Immunological memory to SARS‐CoV ‐2 infection and COVID ‐19 vaccines

Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccination

(2022) Katharina Röltgen et al.   CELL

Germinal center responses to SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals

(2022) Katlyn Lederer et al.   CELL

SARS-CoV-2 breakthrough infections elicit potent, broad, and durable neutralizing antibody responses

(2022) Alexandra C. Walls et al.   CELL

T-cell reactivity to the SARS-CoV-2 Omicron variant is preserved in most but not all individuals

(2022) Vivek Naranbhai et al.   CELL

SARS-CoV-2 vaccination induces immunological T cell memory able to cross-recognize variants from Alpha to Omicron

(2022) Alison Tarke et al.   CELL

Immuno-proteomic profiling reveals aberrant immune cell regulation in the airways of individuals with ongoing post-COVID-19 respiratory disease

(2022) Bavithra Vijayakumar et al.   IMMUNITY

Cutting Edge: Serum but Not Mucosal Antibody Responses Are Associated with Pre-Existing SARS-CoV-2 Spike Cross-Reactive CD4+ T Cells following BNT162b2 Vaccination in the Elderly

(2022) Lil Meyer-Arndt et al.   JOURNAL OF IMMUNOLOGY

Antibody course and memory B-cell response in the first year after SARS-CoV-2 infection

(2022) Judith Kannenberg et al.   JOURNAL OF INFECTIOUS DISEASES

Homologous and Heterologous Covid-19 Booster Vaccinations

(2022) Robert L. Atmar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Population Immunity and Covid-19 Severity with Omicron Variant in South Africa

(2022) Shabir A. Madhi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Protection against the Omicron Variant from Previous SARS-CoV-2 Infection

(2022) Heba N. Altarawneh et al.   NEW ENGLAND JOURNAL OF MEDICINE

SARS-CoV-2 Omicron Variant Neutralization after mRNA-1273 Booster Vaccination

(2022) Rolando Pajon et al.   NEW ENGLAND JOURNAL OF MEDICINE

SARS-CoV-2-Specific T Cell Responses Are Stronger in Children With Multisystem Inflammatory Syndrome Compared to Children With Uncomplicated SARS-CoV-2 Infection

(2022) Susan R. Conway et al.   Frontiers in Immunology

Multiplex Antibody Analysis of IgM, IgA and IgG to SARS-CoV-2 in Saliva and Serum From Infected Children and Their Close Contacts

(2022) Carlota Dobaño et al.   Frontiers in Immunology

COVID-19 Cases and Hospitalizations by COVID-19 Vaccination Status and Previous COVID-19 Diagnosis — California and New York, May–November 2021

(2022) Tomás M. León et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Vaccination before or after SARS-CoV-2 infection leads to robust humoral response and antibodies that effectively neutralize variants

(2022) Timothy A. Bates et al.   Science Immunology

SARS-CoV-2 Omicron-neutralizing memory B-cells are elicited by two doses of BNT162b2 mRNA vaccine

(2022) Ryutaro Kotaki et al.   Science Immunology

Limited induction of SARS-CoV-2–specific T cell responses in children with multisystem inflammatory syndrome compared with COVID-19

(2022) Vidisha Singh et al.   JCI Insight

Large-Scale Study of Antibody Titer Decay following BNT162b2 mRNA Vaccine or SARS-CoV-2 Infection

(2022) Ariel Israel et al.   Vaccines

Immunity to SARS-CoV-2 up to 15 months after infection

(2022) Harold Marcotte et al.   iScience

Imprinted SARS-CoV-2-specific memory lymphocytes define hybrid immunity

(2022) Lauren B. Rodda et al.   CELL

Comparative analysis of the risks of hospitalisation and death associated with SARS-CoV-2 omicron (B.1.1.529) and delta (B.1.617.2) variants in England: a cohort study

(2022) Tommy Nyberg et al.   LANCET

Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge in young adults

(2022) Ben Killingley et al.   NATURE MEDICINE

The immunology and immunopathology of COVID-19

(2022) Miriam Merad et al.   SCIENCE

Understanding T cell responses to COVID-19 is essential for informing public health strategies

(2022) Santosha Vardhana et al.   Science Immunology

Correlates of protection against SARS ‐ CoV ‐2 infection and COVID‐19 disease

(2022) David Goldblatt et al.   IMMUNOLOGICAL REVIEWS

Adaptive immunity to SARS-CoV-2 and COVID-19

(2021) Alessandro Sette et al.   CELL

Interim Results of a Phase 1–2a Trial of Ad26.COV2.S Covid-19 Vaccine

(2021) Jerald Sadoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection

(2021) Jennifer M. Dan et al.   SCIENCE

Severely ill COVID-19 patients display impaired exhaustion features in SARS-CoV-2-reactive CD8+ T cells

(2021) Anthony Kusnadi et al.   Science Immunology

Discordant neutralizing antibody and T cell responses in asymptomatic and mild SARS-CoV-2 infection

(2021) Catherine J. Reynolds et al.   Science Immunology

Maturation and persistence of the anti-SARS-CoV-2 memory B cell response

(2021) Aurélien Sokal et al.   CELL

Binding and Neutralization Antibody Titers After a Single Vaccine Dose in Health Care Workers Previously Infected With SARS-CoV-2

(2021) Saman Saadat et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection

(2021) Nina Le Bert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Persistent cellular immunity to SARS-CoV-2 infection

(2021) Gaëlle Breton et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Prolonged evolution of the human B cell response to SARS-CoV-2 infection

(2021) Mrunal Sakharkar et al.   Science Immunology

Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease.

(2021) Laura Bergamaschi et al.   IMMUNITY

Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children

(2021) Anjali Ramaswamy et al.   IMMUNITY

CD8+ T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity

(2021) Thi H.O. Nguyen et al.   IMMUNITY

Genome-Wide B Cell, CD4+, and CD8+ T Cell Epitopes That Are Highly Conserved between Human and Animal Coronaviruses, Identified from SARS-CoV-2 as Targets for Preemptive Pan-Coronavirus Vaccines

(2021) Swayam Prakash et al.   JOURNAL OF IMMUNOLOGY

Differential T cell reactivity to endemic coronaviruses and SARS-CoV-2 in community and health care workers

(2021) Ricardo da Silva Antunes et al.   JOURNAL OF INFECTIOUS DISEASES

Neutralization of SARS-CoV-2 Variants B.1.429 and B.1.351

(2021) Xiaoying Shen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antibody Persistence through 6 Months after the Second Dose of mRNA-1273 Vaccine for Covid-19

(2021) Nicole Doria-Rose et al.   NEW ENGLAND JOURNAL OF MEDICINE

mRNA vaccination boosts cross-variant neutralizing antibodies elicited by SARS-CoV-2 infection

(2021) Leonidas Stamatatos et al.   SCIENCE

Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil

(2021) Nuno R. Faria et al.   SCIENCE

T cell and antibody kinetics delineate SARS-CoV-2 peptides mediating long-term immune responses in COVID-19 convalescent individuals

(2021) Tatjana Bilich et al.   Science Translational Medicine

CD8+ T cell responses in COVID-19 convalescent individuals target conserved epitopes from multiple prominent SARS-CoV-2 circulating variants

(2021) Andrew D Redd et al.   Open Forum Infectious Diseases

Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals following mRNA vaccination

(2021) Rishi R. Goel et al.   Science Immunology

Cellular immunity predominates over humoral immunity after homologous and heterologous mRNA and vector‐based COVID‐19 vaccine regimens in solid organ transplant recipients

(2021) Tina Schmidt et al.   AMERICAN JOURNAL OF TRANSPLANTATION

SARS-CoV-2 human T cell epitopes: Adaptive immune response against COVID-19

(2021) Alba Grifoni et al.   Cell Host & Microbe

A single dose of the SARS-CoV-2 vaccine BNT162b2 elicits Fc-mediated antibody effector functions and T cell responses

(2021) Alexandra Tauzin et al.   Cell Host & Microbe

Risk of Reinfection After Seroconversion to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): A Population-based Propensity-score Matched Cohort Study

(2021) Antonio Leidi et al.   CLINICAL INFECTIOUS DISEASES

SARS-CoV-2 infection and COVID-19 severity in individuals with prior seasonal coronavirus infection

(2021) Saurabh Gombar et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations

(2021) Frauke Muecksch et al.   IMMUNITY

Rapid induction of antigen-specific CD4+ T cells is associated with coordinated humoral and cellular immunity to SARS-CoV-2 mRNA vaccination

(2021) Mark M. Painter et al.   IMMUNITY

mRNA vaccination of naive and COVID-19-recovered individuals elicits potent memory B cells that recognize SARS-CoV-2 variants

(2021) Aurélien Sokal et al.   IMMUNITY

Comparison of SARS-CoV-2 Antibody Response Following Vaccination With BNT162b2 and mRNA-1273

(2021) Deborah Steensels et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Durable Humoral and Cellular Immune Responses 8 Months after Ad26.COV2.S Vaccination

(2021) Dan H. Barouch et al.   NEW ENGLAND JOURNAL OF MEDICINE

SARS-CoV-2 Neutralization with BNT162b2 Vaccine Dose 3

(2021) Ann R. Falsey et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy of the mRNA-1273 SARS-CoV-2 Vaccine at Completion of Blinded Phase

(2021) Hana M. El Sahly et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination

(2021) Lucie Loyal et al.   SCIENCE

Durability of mRNA-1273 vaccine–induced antibodies against SARS-CoV-2 variants

(2021) Amarendra Pegu et al.   SCIENCE

Low-dose mRNA-1273 COVID-19 vaccine generates durable memory enhanced by cross-reactive T cells

(2021) Jose Mateus et al.   SCIENCE

Immune correlates of protection by mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates

(2021) Kizzmekia S. Corbett et al.   SCIENCE

Hybrid immunity

(2021) Shane Crotty   SCIENCE

Scent of a vaccine

(2021) Frances E. Lund et al.   SCIENCE

Comparative Effectiveness of Moderna, Pfizer-BioNTech, and Janssen (Johnson & Johnson) Vaccines in Preventing COVID-19 Hospitalizations Among Adults Without Immunocompromising Conditions — United States, March–August 2021

(2021) Wesley H. Self et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Evolution of antibody responses up to 13 months after SARS-CoV-2 infection and risk of reinfection

(2021) Floriane Gallais et al.   EBioMedicine

SARS-CoV-2 variants of concern partially escape humoral but not T-cell responses in COVID-19 convalescent donors and vaccinees

(2021) Daryl Geers et al.   Science Immunology

Identification of resident memory CD8 + T cells with functional specificity for SARS-CoV-2 in unexposed oropharyngeal lymphoid tissue

(2021) Julia Niessl et al.   Science Immunology

Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine

(2021) Rebecca P. Payne et al.   CELL

SARS-CoV-2 mRNA vaccination elicits a robust and persistent T follicular helper cell response in humans

(2021) Philip A. Mudd et al.   CELL

Characterization of SARS‐CoV‐2 and common cold coronavirus‐specific T‐cell responses in MIS‐C and Kawasaki disease children

(2021) Li‐En Hsieh et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Persistence of T Cell and Antibody Responses to SARS-CoV-2 Up to 9 Months after Symptom Onset

(2021) Jaclyn C. Law et al.   JOURNAL OF IMMUNOLOGY

Comparative Immunogenicity and Effectiveness of mRNA-1273, BNT162b2, and Ad26.COV2.S COVID-19 Vaccines

(2021) Vivek Naranbhai et al.   JOURNAL OF INFECTIOUS DISEASES

Humoral- and T-Cell–Specific Immune Responses to SARS-CoV-2 mRNA Vaccination in Patients With MS Using Different Disease-Modifying Therapies

(2021) Carla Tortorella et al.   NEUROLOGY

Waning Immunity after the BNT162b2 Vaccine in Israel

(2021) Yair Goldberg et al.   NEW ENGLAND JOURNAL OF MEDICINE

Differential Kinetics of Immune Responses Elicited by Covid-19 Vaccines

(2021) Ai-ris Y. Collier et al.   NEW ENGLAND JOURNAL OF MEDICINE

mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern

(2021) Rishi R. Goel et al.   SCIENCE

Heterogeneity of human anti-viral immunity shaped by virus, tissue, age, and sex

(2021) Maya M.L. Poon et al.   Cell Reports

BNT162b2 vaccination induces durable SARS-CoV-2–specific T cells with a stem cell memory phenotype

(2021) Gisella Guerrera et al.   Science Immunology

Immune signatures underlying post-acute COVID-19 lung sequelae

(2021) I. S. Cheon et al.   Science Immunology

SARS-CoV-2 infection generates tissue-localized immunological memory in humans

(2021) Maya M.L. Poon et al.   Science Immunology

Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals

(2020) Alba Grifoni et al.   CELL

Longitudinal dynamics of the human B cell response to the yellow fever 17D vaccine

(2020) Anna Z. Wec et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comprehensive analyses of B cell compartments across the human body reveal novel subsets and a gut resident memory phenotype

(2020) Nadine Marianne Weisel et al.   BLOOD

Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates

(2020) Kizzmekia S. Corbett et al.   NEW ENGLAND JOURNAL OF MEDICINE

An mRNA Vaccine against SARS-CoV-2 — Preliminary Report

(2020) Lisa A. Jackson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans

(2020) Jose Mateus et al.   SCIENCE

Phenotype and kinetics of SARS-CoV-2-specific T cells in COVID-19 patients with acute respiratory distress syndrome

(2020) Daniela Weiskopf et al.   Science Immunology

Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19

(2020) Takuya Sekine et al.   CELL

The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19

(2020) Camila Rosat Consiglio et al.   CELL

Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19

(2020) Naoki Kaneko et al.   CELL

Imbalance of Regulatory and Cytotoxic SARS-CoV-2-Reactive CD4+ T Cells in COVID-19

(2020) Benjamin J. Meckiff et al.   CELL

Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity

(2020) Carolyn Rydyznski Moderbacher et al.   CELL

Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology

(2020) Luca Piccoli et al.   CELL

Humoral Immune Response to SARS-CoV-2 in Iceland

(2020) Daniel F. Gudbjartsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phase 1–2 Trial of a SARS-CoV-2 Recombinant Spike Protein Nanoparticle Vaccine

(2020) Cheryl Keech et al.   NEW ENGLAND JOURNAL OF MEDICINE

Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19

(2020) Lauren B. Rodda et al.   CELL

Low-Avidity CD4+ T Cell Responses to SARS-CoV-2 in Unexposed Individuals and Humans with Severe COVID-19

(2020) Petra Bacher et al.   IMMUNITY

SARS-CoV-2 Epitopes Are Recognized by a Public and Diverse Repertoire of Human T Cell Receptors

(2020) Alina S. Shomuradova et al.   IMMUNITY

PD-1-Expressing SARS-CoV-2-Specific CD8+ T Cells Are Not Exhausted, but Functional in Patients with COVID-19

(2020) Min-Seok Rha et al.   IMMUNITY

Recent endemic coronavirus infection is associated with less-severe COVID-19

(2020) Manish Sagar et al.   JOURNAL OF CLINICAL INVESTIGATION

Sustained cellular immune dysregulation in individuals recovering from SARS-CoV-2 infection

(2020) Jacob K. Files et al.   JOURNAL OF CLINICAL INVESTIGATION

Prior presumed coronavirus infection reduces COVID-19 risk: A cohort study

(2020) Dvir Aran et al.   JOURNAL OF INFECTION

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

(2020) Fernando P. Polack et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antibody Status and Incidence of SARS-CoV-2 Infection in Health Care Workers

(2020) Sheila F. Lumley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Longitudinal Analysis of the Human B Cell Response to Ebola Virus Infection

(2019) Carl W. Davis et al.   CELL

Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance

(2019) Kimberly M. Cirelli et al.   CELL

T Follicular Helper Cell Biology: A Decade of Discovery and Diseases

(2019) Shane Crotty   IMMUNITY

Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches

(2017) Matthias Pauthner et al.   IMMUNITY

Tfh cells and HIV bnAbs, an immunodominance model of the HIV neutralizing antibody generation problem

(2017) Colin Havenar-Daughton et al.   IMMUNOLOGICAL REVIEWS

Origin and differentiation of human memory CD8 T cells after vaccination

(2017) Rama S. Akondy et al.   NATURE

Do Memory CD4 T Cells Keep Their Cell-Type Programming: Plasticity versus Fate Commitment?

(2017) Shane Crotty   Cold Spring Harbor Perspectives in Biology

Cytotoxic CD4 T Cells—Friend or Foe during Viral Infection?

(2017) Jennifer A. Juno et al.   Frontiers in Immunology

Comparative analysis of activation induced marker (AIM) assays for sensitive identification of antigen-specific CD4 T cells

(2017) Samantha Reiss et al.   PLoS One

Memory T cell responses targeting the SARS coronavirus persist up to 11 years post-infection

(2016) Oi-Wing Ng et al.   VACCINE

Direct Probing of Germinal Center Responses Reveals Immunological Features and Bottlenecks for Neutralizing Antibody Responses to HIV Env Trimer

(2016) Colin Havenar-Daughton et al.   Cell Reports

ICOS+PD-1+CXCR3+ T follicular helper cells contribute to the generation of high-avidity antibodies following influenza vaccination

(2016) Salah-Eddine Bentebibel et al.   Scientific Reports

Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance

(2015) Elizabeth M. Steinert et al.   CELL

Dengue virus infection elicits highly polarized CX3CR1+cytotoxic CD4+T cells associated with protective immunity

(2015) Daniela Weiskopf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T Cell Responses to Whole SARS Coronavirus in Humans

(2014) C. K.-f. Li et al.   JOURNAL OF IMMUNOLOGY

Molecular regulation of effector and memory T cell differentiation

(2014) John T Chang et al.   NATURE IMMUNOLOGY

Human Circulating PD-1+CXCR3−CXCR5+ Memory Tfh Cells Are Highly Functional and Correlate with Broadly Neutralizing HIV Antibody Responses

(2013) Michela Locci et al.   IMMUNITY

Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans

(2012) Tom M Wilkinson et al.   NATURE MEDICINE

Pandemic H1N1 influenza vaccine induces a recall response in humans that favors broadly cross-reactive memory B cells

(2012) G.-M. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Memory B cells, but not long-lived plasma cells, possess antigen specificities for viral escape mutants

(2011) Whitney E. Purtha et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Quantitating T Cell Cross-Reactivity for Unrelated Peptide Antigens

(2009) J. Ishizuka et al.   JOURNAL OF IMMUNOLOGY

Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors

(2008) Xiaocong Yu et al.   NATURE