Article
Multidisciplinary Sciences
Dahoon Park, Yushin Kim
Summary: Recent research has found that inhibiting nerve conduction with a kilohertz frequency through transcutaneous electrical stimulation is effective and safe. This study aimed to demonstrate the hypoalgesic effect of transcutaneous interferential-current nerve inhibition (TINI) on the tibial nerve and compare it with transcutaneous electrical nerve stimulation (TENS) in terms of analgesic effect and comfort. The results showed that TINI significantly increased the pressure pain threshold (PPT) compared to baseline, while TENS did not. Participants also reported TENS to be 36% more uncomfortable than TINI. In conclusion, TINI can inhibit mechanical pain sensitivity effectively and comfortably.
SCIENTIFIC REPORTS
(2023)
Article
Engineering, Biomedical
Thomas Eggers, Joseph Kilgore, David Green, Tina Vrabec, Kevin Kilgore, Niloy Bhadra
Summary: The study successfully combined DC and KHFAC into a waveform named CROW, which can reduce the onset response and achieve effective nerve block, providing broader possibilities for clinical application of electrical nerve block.
JOURNAL OF NEURAL ENGINEERING
(2021)
Review
Clinical Neurology
Clemens Neudorfer, T. Clement Chow, Alexandre Boutet, Aaron Loh, Jurgen Germann, Gavin JB. Elias, D. William Hutchison, M. Andres Lozano
Summary: Electrical stimulation in the kilohertz-frequency range elicits diverse effects on neural tissue, distinct from conventional stimulation, including subthreshold, suprathreshold, synaptic, and thermal effects. These effects offer new therapeutic avenues but are associated with unique challenges and caveats that need to be considered in experimental paradigms.
Article
Engineering, Biomedical
Edgar Pena, Nicole A. Pelot, Warren M. Grill
Summary: Electrical nerve conduction block has the potential to treat diseases by inactivating nerves, but there are obstacles to effective translation. This study evaluated kilohertz-frequency nerve block in rats and found that the lowest frequencies capable of blocking were not the most energy-efficient. Bipolar cuffs required the largest current and power to block, while monopolar and tripolar cuffs required the lowest power. Composite signals combining harmonics at different frequencies were found to reduce block threshold and onset response.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2023)
Article
Engineering, Biomedical
Shane A. Bender, David B. Green, Robert J. Daniels, Stephen P. Ganocy, Niloy Bhadra, Tina L. Vrabec
Summary: Electrical conduction block of the vagus nerve was studied to characterize its effects on heart rate dynamics. The results show that complete block and partial block can be achieved using direct current (DC) at different amplitudes. The amplitude of DC was found to significantly predict the induction time for complete block, and the blocking duration and injected charge were significant in predicting the recovery time.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Engineering, Biomedical
L. Savannah Dewberry, Alexander B. Dru, Maxwell Gravenstine, Brian Nguyen, James Anderson, Sasha Vaziri, Daniel J. Hoh, Kyle D. Allen, Kevin J. Otto
Summary: The study showed that HF block can rapidly reduce tactile sensitivity in a limb with neuropathic injury. No significant increase in gait disability was observed during HF block.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Multidisciplinary Sciences
Geumbee Lee, Emily Ray, Hong -Joon Yoon, Sabrina Genovese, Yeon Sik Choi, Min-Kyu Lee, Samet Sahin, Ying Yan, Hak-Young Ahn, Amay J. Bandodkar, Joohee Kim, Minsu Park, Hanjun Ryu, Sung Soo Kwak, Yei Hwan Jung, Arman Odabas, Umang Khandpur, Wilson Z. Ray, Matthew R. MacEwan, John A. Rogers
Summary: This study introduces a bioresorbable nerve stimulator that can provide pain relief through electrical nerve block without the need for surgical extraction. The device is designed to minimize adverse effects and disappears harmlessly in the body after use, making it a potential alternative to addictive drugs for pain treatment.
Article
Medicine, General & Internal
David Martin-Caro Alvarez, Diego Serrano-Munoz, Juan Jose Fernandez-Perez, Julio Gomez-Soriano, Juan Avendano-Coy
Summary: This study investigated the effects of high-frequency alternating currents (HFAC) on the peripheral nervous system in healthy volunteers. The results showed that percutaneous stimulation with 20 kHz HFAC led to a reversible reduction in strength.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Chemistry, Analytical
M. Ivette Muzquiz, Landan Mintch, M. Ryne Horn, Awadh Alhawwash, Rizwan Bashirullah, Michael Carr, John H. Schild, Ken Yoshida
Summary: The study successfully demonstrated the high degree of nerve block achieved by LFACb waveform in blocking bradycardic effect induced by vagal stimulation in rats, showing its effectiveness and reversibility.
Article
Biochemistry & Molecular Biology
Yi Guo-Sheng, Zhao Qiang, Bai Rui-Feng, Wei Xi-Le, Wang Jiang
Summary: This paper provides a comprehensive review of the preclinical studies on kilohertz frequency alternating current (KHFAC) stimulation for nerve conduction block. It covers various aspects, including the temporal characteristics and methods to reduce onset firing, the duration and underlying mechanisms of poststimulation block, the effects of different stimulus waveform and parameters, the influence of blocking electrode design and position, the potential clinical applications, and the mechanisms involved in KHFAC nerve block. Several key issues for future research are also pointed out.
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Neurosciences
David Martin-Caro Alvarez, Diego Serrano-Munoz, Juan Jose Fernandez-Perez, Julio Gomez-Soriano, Juan Avendano-Coy
Summary: This study evaluated the effect of percutaneous HFAC at 30 kHz on sensory-motor nerve conduction in healthy volunteers. The results showed that the active group had increased pressure pain threshold during and after the stimulation compared to the sham group. Participants in the active group also reported more feelings of numbness and heaviness. No intergroup differences were observed in the remaining outcome variables.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Engineering, Biomedical
Luis Vargas, Eric D. Musselman, Warren M. Grill, Xiaogang Hu
Summary: This study developed a subthreshold high-frequency stimulation waveform to activate axons asynchronously, aiming to achieve finer control of muscle forces. Results from both experiments and simulations demonstrated that the stimulation waveform could induce asynchronous firing patterns of neurons and provide more stable control of muscle forces.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Multidisciplinary Sciences
Emanuel Gunnarsson, Kristian Rodby, Fernando Seoane
Summary: Electro-stimulation has been used successfully for years to alleviate spasticity, pain, and increase mobility. The Mollii-suit by Inerventions utilizes dry conductive rubber electrodes, eliminating the need for frequent replacement. However, fitting the garment on the body is cumbersome. This paper presents the possibility of using knitted dry electrodes instead, which have lower skin friction and can easily be fitted to the body. Through validating the performance of the garment using electrical parameters, it is concluded that knitting techniques can produce a seamlessly integrated garment with beneficial manufacturing and comfort perspectives.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, Research & Experimental
Jialiang Chen, Yihua Zhong, Jicheng Wang, Bing Shen, Jonathan Beckel, William C. de Groat, Changfeng Tai
Summary: This study investigates the impact of temperature on nerve conduction block induced by high-frequency (kHz) stimulation. Results show that at a lower temperature of 15 degrees C, both 2- and 10-kHz stimulations caused an initial muscle contraction followed by nerve block. The threshold for acute block was significantly higher for 10 kHz compared to 2 kHz. However, at a higher temperature of 20 degrees C, the threshold for acute block with 10-kHz stimulation decreased, while 2-kHz stimulation induced a tonic muscle contraction and a poststimulation block.
Article
Engineering, Biomedical
Yihua Zhong, Xu Zhang, Jonathan Beckel, William C. de Groat, Changfeng Tai
Summary: A new axonal conduction model was used to analyze the interaction between intracellular sodium concentration and membrane potential oscillation in axonal conduction block induced by high-frequency biphasic stimulation. The results show that the block duration can be shortened by increasing the HFBS intensity, and the block can be maintained if the intensity is above a certain threshold.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Anesthesiology
Xiaorui Chen, Dandan Ling, Jianfang Cao, Xiaoyan Lin, Xiaodan Cao, Mengying Wang, Junjie Luo, Shuqi Xie, Bin Yu
CLINICAL JOURNAL OF PAIN
(2020)
Article
Oncology
Junjie Luo, Guangyu Cai, Dandan Ling, Na Zhang, Xiaorui Chen, Xiaodan Cao, Bin Yu
ANNALS OF TRANSLATIONAL MEDICINE
(2020)
Article
Anesthesiology
Miao He, Dan-Dan Ling, Guang-Yu Cai, Tian-Xiao Zou, Bin Yu
MINERVA ANESTESIOLOGICA
(2018)