Blinded In Silico Drug Trial Reveals the Minimum Set of Ion Channels for Torsades de Pointes Risk Assessment

β-Adrenergic Receptor Stimulation and Alternans in the Border Zone of a Healed Infarct: An ex vivo Study and Computational Investigation of Arrhythmogenesis

(2019) Jakub Tomek et al.   Frontiers in Physiology

Drug‐induced Shortening of the Electromechanical Window is an Effective Biomarker for in Silico Prediction of Clinical Risk of Arrhythmias

(2019) Elisa Passini et al.   BRITISH JOURNAL OF PHARMACOLOGY

High arrhythmic risk in antero-septal acute myocardial ischemia is explained by increased transmural reentry occurrence

(2019) Hector Martinez-Navarro et al.   Scientific Reports

Improving prediction of torsadogenic risk in the CiPA in silico model by appropriately accounting for clinical exposure

(2019) Derek J. Leishman   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Effects of early afterdepolarizations on excitation patterns in an accurate model of the human ventricles

(2017) Enid Van Nieuwenhuyse et al.   PLoS One

Novel Two-Step Classifier for Torsades de Pointes Risk Stratification from Direct Features

(2017) Jaimit Parikh et al.   Frontiers in Pharmacology

The Electrogenic Na+/K+ Pump Is a Key Determinant of Repolarization Abnormality Susceptibility in Human Ventricular Cardiomyocytes: A Population-Based Simulation Study

(2017) Oliver J. Britton et al.   Frontiers in Physiology

Human In Silico Drug Trials Demonstrate Higher Accuracy than Animal Models in Predicting Clinical Pro-Arrhythmic Cardiotoxicity

(2017) Elisa Passini et al.   Frontiers in Physiology

Improved Prediction of Drug-Induced Torsades de Pointes Through Simulations of Dynamics and Machine Learning Algorithms

(2016) M Cummins Lancaster et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Mechanisms of pro-arrhythmic abnormalities in ventricular repolarisation and anti-arrhythmic therapies in human hypertrophic cardiomyopathy

(2016) Elisa Passini et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

A computational model predicts adjunctive pharmacotherapy for cardiac safety via selective inhibition of the late cardiac Na current

(2016) Pei-Chi Yang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Perpetuation of torsade de pointes in heterogeneous hearts: competing foci or re-entry?

(2016) Nele Vandersickel et al.   JOURNAL OF PHYSIOLOGY-LONDON

Early afterdepolarizations promote transmural reentry in ischemic human ventricles with reduced repolarization reserve

(2016) Sara Dutta et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

An evaluation of 30 clinical drugs against the comprehensive in vitro proarrhythmia assay (CiPA) proposed ion channel panel

(2016) William J. Crumb et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

The Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative — Update on progress

(2016) Thomas Colatsky et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Decreased repolarization reserve increases defibrillation threshold by favoring early afterdepolarizations in an in silico model of human ventricular tissue

(2015) Nele Vandersickel et al.   HEART RHYTHM

In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome

(2015) Lucia Romero et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

A new classifier-based strategy for in-silico ion-channel cardiac drug safety assessment

(2015) Hitesh B. Mistry et al.   Frontiers in Pharmacology

A novel computational model of mouse myocyte electrophysiology to assess the synergy between Na+loading and CaMKII

(2014) S. Morotti et al.   JOURNAL OF PHYSIOLOGY-LONDON

A Study of Early Afterdepolarizations in a Model for Human Ventricular Tissue

(2014) Nele Vandersickel et al.   PLoS One

Rechanneling the cardiac proarrhythmia safety paradigm: A meeting report from the Cardiac Safety Research Consortium

(2013) Philip T. Sager et al.   AMERICAN HEART JOURNAL

Gender Differences in Electrophysiological Gene Expression in Failing and Non-Failing Human Hearts

(2013) Christina M. Ambrosi et al.   PLoS One

MICE Models: Superior to the HERG Model in Predicting Torsade de Pointes

(2013) James Kramer et al.   Scientific Reports

Late Sodium Current Inhibition Reverses Electromechanical Dysfunction in Human Hypertrophic Cardiomyopathy

(2012) Raffaele Coppini et al.   CIRCULATION

Long-QT Syndrome

(2012) Peter J. Schwartz et al.   Circulation-Arrhythmia and Electrophysiology

Ranolazine stabilizes cardiac ryanodine receptors: A novel mechanism for the suppression of early afterdepolarization and torsades de pointes in long QT type 2

(2012) Ashish Parikh et al.   HEART RHYTHM

A Multiscale Investigation of Repolarization Variability and Its Role in Cardiac Arrhythmogenesis

(2011) Esther Pueyo et al.   BIOPHYSICAL JOURNAL

Blockade of ICa suppresses early afterdepolarizations and reduces transmural dispersion of repolarization in a whole heart model of chronic heart failure

(2011) P Milberg et al.   BRITISH JOURNAL OF PHARMACOLOGY

Torsade de pointes associated with bradycardia and takotsubo cardiomyopathy

(2011) Satoshi Kurisu et al.   CANADIAN JOURNAL OF CARDIOLOGY

Simulation of multiple ion channel block provides improved early prediction of compounds’ clinical torsadogenic risk

(2011) Gary R. Mirams et al.   CARDIOVASCULAR RESEARCH

Whole-Heart Modeling

(2011) Natalia A. Trayanova   CIRCULATION RESEARCH

Refining repolarization reserve

(2011) Dan M. Roden et al.   HEART RHYTHM

QT prolongation of the antipsychotic risperidone is predominantly related to its 9-hydroxy metabolite paliperidone

(2011) Yutaro Suzuki et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Local control of β-adrenergic stimulation: Effects on ventricular myocyte electrophysiology and Ca2+-transient

(2011) Jordi Heijman et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

A Computational Model to Predict the Effects of Class I Anti-Arrhythmic Drugs on Ventricular Rhythms

(2011) J. D. Moreno et al.   Science Translational Medicine

Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation

(2011) Thomas O'Hara et al.   PLoS Computational Biology

Early afterdepolarizations and cardiac arrhythmias

(2010) James N. Weiss et al.   HEART RHYTHM

Electrophysiological Properties of HBI-3000: A New Antiarrhythmic Agent With Multiple-channel Blocking Properties in Human Ventricular Myocytes

(2010) Donglin Guo et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

An evaluation of hERG current assay performance: Translating preclinical safety studies to clinical QT prolongation

(2010) Gary Gintant   PHARMACOLOGY & THERAPEUTICS

Investigating dynamic protocol-dependence of hERG potassium channel inhibition at 37°C: Cisapride versus dofetilide

(2010) James T. Milnes et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Increased susceptibility of aged hearts to ventricular fibrillation during oxidative stress

(2009) Norishige Morita et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The role of the Na+/Ca2+ exchanger, INa and ICaL in the genesis of dofetilide-induced torsades de pointes in isolated, AV-blocked rabbit hearts

(2009) Attila S Farkas et al.   BRITISH JOURNAL OF PHARMACOLOGY

Synchronization of chaotic early afterdepolarizations in the genesis of cardiac arrhythmias

(2009) D. Sato et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Repolarization Reserve

(2008) Dan M. Roden   CIRCULATION

Multiscale modelling of drug-induced effects on cardiac electrophysiological activity

(2008) T. Brennan et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Contribution of L-Type Ca2+ Channels to Early Afterdepolarizations Induced by I Kr and I Ks Channel Suppression in Guinea Pig Ventricular Myocytes

(2008) Mitsuhiko Yamada et al.   JOURNAL OF MEMBRANE BIOLOGY