Synergistic anti-tumour effects of tetrandrine and chloroquine combination therapy in human cancer: a potential antagonistic role for p21

Tetrandrine is a potent cell autophagy agonist via activated intracellular reactive oxygen species

(2015) Haiqing Wang et al.   Cell and Bioscience

ABT-263 enhances sorafenib-induced apoptosis associated with Akt activity and the expression of Bax and p21(CIP1/WAF1)in human cancer cells

(2014) Jingru Li et al.   BRITISH JOURNAL OF PHARMACOLOGY

Pemetrexed and Gemcitabine as Combination Therapy for the Treatment of Group3 Medulloblastoma

(2014) Marie Morfouace et al.   CANCER CELL

Atomistic Autophagy: The Structures of Cellular Self-Digestion

(2014) James H. Hurley et al.   CELL

RASSF6promotes p21Cip1/Waf1-dependent cell cycle arrest and apoptosis through activation of the JNK/SAPK pathway in clear cell renal cell carcinoma

(2014) Ying-Ying Liang et al.   CELL CYCLE

Molecular Precision Chemotherapy: Overcoming Resistance to Targeted Therapies?

(2014) Stefan Burdach   CLINICAL CANCER RESEARCH

New Strategies in Lung Cancer: Epigenetic Therapy for Non-Small Cell Lung Cancer

(2014) P. M. Forde et al.   CLINICAL CANCER RESEARCH

Autophagy Is a Survival Mechanism of Acute Myelogenous Leukemia Precursors during Dual mTORC2/mTORC1 Targeting

(2014) J. K. Altman et al.   CLINICAL CANCER RESEARCH

New Use for Old Drugs? Prospective Targets of Chloroquines in Cancer Therapy

(2014) Spiros Vlahopoulos et al.   CURRENT DRUG TARGETS

Inhibition of Autophagy Strengthens Celastrol-Induced Apoptosis in Human Pancreatic Cancer In Vitro and In Vivo Models

(2014) X. Zhao et al.   CURRENT MOLECULAR MEDICINE

Protein kinase inhibitors to treat non-small-cell lung cancer

(2014) Gabriele Minuti et al.   EXPERT OPINION ON PHARMACOTHERAPY

Cytotoxic Autophagy in Cancer Therapy

(2014) Khushboo Sharma et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Population pharmacokinetics of azithromycin and chloroquine in healthy adults and paediatric malaria subjects following oral administration of fixed-dose azithromycin and chloroquine combination tablets

(2014) Qinying Zhao et al.   MALARIA JOURNAL

Tetrandrine blocks autophagic flux and induces apoptosis via energetic impairment in cancer cells

(2014) W Qiu et al.   Cell Death & Disease

Differential autophagic cell death under stress with ectopic cytoplasmic and mitochondrial-specific PPP2R2B in human neuroblastoma cells

(2013) Kang Fang et al.   APOPTOSIS

Reactive oxygen species-mediated activation of the Akt/ASK1/p38 signaling cascade and p21Cip1 downregulation are required for shikonin-induced apoptosis

(2013) Jiwon Ahn et al.   APOPTOSIS

Synthesis and screening of 3-MA derivatives for autophagy inhibitors

(2013) Yanyang Wu et al.   Autophagy

Gambogic acid synergistically potentiates cisplatin-induced apoptosis in non-small-cell lung cancer through suppressing NF-κB and MAPK/HO-1 signalling

(2013) L-H Wang et al.   BRITISH JOURNAL OF CANCER

Synergistic antitumour activity of sorafenib in combination with tetrandrine is mediated by reactive oxygen species (ROS)/Akt signaling

(2013) J Wan et al.   BRITISH JOURNAL OF CANCER

The Concise Guide to PHARMACOLOGY 2013/14: Enzymes

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Plumbagin induces apoptotic and autophagic cell death through inhibition of the PI3K/Akt/mTOR pathway in human non-small cell lung cancer cells

(2013) Yan-Cong Li et al.   CANCER LETTERS

Chloroquine in Cancer Therapy: A Double-Edged Sword of Autophagy

(2013) T. Kimura et al.   CANCER RESEARCH

Cancer therapeutics: Targeting the apoptotic pathway

(2013) Khurum H. Khan et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Autophagy and Cellular Immune Responses

(2013) Yuting Ma et al.   IMMUNITY

Current immunotherapy in rheumatoid arthritis

(2013) Florian MP Meier et al.   Immunotherapy

Lats2 phosphorylates p21/CDKN1A after UV irradiation and regulates apoptosis

(2013) H. Suzuki et al.   JOURNAL OF CELL SCIENCE

Structural Characteristics of Chloroquine-Bridged Ferrocenophane Analogues of Ferroquine May Obviate Malaria Drug-Resistance Mechanisms

(2013) Paloma F. Salas et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of autophagy with chloroquine is effective in melanoma

(2013) Michael E. Egger et al.   JOURNAL OF SURGICAL RESEARCH

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

(2013) Adam J. Pawson et al.   NUCLEIC ACIDS RESEARCH

HSP-90 inhibitor ganetespib is synergistic with doxorubicin in small cell lung cancer

(2013) C-H Lai et al.   ONCOGENE

Phytoagents for Cancer Management: Regulation of Nucleic Acid Oxidation, ROS, and Related Mechanisms

(2013) Wai-Leng Lee et al.   Oxidative Medicine and Cellular Longevity

Tetrandrine Induces Mitochondria-Mediated Apoptosis in Human Gastric Cancer BGC-823 Cells

(2013) Rong Qin et al.   PLoS One

Autophagy in cellular transformation, survival and communication with the tumor microenvironment

(2013) Christian Münz   SEMINARS IN CANCER BIOLOGY

Combination of autophagy inducer rapamycin and oncolytic adenovirus improves antitumor effect in cancer cells

(2013) Pei-Hsin Cheng et al.   Virology Journal

Interpretation of bafilomycin, pH neutralizing or protease inhibitor treatments in autophagic flux experiments

(2012) Gábor Juhász   Autophagy

Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy

(2012) Paola Maycotte et al.   Autophagy

Inhibiting autophagy potentiates the anticancer activity of IFN1@/IFNα in chronic myeloid leukemia cells

(2012) Shan Zhu et al.   Autophagy

CS055 (Chidamide/HBI-8000), a novel histone deacetylase inhibitor, induces G1arrest, ROS-dependent apoptosis and differentiation in human leukaemia cells

(2012) Ke Gong et al.   BIOCHEMICAL JOURNAL

Stabilization of p21 (Cip1/WAF1) following Tip60-dependent acetylation is required for p21-mediated DNA damage response

(2012) M-S Lee et al.   CELL DEATH AND DIFFERENTIATION

Blocked Autophagy Using Lysosomotropic Agents Sensitizes Resistant Prostate Tumor Cells to the Novel Akt Inhibitor AZD5363

(2012) F. Lamoureux et al.   CLINICAL CANCER RESEARCH

The Cyclin-Dependent Kinase Inhibitor p21CDKN1A as a Target of Anti-Cancer Drugs

(2012) L. A. Stivala et al.   CURRENT CANCER DRUG TARGETS

P38 MAP kinase functions as a switch in MS-275-induced reactive oxygen species-dependent autophagy and apoptosis in Human colon Cancer cells

(2012) Yao Zhan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Autophagy-related Gene 7 (ATG7) and Reactive Oxygen Species/Extracellular Signal-regulated Kinase Regulate Tetrandrine-induced Autophagy in Human Hepatocellular Carcinoma

(2012) Ke Gong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chloroquine-Mediated Lysosomal Dysfunction Enhances the Anticancer Effect of Nutrient Deprivation

(2012) Ljubica Harhaji-Trajkovic et al.   PHARMACEUTICAL RESEARCH

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Shikonin, a Chinese plant-derived naphthoquinone, induces apoptosis in hepatocellular carcinoma cells through reactive oxygen species: A potential new treatment for hepatocellular carcinoma

(2011) Ke Gong et al.   FREE RADICAL BIOLOGY AND MEDICINE

Synergistic induction of p53 mediated apoptosis by valproic acid and nutlin-3 in acute myeloid leukemia

(2011) E McCormack et al.   LEUKEMIA

Paclitaxel/Tetrandrine Coloaded Nanoparticles Effectively Promote the Apoptosis of Gastric Cancer Cells Based on “Oxidation Therapy”

(2011) Xiaolin Li et al.   MOLECULAR PHARMACEUTICS

Activation of p21(CIP1/WAF1) in mammary epithelium accelerates mammary tumorigenesis and promotes lung metastasis

(2010) Xiaoyun Cheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

Tetrandrine induces apoptosis by activating reactive oxygen species and repressing Akt activity in human hepatocellular carcinoma

(2010) Chaoyang Liu et al.   INTERNATIONAL JOURNAL OF CANCER

Inhibition of Autophagy by 3-MA Enhances the Effect of 5-FU-Induced Apoptosis in Colon Cancer Cells

(2009) Jie Li et al.   ANNALS OF SURGICAL ONCOLOGY

Synergistic Proapoptotic Activity of Recombinant TRAIL Plus the Akt Inhibitor Perifosine in Acute Myelogenous Leukemia Cells

(2008) P. L. Tazzari et al.   CANCER RESEARCH