Article
Multidisciplinary Sciences
Qing-Bo Lu, Yi Ding, Yao Liu, Zi-Chao Wang, Yu-Jie Wu, Kai -Ming Niu, Ke-Xue Li, Ji -Ru Zhang, Hai-Jian Sun
Summary: Metrnl plays a protective role in diabetic cardiomyopathy and may serve as a therapeutic target or regimen.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Immunology
Rasha Abdelhady, Nancy S. Younis, Omaima Ali, Samah Shehata, Rabab H. Sayed, Rania I. Nadeem
Summary: This study reveals that pazopanib, an FDA-approved anti-cancer drug, has inhibitory effects on the necroptotic pathway implicated in Alzheimer's disease (AD). It improves cognitive impairment, reduces p-Tau and amyloid beta (Aβ) plaques, hampers neuroinflammation, mitigates neuronal death, and suppresses RIPK1/RIPK3/MLKL necroptosis signaling pathway. Pazopanib shows potential as a valuable therapeutic agent for AD.
INFLAMMOPHARMACOLOGY
(2023)
Article
Cell Biology
Abubakar Wani, Sweilem B. Al Rihani, Ankita Sharma, Brenna Weadick, Rajgopal Govindarajan, Sameer U. Khan, Parduman R. Sharma, Ashish Dogra, Utpal Nandi, Chilakala N. Reddy, Sonali S. Bharate, Gurdarshan Singh, Sandip B. Bharate, Ram A. Vishwakarma, Amal Kaddoumi, Ajay Kumar
Summary: This study found that crocetin can induce autophagy in Alzheimer's disease, helping to clear Aβ and improve memory function.
Article
Plant Sciences
Yue Hou, Wei Zhao, Haiyang Yu, Fangfang Zhang, Han-Ting Zhang, Yanmeng Zhou
Summary: This study found that Biochanin A (BCA) treatment can improve learning and memory abilities and alleviate Alzheimer's disease (AD) symptoms in a postmenopausal AD model. BCA acts by reversing the mitochondrial damage caused by ovariectomy, including restoring mitochondrial biogenesis, balancing mitochondrial dynamics, and regulating abnormal mitophagy.
Article
Pharmacology & Pharmacy
Liuran Li, Qinghua Li, Wenbin Huang, Yibing Han, Huiting Tan, Min An, Qianru Xiang, Rui Zhou, Li Yang, Yanzhen Cheng
Summary: The study showed that dapagliflozin can alleviate hepatocyte steatosis by reducing lipogenic enzyme, inducing fatty acid oxidation enzyme, and autophagy, which may be associated with AMPK activation. The results also indicate that dapagliflozin induces autophagy via the AMPK-mTOR pathway, revealing a novel clinical application and functional mechanism in the treatment of NAFLD.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Virology
Ning Wu, Jinzhong Ji, Xiaoqin Gou, Pan Hu, Yao Cheng, Yuhang Liu, Yuanying Wang, Qilong Zhang, Li Zuo
Summary: The global incidence of dengue fever has been increasing in recent years, posing a serious threat to human health. This study identified DENV-2 NS1 as the viral protein most likely responsible for inducing autophagy, and further experiments confirmed that DENV-2 NS1 activates autophagy through the AMPK/ERK/mTOR signaling pathway. This discovery improves our understanding of DENV-2-induced autophagy and contributes to the development of anti-dengue drugs.
Article
Medicine, Research & Experimental
Laetitia Dard, Christophe Hubert, Pauline Esteves, Wendy Blanchard, Ghina Bou About, Lyla Baldasseroni, Elodie Dumon, Chloe Angelini, Megane Delourme, Veronique Guyonnet-Duperat, Stephane Claverol, Laura Fontenille, Karima Kissa, Pierre-Emmanuel Seguela, Jean-Benoit Thambo, Levy Nicolas, Yann Herault, Nadege Bellance, Nivea Dias Amoedo, Frederique Magdinier, Tania Sorg, Didier Lacombe, Rodrigue Rossignol
Summary: This study analyzed the molecular determinants of Costello syndrome and found that mitochondrial proteostasis and bioenergetics play a crucial role in the pathophysiology of the disease. The study suggests that patients with Costello syndrome may benefit from treatment with mitochondrial modulators.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Pharmacology & Pharmacy
Khoa Nguyen, Katherine Hebert, Emily McConnell, Nicole Cullen, Thomas Cheng, Susanna Awoyode, Elizabeth Martin, Weina Chen, Tong Wu, Suresh K. Alahari, Reza Izadpanah, Bridgette M. Collins-Burow, Sean B. Lee, David H. Drewry, Matthew E. Burow
Summary: The liver is an important organ involved in biological functions such as digestion, nutrient storage, and detoxification. It plays an active role in regulating metabolism and is susceptible to hepatocellular carcinoma, which is often associated with chronic inflammation. LKB1 signaling has been found to regulate cellular metabolism and has a tumor suppressive role in many cancers. Using the KMPlotter database, this review correlates RNA levels of LKB1 signaling genes with hepatocellular carcinoma patient survival outcomes and identifies potential biomarkers for clinical use.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Canzhen Liu, Xiaoxu Wang, Xiaonan Wang, Yunfang Zhang, Wenjian Min, Ping Yu, Jinhua Miao, Weiwei Shen, Shuangqin Chen, Shan Zhou, Xiaolong Li, Ping Meng, Qinyu Wu, Fan Fan Hou, Youhua Liu, Peng Yang, Cheng Wang, Xu Lin, Lang Tang, Xuefeng Zhou, Lili Zhou
Summary: In this study, a novel compound PA-S14 was identified as an activator of LKB1, which promotes AMPK activation, triggers autophagosome maturation, and inhibits tubular cell senescence, consequently preventing renal fibrosis.
Article
Genetics & Heredity
Guohui Li, Liang Deng, Nan Huang, Zhongqi Cui, Qi Wu, Ji Ma, Qiuhui Pan, Fenyong Sun
Summary: WTAP knockdown in hepatocellular carcinoma cells promotes autophagy through m6A-dependent regulation of the AMPK pathway. This leads to inhibition of HCC proliferation. Additionally, WTAP can mediate the phosphorylation of AMPK through regulation of the upstream kinase LKB1.
Article
Biochemistry & Molecular Biology
Jun H. Heo, Sang R. Lee, Seong Lae Jo, Je-Won Ko, Hyo-Jung Kwon, Eui-Ju Hong
Summary: The incidence of non-alcoholic fatty liver disease (NAFLD) increases in males aged >45 years, which indicates that androgens are associated with the development and/or progression of NAFLD, although excess dietary intake is the primary causative factor. Our study demonstrates that testosterone can influence the development of NAFLD by increasing the expression of AMP-activated protein kinase (AMPK) and LKB1 and modulating the AMPK-ACC signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Waad A. Samman, Salma M. Selim, Hassan M. El Fayoumi, Norhan M. El-Sayed, Eman T. Mehanna, Reem M. Hazem
Summary: This study aims to investigate the possible mechanisms of the neuroprotective effects of dapagliflozin against aluminum chloride-induced Alzheimer's disease. The results showed that dapagliflozin combats aluminum chloride-induced Alzheimer's disease by inhibiting oxidative stress, enhancing glucose metabolism, and activating AMPK signaling.
Article
Neurosciences
Xin Wang, Xueyan Zhou, Beth Uberseder, Jingyun Lee, Caitlin S. Latimer, Cristina M. Furdui, C. Dirk Keene, Thomas J. Montine, Thomas C. Register, Suzanne Craft, Carol A. Shively, Tao Ma
Summary: The study on NHP model demonstrated an increased activity of AMPK alpha 2 in AD-like neuropathology, unrelated to AMPK alpha 1; CSF Abeta(42) showed a negative correlation with cerebral amyloid plaque density; A beta plaque burden correlated with brain A beta measurement levels.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Chemistry, Medicinal
Maaly A. Abd Elmaaboud, Remon S. Estfanous, Aliaa Atef, Ahmed M. Kabel, Khalid A. Alnemari, Tamer M. Naguib, Shuruq E. Alsufyani, Hany W. Darwish, Hany H. Arab
Summary: In this study, the potential ameliorative effects of dapagliflozin and/or hesperidin on lipopolysaccharide-induced Alzheimer's disease (AD) were investigated. The results showed that both dapagliflozin and hesperidin improved the biochemical parameters, behavioral tests, and histopathological parameters in a rat model of AD. These favorable effects were significantly enhanced when the two agents were used in combination.
Article
Biochemistry & Molecular Biology
Hany H. Arab, Muhammad Y. Al-Shorbagy, Muhammed A. Saad
Summary: Dapagliflozin has a potential protective effect against experimental colitis by enhancing colonic autophagy and suppressing apoptosis through activation of AMPK/mTOR and Nrf2/HO-1 pathways, and inhibition of the HMGB1/RAGE/NF-kappa B cascade.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Medicine, Research & Experimental
Noha F. Abdelkader, Sherehan M. Ibrahim, Passant E. Moustafa, Marawan A. Elbaset
Summary: Inosine alleviated diabetic peripheral neuropathy by modulating various pathways, including restoration of nerve tissue structure, modulation of conduction velocities, maintenance of behavioral responses, improvement of blood glucose metabolism, and reduction of pain. Inosine also showed potential neuroprotective effects through modulation of multiple signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Medicinal
Ahmed S. Kamel, Ahmed F. Mohamed, Mostafa A. Rabie, Marwa E. Elsherbiny, Kawkab A. Ahmed, Mahmoud M. Khattab, Noha F. Abdelkader
Summary: This study evaluated the relationship between subacute exposure to the commonly misused amebicide diiodohydroxyquinoline (DHQ) and the development of motor and sensory abnormalities. Age and gender were identified as possible predisposing factors, with young female rats being more susceptible to DHQ's toxicity. The findings highlight the need to reevaluate the risk/benefit balance of quinoline antibiotics.
Article
Neurosciences
Sherif S. Abdel Mageed, Ramy M. Ammar, Noha N. Nassar, Helmy Moawad, Ahmed S. Kamel
Summary: This study reveals the neuroprotective effect of acetaminophen in a cerebral ischemia/reperfusion rat model and suggests its involvement in the activation of the anandamide/CB1/PI3K/Akt pathway.
Correction
Clinical Neurology
Noha H. Sayed, Nevine Fathy, Mona A. Kortam, Mostafa A. Rabie, Ahmed F. Mohamed, Ahmed S. Kamel
Article
Immunology
Reham A. Ammar, Ahmed F. Mohamed, Mohamed M. Kamal, Marwa M. Safar, Noha F. Abdelkader
Summary: Liraglutide exerts neuroprotection in multiple sclerosis through its anti-inflammatory, autophagic flux activation, NLRP3 inflammasome suppression, and anti-apoptotic mechanisms.
INFLAMMOPHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Noha F. Abdelkader, Marawan A. Elbaset, Passant E. Moustafa, Sherehan M. Ibrahim
Summary: This study aimed to explore the potential of the selective sodium-glucose cotransporter-2 inhibitor empagliflozin (EMPA) to improve diabetic peripheral neuropathy (DPN) and investigate its precise signaling mechanism. The results showed that EMPA improved nerve histopathological changes, nerve fibers' count, and nerve conduction velocity in rats with DPN. EMPA also reduced responses to pain stimuli and improved motor coordination. Moreover, EMPA modulated the AMPK pathway to regulate oxidative and inflammatory burden, extracellular matrix remodeling, and autophagy.
ARCHIVES OF PHARMACAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Noha F. Abdelkader, Ahmed I. El-Batal, Yara M. Amin, Asrar M. Hawas, Seham H. M. Hassan, Nihad I. Eid
Summary: This study investigates the neuroprotective effects of gold nanoparticles and alpha-lipoic acid mixture on brain damage caused by radiation in rats. The results show that the mixture can alleviate oxidative stress, DNA damage, and histopathological changes in brain tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Ahmed S. Kamel, Ahmed Wahid, Noha F. Abdelkader, Weam W. Ibrahim
Summary: This study found that Dapagliflozin (DAPA) has a potential anxiolytic effect as an autophagic enhancer in an animal model of Alzheimer's disease by activating GABA(B2) receptors and inducing the expression of BDNF/TrkB and GABA(A) through the PLC/DAG/PKC pathway in an AMPK-dependent manner.
Article
Pharmacology & Pharmacy
Tarek K. Motawi, Shohda A. El-Maraghy, Ahmed S. Kamel, Salma E. Said, Mona A. Kortam
Summary: This study aimed to verify the action of Clemastine (CLM) on NLRP3 signaling in experimental autoimmune encephalomyelitis (EAE) as an MS rat model. Results showed that CLM has protective roles against neuroinflammation and demyelination in EAE through its anti-inflammatory and anti-pyroptotic actions.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ahmed S. Kamel, Sama M. Farrag, Heba M. Mansour, Noha N. Nassar, Muhammed A. Saad
Summary: This study aimed to investigate the impact of dapagliflozin (DAPA) on the GABA(B) receptor subunit (GABA(B) R2) in an essential tremor (ET) model. The results showed that DAPA enhances the neuronal inhibitory machinery by suppressing the inflammatory and excitotoxicity systems through the LKB1/p-AMPK/GABA(B) R2 signaling pathway, thus offering a potential neuroprotective effect in ET.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2023)
Article
Pharmacology & Pharmacy
Dalia K. Abdulwahab, Weam W. Ibrahim, Rania A. Abd El-Aal, Hekma A. Abdel-Latif, Noha F. Abdelkader
Summary: The study found that treatment with ATV or ATV/GSE attenuated dyslipidemia-induced alterations in serum cholesterol levels, and enhanced male fertility parameters such as testosterone and sperm count. The combined treatment of ATV/GSE showed more pronounced effects on testosterone and sperm count compared to ATV alone.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2021)