Evaluating cepharanthine analogues as natural drugs against SARS‐CoV‐2

Analysis of natural compounds against the activity of SARS-CoV-2 NSP15 protein towards an effective treatment against COVID-19: a theoretical and computational biology approach

(2021) Olaa Motwalli et al.   JOURNAL OF MOLECULAR MODELING

Potential anti-COVID-19 agents, cepharanthine and nelfinavir, and their usage for combination treatment

(2021) Hirofumi Ohashi et al.   iScience

BNT162b2 vaccine breakthrough: clinical characteristics of 152 fully vaccinated hospitalized COVID-19 patients in Israel

(2021) Tal Brosh-Nissimov et al.   CLINICAL MICROBIOLOGY AND INFECTION

COVID-19 Vaccine Breakthrough Infections Reported to CDC — United States, January 1–April 30, 2021

(2021) et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR

(2020) Victor M Corman et al.   Eurosurveillance

The lysosome: A potential juncture between SARS‐CoV‐2 infectivity and Niemann‐Pick disease type C, with therapeutic implications

(2020) Rami A. Ballout et al.   FASEB JOURNAL

Knowledge‐based structural models of SARS‐CoV‐2 proteins and their complexes with potential drugs

(2020) Atsushi Hijikata et al.   FEBS LETTERS

Potential COVID-19 therapeutics from a rare disease: Weaponizing lipid dysregulation to combat viral infectivity

(2020) Stephen Sturley et al.   JOURNAL OF LIPID RESEARCH

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

(2020) Jun Lan et al.   NATURE

Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

(2020) Zhenming Jin et al.   NATURE

Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells

(2020) Shutoku Matsuyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients

(2020) Hai-xia Su et al.   ACTA PHARMACOLOGICA SINICA

Structural stability of SARS-CoV-2 3CLpro and identification of quercetin as an inhibitor by experimental screening

(2020) Olga Abian et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing

(2020) Laura Riva et al.   NATURE

Cepharanthine: a review of the antiviral potential of a Japanese-approved alopecia drug in COVID-19

(2020) Moshe Rogosnitzky et al.   Pharmacological Reports

Natural product-derived phytochemicals as potential agents against coronaviruses: A review

(2020) Janice S. Mani et al.   VIRUS RESEARCH

In vitro evaluation of antiviral activity of single and combined repurposable drugs against SARS-CoV-2

(2020) Andrés Pizzorno et al.   ANTIVIRAL RESEARCH

Spike mutation D614G alters SARS-CoV-2 fitness

(2020) Jessica A. Plante et al.   NATURE

Efficacy and Safety of Hydroxychloroquine vs Placebo for Pre-exposure SARS-CoV-2 Prophylaxis Among Health Care Workers

(2020) Benjamin S. Abella et al.   JAMA Internal Medicine

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

(2020) Merryn Voysey et al.   LANCET

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

(2020) Lindsey R. Baden et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural mechanisms of phospholipid activation of the human TPC2 channel

(2019) Ji She et al.   eLife

Emerging mechanisms of drug-induced phospholipidosis

(2019) Bernadette Breiden et al.   BIOLOGICAL CHEMISTRY

Cepharanthine: An update of its mode of action, pharmacological properties and medical applications

(2019) Christian Bailly   PHYTOMEDICINE

Mining of Ebola virus entry inhibitors identifies approved drugs as two-pore channel pore blockers

(2018) Christopher J. Penny et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

3.3 Å structure of Niemann–Pick C1 protein reveals insights into the function of the C-terminal luminal domain in cholesterol transport

(2017) Xiaochun Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Consensus Docking: Improving the Reliability of Docking in a Virtual Screening Context

(2013) Douglas R. Houston et al.   Journal of Chemical Information and Modeling

Classification of Ligand Molecules in PDB with Fast Heuristic Graph Match Algorithm COMPLIG

(2012) Mihoko Saito et al.   JOURNAL OF MOLECULAR BIOLOGY

KNApSAcK Family Databases: Integrated Metabolite–Plant Species Databases for Multifaceted Plant Research

(2011) Farit Mochamad Afendi et al.   PLANT AND CELL PHYSIOLOGY

Fpocket: An open source platform for ligand pocket detection

(2009) Vincent Le Guilloux et al.   BMC BIOINFORMATICS

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Deficiency of Niemann-Pick Type C-1 Protein Impairs Release of Human Immunodeficiency Virus Type 1 and Results in Gag Accumulation in Late Endosomal/Lysosomal Compartments

(2009) Y. Tang et al.   JOURNAL OF VIROLOGY

Medicinal Chemistry and the Molecular Operating Environment (MOE): Application of QSAR and Molecular Docking to Drug Discovery

(2008) Santiago Vilar et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY