Article
Clinical Neurology
Jessica A. Harder, Raina N. Fichorova, Akanksha Srivastava, Aleta Wiley, Katherine E. Burdick, Joseph J. Locascio, Hadine Joffe
Summary: This study found that BDNF levels are positively correlated with the severity of mood symptoms in women with perimenopausal depression symptoms, resembling the pattern seen in hormonally-sensitive PMDD. This suggests the presence of a hormonally-sensitive mood disorder biomarker profile distinct from that of major depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Younjung Lee, Kye-Hyun Kim, Bun-Hee Lee, Yong-Ku Kim
Summary: The study found that pregnancy and postpartum depression can affect BDNF concentration, and the BDNF concentration in the postpartum depression-recovery group significantly increased at 6 weeks postpartum.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Review
Biology
Massimo Fioranelli, Maria Grazia Roccia, Bianca Przybylek, Maria Luisa Garo
Summary: This systematic review examines the bidirectional relationship between cardiovascular disease (CVD) and depression, with a focus on the potential role of low serum BDNF levels in the development of either disease in the presence of the other. The results suggest a strong association between low serum BDNF levels and the risk of post-stroke depression, but there is limited research on altered serum BDNF levels and other types of CVD, therefore the inverse association between depression and CVD cannot be proven.
Review
Psychiatry
Chunhui Zhang, Xuefang Wang, Qinghua Zhu, Yongxia Mei, Zhenxiang Zhang, Hui Xu
Summary: This study found that serum BDNF levels are lower in poststroke depression (PSD) patients compared to stroke patients without PSD, suggesting that BDNF may serve as a potential biomarker for predicting the risk of PSD among stroke survivors.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Multidisciplinary Sciences
Chi Him Poon, Boon Chin Heng, Lee Wei Lim
Summary: Advancements in understanding the molecular profiles offer insights into the neuropathology of depression. Abnormal BDNF expression is associated with depression, and epigenetic changes of BDNF exons play a crucial role in memory functions and antidepressant effects. Differential epigenetic regulation of specific BDNF exons is linked to depression pathophysiology, and targeting memory extinction through BDNF modulation shows promise for treating depression and anxiety disorders.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Review
Psychiatry
Kyana Jafarabady, Arman Shafiee, Razman Arabzadeh Bahri, Shahryar Rajai Firouzabadi, Ida Mohammadi, Mohammad Javad Amini
Summary: This systematic review and meta-analysis provide evidence of lower BDNF protein levels in individuals diagnosed with perinatal depression (PND), indicating that BDNF dysregulation may play a part in the development of PND.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Article
Psychiatry
Jae-Min Kim, Ju-Wan Kim, Hee-Ju Kang, Ju-Yeon Lee, Sung-Wan Kim, Il-Seon Shin, Byung-Jo Chun, Robert Stewart
Summary: The study found that childhood abuse and serum BDNF levels have individual and interactive effects on suicidal behavior in patients with depressive disorders, both before and after pharmacologic treatment. Combining information on childhood abuse and serum BDNF levels could improve predictions of suicidal behavior in these patients.
BRITISH JOURNAL OF PSYCHIATRY
(2021)
Article
Neurosciences
Rintaro Fujii, Keita Watanabe, Naomichi Okamoto, Tomoya Natsuyama, Hirofumi Tesen, Ryohei Igata, Yuki Konishi, Atsuko Ikenouchi, Shingo Kakeda, Reiji Yoshimura
Summary: This study aimed to explore the relationship between hippocampal subfield volumes and plasma levels of BDNF in first-episode major depression patients. The results showed that there were no differences in total hippocampal volume between the patient group and the control group. However, specific subfields in the patient group, such as the HATA and several regions on the right side, were significantly smaller compared to the control group. Furthermore, the study found different correlations between hippocampal volume and plasma BDNF concentrations in the patient and control groups. These findings suggest that certain hippocampal subfields may already be atrophic at the onset of major depression, and the sensitivity of certain regions to BDNF may differ between the two groups.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Hsin-Tzu Liu, Yu-Ning Lin, Ming-Cheng Tsai, Ya-Chi Wu, Ming-Chung Lee
Summary: The study demonstrates that baicalein can attenuate LPS-induced depression-like behavior by suppressing neuroinflammation and inflammation induced by the peripheral immune response.
Review
Medicine, Research & Experimental
Helia Mojtabavi, Zoha Shaka, Sara Momtazmanesh, Atra Ajdari, Nima Rezaei
Summary: The study confirms that stroke significantly decreases BDNF levels, affecting cognition, affect, and motor function. Patients with depression have lower BDNF levels. Physical training has a short-term positive effect on BDNF levels, while the long-term effects are unclear. Repeated transcranial magnetic stimulation has no effect on BDNF levels.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Clinical Neurology
Leo Sher, Linda M. Bierer, Janine Flory, Iouri Makotkine, Rachel Yehuda
Summary: This study found that plasma BDNF levels were higher among combat veterans who made suicide attempts post-deployment compared to those who did not. BDNF may be involved in the pathophysiology of suicidal behavior in this population.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Psychiatry
Shakila Meshkat, Yazen Alnefeesi, Muhammad Youshay Jawad, Joshua D. Di Vincenzo, Nelson B. Rodrigues, Felicia Ceban, Leanna M. W. Lui, Roger S. McIntyre, Joshua D. Rosenblat
Summary: This synthesis study found that TRD treatments can affect peripheral BDNF levels, but changes in peripheral BDNF levels are not significantly associated with antidepressant effects.
PSYCHIATRY RESEARCH
(2022)
Review
Behavioral Sciences
Beatrice Arosio, Franca Rosa Guerini, Richard C. Oude Voshaar, Ivan Aprahamian
Summary: This article summarizes the neurotrophin hypothesis of depression and the relationship between blood BDNF concentration and MDD. Existing research suggests that changes in BDNF levels are associated with clinical manifestations of depression, but cannot yet be used as a biomarker in clinical practice.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Review
Neurosciences
Shu-Hui Dou, Yu Cui, Shu-Ming Huang, Bo Zhang
Summary: This article reviews the abnormal levels of brain-derived neurotrophic factor (BDNF) in various central nervous system (CNS) diseases and suggests that BDNF may play a role in the pathogenesis of these diseases. It also discusses the potential treatment of these diseases by regulating BDNF signaling. The clinical application status of BDNF is briefly introduced.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Takao Saida, Hajime Baba, Hitoshi Maeshima, Shuntaro Natsume, Naoto Yoshinari, Kentaro Shimizu, Toshihito Suzuki
Summary: The aim of this study was to determine whether serum levels of brain-derived neurotrophic factor (BDNF) in the remitted or acute phase of depression predicted the transition from depression to dementia. The results showed that serum levels of BDNF after remission, but not those in the acute depressive phase, were able to predict the future development of dementia or mild cognitive impairment (MCI).
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Medicine, Research & Experimental
Muhammed A. Saad, Muhammad A. Eltarzy, Rania M. Abdel Salam, Maha A. E. Ahmed
Summary: The study found that the Notch signaling pathway was overexpressed in PCOS rats, leading to cognitive impairment, which was improved by Liraglutide. This suggests that Liraglutide may serve as a novel therapeutic intervention to alleviate PCOS-induced dementia.
Article
Biochemistry & Molecular Biology
Hany H. Arab, Muhammad Y. Al-Shorbagy, Muhammed A. Saad
Summary: Dapagliflozin has a potential protective effect against experimental colitis by enhancing colonic autophagy and suppressing apoptosis through activation of AMPK/mTOR and Nrf2/HO-1 pathways, and inhibition of the HMGB1/RAGE/NF-kappa B cascade.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Muhammad A. E. Saad, Mohamed I. M. Fahmy, Rabab H. Sayed, Muhammad F. El-Yamany, Reham El-Naggar, Ahmed A. E. Hegazy, Muhammad Al-Shorbagy
Summary: Eprosartan demonstrated neuroprotective effects in rats with middle carotid artery occlusion (MCAO)-induced ischemic stroke by attenuating oxidative, apoptotic, and inflammatory pathways. Pretreatment with EPRO protected against motor impairment and decreased oxidative and apoptotic mediators in the hippocampus of rats. The study also confirmed the anti-inflammatory activity of EPRO and its role in downregulating inflammatory mediators.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Toxicology
Muhammed F. El-Yamany, Eman S. Zaki, Sherif A. Shaltout, Muhammed A. Saad
Summary: This study investigated the hepatoprotective effects of BM-MNCs transplantation, NAC, and ALA against CCl4-induced liver toxicity. The combination of NAC, ALA, and BM-MNCs showed significant improvements in liver function and oxidative stress compared to individual treatments.
TOXICOLOGY MECHANISMS AND METHODS
(2021)
Article
Multidisciplinary Sciences
Rofida A. Saleh, Tarek F. Eissa, Dalaal M. Abdallah, Muhammed A. Saad, Hanan S. El-Abhar
Summary: P. harmala enhances cognition and histopathological structures, reduces beta amyloid and phosphorylated tau, and promotes insulin and GLP-1 trajectories, thereby attenuating the progression of Alzheimer's disease.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Noha F. Abdelkader, Sherehan M. Ibrahim, Passant E. Moustafa, Marawan A. Elbaset
Summary: Inosine alleviated diabetic peripheral neuropathy by modulating various pathways, including restoration of nerve tissue structure, modulation of conduction velocities, maintenance of behavioral responses, improvement of blood glucose metabolism, and reduction of pain. Inosine also showed potential neuroprotective effects through modulation of multiple signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Applied
Soha Ramadan, Manal M. Sabry, Muhammed A. Saad, Simone Angeloni, Omar M. Sabry, Giovanni Caprioli, Soheir M. El Zalabani
Summary: The study analyzed the chemical constituents and activities of four herbs, finding that a prepared herbal formula demonstrated better MAO-B inhibitory activity and total phenolic content compared to individual herbs.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Medicinal
Ahmed S. Kamel, Ahmed F. Mohamed, Mostafa A. Rabie, Marwa E. Elsherbiny, Kawkab A. Ahmed, Mahmoud M. Khattab, Noha F. Abdelkader
Summary: This study evaluated the relationship between subacute exposure to the commonly misused amebicide diiodohydroxyquinoline (DHQ) and the development of motor and sensory abnormalities. Age and gender were identified as possible predisposing factors, with young female rats being more susceptible to DHQ's toxicity. The findings highlight the need to reevaluate the risk/benefit balance of quinoline antibiotics.
Article
Neurosciences
Hala El-Safty, Ashraf Ismail, Rania M. Abdelsalam, Ayman E. El-Sahar, Muhammed A. Saad
Summary: Dapagliflozin may have neuroprotective action and alleviate memory and cognition impairment caused by diabetic neuropathy through its antioxidant and anti-apoptotic properties.
BRAIN RESEARCH BULLETIN
(2022)
Article
Pharmacology & Pharmacy
Mohamed S. El-Ghannam, Muhammed A. Saad, Noha N. Nassar, Muhammad Farag El-Yamany, Alshaymaa A. Z. El-Bahy
Summary: Linagliptin shows promising anti-inflammatory activity against acetic acid-induced colitis by alleviating the severity of colitis and attenuating colon inflammation through the activation of the AMPK-SIRT1-PGC-1 alpha pathway and suppression of the JAK2/STAT3 signaling pathway.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Immunology
Weam W. Ibrahim, Ahmed S. Kamel, Ahmed Wahid, Noha F. Abdelkader
Summary: Autophagy and mitochondrial deficits are characteristics of early phase of Alzheimer's disease. This study explored the impact of the sodium-glucose cotransporter-2 inhibitor dapagliflozin on autophagic and mitochondrial pathways in a rat model of ovariectomy and d-galactose injection. The results showed that dapagliflozin could mitigate cognitive deficits and promote neuroprotection through activation of energy sensors and autophagic markers. Additionally, dapagliflozin enhanced mitochondrial function and decreased BACE1 expression.
INFLAMMOPHARMACOLOGY
(2022)
Article
Immunology
Reham A. Ammar, Ahmed F. Mohamed, Mohamed M. Kamal, Marwa M. Safar, Noha F. Abdelkader
Summary: Liraglutide exerts neuroprotection in multiple sclerosis through its anti-inflammatory, autophagic flux activation, NLRP3 inflammasome suppression, and anti-apoptotic mechanisms.
INFLAMMOPHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Noha F. Abdelkader, Marawan A. Elbaset, Passant E. Moustafa, Sherehan M. Ibrahim
Summary: This study aimed to explore the potential of the selective sodium-glucose cotransporter-2 inhibitor empagliflozin (EMPA) to improve diabetic peripheral neuropathy (DPN) and investigate its precise signaling mechanism. The results showed that EMPA improved nerve histopathological changes, nerve fibers' count, and nerve conduction velocity in rats with DPN. EMPA also reduced responses to pain stimuli and improved motor coordination. Moreover, EMPA modulated the AMPK pathway to regulate oxidative and inflammatory burden, extracellular matrix remodeling, and autophagy.
ARCHIVES OF PHARMACAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Noha F. Abdelkader, Ahmed I. El-Batal, Yara M. Amin, Asrar M. Hawas, Seham H. M. Hassan, Nihad I. Eid
Summary: This study investigates the neuroprotective effects of gold nanoparticles and alpha-lipoic acid mixture on brain damage caused by radiation in rats. The results show that the mixture can alleviate oxidative stress, DNA damage, and histopathological changes in brain tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Ahmed S. Kamel, Ahmed Wahid, Noha F. Abdelkader, Weam W. Ibrahim
Summary: This study found that Dapagliflozin (DAPA) has a potential anxiolytic effect as an autophagic enhancer in an animal model of Alzheimer's disease by activating GABA(B2) receptors and inducing the expression of BDNF/TrkB and GABA(A) through the PLC/DAG/PKC pathway in an AMPK-dependent manner.
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)