Alkaloids in genus stephania (Menispermaceae): A comprehensive review of its ethnopharmacology, phytochemistry, pharmacology and toxicology

Cepharanthine hydrochloride inhibits the Wnt/β‑catenin/Hedgehog signaling axis in liver cancer

(2022) Gui-Feng Su et al.   ONCOLOGY REPORTS

Recent Developments on Therapeutic and Diagnostic Approaches for COVID-19

(2021) Joydeb Majumder et al.   AAPS Journal

Mechanism of Tetrandrine Against Endometrial Cancer Based on Network Pharmacology

(2021) Wenqian Shang et al.   Drug Design Development and Therapy

Evaluating cepharanthine analogues as natural drugs against SARS‐CoV‐2

(2021) Atsushi Hijikata et al.   FEBS Open Bio

Amide–Iminoate Isomerism in Antineuroinflammatory Isoquinoline Alkaloids from Stephania cepharantha

(2020) Jiao Xiao et al.   JOURNAL OF NATURAL PRODUCTS

DNA barcodes for the identification of Stephania (Menispermaceae) species

(2020) Xieli Wang et al.   MOLECULAR BIOLOGY REPORTS

Activation of notch 3/c-MYC/CHOP axis regulates apoptosis and promotes sensitivity of lung cancer cells to mTOR inhibitor everolimus

(2020) Ting Li et al.   BIOCHEMICAL PHARMACOLOGY

Aporphine and phenanthrene alkaloids with antioxidant activity from the roots of Stephania tetrandra

(2020) Renzhong Wang et al.   FITOTERAPIA

Cepharanthine: a review of the antiviral potential of a Japanese-approved alopecia drug in COVID-19

(2020) Moshe Rogosnitzky et al.   Pharmacological Reports

Natural neuroprotective alkaloids from Stephania japonica (Thunb.) Miers

(2019) Jiao Xiao et al.   BIOORGANIC CHEMISTRY

Natural Bis-Benzylisoquinoline Alkaloids-Tetrandrine, Fangchinoline, and Cepharanthine, Inhibit Human Coronavirus OC43 Infection of MRC-5 Human Lung Cells

(2019) Kim et al.   Biomolecules

Identification and characterization of methyltransferases involved in benzylisoquinoline alkaloids biosynthesis from Stephania intermedia

(2019) Wanli Zhao et al.   BIOTECHNOLOGY LETTERS

Differentiation, chemical profiles and quality evaluation of five medicinal Stephania species (Menispermaceae) through integrated DNA barcoding, HPLC-QTOF-MS/MS and UHPLC-DAD

(2019) Wanli Zhao et al.   FITOTERAPIA

Synergistic Inhibition of Acetylcholinesterase by Alkaloids Derived from Stephaniae Tetrandrae Radix, Coptidis Rhizoma and Phellodendri Chinensis Cortex

(2019) Xiang-Peng Kong et al.   MOLECULES

Two new glycoalkaloids from Stephania succifera

(2019) Shi-Ting Wang et al.   Phytochemistry Letters

Alkaloids from Stephania venosa as Chemo-Sensitizers in SKOV3 Ovarian Cancer Cells via Akt/NF-κB Signaling

(2018) May Thuu Mon et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Cytotoxic Alkaloids from Stephania dielsiana

(2018) Dao Duc Thien et al.   CHEMISTRY OF NATURAL COMPOUNDS

Rapid characterization of TCM Qianjinteng by UPLC-QTOF-MS and its application in the evaluation of three species of Stephania

(2018) Jiao Xiao et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Tetrandrine enhances the antifungal activity of fluconazole in a murine model of disseminated candidiasis

(2018) Jianping Shi et al.   PHYTOMEDICINE

Overcoming P-Glycoprotein-Mediated Multidrug Resistance in Colorectal Cancer: Potential Reversal Agents among Herbal Medicines

(2018) Gayoung Lee et al.   Evidence-based Complementary and Alternative Medicine

Simultaneous determination of alkaloids dicentrine and sinomenine in Stephania epigeae by 1H NMR spectroscopy

(2018) Jian-Wei Dong et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Aporphine Alkaloids from Stephania dielsiana

(2018) De-Xiong Zhou et al.   CHEMISTRY OF NATURAL COMPOUNDS

Cepharanthine Inhibits IFN-γ-Induced CXCL10 by Suppressing the JAK2/STAT1 Signal Pathway in Human Salivary Gland Ductal Cells

(2017) Keiko Aota et al.   INFLAMMATION

Cepharanthine exerts antitumor activity on choroidal melanoma by reactive oxygen species production and c-Jun N-terminal kinase activation

(2017) Qi Zhu et al.   Oncology Letters

Tetrandrine has anti-adipogenic effect on 3T3-L1 preadipocytes through the reduced expression and/or phosphorylation levels of C/EBP-α, PPAR-γ, FAS, perilipin A, and STAT-3

(2016) Byeong-Churl Jang   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cepharanthine induces apoptosis through the mitochondria/caspase pathway in murine dendritic cells

(2016) Tomofumi Uto et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Tetrandrine suppresses articular inflammatory response by inhibiting pro-inflammatory factors via NF-κB inactivation

(2016) Li-Na Gao et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Neuroprotective effects of tetrandrine against vascular dementia

(2016) Li-xue Chen et al.   Neural Regeneration Research

Tetrandrine, an alkaloid from S. tetrandra exhibits anti-hypertensive and sleep-enhancing effects in SHR via different mechanisms

(2016) Yuan-Li Huang et al.   PHYTOMEDICINE

Cepharanthine inhibits in vitro VSMC proliferation and migration and vascular inflammatory responses mediated by RAW264.7

(2016) Keshav Raj Paudel et al.   TOXICOLOGY IN VITRO

Tetrandrine reverses human cardiac myofibroblast activation and myocardial fibrosis

(2015) Guoqi Teng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

CYP3A5 mediates bioactivation and cytotoxicity of tetrandrine

(2015) Ye Tian et al.   ARCHIVES OF TOXICOLOGY

Cepharanthine induces apoptosis through reactive oxygen species and mitochondrial dysfunction in human non-small-cell lung cancer cells

(2015) Peiyan Hua et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Synergistic anti-tumour effects of tetrandrine and chloroquine combination therapy in human cancer: a potential antagonistic role for p21

(2015) Liufeng Mei et al.   BRITISH JOURNAL OF PHARMACOLOGY

Identification of alkaloid constituents fromFangchispecies using pH control liquid-liquid extraction and liquid chromatography coupled to quadrupole time-of-flight mass spectrometry

(2015) Hee-Jung Sim et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Inhibition on Proteasome β1 Subunit Might Contribute to the Anti-Cancer Effects of Fangchinoline in Human Prostate Cancer Cells

(2015) Dong Li et al.   PLoS One

Antimicrobial Alkaloids from the Tubers of Stephania succifera

(2015) De-Lan Yang et al.   ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES

Induction of formation and conformational conversion of DNA G-quadruplexes by fangchinoline

(2014) Wei Tan et al.   Analytical Methods

Antimicrobial glycoalkaloids from the tubers of Stephania succifera

(2014) Yan-Bo Zeng et al.   ARCHIVES OF PHARMACAL RESEARCH

Tetrandrine induces apoptosis Via caspase-8, -9, and -3 and poly (ADP ribose) polymerase dependent pathways and autophagy through beclin-1/ LC3-I, II signaling pathways in human oral cancer HSC-3 cells

(2014) Fu-Shun Yu et al.   ENVIRONMENTAL TOXICOLOGY

Tetrandrine suppresses pro-inflammatory mediators in PMA plus A23187-induced HMC-1 cells

(2014) OK-HWA KANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Beneficial effect of tetrandrine on refractory epilepsy via suppressing P-glycoprotein

(2014) Yinghui Chen et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Efficacy and safety ofStephania glabra: an alkaloid-rich traditional medicinal plant

(2014) Deepak Kumar Semwal et al.   NATURAL PRODUCT RESEARCH

Therapeutic potential of the biscoclaurine alkaloid, cepharanthine, for a range of clinical conditions

(2014) Moshe Rogosnitzky et al.   Pharmacological Reports

Tetrandrine and fangchinoline, bisbenzylisoquinoline alkaloids from Stephania tetrandra can reverse multidrug resistance by inhibiting P-glycoprotein activity in multidrug resistant human cancer cells

(2014) Yan Fang Sun et al.   PHYTOMEDICINE

Tetrandrine Suppresses Lipopolysaccharide-Induced Microglial Activation by Inhibiting NF-κB and ERK Signaling Pathways in BV2 Cells

(2014) Yalong Dang et al.   PLoS One

Microwave-assisted extraction of bioactive alkaloids from Stephania sinica

(2014) Dao-Tao Xie et al.   SEPARATION AND PURIFICATION TECHNOLOGY

Alkaloids from Stephania macrantha

(2013) Ai-Xue Zuo et al.   CHEMISTRY OF NATURAL COMPOUNDS

Three New Hasubanan Alkaloids fromStephania hernandifolia(Willd.)Walp.

(2013) Li-Jia Tang et al.   HELVETICA CHIMICA ACTA

A new antibacterial denitroaristolochic acid from the tubers ofStephania succifera

(2013) De-Lan Yang et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Inhibition of the STAT3 signaling pathway is involved in the antitumor activity of cepharanthine in SaOS2 cells

(2012) Zan Chen et al.   ACTA PHARMACOLOGICA SINICA

Analysis of active alkaloids in the Menispermaceae family by nonaqueous capillary electrophoresis-ion trap mass spectrometry

(2012) Qinhua Chen et al.   JOURNAL OF SEPARATION SCIENCE

Fangchinoline Inhibits Human Immunodeficiency Virus Type 1 Replication by Interfering with gp160 Proteolytic Processing

(2012) Zhitao Wan et al.   PLoS One

Testing of the estrogenic activity and toxicity ofStephania venosaherb in ovariectomized rats

(2012) Sarawoot Gomuttapong et al.   TOXICOLOGY MECHANISMS AND METHODS

Enhancement of Radiosensitivity and the Potential Mechanism on Human Esophageal Carcinoma Cells by Tetrandrine

(2011) Jingping Yu et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Comprehensive separation and analysis of alkaloids from Stephania yunnanensis by counter-current chromatography coupled with liquid chromatography tandem mass spectrometry analysis

(2011) Xiaojing Dai et al.   JOURNAL OF CHROMATOGRAPHY A

Combinative application of pH-zone-refining and conventional high-speed counter-current chromatography for preparative separation of alkaloids from Stephania kwangsiensis

(2011) Hongjing Dong et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Anti-inflammatory activities of Chinese herbal medicine sinomenine and Liang Miao San on tumor necrosis factor-α-activated human fibroblast-like synoviocytes in rheumatoid arthritis

(2011) Da-Peng Chen et al.   JOURNAL OF ETHNOPHARMACOLOGY

Cepharatines A−D, Hasubanan-Type Alkaloids fromStephania cepharantha

(2011) Li He et al.   JOURNAL OF NATURAL PRODUCTS

Synergistic Antibacterial and Antibiotic Effects of Bisbenzylisoquinoline Alkaloids on Clinical Isolates of Methicillin-Resistant Staphylococcus Aureus (MRSA)

(2011) Guo-Ying Zuo et al.   MOLECULES

Antinociceptive effects of intragastric dl-tetrahydropalmatine on visceral and somatic persistent nociception and pain hypersensitivity in rats

(2011) Fa-Le Cao et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Novel N-oxide derivatives of benzyltetrahydroisoquinoline alkaloid from the tubers of Stephania viridiflavens H.S. Lo et M. Yang

(2011) Mao-Sheng Zhang et al.   Phytochemistry Letters

Antimicrobial activity of extract and two alkaloids from traditional Chinese medicinal plant Stephania dielsiana

(2010) Yecheng Deng et al.   FOOD CHEMISTRY

Anti-hyperglycemic effect of 11-hydroxypalmatine, a palmatine derivative fromStephania glabratubers

(2010) Deepak Kumar Semwal et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Preparative separation of isoquinoline alkaloids from Stephania yunnanensis by pH-zone-refining counter-current chromatography

(2010) Ruilin Hu et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

The genus Stephania (Menispermaceae): Chemical and pharmacological perspectives

(2010) Deepak Kumar Semwal et al.   JOURNAL OF ETHNOPHARMACOLOGY

Hasubanan Alkaloids with δ-Opioid Binding Affinity from the Aerial Parts ofStephania japonica

(2010) Anthony R. Carroll et al.   JOURNAL OF NATURAL PRODUCTS

Cepharanthine Exerts Anti-Inflammatory Effects Via NF-κB Inhibition in a LPS-Induced Rat Model of Systemic Inflammation

(2010) Kyosuke Kudo et al.   JOURNAL OF SURGICAL RESEARCH

Aporphine alkaloids from the roots ofStephania viridiflavens

(2010) Maosheng Zhang et al.   NATURAL PRODUCT RESEARCH

Inhibitory effects of tetrandrine on the Na+ channel of human atrial fibrillation myocardium

(2009) Li Chen et al.   ACTA PHARMACOLOGICA SINICA

Aporphine, protoberberine and morphine alkaloids from the tubers of Stephania yunnanensis

(2009) Lai-Bin Zhang et al.   BIOCHEMICAL SYSTEMATICS AND ECOLOGY

Gindarudine, a novel morphine alkaloid from Stephania glabra

(2009) Deepak Kumar Semwal et al.   CHINESE CHEMICAL LETTERS

Antioxidant activity of bisbenzylisoquinoline alkaloids from Stephania rotunda: cepharanthine and fangchinoline

(2009) İlhami Gülçin et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Antimicrobial Hasubanalactam Alkaloid fromStephania glabra

(2009) Deepak Semwal et al.   PLANTA MEDICA

Tetrandrine suppresses lipopolysaccharide-induced microglial activation by inhibiting NF-κB pathway

(2008) Yang XUE et al.   ACTA PHARMACOLOGICA SINICA

A Study of Genetic Structure of Stephania yunnanensis (Menispermaceae) by DALP

(2008) Yun-shu Ma et al.   BIOCHEMICAL GENETICS

Evaluation of the interaction of bioactive compounds in Cortex Pseudolarix and Radix Stephaniae by the microdialysis probe coupled with high performance liquid chromatography–mass spectrometry

(2008) Xiaoyuan Lei et al.   JOURNAL OF CHROMATOGRAPHY A