Article
Surgery
Pan Chen, Rui Dai, Youjun She, Qian Fu, Min Huang, Xiao Chen, Changxi Wang
Summary: This study evaluated the pharmacokinetic interaction between Wuzhi and tacrolimus (TAC) and identified CYP3A5 genotypes, baseline C0/D, and hematocrit (Hct) as determinants of this interaction.
CLINICAL TRANSPLANTATION
(2022)
Article
Chemistry, Medicinal
Qing Sun, Li Li, Quan Zhou
Summary: This study investigated the effects of Wuzhi capsule on the pharmacokinetics of rosuvastatin in rats. The results showed that acute or long-term intake of Wuzhi capsule did not have a significant impact on the pharmacokinetics of rosuvastatin. Therefore, rosuvastatin could be considered as an alternative to atorvastatin and simvastatin when co-administered with Wuzhi capsule.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Plant Sciences
Xiangling Feng, Youquan Shi, Yufeng Ding, Heng Zheng
Summary: Combining Colquhounia root tablet (CRT) with Tacrolimus (TAC) can enhance the treatment effect of nephrotic syndrome and reduce adverse effects. However, there is limited research on the interaction between the two substances.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Xizi Liu, Shiyi Han, Qian Yang, Siyang Fan
Summary: This study investigated the pharmacokinetic and pharmacodynamic mechanism of the interaction between GAD and BBR. The results showed that GAD had significant effects on the PK interaction and regulation of drug-metabolizing enzymes.
Article
Plant Sciences
Xizi Liu, Shiyi Han, Qian Yang, Siyang Fan
Summary: The study demonstrated that the combination of GAD and BBR enhanced the efficacy of BBR and provided insights into the pharmacokinetic mechanisms of the interaction between these two substances, showing a potential synergistic effect from the PK interaction partially mediated by CYP2C11(9) and enterohepatic recycling.
Review
Pharmacology & Pharmacy
Young Hee Choi, Young-Won Chin
Summary: Studies have shown that metabolic enzyme and/or transporter-mediated pharmacokinetic changes in a drug caused by concomitant herbal products may affect efficacy and toxicity, but discrepancies between predictive data and clinical significance still exist, adding to confusion regarding the use of herbal products and drug combinations.
Article
Pharmacology & Pharmacy
Fei Teng, Wei Wang, Weiyue Zhang, Jinlong Qu, Binguo Liu, Jiani Chen, Shiyi Liu, Mingming Li, Wansheng Chen, Hua Wei
Summary: This study investigated the dose-effect relationship between WZC and tacrolimus, as well as the influence of CYP3A5 and MDR1 genetic polymorphisms on the dosage of WZC. The results showed that when co-administered with WZC, the T-max of tacrolimus was increased significantly while the apparent oral clearance was decreased. The plasma tacrolimus level was much lower in volunteers with high CYP3A5 expression compared to those with mutant CYP3A5. However, polymorphisms of MDR1 were not associated with plasma tacrolimus levels.
BIOPHARMACEUTICS & DRUG DISPOSITION
(2022)
Article
Chemistry, Analytical
Hao Chen, Li Yuan, Xue Ma, Zi-Peng Gong, Yue-Ting Li, Si-Ying Chen, Jie Pan, Ai-Min Wang, Lin Zheng, Yong Huang
Summary: The study revealed a potential herb-drug interaction between P. capitatum and levofloxacin, with interacting targets possibly localized in the intestine during absorption.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Pharmacology & Pharmacy
Jinlong Qu, Rongrong Bian, Binguo Liu, Jiani Chen, Jingwen Zhai, Fei Teng, Wenyuan Guo, Hua Wei
Summary: This study aimed to investigate the interaction between Wuzhi Capsule (WZC) and tacrolimus in liver transplant patients. The results showed that WZC could influence the metabolism of tacrolimus, and CYP3A5 genotypes also had an impact on the pharmacokinetics of tacrolimus.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Shu-Fang Zhang, Bo-Hao Tang, An-Hua Wei, Yue Du, Zi-Wan Guan, Yan Li
Summary: A population pharmacokinetic model was established to explore the effects of combined use of Wuzhi capsules/echinocandins and patients' biochemical parameters on blood concentrations and target doses of tacrolimus in renal transplant patients with different CYP3A5 genotypes.
Article
Plant Sciences
Zhe Zhang, Yiyun Deng, Lijuan Feng, Yong Su, Dujuan Xu
Summary: The study aimed to evaluate the ameliorative effect of WZ on MMF-induced intestinal injury in mice and its underlying mechanisms. The results suggested that MMF can cause intestinal injury; by contrast, WZ may exert anti-inflammatory, antioxidant, and apoptosis-reducing effects to alleviate MMF-induced intestinal injury.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Analytical
Chun-Hao Chang, Wen-Ya Peng, Wan-Hsin Lee, Tung-Yi Lin, Muh-Hwa Yang, Jeffrey W. Dalley, Tung-Hu Tsai
Summary: The aim of this study was to investigate the effects of herbal drug interactions on the biotransformation of molnupiravir and its metabolite NHC in the blood and brain. The results showed that molnupiravir was rapidly metabolized to NHC and penetrated into the brain.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Medicine, Research & Experimental
Daan A. C. Lanser, Maud B. A. Van der Kleij, G. D. Marijn Veerman, Neeltje Steeghs, Alwin D. R. Huitema, Ron H. J. Mathijssen, Esther Oomen-de Hoop
Summary: Polypharmacy is increasing in society, which poses greater risks of drug-drug interactions for patients. This is particularly concerning in oncology due to the prevalence of neoplasms with age and polypharmacy. In addition to drug-drug interactions, herb-drug and food-drug interactions may also occur. Understanding these interactions is crucial for safe and effective anti-cancer treatment. A cross-over pharmacokinetic study is commonly used to study interaction effects, but various factors need to be considered. This article provides an overview of these factors and discusses their impact.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Engineering, Chemical
Muzaffar Iqbal, Mohammad Raish, Ajaz Ahmad, Essam A. Ali, Yousef A. Bin Jardan, Mushtaq A. Ansari, Mudassar Shahid, Abdul Ahad, Khalid M. Alkharfy, Fahad I. Al-Jenoobi
Summary: The study found that when Ibrutinib interacts with Sinapic acid, it may influence the pharmacokinetics of Ibrutinib and result in increased bioavailability. This may be due to the inhibition of IBR metabolism in the liver and intestines by SA.
Article
Biochemistry & Molecular Biology
Qingfeng He, Fengjiao Bu, Qizhen Wang, Min Li, Jiaying Lin, Zhijia Tang, Wen Yao Mak, Xiaomei Zhuang, Xiao Zhu, Hai-Shu Lin, Xiaoqiang Xiang
Summary: Schizandrol A and schizandrol B, two active ingredients of Wuzhi capsule, have been found to potentially interact with tacrolimus. A pharmacokinetic model was used to predict the impact of these herbal ingredients on tacrolimus metabolism. This finding highlights the importance of considering the combined use of Wuzhi capsule and tacrolimus in clinical practice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)