Touch and Go: Membrane Contact Sites Between Lipid Droplets and Other Organelles

Seipin traps triacylglycerols to facilitate their nanoscale clustering in the endoplasmic reticulum membrane

(2021) Xavier Prasanna et al.   PLOS BIOLOGY

Seipin accumulates and traps diacylglycerols and triglycerides in its ring-like structure

(2021) Valeria Zoni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An ESCRT-dependent step in fatty acid transfer from lipid droplets to mitochondria through VPS13D−TSG101 interactions

(2021) Jingru Wang et al.   Nature Communications

A Unique Junctional Interface at Contact Sites Between the Endoplasmic Reticulum and Lipid Droplets

(2021) Vineet Choudhary et al.   Frontiers in Cell and Developmental Biology

A Mammalian Target of Rapamycin‐Perilipin 3 (mTORC1‐Plin3) Pathway is essential to Activate Lipophagy and Protects Against Hepatosteatosis

(2021) Marina Garcia‐Macia et al.   HEPATOLOGY

Perspectives on Mitochondria–ER and Mitochondria–Lipid Droplet Contact in Hepatocytes and Hepatic Lipid Metabolism

(2021) Xiaowen Ma et al.   Cells

Lipid Droplet-Organelle Contact Sites as Hubs for Fatty Acid Metabolism, Trafficking, and Metabolic Channeling

(2021) Mike F. Renne et al.   Frontiers in Cell and Developmental Biology

Roles for L o microdomains and ESCRT in ER stress-induced lipid droplet microautophagy in budding yeast

(2021) Pin-Chao Liao et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanism of lipid droplet formation by the yeast Sei1/Ldb16 Seipin complex

(2021) Yoel A. Klug et al.   Nature Communications

Plant Lipid Bodies Traffic on Actin to Plasmodesmata Motorized by Myosin XIs

(2020) Manikandan Veerabagu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The cell biology of mitochondrial membrane dynamics

(2020) Marta Giacomello et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via PEX5

(2020) Jinuk Kong et al.   Nature Communications

Seipin and Nem1 establish discrete ER subdomains to initiate yeast lipid droplet biogenesis

(2020) Vineet Choudhary et al.   JOURNAL OF CELL BIOLOGY

Protein Quality Control and Lipid Droplet Metabolism

(2020) Melissa A. Roberts et al.   Annual Review of Cell and Developmental Biology

Membrane dynamics and protein targets of lipid droplet microautophagy during ER stress-induced proteostasis in the budding yeast, Saccharomyces cerevisiae

(2020) Enrique J. Garcia et al.   Autophagy

Yeast FIT2 homolog is necessary to maintain cellular proteostasis and membrane lipid homeostasis

(2020) Wei Sheng Yap et al.   JOURNAL OF CELL SCIENCE

Plasma Membrane Protein Nce102 Modulates Morphology and Function of the Yeast Vacuole

(2020) Katarina Vaskovicova et al.   Biomolecules

Direct lysosome-based autophagy of lipid droplets in hepatocytes

(2020) Ryan J. Schulze et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Perilipin 5 Deletion in Hepatocytes Remodels Lipid Metabolism and Causes Hepatic Insulin Resistance in Mice

(2019) Stacey N. Keenan et al.   DIABETES

Coming together to define membrane contact sites

(2019) Luca Scorrano et al.   Nature Communications

Plin3 protects against alcoholic liver injury by facilitating lipid export from the endoplasmic reticulum

(2019) Yu Gu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Alcohol-induced microtubule acetylation leads to the accumulation of large, immobile lipid droplets

(2019) Jennifer L. Groebner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Insulin activates intracellular transport of lipid droplets to release triglycerides from the liver

(2019) Mukesh Kumar et al.   JOURNAL OF CELL BIOLOGY

The many functions of ESCRTs

(2019) Marina Vietri et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Come a little bit closer! Lipid droplet-ER contact sites are getting crowded

(2019) Marie Hugenroth et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

LDAF1 and Seipin Form a Lipid Droplet Assembly Complex

(2019) Jeeyun Chung et al.   DEVELOPMENTAL CELL

MIGA2 Links Mitochondria, the ER, and Lipid Droplets and Promotes De Novo Lipogenesis in Adipocytes

(2019) Christophe A.C. Freyre et al.   MOLECULAR CELL

AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity

(2018) Hui Luo et al.   Cell Metabolism

Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics, Composition, and Dynamics that Support Lipid Droplet Expansion

(2018) Ilan Y. Benador et al.   Cell Metabolism

Architecture of Lipid Droplets in Endoplasmic Reticulum Is Determined by Phospholipid Intrinsic Curvature

(2018) Vineet Choudhary et al.   CURRENT BIOLOGY

A Proximity Labeling Strategy Provides Insights into the Composition and Dynamics of Lipid Droplet Proteomes

(2018) Kirill Bersuker et al.   DEVELOPMENTAL CELL

Lipid droplet autophagy during energy mobilization lipid homeostasis and protein quality control

(2018) Liza A Pon   Frontiers in Bioscience-Landmark

The coming of age of chaperone-mediated autophagy

(2018) Susmita Kaushik et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Super-resolution microscopy localizes perilipin 5 at lipid droplet-mitochondria interaction sites and at lipid droplets juxtaposing to perilipin 2

(2018) Anne Gemmink et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Long-chain acyl-CoA synthetase 1 interacts with key proteins that activate and direct fatty acids into niche hepatic pathways

(2018) Pamela A. Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ivy1 is a negative regulator of Gtr-dependent TORC1 activation

(2018) Natalia V. Varlakhanova et al.   JOURNAL OF CELL SCIENCE

Lipid droplet and peroxisome biogenesis occur at the same ER subdomains

(2018) Amit S. Joshi et al.   Nature Communications

Seipin and the membrane-shaping protein Pex30 cooperate in organelle budding from the endoplasmic reticulum

(2018) Sihui Wang et al.   Nature Communications

Human SEIPIN Binds Anionic Phospholipids

(2018) Renhong Yan et al.   DEVELOPMENTAL CELL

Cryo–electron microscopy structure of the lipid droplet–formation protein seipin

(2018) Xuewu Sui et al.   JOURNAL OF CELL BIOLOGY

Dynamics and functions of lipid droplets

(2018) James A. Olzmann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphorylation of PLIN3 by AMPK promotes dispersion of lipid droplets during starvation

(2018) Jianxi Zhu et al.   Protein & Cell

Sterol transporters at membrane contact sites regulate TORC1 and TORC2 signaling

(2017) Andrew Murley et al.   JOURNAL OF CELL BIOLOGY

Evidence for ESCRT- and clathrin-dependent microautophagy

(2017) Masahide Oku et al.   JOURNAL OF CELL BIOLOGY

Applying systems-level spectral imaging and analysis to reveal the organelle interactome

(2017) Alex M. Valm et al.   NATURE

Myosin-1 inhibition by PClP affects membrane shape, cortical actin distribution and lipid droplet dynamics in early Zebrafish embryos

(2017) Prabuddha Gupta et al.   PLoS One

Kinesin-dependent mechanism for controlling triglyceride secretion from the liver

(2017) Priyanka Rai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role for formin-like 1-dependent acto-myosin assembly in lipid droplet dynamics and lipid storage

(2017) Simon G. Pfisterer et al.   Nature Communications

The Role of Lipid Droplets in Mortierella alpina Aging Revealed by Integrative Subcellular and Whole-Cell Proteome Analysis

(2017) Yadong Yu et al.   Scientific Reports

Niemann-Pick type C proteins promote microautophagy by expanding raft-like membrane domains in the yeast vacuole

(2017) Takuma Tsuji et al.   eLife

AMPK and vacuole-associated Atg14p orchestrate μ-lipophagy for energy production and long-term survival under glucose starvation

(2017) Arnold Y Seo et al.   eLife

Comparative Lipidomics and Proteomics of Lipid Droplets in the Mesocarp and Seed Tissues of Chinese Tallow (Triadica sebifera)

(2017) Yao Zhi et al.   Frontiers in Plant Science

Proteomic Analysis of Lipid Droplets from Arabidopsis Aging Leaves Brings New Insight into Their Biogenesis and Functions

(2017) Lysiane Brocard et al.   Frontiers in Plant Science

AMPK-dependent phosphorylation of lipid droplet protein PLIN2 triggers its degradation by CMA

(2016) Susmita Kaushik et al.   Autophagy

Yeast Ivy1p Is a Putative I-BAR-domain Protein with pH-sensitive Filament Forming Ability in vitro

(2016) Yuzuru Itoh et al.   CELL STRUCTURE AND FUNCTION

Spatial control of lipid droplet proteins by the ERAD ubiquitin ligase Doa10

(2016) Annamaria Ruggiano et al.   EMBO JOURNAL

Seipin regulates ER–lipid droplet contacts and cargo delivery

(2016) Veijo T Salo et al.   EMBO JOURNAL

Sucrose Production Mediated by Lipid Metabolism Suppresses the Physical Interaction of Peroxisomes and Oil Bodies during Germination ofArabidopsis thaliana

(2016) Songkui Cui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A family of membrane-shaping proteins at ER subdomains regulates pre-peroxisomal vesicle biogenesis

(2016) Amit S. Joshi et al.   JOURNAL OF CELL BIOLOGY

Mitoguardin Regulates Mitochondrial Fusion through MitoPLD and Is Required for Neuronal Homeostasis

(2016) Yongping Zhang et al.   MOLECULAR CELL

Hepatic Retinyl Ester Hydrolases and the Mobilization of Retinyl Ester Stores

(2016) Lukas Grumet et al.   Nutrients

Seipin is required for converting nascent to mature lipid droplets

(2016) Huajin Wang et al.   eLife

Lipid droplet remodeling and interaction with mitochondria in mouse brown adipose tissue during cold treatment

(2015) Jinhai Yu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Breaking the Barrier—Chaperone-Mediated Autophagy of Perilipins Regulates the Lipolytic Degradation of Fat

(2015) Martina Schweiger et al.   Cell Metabolism

Role for Lipid Droplet Biogenesis and Microlipophagy in Adaptation to Lipid Imbalance in Yeast

(2015) Jason D. Vevea et al.   DEVELOPMENTAL CELL

Fatty Acid Trafficking in Starved Cells: Regulation by Lipid Droplet Lipolysis, Autophagy, and Mitochondrial Fusion Dynamics

(2015) Angelika S. Rambold et al.   DEVELOPMENTAL CELL

The small GTPase Rab7 as a central regulator of hepatocellular lipophagy

(2015) Barbara Schroeder et al.   HEPATOLOGY

Ltc1 is an ER-localized sterol transporter and a component of ER–mitochondria and ER–vacuole contacts

(2015) Andrew Murley et al.   JOURNAL OF CELL BIOLOGY

A conserved family of proteins facilitates nascent lipid droplet budding from the ER

(2015) Vineet Choudhary et al.   JOURNAL OF CELL BIOLOGY

The I-BAR protein Ivy1 is an effector of the Rab7 GTPase Ypt7 involved in vacuole membrane homeostasis

(2015) J. Numrich et al.   JOURNAL OF CELL SCIENCE

Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis

(2015) Susmita Kaushik et al.   NATURE CELL BIOLOGY

Transport and Retention Mechanisms Govern Lipid Droplet Inheritance inSaccharomyces cerevisiae

(2015) Barbara Knoblach et al.   TRAFFIC

AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation

(2015) Albert Herms et al.   Nature Communications

Turnover of the actomyosin complex in zebrafish embryos directs geometric remodelling and the recruitment of lipid droplets

(2015) Asmita Dutta et al.   Scientific Reports

Entering the lysosome through a transient gate by chaperone-mediated autophagy

(2014) Urmi Bandyopadhyay et al.   Autophagy

Regulation of diacylglycerol acyltransferase 2 protein stability by gp78-associated endoplasmic-reticulum-associated degradation

(2014) Kwangman Choi et al.   FEBS Journal

Storage lipid synthesis is necessary for autophagy induced by nitrogen starvation

(2014) Dan Li et al.   FEBS LETTERS

A sterol-enriched vacuolar microdomain mediates stationary phase lipophagy in budding yeast

(2014) Chao-Wen Wang et al.   JOURNAL OF CELL BIOLOGY

Cleaning up in the endoplasmic reticulum: ubiquitin in charge

(2014) John C Christianson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting

(2014) Florian Wilfling et al.   eLife

Composition, structure and properties of POPC–triolein mixtures. Evidence of triglyceride domains in phospholipid bilayers

(2013) Lars Duelund et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Triacylglycerol Synthesis Enzymes Mediate Lipid Droplet Growth by Relocalizing from the ER to Lipid Droplets

(2013) Florian Wilfling et al.   DEVELOPMENTAL CELL

Acyl-CoA synthetase 3 promotes lipid droplet biogenesis in ER microdomains

(2013) Adam Kassan et al.   JOURNAL OF CELL BIOLOGY

Direct imaging reveals stable, micrometer-scale lipid domains that segregate proteins in live cells

(2013) Alexandre Toulmay et al.   JOURNAL OF CELL BIOLOGY

Retinol and retinyl esters: biochemistry and physiology

(2013) Sheila M. O'Byrne et al.   JOURNAL OF LIPID RESEARCH

Lipid droplet autophagy in the yeast Saccharomyces cerevisiae

(2013) Tim van Zutphen et al.   MOLECULAR BIOLOGY OF THE CELL

The biophysics and cell biology of lipid droplets

(2013) Abdou Rachid Thiam et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Perilipin 5, a Lipid Droplet-binding Protein, Protects Heart from Oxidative Burden by Sequestering Fatty Acid from Excessive Oxidation

(2012) Kenta Kuramoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative optical trapping on single organelles in cell extract

(2012) Pradeep Barak et al.   NATURE METHODS

Hypoxic stress activates chaperone-mediated autophagy and modulates neuronal cell survival

(2012) Eisuke Dohi et al.   NEUROCHEMISTRY INTERNATIONAL

Inhibitory effect of dietary lipids on chaperone-mediated autophagy

(2012) J. A. Rodriguez-Navarro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytoskeleton disruption in J774 macrophages: Consequences for lipid droplet formation and cholesterol flux

(2011) Ginny L. Weibel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Retinyl ester hydrolases and their roles in vitamin A homeostasis

(2011) Renate Schreiber et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis

(2011) Kezhong Zhang et al.   EMBO JOURNAL

Closer association of mitochondria with lipid droplets in hepatocytes and activation of Kupffer cells in resveratrol-treated senescence-accelerated mice

(2011) Motoko Shiozaki et al.   HISTOCHEMISTRY AND CELL BIOLOGY

The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria

(2011) Madeleen Bosma et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Unique Regulation of Adipose Triglyceride Lipase (ATGL) by Perilipin 5, a Lipid Droplet-associated Protein

(2011) Hong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The yeast lipin orthologue Pah1p is important for biogenesis of lipid droplets

(2011) Oludotun Adeyo et al.   JOURNAL OF CELL BIOLOGY

Lipid droplets are functionally connected to the endoplasmic reticulum in Saccharomyces cerevisiae

(2011) N. Jacquier et al.   JOURNAL OF CELL SCIENCE

Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria

(2011) Hong Wang et al.   JOURNAL OF LIPID RESEARCH

Interaction of Salicylate and a Terpenoid Plant Extract with Model Membranes: Reconciling Experiments and Simulations

(2010) Himanshu Khandelia et al.   BIOPHYSICAL JOURNAL

Interactions of Perilipin-5 (Plin5) with Adipose Triglyceride Lipase

(2010) James G. Granneman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction of Liver Steatosis and Lipid Droplet Formation in ATF6α-Knockout Mice Burdened with Pharmacological Endoplasmic Reticulum Stress

(2010) Keisuke Yamamoto et al.   MOLECULAR BIOLOGY OF THE CELL

Conditions of endoplasmic reticulum stress stimulate lipid droplet formation inSaccharomyces cerevisiae

(2009) Weihua Fei et al.   BIOCHEMICAL JOURNAL

Lipid droplets interact with mitochondria using SNAP23

(2009) Sara Jägerström et al.   CELL BIOLOGY INTERNATIONAL

Sterol and Diacylglycerol Acyltransferase Deficiency Triggers Fatty Acid-mediated Cell Death

(2009) Jeanne Garbarino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting sequences of UBXD8 and AAM-B reveal that the ER has a direct role in the emergence and regression of lipid droplets

(2009) J. K. Zehmer et al.   JOURNAL OF CELL SCIENCE

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Consequences of Motor Copy Number on the Intracellular Transport of Kinesin-1-Driven Lipid Droplets

(2008) George T. Shubeita et al.   CELL

Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast

(2008) Weihua Fei et al.   JOURNAL OF CELL BIOLOGY

Genetic structure and genealogy in the Sphagnum subsecundum complex (Sphagnaceae: Bryophyta)

(2008) A.J. Shaw et al.   MOLECULAR PHYLOGENETICS AND EVOLUTION