Improved Prediction of Drug-Induced Torsades de Pointes Through Simulations of Dynamics and Machine Learning Algorithms

Synchronous Systolic Subcellular Ca2+-Elevations Underlie Ventricular Arrhythmia in Drug-Induced Long QT Type 2

(2015) Jong J. Kim et al.   Circulation-Arrhythmia and Electrophysiology

Screening for Acute I Kr Block Is Insufficient to Detect Torsades de Pointes Liability

(2014) Tao Yang et al.   CIRCULATION

Hyperphosphorylation of RyRs Underlies Triggered Activity in Transgenic Rabbit Model of LQT2 Syndrome

(2014) Dmitry Terentyev et al.   CIRCULATION RESEARCH

Exome Sequencing Implicates an Increased Burden of Rare Potassium Channel Variants in the Risk of Drug-Induced Long QT Interval Syndrome

(2014) Peter Weeke et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Inter-Subject Variability in Human Atrial Action Potential in Sinus Rhythm versus Chronic Atrial Fibrillation

(2014) Carlos Sánchez et al.   PLoS One

Comprehensive Analyses of Ventricular Myocyte Models Identify Targets Exhibiting Favorable Rate Dependence

(2014) Megan A. Cummins et al.   PLoS Computational Biology

Rechanneling the cardiac proarrhythmia safety paradigm: A meeting report from the Cardiac Safety Research Consortium

(2013) Philip T. Sager et al.   AMERICAN HEART JOURNAL

Cardiovascular Safety of Tyrosine Kinase Inhibitors: With a Special Focus on Cardiac Repolarisation (QT Interval)

(2013) Rashmi R. Shah et al.   DRUG SAFETY

Quantifying the origins of population variability in cardiac electrical activity through sensitivity analysis of the electrocardiogram

(2013) Arash Sadrieh et al.   JOURNAL OF PHYSIOLOGY-LONDON

Experimentally calibrated population of models predicts and explains intersubject variability in cardiac cellular electrophysiology

(2013) Oliver J. Britton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MICE Models: Superior to the HERG Model in Predicting Torsade de Pointes

(2013) James Kramer et al.   Scientific Reports

Epistatic Effects of Potassium Channel Variation on Cardiac Repolarization and Atrial Fibrillation Risk

(2012) Stefan A. Mann et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The electro-mechanical window in anaesthetized guinea pigs: a new marker in screening for Torsade de Pointes risk

(2011) P-J Guns et al.   BRITISH JOURNAL OF PHARMACOLOGY

Simulation of multiple ion channel block provides improved early prediction of compounds’ clinical torsadogenic risk

(2011) Gary R. Mirams et al.   CARDIOVASCULAR RESEARCH

Reduced Ventricular Proarrhythmic Potential of the Novel Combined Ion-Channel Blocker AZD1305 Versus Dofetilide in Dogs With Remodeled Hearts

(2011) Daniel M. Johnson et al.   Circulation-Arrhythmia and Electrophysiology

Quantification of repolarization reserve to understand interpatient variability in the response to proarrhythmic drugs: A computational analysis

(2011) Amrita X. Sarkar et al.   HEART RHYTHM

Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation

(2011) Thomas O'Hara et al.   PLoS Computational Biology

Late Na+Current Inhibition by Ranolazine Reduces Torsades de Pointes in the Chronic Atrioventricular Block Dog Model

(2010) Gudrun Antoons et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

An evaluation of hERG current assay performance: Translating preclinical safety studies to clinical QT prolongation

(2010) Gary Gintant   PHARMACOLOGY & THERAPEUTICS

Parameter Sensitivity Analysis in Electrophysiological Models Using Multivariable Regression

(2009) Eric A. Sobie   BIOPHYSICAL JOURNAL

Uniqueness and Stability of Action Potential Models during Rest, Pacing, and Conduction Using Problem-Solving Environment

(2009) Leonid Livshitz et al.   BIOPHYSICAL JOURNAL

A novel computational model of the human ventricular action potential and Ca transient

(2009) Eleonora Grandi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Support Vector Machines and Kernels for Computational Biology

(2008) Asa Ben-Hur et al.   PLoS Computational Biology