The Mitochondrial Citrate Carrier SLC25A1/CIC and the Fundamental Role of Citrate in Cancer, Inflammation and Beyond

Inhibition of the mitochondrial citrate carrier, Slc25a1, reverts steatosis, glucose intolerance, and inflammation in preclinical models of NAFLD/NASH

(2020) Mingjun Tan et al.   CELL DEATH AND DIFFERENTIATION

Long non‑coding RNA BRM promotes proliferation and invasion of papillary thyroid carcinoma by regulating the microRNA‑331‑3p/SLC25A1 axis

(2020) Shihong Liu et al.   Oncology Letters

Spatial modeling of prostate cancer metabolic gene expression reveals extensive heterogeneity and selective vulnerabilities

(2020) Yuliang Wang et al.   Scientific Reports

Diseases Caused by Mutations in Mitochondrial Carrier Genes SLC25: A Review

(2020) Ferdinando Palmieri et al.   Biomolecules

The cellular pathways of liver fibrosis in non-alcoholic steatohepatitis

(2020) Nahum Méndez-Sánchez et al.   Annals of Translational Medicine

Mitochondrial Metabolism as a Target for Cancer Therapy

(2020) Karthik Vasan et al.   Cell Metabolism

Crosstalk Between Liver Macrophages and Surrounding Cells in Nonalcoholic Steatohepatitis

(2020) Haiou Li et al.   Frontiers in Immunology

The SLC25 Carrier Family: Important Transport Proteins in Mitochondrial Physiology and Pathology

(2020) Edmund R. S. Kunji et al.   PHYSIOLOGY

Metabolic Reprogramming in Breast Cancer and Its Therapeutic Implications

(2019) Nishant Gandhi et al.   Cells

Potential Use of Gluconate in Cancer Therapy

(2019) Maria E. Mycielska et al.   Frontiers in Oncology

Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells

(2019) Pei-Hsuan Chen et al.   MOLECULAR CELL

2-Hydroxyglutarate in Cancer Cells

(2019) Petr Ježek   ANTIOXIDANTS & REDOX SIGNALING

Missense mutations in SLC25A1 are associated with congenital myasthenic syndrome type 23

(2019) Amna Al‐Futaisi et al.   CLINICAL GENETICS

Chronic inflammation in the etiology of disease across the life span

(2019) David Furman et al.   NATURE MEDICINE

Extracellular Citrate Affects Critical Elements of Cancer Cell Metabolism and Supports Cancer DevelopmentIn Vivo

(2018) Maria E. Mycielska et al.   CANCER RESEARCH

The mitochondrial citrate carrier, SLC25A1, drives stemness and therapy resistance in non-small cell lung cancer

(2018) Harvey R. Fernandez et al.   CELL DEATH AND DIFFERENTIATION

New Insights into Behçet’s Syndrome Metabolic Reprogramming: Citrate Pathway Dysregulation

(2018) Anna Santarsiero et al.   MEDIATORS OF INFLAMMATION

Combination of Mitochondrial and Plasma Membrane Citrate Transporter Inhibitors Inhibits De Novo Lipogenesis Pathway and Triggers Apoptosis in Hepatocellular Carcinoma Cells

(2018) Wan-angkan Poolsri et al.   Biomed Research International

Antiviral effects of ferric ammonium citrate

(2018) Hongbin Wang et al.   Cell Discovery

The Mitochondrial Citrate Carrier (SLC25A1) Sustains Redox Homeostasis and Mitochondrial Metabolism Supporting Radioresistance of Cancer Cells With Tolerance to Cycling Severe Hypoxia

(2018) Julian Hlouschek et al.   Frontiers in Oncology

ACSS2 promotes systemic fat storage and utilization through selective regulation of genes involved in lipid metabolism

(2018) Zhiguang Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Citrate targets FBPase and constitutes an emerging novel approach for cancer therapy

(2018) Philippe Icard et al.   Cancer Cell International

An overview of combined D-2- and L-2-hydroxyglutaric aciduria: functional analysis of CIC variants

(2017) Ana Pop et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Chemotherapy diminishes lipid storage capacity of adipose tissue in a preclinical model of colon cancer

(2017) Maryam Ebadi et al.   Lipids in Health and Disease

Quantitative metabolic flux analysis reveals an unconventional pathway of fatty acid synthesis in cancer cells deficient for the mitochondrial citrate transport protein

(2017) Lei Jiang et al.   METABOLIC ENGINEERING

L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH

(2017) Andrew M Intlekofer et al.   Nature Chemical Biology

INDY—A New Link to Metabolic Regulation in Animals and Humans

(2017) Blanka Rogina   Frontiers in Genetics

The contribution of the citrate pathway to oxidative stress in Down syndrome

(2016) Paolo Convertini et al.   IMMUNOLOGY

Reductive carboxylation supports redox homeostasis during anchorage-independent growth

(2016) Lei Jiang et al.   NATURE

LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells

(2016) Pingping Zhu et al.   Nature Communications

Inhibition of citrate cotransporter Slc13a5/mINDY by RNAi improves hepatic insulin sensitivity and prevents diet-induced non-alcoholic fatty liver disease in mice

(2016) Sebastian Brachs et al.   Molecular Metabolism

Targeting Mitochondrial Citrate Transport in Breast Cancer Cell Lines

(2015) Ali Ozkaya et al.   Anti-Cancer Agents in Medicinal Chemistry

Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress

(2015) Zachary T. Schug et al.   CANCER CELL

Mitochondrial Citrate Transporter-dependent Metabolic Signature in the 22q11.2 Deletion Syndrome

(2015) Eleonora Napoli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pyruvate carboxylase is critical for non–small-cell lung cancer proliferation

(2015) Katherine Sellers et al.   JOURNAL OF CLINICAL INVESTIGATION

The mitochondrial citrate transporter, CIC, is essential for mitochondrial homeostasis.

(2015) Olga Catalina-Rodriguez et al.   Oncotarget

SLC25A1, or CIC, is a novel transcriptional target of mutant p53 and a negative tumor prognostic marker.

(2015) Vamsi K. Kolukula et al.   Oncotarget

Human Phosphoglycerate Dehydrogenase Produces the Oncometabolite d-2-Hydroxyglutarate

(2014) Jing Fan et al.   ACS Chemical Biology

A key role of the mitochondrial citrate carrier (SLC25A1) in TNFα- and IFNγ-triggered inflammation

(2014) Vittoria Infantino et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Enhanced detection of metastatic prostate cancer cells in human plasma with lipid bodies staining

(2014) Ranjana Mitra et al.   BMC CANCER

Hypoxic Regulation of Glutamine Metabolism through HIF1 and SIAH2 Supports Lipid Synthesis that Is Necessary for Tumor Growth

(2014) Ramon C. Sun et al.   Cell Metabolism

Deficiency in SLC25A1, Encoding the Mitochondrial Citrate Carrier, Causes Combined D-2- and L-2-Hydroxyglutaric Aciduria

(2013) Benjamin Nota et al.   AMERICAN JOURNAL OF HUMAN GENETICS

ATP-citrate lyase is essential for macrophage inflammatory response

(2013) Vittoria Infantino et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Agenesis of corpus callosum and optic nerve hypoplasia due to mutations inSLC25A1encoding the mitochondrial citrate transporter

(2013) Simon Edvardson et al.   JOURNAL OF MEDICAL GENETICS

Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells

(2013) Sarah-Maria Fendt et al.   Nature Communications

IDH1 and IDH2 have critical roles in 2-hydroxyglutarate production in D-2-hydroxyglutarate dehydrogenase depleted cells

(2012) Hironori Matsunaga et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Citrate carrier promoter is target of peroxisome proliferator-activated receptor alpha and gamma in hepatocytes and adipocytes

(2012) Fabrizio Damiano et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Progress in understanding 2-hydroxyglutaric acidurias

(2012) Martijn Kranendijk et al.   JOURNAL OF INHERITED METABOLIC DISEASE

The mitochondrial citrate carrier: a new player in inflammation

(2011) Vittoria Infantino et al.   BIOCHEMICAL JOURNAL

PGC1  Promotes Tumor Growth by Inducing Gene Expression Programs Supporting Lipogenesis

(2011) K. Bhalla et al.   CANCER RESEARCH

Reductive carboxylation supports growth in tumour cells with defective mitochondria

(2011) Andrew R. Mullen et al.   NATURE

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Molecular origin of plasma membrane citrate transporter in human prostate epithelial cells

(2010) Maciej P Mazurek et al.   EMBO REPORTS

Role of FOXA in mitochondrial citrate carrier gene expression and insulin secretion

(2009) Vito Iacobazzi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A conserved role for the mitochondrial citrate transporter Sea/SLC25A1 in the maintenance of chromosome integrity

(2009) Patrizia Morciano et al.   HUMAN MOLECULAR GENETICS

Mitochondrial localization and function of a subset of 22q11 deletion syndrome candidate genes

(2008) T.M. Maynard et al.   MOLECULAR AND CELLULAR NEUROSCIENCE