Optimization of an In silico Cardiac Cell Model for Proarrhythmia Risk Assessment

The Electrogenic Na+/K+ Pump Is a Key Determinant of Repolarization Abnormality Susceptibility in Human Ventricular Cardiomyocytes: A Population-Based Simulation Study

(2017) Oliver J. Britton et al.   Frontiers in Physiology

Improved Prediction of Drug-Induced Torsades de Pointes Through Simulations of Dynamics and Machine Learning Algorithms

(2016) M Cummins Lancaster et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Convergence of models of human ventricular myocyte electrophysiology after global optimization to recapitulate clinical long QT phenotypes

(2016) Stefan A. Mann et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

An evaluation of 30 clinical drugs against the comprehensive in vitro proarrhythmia assay (CiPA) proposed ion channel panel

(2016) William J. Crumb et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

The Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative — Update on progress

(2016) Thomas Colatsky et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Ranolazine in Cardiac Arrhythmia

(2015) Marwan Saad et al.   CLINICAL CARDIOLOGY

Late sodium current block for drug-induced long QT syndrome: Results from a prospective clinical trial

(2015) L Johannesen et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Solving Differential Equations inR: PackagedeSolve

(2015) Karline Soetaert et al.   Journal of Statistical Software

Comprehensive Analyses of Ventricular Myocyte Models Identify Targets Exhibiting Favorable Rate Dependence

(2014) Megan A. Cummins et al.   PLoS Computational Biology

Rechanneling the cardiac proarrhythmia safety paradigm: A meeting report from the Cardiac Safety Research Consortium

(2013) Philip T. Sager et al.   AMERICAN HEART JOURNAL

hERG Inhibitors with Similar Potency But Different Binding Kinetics Do Not Pose the Same Proarrhythmic Risk: Implications for Drug Safety Assessment

(2013) GIOVANNI Y. DI VEROLI et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

MICE Models: Superior to the HERG Model in Predicting Torsade de Pointes

(2013) James Kramer et al.   Scientific Reports

High-throughput screening of drug-binding dynamics to HERG improves early drug safety assessment

(2012) Giovanni Y. Di Veroli et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Pro- and antiarrhythmic effects of ATP-sensitive potassium current activation on reentry during early afterdepolarization-mediated arrhythmias

(2012) Marvin G. Chang et al.   HEART RHYTHM

Mechanisms, Risk Factors, and Management of Acquired Long QT Syndrome: A Comprehensive Review

(2012) Eleftherios M. Kallergis et al.   TheScientificWorldJOURNAL

Simulation of multiple ion channel block provides improved early prediction of compounds’ clinical torsadogenic risk

(2011) Gary R. Mirams et al.   CARDIOVASCULAR RESEARCH

Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation

(2011) Thomas O'Hara et al.   PLoS Computational Biology

So Little Source, So Much Sink: Requirements for Afterdepolarizations to Propagate in Tissue

(2010) Yuanfang Xie et al.   BIOPHYSICAL JOURNAL

Early afterdepolarizations and cardiac arrhythmias

(2010) James N. Weiss et al.   HEART RHYTHM

A novel computational model of the human ventricular action potential and Ca transient

(2009) Eleonora Grandi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Regional Difference in Dynamical Property of Sinoatrial Node Pacemaking: Role of Na+ Channel Current

(2008) Yasutaka Kurata et al.   BIOPHYSICAL JOURNAL

Excito-oscillatory dynamics as a mechanism of ventricular fibrillation

(2008) Richard A. Gray et al.   HEART RHYTHM

Preclinical Torsades-de-Pointes Screens: Advantages and limitations of surrogate and direct approaches in evaluating proarrhythmic risk

(2008) Gary A. Gintant   PHARMACOLOGY & THERAPEUTICS