Seipin traps triacylglycerols to facilitate their nanoscale clustering in the endoplasmic reticulum membrane

Membrane Curvature Catalyzes Lipid Droplet Assembly

(2020) Alexandre Santinho et al.   CURRENT BIOLOGY

Promethin Is a Conserved Seipin Partner Protein

(2019) Inês G. Castro et al.   Cells

Multiscale Simulations of Biological Membranes: The Challenge To Understand Biological Phenomena in a Living Substance

(2019) Giray Enkavi et al.   CHEMICAL REVIEWS

Spatial compartmentalization of lipid droplet biogenesis

(2019) Mike Henne et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Membrane Asymmetry Imposes Directionality on Lipid Droplet Emergence from the ER

(2019) Aymeric Chorlay et al.   DEVELOPMENTAL CELL

Seipin Facilitates Triglyceride Flow to Lipid Droplet and Counteracts Droplet Ripening via Endoplasmic Reticulum Contact

(2019) Veijo T. Salo et al.   DEVELOPMENTAL CELL

Dietary fatty acids promote lipid droplet diversity through seipin enrichment in an ER subdomain

(2019) Zhe Cao et al.   Nature Communications

Lipid droplet biogenesis

(2019) Catherine L Jackson   CURRENT OPINION IN CELL BIOLOGY

ilastik: interactive machine learning for (bio)image analysis

(2019) Stuart Berg et al.   NATURE METHODS

An efficient auxin-inducible degron system with low basal degradation in human cells

(2019) Shiqian Li et al.   NATURE METHODS

LDAF1 and Seipin Form a Lipid Droplet Assembly Complex

(2019) Jeeyun Chung et al.   DEVELOPMENTAL CELL

Architecture of Lipid Droplets in Endoplasmic Reticulum Is Determined by Phospholipid Intrinsic Curvature

(2018) Vineet Choudhary et al.   CURRENT BIOLOGY

Mechanism and Determinants of Amphipathic Helix-Containing Protein Targeting to Lipid Droplets

(2018) Coline Prévost et al.   DEVELOPMENTAL CELL

The assembly of lipid droplets and their roles in challenged cells

(2018) W Mike Henne et al.   EMBO JOURNAL

A giant amphipathic helix from a perilipin that is adapted for coating lipid droplets

(2018) Alenka Čopič et al.   Nature Communications

Molecular Dynamics Simulation for All

(2018) Scott A. Hollingsworth et al.   NEURON

Seipin and the membrane-shaping protein Pex30 cooperate in organelle budding from the endoplasmic reticulum

(2018) Sihui Wang et al.   Nature Communications

Human SEIPIN Binds Anionic Phospholipids

(2018) Renhong Yan et al.   DEVELOPMENTAL CELL

Cryo–electron microscopy structure of the lipid droplet–formation protein seipin

(2018) Xuewu Sui et al.   JOURNAL OF CELL BIOLOGY

Dynamics and functions of lipid droplets

(2018) James A. Olzmann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Moving out but keeping in touch: contacts between endoplasmic reticulum and lipid droplets

(2018) Veijo T Salo et al.   CURRENT OPINION IN CELL BIOLOGY

Identification of seipin-linked factors that act as determinants of a lipid droplet subpopulation

(2017) Michal Eisenberg-Bord et al.   JOURNAL OF CELL BIOLOGY

Regulation of lipid droplets by metabolically controlled Ldo isoforms

(2017) Vitor Teixeira et al.   JOURNAL OF CELL BIOLOGY

Role for formin-like 1-dependent acto-myosin assembly in lipid droplet dynamics and lipid storage

(2017) Simon G. Pfisterer et al.   Nature Communications

The physics of lipid droplet nucleation, growth and budding

(2016) Abdou Rachid Thiam et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Seipin regulates ER–lipid droplet contacts and cargo delivery

(2016) Veijo T Salo et al.   EMBO JOURNAL

Crystal structure of the human σ1 receptor

(2016) Hayden R. Schmidt et al.   NATURE

CHARMM36m: an improved force field for folded and intrinsically disordered proteins

(2016) Jing Huang et al.   NATURE METHODS

Versatile protein tagging in cells with split fluorescent protein

(2016) Daichi Kamiyama et al.   Nature Communications

SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase

(2016) Martin Pagac et al.   Cell Reports

Microscopy Image Browser: A Platform for Segmentation and Analysis of Multidimensional Datasets

(2016) Ilya Belevich et al.   PLOS BIOLOGY

Seipin is required for converting nascent to mature lipid droplets

(2016) Huajin Wang et al.   eLife

The seipin complex Fld1/Ldb16 stabilizes ER–lipid droplet contact sites

(2015) Alexandra Grippa et al.   JOURNAL OF CELL BIOLOGY

A conserved family of proteins facilitates nascent lipid droplet budding from the ER

(2015) Vineet Choudhary et al.   JOURNAL OF CELL BIOLOGY

Seipin performs dissectible functions in promoting lipid droplet biogenesis and regulating droplet morphology

(2015) Bethany R. Cartwright et al.   MOLECULAR BIOLOGY OF THE CELL

Acyl-CoA synthetase 3 promotes lipid droplet biogenesis in ER microdomains

(2013) Adam Kassan et al.   JOURNAL OF CELL BIOLOGY

CHARMM36 all-atom additive protein force field: Validation based on comparison to NMR data

(2013) Jing Huang et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Computational analysis of local membrane properties

(2013) Vytautas Gapsys et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

A new seipin-associated neurodegenerative syndrome

(2013) Encarna Guillén-Navarro et al.   JOURNAL OF MEDICAL GENETICS

Alleviation of seipinopathy-related ER stress by triglyceride storage

(2012) M. Holtta-Vuori et al.   HUMAN MOLECULAR GENETICS

Improved Parameters for the Martini Coarse-Grained Protein Force Field

(2012) Djurre H. de Jong et al.   Journal of Chemical Theory and Computation

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

CHARMM Additive All-Atom Force Field for Carbohydrate Derivatives and Its Utility in Polysaccharide and Carbohydrate–Protein Modeling

(2011) Olgun Guvench et al.   Journal of Chemical Theory and Computation

Update of the CHARMM All-Atom Additive Force Field for Lipids: Validation on Six Lipid Types

(2010) Jeffery B. Klauda et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Triglyceride Blisters in Lipid Bilayers: Implications for Lipid Droplet Biogenesis and the Mobile Lipid Signal in Cancer Cell Membranes

(2010) Himanshu Khandelia et al.   PLoS One

Role of Lipids in Spheroidal High Density Lipoproteins

(2010) Timo Vuorela et al.   PLoS Computational Biology

The Human Lipodystrophy Gene Product Berardinelli-Seip Congenital Lipodystrophy 2/Seipin Plays a Key Role in Adipocyte Differentiation

(2009) Weiqin Chen et al.   ENDOCRINOLOGY

An auxin-based degron system for the rapid depletion of proteins in nonplant cells

(2009) Kohei Nishimura et al.   NATURE METHODS

Live Cell Multicolor Imaging of Lipid Droplets with a New Dye, LD540

(2009) Johanna Spandl et al.   TRAFFIC

Seipinopathy: a novel endoplasmic reticulum stress-associated disease

(2008) Daisuke Ito et al.   BRAIN

The Human Lipodystrophy Gene BSCL2/Seipin May Be Essential for Normal Adipocyte Differentiation

(2008) V. A. Payne et al.   DIABETES

Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast

(2008) Weihua Fei et al.   JOURNAL OF CELL BIOLOGY

Lipid droplets are arrested in the ER membrane by tight binding of lipidated apolipoprotein B-100

(2008) Y. Ohsaki et al.   JOURNAL OF CELL SCIENCE

The MARTINI Coarse-Grained Force Field: Extension to Proteins

(2008) Luca Monticelli et al.   Journal of Chemical Theory and Computation

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic Receptor

(2008) Michael A. Hanson et al.   STRUCTURE