Inhibitory effects of traditional Chinese medicine colquhounia root tablet on the pharmacokinetics of tacrolimus in rats

Triptolide and atorvastatin synergistically promote hepatotoxicity in cultured hepatocytes and female Sprague-Dawley rats by inhibiting pregnane X receptor-mediated transcriptional activation of CYP3A4

(2021) Nan Zheng et al.   TOXICOLOGY LETTERS

Effect and safety evaluation of tacrolimus and tripterygium glycosides combined therapy in treatment of Henoch–Schönlein purpura nephritis

(2021) Huiwu Zhang et al.   INTERNATIONAL JOURNAL OF UROLOGY

Tripterygium hypoglaucum (Lévl.) Hutch and Its Main Bioactive Components: Recent Advances in Pharmacological Activity, Pharmacokinetics and Potential Toxicity

(2021) Junqi Zhao et al.   Frontiers in Pharmacology

Immunosuppressive therapy post-transplantation in children: what the clinician needs to know

(2020) Burkhard Tönshoff   Expert Review of Clinical Immunology

Co-administration of Wuzhi tablet (Schisandra sphenanthera extract) alters tacrolimus pharmacokinetics in a dose- and time-dependent manner in rats

(2020) Xiao-ling Qin et al.   JOURNAL OF ETHNOPHARMACOLOGY

Catalpol coordinately regulates phase I and II detoxification enzymes of Triptolide through CAR and NRF2 pathways to reduce Triptolide-induced hepatotoxicity

(2020) Ling Fu et al.   BIOMEDICINE & PHARMACOTHERAPY

Inhibition effect of epigallocatechin-3-gallate on the pharmacokinetics of calcineurin inhibitors, tacrolimus and cyclosporine A, in rats

(2020) Xixi Huang et al.   Expert Opinion on Drug Metabolism & Toxicology

CYP450s-Activity Relations of Celastrol to Interact with Triptolide Reveal the Reasons of Hepatotoxicity of Tripterygium wilfordii

(2019) Chunhuan Jin et al.   MOLECULES

The genus Tripterygium: A phytochemistry and pharmacological review

(2019) Huawei Lv et al.   FITOTERAPIA

A metabolomics study on the immunosuppressive effect of Tripterygium hypoglaucum (Levl.) Hutch in mice: The discovery of pathway differences in serum metabolites

(2018) Yanlei Guo et al.   CLINICA CHIMICA ACTA

Pharmacokinetics, Pharmacodynamics and Pharmacogenetics of Tacrolimus in Kidney Transplantation

(2018) Meng Yu et al.   CURRENT DRUG METABOLISM

Effects of triptolide on pharmacokinetics of amlodipine in rats by using LC–MS/MS

(2018) Chengyin Zhang et al.   PHARMACEUTICAL BIOLOGY

Effects of diclofenac on the pharmacokinetics of celastrol in rats and its transport

(2018) Zengfu Wang et al.   PHARMACEUTICAL BIOLOGY

Wilforine, the Q-marker and PK-maker of Tripterygium glycosides tablet: Based on preparation quantitative analysis and PK-PD study

(2018) Xue Gao et al.   PHYTOMEDICINE

Effects of triptolide on pharmacokinetics of fenofibrate in rats and its potential mechanism

(2018) Tonghui Li et al.   XENOBIOTICA

Retrospective analysis of tacrolimus combined with Tripterygium wilfordii polyglycoside for treating idiopathic membranous nephropathy

(2018) Shun-Lai Shang et al.   BMC Nephrology

The effects of triptolide on the pharmacokinetics of sorafenib in rats and its potential mechanism

(2017) Xianming Wang et al.   PHARMACEUTICAL BIOLOGY

Phylogeographic and phylogenetic analysis for Tripterygium species delimitation

(2017) Baowei Ma et al.   Ecology and Evolution

Inhibitory Effects of Triptolide on Human Liver Cytochrome P450 Enzymes and P-Glycoprotein

(2016) Hanhua Zhang et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Triptolide Modulates TREM-1 Signal Pathway to Inhibit the Inflammatory Response in Rheumatoid Arthritis

(2016) Danping Fan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Elucidation of the Intestinal Absorption Mechanism of Celastrol Using the Caco-2 Cell Transwell Model

(2016) Hong Li et al.   PLANTA MEDICA

Triptolide Reduces the Required Dose of Tacrolimus by Attenuating Inflammation, Enhancing Immunosuppression, and Increasing Donor Chimerism in a Heterotopic Hindlimb Transplantation Model

(2016) Chuan Gu et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Effects of natural nuclear factor-kappa B inhibitors on anticancer drug efflux transporter human P-glycoprotein

(2015) Tomohiro Nabekura et al.   BIOMEDICINE & PHARMACOTHERAPY

Celastrol Protects against Obesity and Metabolic Dysfunction through Activation of a HSF1-PGC1α Transcriptional Axis

(2015) Xinran Ma et al.   Cell Metabolism

Comprehensive two-dimensional liquid chromatography coupled with quadrupole time-of-flight mass spectrometry for chemical constituents analysis of tripterygium glycosides tablets

(2015) Liang Qu et al.   JOURNAL OF CHROMATOGRAPHY A

Inhibitory mechanisms of celastrol on human liver cytochrome P450 1A2, 2C19, 2D6, 2E1 and 3A4

(2015) Chunhuan Jin et al.   XENOBIOTICA

Tacrolimus in preventing transplant rejection in Chinese patients – optimizing use

(2015) Liang Li et al.   Drug Design Development and Therapy

Inhibition of P-glycoprotein Gene Expression and Function Enhances Triptolide-induced Hepatotoxicity in Mice

(2015) Ling-Lei Kong et al.   Scientific Reports

Effects of triptolide on the pharmacokinetics of cyclophosphamide in rats: A possible role of CytochromeP3A4 inhibition

(2014) Xi-feng Zhang et al.   Chinese Journal of Integrative Medicine

Role of CYP3A in regulating hepatic clearance and hepatotoxicity of triptolide in rat liver microsomes and sandwich-cultured hepatocytes

(2014) Guolin Shen et al.   FOOD AND CHEMICAL TOXICOLOGY

Multifaceted interaction of the traditional Chinese medicinal herb Schisandra chinensis with cytochrome P450-mediated drug metabolism in rats

(2014) Baolian Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Glycyrrhizin accelerates the metabolism of triptolide through induction of CYP3A in rats

(2014) Ting Tai et al.   JOURNAL OF ETHNOPHARMACOLOGY

Chemical comparison of Tripterygium wilfordii and Tripterygium hypoglaucum based on quantitative analysis and chemometrics methods

(2014) Long Guo et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Sorafenib and triptolide as combination therapy for hepatocellular carcinoma

(2014) Osama A. Alsaied et al.   SURGERY

Multidrug Resistance-Associated Protein 2 (MRP2/ABCC2) Haplotypes Significantly Affect the Pharmacokinetics of Tacrolimus in Kidney Transplant Recipients

(2013) Ken Ogasawara et al.   CLINICAL PHARMACOKINETICS

Inhibitory effects of celastrol on rat liver cytochrome P450 1A2, 2C11, 2D6, 2E1 and 3A2 activity

(2013) Min Sun et al.   FITOTERAPIA

Triptolide markedly attenuates albuminuria and podocyte injury in an animal model of diabetic nephropathy

(2013) RUIXIA MA et al.   Experimental and Therapeutic Medicine

Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters

(2012) Yakun Chen et al.   BIOCHEMICAL PHARMACOLOGY

Influence of CYP3A4, CYP3A5 and MDR-1 polymorphisms on tacrolimus pharmacokinetics and early renal dysfunction in liver transplant recipients

(2012) Yunying Shi et al.   GENE

Oral bioavailability and gender-related pharmacokinetics of celastrol following administration of pure celastrol and its related tablets in rats

(2012) Jun Zhang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Citrus grandis Peel Increases the Bioavailability of Cyclosporine and Tacrolimus, Two Important Immunosuppressants, in Rats

(2011) Shiuan-Pey Lin et al.   JOURNAL OF MEDICINAL FOOD

Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR

(2010) Antonia H. Tolson et al.   ADVANCED DRUG DELIVERY REVIEWS

Mechanistic understanding of the different effects of Wuzhi Tablet (Schisandra sphenanthera extract) on the absorption and first-pass intestinal and hepatic metabolism of Tacrolimus (FK506)

(2010) Xiao Ling Qin et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Tripterygium Wilfordii Hook F Increase the Blood Concentration of Tacrolimus

(2008) J. Wen et al.   TRANSPLANTATION PROCEEDINGS