Considering population variability of electrophysiological models improves the in silico assessment of drug-induced torsadogenic risk

Sex‐Specific Classification of Drug‐Induced Torsade de Pointes Susceptibility Using Cardiac Simulations and Machine Learning

(2021) Alex Fogli Iseppe et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Inflammation as a Risk Factor in Cardiotoxicity: An Important Consideration for Screening During Drug Development

(2021) Chiara Campana et al.   Frontiers in Pharmacology

When Does the IC50 Accurately Assess the Blocking Potency of a Drug?

(2020) Julio Gomis-Tena et al.   Journal of Chemical Information and Modeling

Combining an in silico proarrhythmic risk assay with a tPKPD model to predict QTc interval prolongation in the anesthetized guinea pig assay

(2020) Pierre Morissette et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Blinded In Silico Drug Trial Reveals the Minimum Set of Ion Channels for Torsades de Pointes Risk Assessment

(2020) Xin Zhou et al.   Frontiers in Pharmacology

A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm

(2020) Bradley J. Ridder et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

In-Silico Classifiers for the Assessment of Drug Proarrhythmicity

(2020) Jordi Llopis Lorente et al.   Journal of Chemical Information and Modeling

Sex differences in GBM revealed by analysis of patient imaging, transcriptome, and survival data

(2019) Wei Yang et al.   Science Translational Medicine

Drug‐induced Shortening of the Electromechanical Window is an Effective Biomarker for in Silico Prediction of Clinical Risk of Arrhythmias

(2019) Elisa Passini et al.   BRITISH JOURNAL OF PHARMACOLOGY

General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy

(2019) Zhihua Li et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

In Silico QT and APD Prolongation Assay for Early Screening of Drug-Induced Proarrhythmic Risk

(2018) Lucia Romero et al.   Journal of Chemical Information and Modeling

A Heart for Diversity: Simulating Variability in Cardiac Arrhythmia Research

(2018) Haibo Ni et al.   Frontiers in Physiology

Assessment of an In Silico Mechanistic Model for Proarrhythmia Risk Prediction Under the CiPA Initiative

(2018) Zhihua Li et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Phenotypic variability in LQT3 human induced pluripotent stem cell-derived cardiomyocytes and their response to antiarrhythmic pharmacologic therapy: An in silico approach

(2017) Michelangelo Paci et al.   HEART RHYTHM

Radiomic analysis of soft tissues sarcomas can distinguish intermediate from high-grade lesions

(2017) Valentina D.A. Corino et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Novel Two-Step Classifier for Torsades de Pointes Risk Stratification from Direct Features

(2017) Jaimit Parikh et al.   Frontiers in Pharmacology

Uncertainty Quantification Reveals the Importance of Data Variability and Experimental Design Considerations for in Silico Proarrhythmia Risk Assessment

(2017) Kelly C. Chang et al.   Frontiers in Physiology

Optimization of an In silico Cardiac Cell Model for Proarrhythmia Risk Assessment

(2017) Sara Dutta et al.   Frontiers in Physiology

Quantitative Comparison of Effects of Dofetilide, Sotalol, Quinidine, and Verapamil between Human Ex vivo Trabeculae and In silico Ventricular Models Incorporating Inter-Individual Action Potential Variability

(2017) Oliver J. Britton et al.   Frontiers in Physiology

Human In Silico Drug Trials Demonstrate Higher Accuracy than Animal Models in Predicting Clinical Pro-Arrhythmic Cardiotoxicity

(2017) Elisa Passini et al.   Frontiers in Physiology

Improved Prediction of Drug-Induced Torsades de Pointes Through Simulations of Dynamics and Machine Learning Algorithms

(2016) M Cummins Lancaster et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Variability in cardiac electrophysiology: Using experimentally-calibrated populations of models to move beyond the single virtual physiological human paradigm

(2016) Anna Muszkiewicz et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

The Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative — Update on progress

(2016) Thomas Colatsky et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Rechanneling the cardiac proarrhythmia safety paradigm: A meeting report from the Cardiac Safety Research Consortium

(2013) Philip T. Sager et al.   AMERICAN HEART JOURNAL

Experimentally calibrated population of models predicts and explains intersubject variability in cardiac cellular electrophysiology

(2013) Oliver J. Britton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MICE Models: Superior to the HERG Model in Predicting Torsade de Pointes

(2013) James Kramer et al.   Scientific Reports

Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment

(2013) Ryan C. Elkins et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Late Sodium Current Inhibition Reverses Electromechanical Dysfunction in Human Hypertrophic Cardiomyopathy

(2012) Raffaele Coppini et al.   CIRCULATION

Ionic mechanisms of electrophysiological properties and repolarization abnormalities in rabbit Purkinje fibers

(2011) Alberto Corrias et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Simulation of multiple ion channel block provides improved early prediction of compounds’ clinical torsadogenic risk

(2011) Gary R. Mirams et al.   CARDIOVASCULAR RESEARCH

Effects of cilostazol in the heart

(2011) Natnicha Kanlop et al.   Journal of Cardiovascular Medicine

Thorough QT/QTc Study of Ritonavir-Boosted Saquinavir Following Multiple-Dose Administration of Therapeutic and Supratherapeutic Doses in Healthy Participants

(2011) Xiaoping Zhang et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation

(2011) Thomas O'Hara et al.   PLoS Computational Biology

Impact of ionic current variability on human ventricular cellular electrophysiology

(2009) Lucía Romero et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Parameter Sensitivity Analysis in Electrophysiological Models Using Multivariable Regression

(2009) Eric A. Sobie   BIOPHYSICAL JOURNAL

A novel computational model of the human ventricular action potential and Ca transient

(2009) Eleonora Grandi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY