endocrine and metabolic functions

(2018) Mohamed Omer Mahgoub et al.   PEPTIDES

CXCL14, a Brown Adipokine that Mediates Brown-Fat-to-Macrophage Communication in Thermogenic Adaptation

(2018) Rubén Cereijo et al.   Cell Metabolism

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors

(2018) Hyeonwoo Kim et al.   CELL

Blind Spot for Sedentarism: Redefining the Diseasome of Physical Inactivity in View of Circadian System and the Irisin/BDNF Axis

(2018) Judit Zsuga et al.   Frontiers in Neurology

CXCL1/CXCR2 signaling in pathological pain: Role in peripheral and central sensitization

(2017) Rangel L. Silva et al.   NEUROBIOLOGY OF DISEASE

Mapping of human brown adipose tissue in lean and obese young men

(2017) Brooks P. Leitner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Central inhibitory effects on feeding induced by the adipo-myokine irisin

(2016) Claudio Ferrante et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Irisin ameliorates hepatic glucose/lipid metabolism and enhances cell survival in insulin-resistant human HepG2 cells through adenosine monophosphate-activated protein kinase signaling

(2016) Wing Yan So et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Autocrine effect of vascular endothelial growth factor-A is essential for mitochondrial function in brown adipocytes

(2016) Kiana Mahdaviani et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Human 'brite/beige' adipocytes develop from capillary networks and their implantation improves metabolic homeostasis in mice

(2016) So Yun Min et al.   NATURE MEDICINE

Brown adipose tissue as a secretory organ

(2016) Francesc Villarroya et al.   Nature Reviews Endocrinology

Irisin Inhibits Hepatic Cholesterol Synthesis via AMPK-SREBP2 Signaling

(2016) Hong Tang et al.   EBioMedicine

Irisin improves endothelial function in obese mice through the AMPK-eNOS pathway

(2015) Fang Han et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

FNDC5 overexpression and irisin ameliorate glucose/lipid metabolic derangements and enhance lipolysis in obesity

(2015) Xiao-Qing Xiong et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Brown and Beige Fat: Physiological Roles beyond Heat Generation

(2015) Shingo Kajimura et al.   Cell Metabolism

Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry

(2015) Mark P. Jedrychowski et al.   Cell Metabolism

Irisin improves fatty acid oxidation and glucose utilization in type 2 diabetes by regulating the AMPK signaling pathway

(2015) C Xin et al.   INTERNATIONAL JOURNAL OF OBESITY

Distinct regulatory mechanisms governing embryonic versus adult adipocyte maturation

(2015) Qiong A. Wang et al.   NATURE CELL BIOLOGY

Irisin Controls Growth, Intracellular Ca2+ Signals, and Mitochondrial Thermogenesis in Cardiomyoblasts

(2015) Chao Xie et al.   PLoS One

Interaction of differentiated human adipocytes with macrophages leads to trogocytosis and selective IL-6 secretion

(2015) A K Sárvári et al.   Cell Death & Disease

Laser-scanning cytometry can quantify human adipocyte browning and proves effectiveness of irisin

(2015) Endre Kristóf et al.   Scientific Reports

What We Talk About When We Talk About Fat

(2014) Evan D. Rosen et al.   CELL

Irisin and FGF21 Are Cold-Induced Endocrine Activators of Brown Fat Function in Humans

(2014) Paul Lee et al.   Cell Metabolism

Irisin stimulates muscle growth-related genes and regulates adipocyte differentiation and metabolism in humans

(2014) J Y Huh et al.   INTERNATIONAL JOURNAL OF OBESITY

Brown adipose tissue derived VEGF-A modulates cold tolerance and energy expenditure

(2014) Kai Sun et al.   Molecular Metabolism

NF-κB and STAT1 control CXCL1 and CXCL2 gene transcription

(2013) Susan J. Burke et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

A Classical Brown Adipose Tissue mRNA Signature Partly Overlaps with Brite in the Supraclavicular Region of Adult Humans

(2013) Naja Zenius Jespersen et al.   Cell Metabolism

Combined B- and T-cell deficiency does not protect against obesity-induced glucose intolerance and inflammation

(2013) Dov B. Ballak et al.   CYTOKINE

High content analysis of differentiation and cell death in human adipocytes

(2013) Minh X. Q. Doan et al.   CYTOMETRY PART A

Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling

(2013) Y. Zhang et al.   DIABETES

Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat

(2013) Aaron M Cypess et al.   NATURE MEDICINE

Cardiac, skeletal muscle and serum irisin responses to with or without water exercise in young and old male rats: Cardiac muscle produces more irisin than skeletal muscle

(2013) Suna Aydin et al.   PEPTIDES

Evidence against a Beneficial Effect of Irisin in Humans

(2013) Silja Raschke et al.   PLoS One

Metabolically Active Human Brown Adipose Tissue Derived Stem Cells

(2013) Francisco J Silva et al.   STEM CELLS

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Implications of nonshivering thermogenesis for energy balance regulation in humans

(2011) Wouter D. van Marken Lichtenbelt et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Thermogenic Activation Induces FGF21 Expression and Release in Brown Adipose Tissue

(2011) Elayne Hondares et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gene expression in human brown adipose tissue

(2010) Svensson   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Hypoxia-Independent Angiogenesis in Adipose Tissues during Cold Acclimation

(2009) Yuan Xue et al.   Cell Metabolism

High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans: Effects of Cold Exposure and Adiposity

(2009) M. Saito et al.   DIABETES

Functional Brown Adipose Tissue in Healthy Adults

(2009) Kirsi A. Virtanen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cold-Activated Brown Adipose Tissue in Healthy Men

(2009) Wouter D. van Marken Lichtenbelt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

Human SGBS Cells – a Unique Tool for Studies of Human Fat Cell Biology

(2008) Pamela Fischer-Posovszky et al.   Obesity Facts