Empagliflozin mitigates type 2 diabetes-associated peripheral neuropathy: a glucose-independent effect through AMPK signaling

Experimental Evidence for Diiodohydroxyquinoline-Induced Neurotoxicity: Characterization of Age and Gender as Predisposing Factors

(2022) Ahmed S. Kamel et al.   Pharmaceuticals

Dapagliflozin as an autophagic enhancer via LKB1/AMPK/SIRT1 pathway in ovariectomized/d-galactose Alzheimer’s rat model

(2022) Weam W. Ibrahim et al.   INFLAMMOPHARMACOLOGY

Inosine mitigated diabetic peripheral neuropathy via modulating GLO1/AGEs/RAGE/NF-κB/Nrf2 and TGF-β/PKC/TRPV1 signaling pathways

(2021) Noha F. Abdelkader et al.   BIOMEDICINE & PHARMACOTHERAPY

Blunting p38 MAPKα and ERK1/2 activities by empagliflozin enhances the antifibrotic effect of metformin and augments its AMPK-induced NF-κB inactivation in mice intoxicated with carbon tetrachloride

(2021) Amir Mohamed Abdelhamid et al.   LIFE SCIENCES

Metformin and trimetazidine ameliorate diabetes-induced cognitive impediment in status epileptic rats

(2020) Marwan Abd Elbaset Mohamed et al.   EPILEPSY & BEHAVIOR

Treatment of diabetic peripheral neuropathy: a review

(2020) Maher R. Khdour   JOURNAL OF PHARMACY AND PHARMACOLOGY

Empagliflozin Ameliorates Obesity-Related Cardiac Dysfunction by Regulating Sestrin2-Mediated AMPK-mTOR Signaling and Redox Homeostasis in High-Fat Diet–Induced Obese Mice

(2020) Xiaodong Sun et al.   DIABETES

Empagliflozin protects heart from inflammation and energy depletion via AMPK activation

(2020) Chintan N. Koyani et al.   PHARMACOLOGICAL RESEARCH

Cognitive enhancing effect of diapocynin in D-galactose-ovariectomy-induced Alzheimer's-like disease in rats: Role of ERK, GSK-3β, and JNK signaling

(2020) Weam W. Ibrahim et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Differential Effects of Empagliflozin on Microvascular Complications in Murine Models of Type 1 and Type 2 Diabetes

(2020) Stephanie A. Eid et al.   Biology-Basel

AMPK activation attenuates inflammatory pain through inhibiting NF-κB activation and IL-1β expression

(2019) Hong-Chun Xiang et al.   Journal of Neuroinflammation

Contributions of mTOR Activation-Mediated Upregulation of Synapsin II and Neurite Outgrowth to Hyperalgesia in STZ-Induced Diabetic Rats

(2019) Wan-you He et al.   ACS Chemical Neuroscience

WITHDRAWN: Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition

(2019) Pouya Saeedi et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Kilohertz high-frequency alternating current blocks nerve conduction without causing nerve damage in rats

(2019) Dandan Ling et al.   Annals of Translational Medicine

Empagliflozin attenuates ischemia and reperfusion injury through LKB1/AMPK signaling pathway

(2019) Qingguo Lu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Empagliflozin reduces high glucose-induced oxidative stress and miR-21-dependent TRAF3IP2 induction and RECK suppression, and inhibits human renal proximal tubular epithelial cell migration and epithelial-to-mesenchymal transition

(2019) Nitin A. Das et al.   CELLULAR SIGNALLING

Extracellular Matrix Remodeling and Modulation of Inflammation and Oxidative Stress by Sulforaphane in Experimental Diabetic Peripheral Neuropathy

(2018) Passant E. Moustafa et al.   INFLAMMATION

Lycium barbarum polysaccharide protects diabetic peripheral neuropathy by enhancing autophagy via mTOR/p70S6K inhibition in Streptozotocin-induced diabetic rats

(2018) Si-Yang Liu et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Liraglutide ameliorated peripheral neuropathy in diabetic rats: Involvement of oxidative stress, inflammation and extracellular matrix remodeling

(2018) Passant E. Moustafa et al.   JOURNAL OF NEUROCHEMISTRY

Empagliflozin rescues diabetic myocardial microvascular injury via AMPK-mediated inhibition of mitochondrial fission

(2018) Hao Zhou et al.   Redox Biology

Effect of Empagliflozin, a Selective Sodium-Glucose Cotransporter 2 Inhibitor, on Kidney and Peripheral Nerves in Streptozotocin-Induced Diabetic Rats

(2018) Kyung Ae Lee et al.   Diabetes & Metabolism Journal

SGLT2 inhibitors for primary and secondary prevention of cardiovascular and renal outcomes in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials

(2018) Thomas A Zelniker et al.   LANCET

L-carnitine ameliorates peripheral neuropathy in diabetic mice with a corresponding increase in insulin‑like growth factor‑1 level

(2018) Rui Wang et al.   Molecular Medicine Reports

AMPK in microvascular complications of diabetes and the beneficial effects of AMPK activators from plants

(2018) C.B. Shrikanth et al.   PHYTOMEDICINE

Activation of AMPK is neuroprotective in the oxidative stress by advanced glycosylation end products in human neural stem cells

(2017) Chien-Hung Lin et al.   EXPERIMENTAL CELL RESEARCH

Neuroprotective effect of nebivolol against cisplatin-associated depressive-like behavior in rats

(2017) Noha F. Abdelkader et al.   JOURNAL OF NEUROCHEMISTRY

Differential Impact of miR-21 on Pain and Associated Affective and Cognitive Behavior after Spared Nerve Injury in B7-H1 ko Mouse

(2017) Franziska Karl et al.   Frontiers in Molecular Neuroscience

Effects of Sodium-Glucose Cotransporter 2 Inhibitors for the Treatment of Patients With Heart Failure

(2017) Milton Packer et al.   JAMA Cardiology

The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels

(2016) Simon A. Hawley et al.   DIABETES

Role of Matrix Metalloproteinases in Photoaging and Photocarcinogenesis

(2016) Pavida Pittayapruek et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Adenosine Monophosphate-Activated Protein Kinase Abates Hyperglycaemia-Induced Neuronal Injury in Experimental Models of Diabetic Neuropathy: Effects on Mitochondrial Biogenesis, Autophagy and Neuroinflammation

(2016) Veera Ganesh Yerra et al.   MOLECULAR NEUROBIOLOGY

Healthcare utilization and costs in diabetes relative to the clinical spectrum of painful diabetic peripheral neuropathy

(2015) Alesia Sadosky et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Empagliflozin: A Review of Its Use in Patients with Type 2 Diabetes Mellitus

(2014) Lesley J. Scott   DRUGS

Allodynia and hyperalgesia in neuropathic pain: clinical manifestations and mechanisms

(2014) Troels S Jensen et al.   LANCET NEUROLOGY

The Effect of Angipars on Diabetic Neuropathy in STZ-Induced Diabetic Male Rats: A Study on Behavioral, Electrophysiological, Sciatic Histological and Ultrastructural Indices

(2014) Nasser Zangiabadi et al.   TheScientificWorldJOURNAL

Empagliflozin improves glycaemic and weight control as add-on therapy to pioglitazone or pioglitazone plus metformin in patients with type 2 diabetes: a 24-week, randomized, placebo-controlled trial

(2013) C. S. Kovacs et al.   DIABETES OBESITY & METABOLISM

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

Impaired adenosine monophosphate-activated protein kinase signalling in dorsal root ganglia neurons is linked to mitochondrial dysfunction and peripheral neuropathy in diabetes

(2012) Subir K. Roy Chowdhury et al.   BRAIN

Bradley’s Neurology in Clinical Practice

(2012) Richard J. Lederman   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Improvement of Cardiac Functions by Chronic Metformin Treatment Is Associated With Enhanced Cardiac Autophagy in Diabetic OVE26 Mice

(2011) Z. Xie et al.   DIABETES

Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: characterisation and comparison with other SGLT-2 inhibitors

(2011) R. Grempler et al.   DIABETES OBESITY & METABOLISM

Clinical trial of the p38 MAP kinase inhibitor dilmapimod in neuropathic pain following nerve injury

(2011) Praveen Anand et al.   EUROPEAN JOURNAL OF PAIN

Date Fruit Extract Is a Neuroprotective Agent in Diabetic Peripheral Neuropathy in Streptozotocin-Induced Diabetic Rats: A Multimodal Analysis

(2011) Nasser Zangiabadi et al.   Oxidative Medicine and Cellular Longevity

Effect of lacidipine pre-treatment on diabetic neuropathy in rats

(2010) Janardhan Singh et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Diagnosis and Classification of Diabetes Mellitus

(2009)   DIABETES CARE

Pathological and protective roles of glia in chronic pain

(2008) Erin D. Milligan et al.   NATURE REVIEWS NEUROSCIENCE