Article
Integrative & Complementary Medicine
Chen Xiao-Chao, Lu Yun, Liu Yuan, Zhou Jia-Wei, Zhang Yi-Feng, Gao Hai-Yun, Li Dan, Gao Wei
Summary: Tripterygium hypoglaucum (Levl.) Hutch, a traditional Chinese medicinal herb, contains celastrol, a potential anti-cancer and anti-obesity drug. The lack of sustainable sources of celastrol and its derivatives necessitates the development of novel sources through synthetic biology. A cytochrome P450 ThCYP712K1 from Tripterygium hypoglaucum was found to catalyze the oxidation of friedelin into polpuonic acid, a vital step in celastrol biosynthesis.
CHINESE JOURNAL OF NATURAL MEDICINES
(2022)
Article
Medicine, Research & Experimental
Junping Zheng, Jianghui Hu, Yong Yang, Lei Xiong, Huabing Yang, Zhigang Zhang, Nan Jiang, Hongtao Liu
Summary: This study reveals the critical role of bile acid-mediated gut-joint axis and inflammasome in the mechanism of Tripterygium hypoglaucum's alleviation of rheumatoid arthritis. The study shows that Tripterygium hypoglaucum treatment can suppress NLRP3-mediated inflammasome and remodel bile acid profiles, resulting in reduced joint swelling and disease scores in rheumatoid arthritis mice.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Plant Sciences
Chengyan Long, Yang Yang, Yunhong Wang, Xiaomei Zhang, Li Zhang, Sixing Huang, Dajian Yang, Xingfang Qiao, Yong Yang, Yanlei Guo
Summary: The study demonstrated that THH extract showed beneficial effects on rheumatoid arthritis in a rat model, improving body weight, reducing joint damage, and modulating immune responses. Metabolomics analysis identified important metabolic pathways affected by THHE administration, suggesting potential targets for therapy development.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Integrative & Complementary Medicine
Dan Zhang, Yizhu Dong, Jintao Lv, Bing Zhang, Xiaomeng Zhang, Zhijian Lin
Summary: This study elucidated the synergistic interaction and mechanism of efficacy and toxicity for Tripterygium hypoglaucum Hutch (THH) in the treatment of rheumatoid arthritis and systemic lupus erythematosus. The research also revealed the mechanism of adverse reactions induced by THH and the superior binding activities between active ingredients and crucial targets through molecular docking simulation.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2021)
Review
Plant Sciences
Fazhi Su, Yanping Sun, Wenbo Zhu, Chenxi Bai, Wensen Zhang, Yumeng Luo, Bingyou Yang, Haixue Kuang, Qiuhong Wang
Summary: Plants in the genus Arisaema, belonging to the family Araceae, have wide-ranging pharmacological functions and potential therapeutic value. This review comprehensively summarizes the botany, uses, phytochemistry, pharmacology, toxicity, quality control, and pharmacokinetics of plants in this genus, providing novel insights for future research in this field. However, further studies on active ingredients, germplasm, and mechanistic studies are needed to ensure effectiveness, safety, and drug quality.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Rui Dang, Huida Guan, Changhong Wang
Summary: Sinapis Semen (SS), the dried mature seed of Sinapis alba L. and Brassica juncea (L.) Czern. et Coss., is a traditional Chinese medicinal material with broad pharmacological effects. It is used for asthma, cough and other ailments. SS is also widely used in food agriculture, medicine, and other industries in North America and South Asia. This review provides an initial aggregation of the research on phytochemistry, pharmacology, toxicity, analytical methods, and pharmacokinetics of SS, and offers useful data for follow-up research and safe clinical application.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Yanru Guo, Linjun Zhao, Botao Chang, Jia Yu, Jiangping Bao, Qi Yao, Jun Luo
Summary: Corydalis saxicola Bunting (CSB) is a perennial herb used in traditional Chinese medicine to treat various diseases. Both traditional and modern pharmacological studies have shown its efficacy in heat-clearing, detoxification, pain relief, and stopping bleeding. The main constituents of CSB, total alkaloids, exhibit significant pharmacological effects with mild and reversible toxicity.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Plant Sciences
Yage Liu, Hao Zhang, Xuan Dai, Ruyuan Zhu, Beibei Chen, Bingke Xia, Zimengwei Ye, Dandan Zhao, Sihua Gao, Alexander N. Orekhov, Dongwei Zhang, Lili Wang, Shuzhen Guo
Summary: Ginseng has been used for over 1000 years in managing diabetes and its complications. This review summarizes the phytochemistry and pharmacokinetics of Ginseng, providing evidence for its antidiabetic effects through the regulation of multiple signaling pathways. Efforts on understanding the underlying mechanisms with controlled animal models and well-designed clinical trials will be crucial for the translational value of Ginseng in diabetes management.
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Akansha Bisht, Smita Jain, Apoorva Misra, Jaya Dwivedi, Sarvesh Paliwal, Swapnil Sharma
Summary: Cedrus deodara is a medicinal tree traditionally used for treating various diseases, with its chemical constituents mainly belonging to terpenoids and flavonoids. Its pharmacological activities include anticancer, antimicrobial, antifungal, analgesic, anti-inflammatory, neuroprotective, antidiabetic, antiurolithiatic, antiarthritic, and antiasthmatic properties.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Plant Sciences
Li Yang, Junwei He
Summary: Hosta species are valuable plants rich in steroids and flavonoids, known for their anti-inflammatory, analgesic, and antioxidant properties. However, gaps in understanding traditional uses exist, requiring further high-quality research to assess safety and efficacy.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Qiuyue Wang, Zhihua Yang, Liuli Guo, Zhenzhen Li, Yangxi Liu, Shaoling Feng, Yanxia Wang
Summary: GuHong injection, composed of safflower and N-acetyl-L-glutamine, is used in clinical practice for treating cerebrovascular diseases such as ischemic stroke. This systematic review aims to comprehensively summarize the recent research on GuHong in stroke treatment, including its chemical composition, clinical studies, pharmacological mechanisms, and pharmacokinetics. The review shows that GuHong injection acts through various mechanisms, including anti-inflammatory, anti-oxidative stress, anti-coagulation, neuroprotective, and anti-apoptotic effects. It also highlights the main substances found in rat plasma after GuHong administration and their ability to cross the blood-brain barrier. Overall, GuHong injection has significant value in drug research and clinical treatment, particularly for ischemic stroke.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Plant Sciences
Jincai Liu, Xiang Li, Huixin Bai, Xu Yang, Jun Mu, Ruonan Yan, Siwang Wang
Summary: Moutan Cortex, also known as Mu dan pi, is a traditional herbal medication widely used in China, Japan, and Korea for the treatment of female genital, cardiovascular, and blood-related disorders. This review summarizes the traditional uses, phytochemistry, pharmacology, and pharmacokinetics of Moutan Cortex, and discusses its potential for developing new drugs based on traditional uses and pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Integrative & Complementary Medicine
Jianghui Hu, Jimin Ni, Junping Zheng, Yanlei Guo, Yong Yang, Cheng Ye, Xiongjie Sun, Hui Xia, Yanju Liu, Hongtao Liu
Summary: This study found that Tripterygium hypoglaucum extract can protect against rheumatoid arthritis by manipulating the gut microbiota and regulating the TLR4/ MyD88/ MAPK signaling pathway. Additionally, treatment with Tripterygium hypoglaucum extract failed to improve arthritis symptoms and signaling pathways in pseudo germ-free mice, further validating the importance of the gut microbiota.
CHINESE JOURNAL OF NATURAL MEDICINES
(2023)
Review
Biochemistry & Molecular Biology
Jiangping Wu, Jianping Zhao, Tao Zhang, Yucheng Gu, Ikhlas A. Khan, Zhongmei Zou, Qiongming Xu
Summary: Physalins are a class of highly oxygenated ergostane-type steroids commonly found in Physalis plants, exhibiting a wide range of pharmacological activities including anticancer, anti-inflammatory, immunoregulatory, and antimicrobial effects. Studies on physalins in China, focusing on phytochemistry, pharmacology, pharmacokinetics, and applications, have been systematically presented and discussed for the first time from 1970 to 2021.
Review
Chemistry, Medicinal
Xiao Ma, Yinxiao Jiang, Wenwen Zhang, Jiabo Wang, Ruilin Wang, Lifu Wang, Shizhang Wei, Jianxia Wen, Haotian Li, Yanling Zhao
PHYTOTHERAPY RESEARCH
(2020)
Review
Pharmacology & Pharmacy
Xiao Ma, Wenwen Zhang, Yinxiao Jiang, Jianxia Wen, Shizhang Wei, Yanling Zhao
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Pharmacology & Pharmacy
Yinxiao Jiang, Jianxia Wen, Wenwen Zhang, Zhijie Ma, Congen Zhang, Jian Wang, Yao Dai, Qichao Hu, Zhibei Li, Xiao Ma
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2020)
Review
Integrative & Complementary Medicine
Xiaoqi Pan, Xiao Ma, Yinxiao Jiang, Jianxia Wen, Lian Yang, Dayi Chen, Xiaoyu Cao, Cheng Peng
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2020)
Article
Mathematical & Computational Biology
Qichao Hu, Shizhang Wei, Jianxia Wen, Wenwen Zhang, Yinxiao Jiang, Caiyan Qu, Junbao Xiang, Yanling Zhao, Xi Peng, Xiao Ma
Review
Integrative & Complementary Medicine
Qichao Hu, Caiyan Qu, Xiaolin Xiao, Wenwen Zhang, Yinxiao Jiang, Zhao Wu, Dan Song, Xi Peng, Xiao Ma, YanLing Zhao
Summary: Flavonoids, a class of active natural products with a wide range of pharmacological effects, have been found to alleviate diabetic nephropathy by regulating oxidative stress and inflammation. The review systematically summarizes the use of common flavonoids for the treatment of diabetic nephropathy, showing promising potential as drugs for this condition.
Review
Integrative & Complementary Medicine
Wenwen Zhang, Fangling Zhang, Qichao Hu, Xiaolin Xiao, Linbo Ou, Yuan Chen, Shiqing Luo, Yonghong Cheng, Yinxiao Jiang, Xiao Ma, Yanling Zhao
Summary: Geniposide, an active ingredient isolated from natural plants, has shown significant effects in treating various diseases, especially in brain protection. This article reviews the effects of geniposide in cerebral ischemia models, illustrating its efficacy in reducing cerebral infarction area and neuronal damage through multiple mechanisms.
Review
Pharmacology & Pharmacy
Xiaolin Xiao, Qichao Hu, Xinyu Deng, Kaiyun Shi, Wenwen Zhang, Yinxiao Jiang, Xiao Ma, Jinhao Zeng, Xiaoyin Wang
Summary: Kaempferol (KP) has shown good pharmacological effects on a series of complex liver diseases by regulating precise signaling targets and is expected to become an emerging therapeutic opportunity to treat liver diseases in the future.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Chemistry, Medicinal
Penghui Ye, Hefei Wu, Yinxiao Jiang, Xiaolin Xiao, Dan Song, Nuo Xu, Xiao Ma, Jinhao Zeng, Yaoguang Guo
Summary: Polydatin (PD) is a natural product extracted from Polygonum cuspidatum Sieb. et Zucc, with various biological activities. It is likely to be used in cardiac and cerebral ischemia-related diseases, and atherosclerosis. PD shows therapeutic effects primarily through antioxidative, antiinflammatory, autophagy and apoptosis regulation, maintenance of mitochondrial function, and lipid regulation mechanisms.
PHYTOTHERAPY RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Fangling Zhang, Xiaolin Xiao, Yong Li, Hefei Wu, Xinyu Deng, Yinxiao Jiang, Wenwen Zhang, Jian Wang, Xiao Ma, Yanling Zhao
Summary: This review summarizes the function and mechanisms of GPBAR1 in cholestatic liver disease. GPBAR1 regulates cholestasis through various pathways and plays an important role in protecting against diseases and injuries. However, its proliferative properties also increase the risk of cholangiocarcinoma.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Yinxiao Jiang, Haotian Li, Dan Song, Penghui Ye, Nuo Xu, Yuan Chen, Wenwen Zhang, Qichao Hu, Xiao Ma, Jianxia Wen, Yeyu Li, Yanling Zhao
Summary: This study found that the combined use of Chinese prescriptions or patent medicines with UDCA was generally more effective than using UDCA alone in the treatment of ICP, and the dosage of IP-f might be a beneficial therapeutic method for clinical medication of ICP.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Jiayue Yang, Heng Yang, Yao Dai, Yinxiao Jiang, Yuhao Long, Jinhao Zeng, Xiao Ma
Summary: This study utilized Bayesian network meta-analysis to investigate the efficacy and safety of Chinese herbal formulae and conventional triple therapy in the treatment of Helicobacter pylori-positive peptic ulcer disease. The results demonstrated that supplementation with Chinese herbal formulae significantly improved the eradication rate, clinical efficiency, and reduced recurrence rate of H. pylori compared to the single conventional triple therapy group. CON+XSD emerged as the most satisfactory therapeutic strategy, highlighting the potential value of combining Chinese herbal formulae with conventional chemotherapy.
Article
Pharmacology & Pharmacy
Wenwen Zhang, Jianxia Wen, Yinxiao Jiang, Qichao Hu, Jian Wang, Shizhang Wei, Haotian Li, Xiao Ma
Summary: This study utilized a pMCAO model to simulate cerebral ischaemia in rats and found that L-borneol can achieve brain protection by regulating MCU-related signaling pathways and inhibiting neuronal apoptosis.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2021)