Integrin-Ligand Interactions in Inflammation, Cancer, and Metabolic Disease: Insights Into the Multifaceted Roles of an Emerging Ligand Irisin

Irisin in elderly people with hypertension, diabetes mellitus type 2, and overweight and obesity

(2020) Xiaorong Guo et al.   International Journal of Diabetes in Developing Countries

Irisin induces trophoblast differentiation via AMPK activation in the human placenta

(2020) Sascha Drewlo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Targeted remodeling of breast cancer and immune cell homing niches by exosomal integrins

(2020) Phyoe Kyawe Myint et al.   Diagnostic Pathology

Apoptotic Cell–Directed Resolution of Lung Inflammation Requires Myeloid αv Integrin–Mediated Induction of Regulatory T Lymphocytes

(2020) Ailiang Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling

(2020) Yasuo Oguri et al.   CELL

Irisin, an exercise myokine, potently suppresses tumor proliferation, invasion, and growth in glioma

(2020) Chiun‐Wei Huang et al.   FASEB JOURNAL

Irisin directly stimulates osteoclastogenesis and bone resorption in vitro and in vivo

(2020) Eben G Estell et al.   eLife

CD4+ T Cell Interstitial Migration Controlled by Fibronectin in the Inflamed Skin

(2020) Ninoshka R. J. Fernandes et al.   Frontiers in Immunology

Effect of irisin on endometrial receptivity of rats with polycystic ovary syndrome

(2019) Chenggang Li et al.   GYNECOLOGICAL ENDOCRINOLOGY

Connexins and Integrins in Exosomes

(2019) Motomu Shimaoka et al.   Cancers

Anti-adhesive effects of human soluble thrombomodulin and its domains

(2019) Eiji Kawamoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Integrin β3 Modulates TLR4-Mediated Inflammation by Regulation Of CD14 Expression In Macrophages In Septic Condition

(2019) Zhixia Chen et al.   SHOCK

Integrins as biomechanical sensors of the microenvironment

(2019) Jenny Z. Kechagia et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Novel Ligands Targeting α4β1 Integrin: Therapeutic Applications and Perspectives

(2019) Monica Baiula et al.   Frontiers in Chemistry

Are Integrins Still Practicable Targets for Anti-Cancer Therapy?

(2019) Alday-Parejo et al.   Cancers

Irisin Enhances Doxorubicin-Induced Cell Apoptosis in Pancreatic Cancer by Inhibiting the PI3K/AKT/NF-κB Pathway

(2019) Jiayu Liu et al.   MEDICAL SCIENCE MONITOR

Irisin reverses intestinal epithelial barrier dysfunction during intestinal injury via binding to the integrin αVβ5 receptor

(2019) Jianbin Bi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The Role of Intercellular Adhesion Molecule-1 in the Pathogenesis of Psychiatric Disorders

(2019) Norbert Müller   Frontiers in Pharmacology

Tumor Angiogenesis and Anti-Angiogenic Strategies for Cancer Treatment

(2019) Raluca Ioana Teleanu et al.   Journal of Clinical Medicine

Loss of Response to Vedolizumab and Ability of Dose Intensification to Restore Response in Patients With Crohn’s Disease or Ulcerative Colitis: a Systematic Review and Meta-analysis

(2018) Laurent Peyrin-Biroulet et al.   Clinical Gastroenterology and Hepatology

Extracellular matrix as a driver of progressive fibrosis

(2018) Jeremy Herrera et al.   JOURNAL OF CLINICAL INVESTIGATION

Serum irisin associates with breast cancer to spinal metastasis

(2018) Zheng-ping Zhang et al.   MEDICINE

Irisin and leptin concentrations in relation to obesity, and developing type 2 diabetes: A cross sectional and a prospective case-control study nested in the Normative Aging Study

(2018) Ayse Sahin-Efe et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

FNDC5 attenuates adipose tissue inflammation and insulin resistance via AMPK-mediated macrophage polarization in obesity

(2018) Xiao-Qing Xiong et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

LFA-1 in T Cell Migration and Differentiation

(2018) Brandon L. Walling et al.   Frontiers in Immunology

MFG-E8/integrin β3 signaling contributes to airway inflammation response and airway remodeling in an ovalbumin-induced murine model of asthma

(2018) Yueli Zhi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Irisin promotes cardiac progenitor cell-induced myocardial repair and functional improvement in infarcted heart

(2018) Yu Tina Zhao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The diagnostic value of FNDC5/Irisin in renal Cell Cancer

(2018) Diler Us Altay et al.   International Braz J Urol

Serum and Adipose Tissue mRNA Levels of ATF3 and FNDC5/Irisin in Colorectal Cancer Patients With or Without Obesity

(2018) Huijuan Zhu et al.   Frontiers in Physiology

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors

(2018) Hyeonwoo Kim et al.   CELL

Fibroblast‐specific integrin alpha V differentially regulates type 17 and type 2 driven inflammation and fibrosis

(2018) Joshua C. Sciurba et al.   JOURNAL OF PATHOLOGY

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models

(2018) Mychael V. Lourenco et al.   NATURE MEDICINE

Irisin a Novel Metabolic Biomarker: Present Knowledge and Future Directions

(2018) Ilse Yessabel Martinez Munoz et al.   International Journal of Endocrinology

Fibronectin type III domain-containing protein 5 interacts with APP and decreases amyloid β production in Alzheimer’s disease

(2018) Yasuha Noda et al.   Molecular Brain

Anti-Inflammatory Properties of Irisin, Mediator of Physical Activity, Are Connected with TLR4/MyD88 Signaling Pathway Activation

(2017) Agnieszka Irena Mazur-Bialy et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Unique charge-dependent constraint on collagen recognition by integrin α10β1

(2017) Samir W. Hamaia et al.   MATRIX BIOLOGY

Irisin reverses the IL-6 induced epithelial-mesenchymal transition in osteosarcoma cell migration and invasion through the STAT3/Snail signaling pathway

(2017) Gang Kong et al.   ONCOLOGY REPORTS

Increased FNDC5/Irisin expression in human hepatocellular carcinoma

(2017) Melania Gaggini et al.   PEPTIDES

αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin

(2017) Mitasha Bharadwaj et al.   Nature Communications

The fibronectin synergy site re-enforces cell adhesion and mediates a crosstalk between integrin classes

(2017) Maria Benito-Jardón et al.   eLife

Exploring the Role of RGD-Recognizing Integrins in Cancer

(2017) Markus Nieberler et al.   Cancers

LFA-1 and Mac-1 integrins bind to the serine/threonine-rich domain of thrombomodulin

(2016) Eiji Kawamoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Irisin immunohistochemistry in gastrointestinal system cancers

(2016) S Aydin et al.   BIOTECHNIC & HISTOCHEMISTRY

αv integrins: key regulators of tissue fibrosis

(2016) Kylie P. Conroy et al.   CELL AND TISSUE RESEARCH

Regulation of tissue infiltration by neutrophils

(2016) Pallavi Subramanian et al.   CURRENT OPINION IN HEMATOLOGY

Clearance of apoptotic neutrophils and resolution of inflammation

(2016) Mallary C. Greenlee-Wacker   IMMUNOLOGICAL REVIEWS

Irisin Lowers Blood Pressure by Improvement of Endothelial Dysfunction via AMPK‐Akt‐eNOS‐NO Pathway in the Spontaneously Hypertensive Rat

(2016) Jinjuan Fu et al.   Journal of the American Heart Association

Serum irisin levels are lower in patients with breast cancer: association with disease diagnosis and tumor characteristics

(2015) Xeni Provatopoulou et al.   BMC CANCER

Remodeling of extracellular matrix by normal and tumor-associated fibroblasts promotes cervical cancer progression

(2015) Alexandra Fullár et al.   BMC CANCER

Central and Peripheral Irisin Differentially Regulate Blood Pressure

(2015) Weizhen Zhang et al.   CARDIOVASCULAR DRUGS AND THERAPY

Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry

(2015) Mark P. Jedrychowski et al.   Cell Metabolism

Integration of cell–cell and cell–ECM adhesion in vertebrate morphogenesis

(2015) Patrick McMillen et al.   CURRENT OPINION IN CELL BIOLOGY

Running with neighbors: coordinating cell migration and cell–cell adhesion

(2015) Caitlin Collins et al.   CURRENT OPINION IN CELL BIOLOGY

Serum Irisin Levels Are Regulated by Acute Strenuous Exercise

(2015) Dennis Löffler et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Optimal T Cell Activation and B Cell Antibody Responses In Vivo Require the Interaction between Leukocyte Function–Associated Antigen-1 and Kindlin-3

(2015) Vicky Louise Morrison et al.   JOURNAL OF IMMUNOLOGY

Resistance exercise induces a greater irisin response than endurance exercise

(2015) Yoshifumi Tsuchiya et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Current status and future directions of anti-angiogenic therapy for gliomas

(2015) Wolfgang Wick et al.   NEURO-ONCOLOGY

Irisin Controls Growth, Intracellular Ca2+ Signals, and Mitochondrial Thermogenesis in Cardiomyoblasts

(2015) Chao Xie et al.   PLoS One

Irisin and Myonectin Regulation in the Insulin Resistant Muscle: Implications to Adipose Tissue: Muscle Crosstalk

(2015) Luis Gamas et al.   Journal of Diabetes Research

Irisin Induces Angiogenesis in Human Umbilical Vein Endothelial Cells In Vitro and in Zebrafish Embryos In Vivo via Activation of the ERK Signaling Pathway

(2015) Fei Wu et al.   PLoS One

Plasma irisin levels progressively increase in response to increasing exercise workloads in young, healthy, active subjects

(2014) Stella S Daskalopoulou et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Effects of the exercise-inducible myokine irisin on malignant and non-malignant breast epithelial cell behaviorin vitro

(2014) Nicholas P. Gannon et al.   INTERNATIONAL JOURNAL OF CANCER

Leukocyte extravasation and vascular permeability are each controlled in vivo by different tyrosine residues of VE-cadherin

(2014) Florian Wessel et al.   NATURE IMMUNOLOGY

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A comprehensive immunohistochemical examination of the distribution of the fat-burning protein irisin in biological tissues

(2014) Suleyman Aydin et al.   PEPTIDES

Three new players in energy regulation: Preptin, adropin and irisin

(2014) Suleyman Aydin   PEPTIDES

Association of Serum Irisin with Metabolic Syndrome in Obese Chinese Adults

(2014) Bing Yan et al.   PLoS One

High-Intensity Exercise Causes Greater Irisin Response Compared with Low-Intensity Exercise under Similar Energy Consumption

(2014) Yoshifumi Tsuchiya et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Association of Irisin with Fat Mass, Resting Energy Expenditure, and Daily Activity in Conditions of Extreme Body Mass Index

(2014) María Pardo et al.   International Journal of Endocrinology

Thrombomodulin and the vascular endothelium: insights into functional, regulatory, and therapeutic aspects

(2013) Fiona A. Martin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

TGF-β Activation and Function in Immunity

(2013) Mark A. Travis et al.   Annual Review of Immunology

Extracellular protein disulfide isomerase regulates ligand-binding activity of  M 2 integrin and neutrophil recruitment during vascular inflammation

(2013) E. Hahm et al.   BLOOD

Irisin and exercise training in humans – Results from a randomized controlled training trial

(2013) Anne Hecksteden et al.   BMC Medicine

Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway

(2013) Christiane D. Wrann et al.   Cell Metabolism

The role of transforming growth factor (TGF)-β in modulating the immune response and fibrogenesis in the gut

(2013) Paolo Biancheri et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling

(2013) Y. Zhang et al.   DIABETES

Serum irisin levels in new-onset type 2 diabetes

(2013) Yeon-Kyung Choi et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Resolution of inflammation: an integrated view

(2013) Almudena Ortega-Gómez et al.   EMBO Molecular Medicine

Irisin as a predictor of glucose metabolism in children: sexually dimorphic effects

(2013) Nasser M. Al-Daghri et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Myostatin knockout drives browning of white adipose tissue through activating the AMPK-PGC1α-Fndc5 pathway in muscle

(2013) Tizhong Shan et al.   FASEB JOURNAL

Effect of endurance training on skeletal muscle myokine expression in obese men: identification of apelin as a novel myokine

(2013) A Besse-Patin et al.   INTERNATIONAL JOURNAL OF OBESITY

The Structure of Irisin Reveals a Novel Intersubunit β-Sheet Fibronectin Type III (FNIII) Dimer

(2013) Maria A. Schumacher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Irisin Is Expressed and Produced by Human Muscle and Adipose Tissue in Association With Obesity and Insulin Resistance

(2013) José María Moreno-Navarrete et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Lower circulating irisin is associated with type 2 diabetes mellitus

(2013) Jian-Jun Liu et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Integrin Regulation during Leukocyte Recruitment

(2013) J. Herter et al.   JOURNAL OF IMMUNOLOGY

Effects of obesity, diabetes and exercise onFndc5gene expression and irisin release in human skeletal muscle and adipose tissue:in vivoandin vitrostudies

(2013) Timea Kurdiova et al.   JOURNAL OF PHYSIOLOGY-LONDON

Pharmacological concentrations of irisin increase cell proliferation without influencing markers of neurite outgrowth and synaptogenesis in mouse H19-7 hippocampal cell lines

(2013) Hyun-Seuk Moon et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Regulation of cell proliferation and malignant potential by irisin in endometrial, colon, thyroid and esophageal cancer cell lines

(2013) Hyun-Seuk Moon et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Inflammation-induced interstitial migration of effector CD4+ T cells is dependent on integrin αV

(2013) Michael G Overstreet et al.   NATURE IMMUNOLOGY

Vedolizumab as Induction and Maintenance Therapy for Ulcerative Colitis

(2013) Brian G. Feagan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vedolizumab as Induction and Maintenance Therapy for Crohn's Disease

(2013) William J. Sandborn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mac-1 Directly Binds to the Endothelial Protein C-Receptor: A Link between the Protein C Anticoagulant Pathway and Inflammation?

(2013) Katrin Fink et al.   PLoS One

Integrins and metastasis

(2013) Kirat Kumar Ganguly et al.   Cell Adhesion & Migration

 v Integrins in Angiogenesis and Cancer

(2013) S. M. Weis et al.   Cold Spring Harbor Perspectives in Medicine

Expression of the Irisin Precursor FNDC5 in Skeletal Muscle Correlates With Aerobic Exercise Performance in Patients With Heart Failure

(2012) Stewart H. Lecker et al.   Circulation-Heart Failure

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

The origins of the molecular era of adhesion research

(2012) Alan Rick Horwitz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Governing epidermal homeostasis by coupling cell-cell adhesion to integrin and growth factor signaling, proliferation, and apoptosis

(2012) G. Livshits et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recombinant thrombomodulin improves the visceral microcirculation by attenuating the leukocyte-endothelial interaction in a rat LPS model

(2012) Toshiaki Iba et al.   THROMBOSIS RESEARCH

Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow

(2011) A. Zarbock et al.   BLOOD

Integrin inside-out signaling and the immunological synapse

(2011) Timothy A Springer et al.   CURRENT OPINION IN CELL BIOLOGY

Preferential Expression of Integrin αvβ8 Promotes Generation of Regulatory T Cells by Mouse CD103+ Dendritic Cells

(2011) Helena Païdassi et al.   GASTROENTEROLOGY

Contact-Dependent T Cell Activation and T Cell Stopping Require Talin1

(2011) S. A. Wernimont et al.   JOURNAL OF IMMUNOLOGY

Emerging mechanisms of neutrophil recruitment across endothelium

(2011) Marcie R. Williams et al.   TRENDS IN IMMUNOLOGY

Fibronectins, Their Fibrillogenesis, and In Vivo Functions

(2011) J. E. Schwarzbauer et al.   Cold Spring Harbor Perspectives in Biology

PGC-1α regulation by exercise training and its influences on muscle function and insulin sensitivity

(2010) Vitor A. Lira et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Vascular Cell Adhesion Molecule-1 Expression and Signaling During Disease: Regulation by Reactive Oxygen Species and Antioxidants

(2010) Joan M. Cook-Mills et al.   ANTIOXIDANTS & REDOX SIGNALING

The PI3K p110α isoform regulates endothelial adherens junctions via Pyk2 and Rac1

(2010) Robert J. Cain et al.   JOURNAL OF CELL BIOLOGY

LFA-1 and Mac-1 Define Characteristically Different Intralumenal Crawling and Emigration Patterns for Monocytes and Neutrophils In Situ

(2010) R. Sumagin et al.   JOURNAL OF IMMUNOLOGY

Regulation of integrin activity and signalling

(2009) Carl G. Gahmberg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Integrins

(2009) Malgorzata Barczyk et al.   CELL AND TISSUE RESEARCH

Lymphocyte Crawling and Transendothelial Migration Require Chemokine Triggering of High-Affinity LFA-1 Integrin

(2009) Ziv Shulman et al.   IMMUNITY

Integrin α3β1–dependent β-catenin phosphorylation links epithelial Smad signaling to cell contacts

(2009) Young Kim et al.   JOURNAL OF CELL BIOLOGY

Regulation of  4-integrin expression by epigenetic modifications in the mammary gland and during the epithelial-to-mesenchymal transition

(2009) X. Yang et al.   JOURNAL OF CELL SCIENCE

The Role of Integrin-Mediated Cell Adhesion in Atherosclerosis: Pathophysiology and Clinical Opportunities

(2008) X. Lu et al.   CURRENT PHARMACEUTICAL DESIGN

Integrin αvβ3-targeted cancer therapy

(2008) Zhaofei Liu et al.   DRUG DEVELOPMENT RESEARCH