Hepatic Retinyl Ester Hydrolases and the Mobilization of Retinyl Ester Stores

Lipid droplets, lipophagy, and beyond

(2016) Chao-Wen Wang   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Retinoid and carotenoid status in serum and liver among patients at high-risk for liver cancer

(2016) Yachana Kataria et al.   BMC GASTROENTEROLOGY

Assessment of indicators of vitamin A status in non-cirrhotic chronic hepatitis C patients

(2016) R.C. Santana et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Patatin-like phospholipase domain-containing protein 3 is involved in hepatic fatty acid and triglyceride metabolism through X-box binding protein 1 and modulation of endoplasmic reticulum stress in mice

(2016) Tsunehiro Ochi et al.   HEPATOLOGY RESEARCH

PNPLA3 overexpression results in reduction of proteins predisposing to fibrosis

(2016) Piero Pingitore et al.   HUMAN MOLECULAR GENETICS

Lysosomal Acid Lipase Hydrolyzes Retinyl Ester and Affects Retinoid Turnover

(2016) Lukas Grumet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATGL and DGAT1 are involved in the turnover of newly synthesized triacylglycerols in hepatic stellate cells

(2016) Maidina Tuohetahuntila et al.   JOURNAL OF LIPID RESEARCH

Regulation and Functions of Autophagic Lipolysis

(2016) Francesca Cingolani et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Autophagy and Lipid Droplets in the Liver

(2015) Nuria Martinez-Lopez et al.   Annual Review of Nutrition

Adipose triglyceride lipase is involved in the mobilization of triglyceride and retinoid stores of hepatic stellate cells

(2015) Ulrike Taschler et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The link between Hepatic Vitamin A Metabolism and Nonalcoholic Fatty Liver Disease

(2015) Guoxun Chen   CURRENT DRUG TARGETS

The Genetic Variant I148M inPNPLA3Is Associated With Increased Hepatic Retinyl-Palmitate Storage in Humans

(2015) Marketa Kovarova et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Mechanisms of liver fibrosis resolution

(2015) Frank Tacke et al.   JOURNAL OF HEPATOLOGY

ATGL and CGI-58 are lipid droplet proteins of the hepatic stellate cell line HSC-T6

(2015) Thomas O. Eichmann et al.   JOURNAL OF LIPID RESEARCH

PNPLA3 I148M Variant Influences Circulating Retinol in Adults with Nonalcoholic Fatty Liver Disease or Obesity

(2015) Alison Mondul et al.   JOURNAL OF NUTRITION

PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells

(2014) Carlo Pirazzi et al.   HUMAN MOLECULAR GENETICS

Endocytosis of Secreted Carboxyl Ester Lipase in a Syndrome of Diabetes and Pancreatic Exocrine Dysfunction

(2014) Janniche Torsvik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recombinant PNPLA3 protein shows triglyceride hydrolase activity and its I148M mutation results in loss of function

(2013) Piero Pingitore et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Retinoic Acid Actions through Mammalian Nuclear Receptors

(2013) Pengxiang Huang et al.   CHEMICAL REVIEWS

Hepatic stellate cells in liver development, regeneration, and cancer

(2013) Chunyue Yin et al.   JOURNAL OF CLINICAL INVESTIGATION

Global burden of alcoholic liver diseases

(2013) Jürgen Rehm et al.   JOURNAL OF HEPATOLOGY

Retinol and retinyl esters: biochemistry and physiology

(2013) Sheila M. O'Byrne et al.   JOURNAL OF LIPID RESEARCH

Regulation of membrane trafficking by signalling on endosomal and lysosomal membranes

(2013) Xinran Li et al.   JOURNAL OF PHYSIOLOGY-LONDON

Association Between Liver Vitamin A Reserves and Severity of Nonalcoholic Fatty Liver Disease in the Class III Obese Following Bariatric Surgery

(2013) Gabriela Villaça Chaves et al.   OBESITY SURGERY

Dynamic Regulation of Hepatic Lipid Droplet Properties by Diet

(2013) Amanda E. Crunk et al.   PLoS One

Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology

(2013) Ingmar Mederacke et al.   Nature Communications

Absorption of Vitamin A and Carotenoids by the Enterocyte: Focus on Transport Proteins

(2013) Emmanuelle Reboul   Nutrients

Regulation of lipid stores and metabolism by lipophagy

(2012) K Liu et al.   CELL DEATH AND DIFFERENTIATION

Adiponutrin Functions as a Nutritionally Regulated Lysophosphatidic Acid Acyltransferase

(2012) Manju Kumari et al.   Cell Metabolism

Autophagy Releases Lipid That Promotes Fibrogenesis by Activated Hepatic Stellate Cells in Mice and in Human Tissues

(2012) Virginia Hernández–Gea et al.   GASTROENTEROLOGY

Liver specific inactivation of carboxylesterase 3/triacylglycerol hydrolase decreases blood lipids without causing severe steatosis in mice

(2012) Jihong Lian et al.   HEPATOLOGY

The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association

(2012) Naga Chalasani et al.   HEPATOLOGY

Liver Retinol Transporter and Receptor for Serum Retinol-binding Protein (RBP4)

(2012) Philomena Alapatt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Assessment of the Relative Dose-Response Test as Indicators of Hepatic Vitamin A Stores in Various Stages of Chronic Liver Disease

(2012) Wilza Arantes Ferreira Peres et al.   NUTRITION IN CLINICAL PRACTICE

Replacement of Retinyl Esters by Polyunsaturated Triacylglycerol Species in Lipid Droplets of Hepatic Stellate Cells during Activation

(2012) Nicole Testerink et al.   PLoS One

Vitamin A: biomarkers of nutrition for development

(2011) Sherry A Tanumihardjo   AMERICAN JOURNAL OF CLINICAL NUTRITION

Retinyl ester hydrolases and their roles in vitamin A homeostasis

(2011) Renate Schreiber et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Hepatic metabolism of retinoids and disease associations

(2011) Yohei Shirakami et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A role for autophagy during hepatic stellate cell activation

(2011) Lien F.R. Thoen et al.   JOURNAL OF HEPATOLOGY

Role of endoplasmic reticulum neutral lipid hydrolases

(2011) Ariel D. Quiroga et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Vitamin A Metabolism: An Update

(2011) Diana N. D’Ambrosio et al.   Nutrients

Hepatic stellate cell (vitamin A-storing cell) and its relative – past, present and future

(2010) Haruki Senoo et al.   CELL BIOLOGY INTERNATIONAL

Loss of TGH/Ces3 in Mice Decreases Blood Lipids, Improves Glucose Tolerance, and Increases Energy Expenditure

(2010) Enhui Wei et al.   Cell Metabolism

Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease

(2010) Luca Valenti et al.   HEPATOLOGY

Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome

(2010) Mahesh K. Basantani et al.   JOURNAL OF LIPID RESEARCH

Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins

(2010) Roger S. Holmes et al.   MAMMALIAN GENOME

Lipolysis – A highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores

(2010) Achim Lass et al.   PROGRESS IN LIPID RESEARCH

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Nonalcoholic fatty liver disease: A manifestation of the metabolic syndrome

(2009) C. H. KIM et al.   CLEVELAND CLINIC JOURNAL OF MEDICINE

The metabolic syndrome and nonalcoholic fatty liver disease in children

(2009) Shikha S Sundaram et al.   CURRENT OPINION IN PEDIATRICS

Hormone-sensitive lipase (HSL) is also a retinyl ester hydrolase: evidence from mice lacking HSL

(2009) Kristoffer Ström et al.   FASEB JOURNAL

A Sequence Variation (I148M) in PNPLA3 Associated with Nonalcoholic Fatty Liver Disease Disrupts Triglyceride Hydrolysis

(2009) Shaoqing He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Esterase 22 and beta-glucuronidase hydrolyze retinoids in mouse liver

(2009) Renate Schreiber et al.   JOURNAL OF LIPID RESEARCH

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Liver architecture, cell function, and disease

(2009) Hiromi Ishibashi et al.   Seminars in Immunopathology

Expression of carboxylesterase and lipase genes in rat liver cell-types

(2008) Tommaso Mello et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hepatic stellate cell lipid droplets: A specialized lipid droplet for retinoid storage

(2008) William S. Blaner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Mechanisms of Hepatic Fibrogenesis

(2008) Scott L. Friedman   GASTROENTEROLOGY

Hepatic Overexpression of Hormone-sensitive Lipase and Adipose Triglyceride Lipase Promotes Fatty Acid Oxidation, Stimulates Direct Release of Free Fatty Acids, and Ameliorates Steatosis

(2008) Brendan N. Reid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular mechanism of hepatic stellate cell activation and antifibrotic therapeutic strategies

(2008) Jing-Ting Li et al.   JOURNAL OF GASTROENTEROLOGY

Anti-angiogenic pigment epithelium-derived factor regulates hepatocyte triglyceride content through adipose triglyceride lipase (ATGL)

(2008) Chuhan Chung et al.   JOURNAL OF HEPATOLOGY

Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores

(2008) Rudolf Zechner et al.   JOURNAL OF LIPID RESEARCH

Hormone-sensitive lipase is involved in hepatic cholesteryl ester hydrolysis

(2008) Motohiro Sekiya et al.   JOURNAL OF LIPID RESEARCH

Structure and Catalytic Properties of Carboxylesterase Isozymes Involved in Metabolic Activation of Prodrugs

(2008) Masakiyo Hosokawa   MOLECULES

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

(2008) Scott L. Friedman   PHYSIOLOGICAL REVIEWS