Journal
DIABETES & METABOLISM JOURNAL
Volume 42, Issue 4, Pages 338-342Publisher
KOREAN DIABETES ASSOC
DOI: 10.4093/dmj.2017.0095
Keywords
Diabetes mellitus, experimental; Diabetic nephropathies; Diabetic neuropathies; Peripheral nerves; Sodium-glucose transporter 2
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Funding
- Korean Diabetes Association
- Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital
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The effect of sodium-glucose cotransporter 2 inhibitors on peripheral nerves and kidneys in diabetes mellitus (DM) remains unexplored. Therefore, this study aimed to explore the effect of empagliflozin in diabetic rats. DM in rats was induced by streptozotocin injection, and diabetic rats were treated with empagliflozin 3 or 10 mg/kg. Following 24-week treatment, response thresholds to four different stimuli were tested and found to be lower in diabetic rats than in normal rats. Empagliflozin significantly prevented hypersensitivity (P<0.05) and the loss of skin intraepidermal nerve fibers, and mesangial matrix expansion in diabetic rats. Results of this study demonstrate the potential therapeutic effects of empagliflozin for the treatment of diabetic peripheral neuropathy and nephropathy.
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