A gas chromatography–mass spectrometry-based whole-cell screening assay for target identification in distal cholesterol biosynthesis

Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons

(2019) Rik van der Kant et al.   Cell Stem Cell

Desmosterolosis presenting with multiple congenital anomalies

(2018) Mersedeh Rohanizadegan et al.   European Journal of Medical Genetics

Analysis by LC–MS/MS of endogenous steroids from human serum, plasma, endometrium and endometriotic tissue

(2018) Merja R. Häkkinen et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Functional importance for developmental regulation of sterol biosynthesis in Acanthamoeba castellanii

(2018) Wenxu Zhou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination

(2018) Zita Hubler et al.   NATURE

Lamin B receptor-related disorder is associated with a spectrum of skeletal dysplasia phenotypes

(2018) Eliza Thompson et al.   BONE

New chemotype of selective and potent inhibitors of human delta 24-dehydrocholesterol reductase

(2017) Christoph Müller et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Desmosterol accumulation in users of amiodarone

(2017) P. Simonen et al.   JOURNAL OF INTERNAL MEDICINE

Cholesterol and desmosterol dancing to the beat of a different drug

(2017) A. J. Brown et al.   JOURNAL OF INTERNAL MEDICINE

Vulnerability ofDHCR7+/−mutation carriers to aripiprazole and trazodone exposure

(2017) Zeljka Korade et al.   JOURNAL OF LIPID RESEARCH

Antifungal drug testing by combining minimal inhibitory concentration testing with target identification by gas chromatography–mass spectrometry

(2017) Christoph Müller et al.   Nature Protocols

Effect of psychotropic drug treatment on sterol metabolism

(2017) Željka Korade et al.   SCHIZOPHRENIA RESEARCH

Antifungal defense of probiotic Lactobacillus rhamnosus GG is mediated by blocking adhesion and nutrient depletion

(2017) Daniela Mailänder-Sánchez et al.   PLoS One

Cholesterol Biosynthesis: A Mechanistic Overview

(2016) Nuno M. F. S. A. Cerqueira et al.   BIOCHEMISTRY

Inhibitors of 7-Dehydrocholesterol Reductase: Screening of a Collection of Pharmacologically Active Compounds in Neuro2a Cells

(2016) Hye-Young H. Kim et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Arylpiperidines as a new class of oxidosqualene cyclase inhibitors

(2016) Marco Keller et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Effect of Small Molecules on Sterol Homeostasis: Measuring 7-Dehydrocholesterol in Dhcr7-Deficient Neuro2a Cells and Human Fibroblasts

(2016) Zeljka Korade et al.   JOURNAL OF MEDICINAL CHEMISTRY

Investigation of 7-dehydrocholesterol reductase pathway to elucidate off-target prenatal effects of pharmaceuticals: a systematic review

(2016) M R Boland et al.   PHARMACOGENOMICS JOURNAL

Oxysterols: From cholesterol metabolites to key mediators

(2016) Valentin Mutemberezi et al.   PROGRESS IN LIPID RESEARCH

Identification of Environmental Quaternary Ammonium Compounds as Direct Inhibitors of Cholesterol Biosynthesis

(2016) Josi Herron et al.   TOXICOLOGICAL SCIENCES

Analytical pitfalls and challenges in clinical metabolomics

(2016) Isabelle Kohler et al.   Bioanalysis

Reduced cholesterol levels impair Smoothened activation in Smith–Lemli–Opitz syndrome

(2015) Robert Blassberg et al.   HUMAN MOLECULAR GENETICS

Fungal sterol C22-desaturase is not an antimycotic target as shown by selective inhibitors and testing on clinical isolates

(2015) Christoph Müller et al.   STEROIDS

Sustained and selective suppression of intestinal cholesterol synthesis by Ro 48-8071, an inhibitor of 2,3-oxidosqualene:lanosterol cyclase, in the BALB/c mouse

(2014) Jen-Chieh Chuang et al.   BIOCHEMICAL PHARMACOLOGY

Analysis and Experimental Inhibition of Distal Cholesterol Biosynthesis

(2014) Martin Giera et al.   CHROMATOGRAPHIA

Antifungal drugs during pregnancy: an updated review

(2014) B. Pilmis et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Desmosterolosis: an illustration of diagnostic ambiguity of cholesterol synthesis disorders

(2014) Cristina Dias et al.   Orphanet Journal of Rare Diseases

Comprehensive gas chromatography-electron ionisation mass spectrometric analysis of fatty acids and sterols using sequential one-pot silylation: quantification and isotopologue analysis

(2014) Dick-Paul Kloos et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Analysis of biologically-active, endogenous carboxylic acids based on chromatography-mass spectrometry

(2014) D. Kloos et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

High susceptibility to fatty liver disease in two-pore channel 2-deficient mice

(2014) Christian Grimm et al.   Nature Communications

Steroidomimetic Aminomethyl Spiroacetals as Novel Inhibitors of the Enzyme Δ8,7-Sterol Isomerase in Cholesterol Biosynthesis

(2013) Melanie Krojer et al.   ARCHIV DER PHARMAZIE

The role of sterol-C4-methyl oxidase in epidermal biology

(2013) Miao He et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Stereoselective synthesis of a new class of potent and selective inhibitors of human Δ8,7-sterol isomerase

(2013) Mathias König et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Cholesterol precursors

(2013) Andrew J. Brown et al.   CURRENT OPINION IN LIPIDOLOGY

Sterol metabolism disorders and neurodevelopment-an update

(2013) Shibani Kanungo et al.   Developmental Disabilities Research Reviews

Controlling Cholesterol Synthesis beyond 3-Hydroxy-3-methylglutaryl-CoA Reductase (HMGCR)

(2013) Laura J. Sharpe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Desmosterol and DHCR24: Unexpected new directions for a terminal step in cholesterol synthesis

(2013) Eser J. Zerenturk et al.   PROGRESS IN LIPID RESEARCH

A convenient cellular assay for the identification of the molecular target of ergosterol biosynthesis inhibitors and quantification of their effects on total ergosterol biosynthesis

(2013) Christoph Müller et al.   STEROIDS

A comprehensive method for extraction and quantitative analysis of sterols and secosteroids from human plasma

(2012) Jeffrey G. McDonald et al.   JOURNAL OF LIPID RESEARCH

Atypical antipsychotics alter cholesterol and fatty acid metabolism in vitro

(2012) Alberto Canfrán-Duque et al.   JOURNAL OF LIPID RESEARCH

A New Class of Selective and Potent 7-Dehydrocholesterol Reductase Inhibitors

(2012) Aline Horling et al.   JOURNAL OF MEDICINAL CHEMISTRY

Analysis of oxysterol metabolomes

(2011) William J. Griffiths et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Biosynthesis of Cholesterol and Other Sterols

(2011) W. David Nes   CHEMICAL REVIEWS

Synthetic LXR Agonist Suppresses Endogenous Cholesterol Biosynthesis and Efficiently Lowers Plasma Cholesterol

(2011) Thomas Pfeifer et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Smith–Lemli–Opitz syndrome

(2011) Andrea E. DeBarber et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Selection of the derivatization reagent—The case of human blood cholesterol, its precursors and phytosterols GC–MS analyses

(2011) David Saraiva et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Malformation syndromes caused by disorders of cholesterol synthesis

(2010) Forbes D. Porter et al.   JOURNAL OF LIPID RESEARCH

Gas chromatography/mass spectrometry (GC/MS) remains a pre-eminent discovery tool in clinical steroid investigations even in the era of fast liquid chromatography tandem mass spectrometry (LC/MS/MS)

(2010) Nils Krone et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Haloperidol disrupts lipid rafts and impairs insulin signaling in SH-SY5Y cells

(2010) J. Sánchez-Wandelmer et al.   NEUROSCIENCE

Perspectives of the non-statin hypolipidemic agents

(2010) Damjana Rozman et al.   PHARMACOLOGY & THERAPEUTICS

Are azole fungicides a teratogenic risk for human conceptus?

(2010) E. Giavini et al.   TOXICOLOGY LETTERS

Inhibition of cholesterol biosynthesis disrupts lipid raft/caveolae and affects insulin receptor activation in 3T3-L1 preadipocytes

(2009) Jana Sánchez-Wandelmer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Side chain azasteroids and thiasteroids as sterol methyltransferase inhibitors in ergosterol biosynthesis

(2009) Delphine Renard et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Combined gas chromatographic/mass spectrometric analysis of cholesterol precursors and plant sterols in cultured cells

(2009) Jure Acimovic et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Bile acids: analysis in biological fluids and tissues

(2009) William J. Griffiths et al.   JOURNAL OF LIPID RESEARCH

Steroid metabolome in plasma from the umbilical artery, umbilical vein, maternal cubital vein and in amniotic fluid in normal and preterm labor

(2009) Martin Hill et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Highly sensitive analysis of sterol profiles in human serum by LC-ESI-MS/MS

(2008) Akira Honda et al.   JOURNAL OF LIPID RESEARCH

Lathosterol side chain amides—A new class of human lathosterol oxidase inhibitors

(2007) Martin Giera et al.   STEROIDS