Uncertainty Quantification Reveals the Importance of Data Variability and Experimental Design Considerations for in Silico Proarrhythmia Risk Assessment

Optimization of an In silico Cardiac Cell Model for Proarrhythmia Risk Assessment

(2017) Sara Dutta et al.   Frontiers in Physiology

Estimability Analysis and Optimal Design in Dynamic Multi-scale Models of Cardiac Electrophysiology

(2016) Matthew S. Shotwell et al.   JOURNAL OF AGRICULTURAL BIOLOGICAL AND ENVIRONMENTAL STATISTICS

Uncertainty and variability in models of the cardiac action potential: Can we build trustworthy models?

(2016) Ross H. Johnstone et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Uncertainty and variability in computational and mathematical models of cardiac physiology

(2016) Gary R. Mirams et al.   JOURNAL OF PHYSIOLOGY-LONDON

Evolution of strategies to improve preclinical cardiac safety testing

(2016) Gary Gintant et al.   NATURE REVIEWS DRUG DISCOVERY

A temperature-dependent in silico model of the human ether-à-go-go- related (hERG) gene channel

(2016) Zhihua Li et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

An evaluation of 30 clinical drugs against the comprehensive in vitro proarrhythmia assay (CiPA) proposed ion channel panel

(2016) William J. Crumb et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

The Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative — Update on progress

(2016) Thomas Colatsky et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Uncertainty quantification of fast sodium current steady-state inactivation for multi-scale models of cardiac electrophysiology

(2015) Pras Pathmanathan et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Inverse Modelling, Sensitivity and Monte Carlo Analysis inRUsing PackageFME

(2015) Karline Soetaert et al.   Journal of Statistical Software

Solving Differential Equations inR: PackagedeSolve

(2015) Karline Soetaert et al.   Journal of Statistical Software

Experimentally calibrated population of models predicts and explains intersubject variability in cardiac cellular electrophysiology

(2013) Oliver J. Britton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment

(2013) Ryan C. Elkins et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Ensuring reliability of safety-critical clinical applications of computational cardiac models

(2013) Pras Pathmanathan et al.   Frontiers in Physiology

Quantification of repolarization reserve to understand interpatient variability in the response to proarrhythmic drugs: A computational analysis

(2011) Amrita X. Sarkar et al.   HEART RHYTHM

Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation

(2011) Thomas O'Hara et al.   PLoS Computational Biology

Investigating dynamic protocol-dependence of hERG potassium channel inhibition at 37°C: Cisapride versus dofetilide

(2010) James T. Milnes et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Markov models for ion channels: versatility versus identifiability and speed

(2009) M. Fink et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES