Perspectives on Mitochondria–ER and Mitochondria–Lipid Droplet Contact in Hepatocytes and Hepatic Lipid Metabolism

Two Types of Contact Between Lipid Droplets and Mitochondria

(2021) Liujuan Cui et al.   Frontiers in Cell and Developmental Biology

An ESCRT-dependent step in fatty acid transfer from lipid droplets to mitochondria through VPS13D−TSG101 interactions

(2021) Jingru Wang et al.   Nature Communications

Mechanisms and disease consequences of nonalcoholic fatty liver disease

(2021) Rohit Loomba et al.   CELL

TMEM41B acts as an ER scramblase required for lipoprotein biogenesis and lipid homeostasis

(2021) Dong Huang et al.   Cell Metabolism

VPS13D promotes peroxisome biogenesis

(2021) Heather A. Baldwin et al.   JOURNAL OF CELL BIOLOGY

VPS13D bridges the ER to mitochondria and peroxisomes via Miro

(2021) Andrés Guillén-Samander et al.   JOURNAL OF CELL BIOLOGY

TMEM41B and VMP1 are scramblases and regulate the distribution of cholesterol and phosphatidylserine

(2021) Yang Emma Li et al.   JOURNAL OF CELL BIOLOGY

A model for a partnership of lipid transfer proteins and scramblases in membrane expansion and organelle biogenesis

(2021) Alireza Ghanbarpour et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondria-rough-ER contacts in the liver regulate systemic lipid homeostasis

(2021) Irene Anastasia et al.   Cell Reports

Vmp1, Vps13D, and Marf/Mfn2 function in a conserved pathway to regulate mitochondria and ER contact in development and disease

(2021) James L. Shen et al.   CURRENT BIOLOGY

Mutual interaction between endoplasmic reticulum and mitochondria in nonalcoholic fatty liver disease

(2020) Jin Wang et al.   Lipids in Health and Disease

Endoplasmic Reticulum–Mitochondria Contact Sites and Neurodegeneration

(2020) Lingna Xu et al.   Frontiers in Cell and Developmental Biology

Coming together to define membrane contact sites

(2019) Luca Scorrano et al.   Nature Communications

The Expanding and Unexpected Functions of Mitochondria Contact Sites

(2019) Laura L. Lackner   TRENDS IN CELL BIOLOGY

Mitochondria Bound to Lipid Droplets: Where Mitochondrial Dynamics Regulate Lipid Storage and Utilization

(2019) Ilan Y. Benador et al.   Cell Metabolism

TMEM41B functions with VMP1 in autophagosome formation

(2019) Keigo Morita et al.   Autophagy

ATG2 transports lipids to promote autophagosome biogenesis

(2019) Diana P. Valverde et al.   JOURNAL OF CELL BIOLOGY

Past, present and future perspectives in nonalcoholic fatty liver disease

(2019) Arun J. Sanyal   Nature Reviews Gastroenterology & Hepatology

Calcium Signaling As a Therapeutic Target for Liver Steatosis

(2019) Eunüs S. Ali et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

A critical role of VMP1 in lipoprotein secretion

(2019) Hideaki Morishita et al.   eLife

The functional universe of membrane contact sites

(2019) William A. Prinz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lipid droplets and mitochondria are anchored during brown adipocyte differentiation

(2019) Liujuan Cui et al.   Protein & Cell

MIGA2 Links Mitochondria, the ER, and Lipid Droplets and Promotes De Novo Lipogenesis in Adipocytes

(2019) Christophe A.C. Freyre et al.   MOLECULAR CELL

Impaired Fasting-Induced Adaptive Lipid Droplet Biogenesis in Liver-Specific Atg5 -Deficient Mouse Liver Is Mediated by Persistent Nuclear Factor-Like 2 Activation

(2018) Yuan Li et al.   AMERICAN JOURNAL OF PATHOLOGY

Recessive mutations in >VPS13D cause childhood onset movement disorders

(2018) Julie Gauthier et al.   ANNALS OF NEUROLOGY

Mutations in VPS13D lead to a new recessive ataxia with spasticity and mitochondrial defects

(2018) Eunju Seong et al.   ANNALS OF NEUROLOGY

Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics, Composition, and Dynamics that Support Lipid Droplet Expansion

(2018) Ilan Y. Benador et al.   Cell Metabolism

Vps13D Encodes a Ubiquitin-Binding Protein that Is Required for the Regulation of Mitochondrial Size and Clearance

(2018) Allyson L. Anding et al.   CURRENT BIOLOGY

Understanding the diversity of membrane lipid composition

(2018) Takeshi Harayama et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TMEM41B is a novel regulator of autophagy and lipid mobilization

(2018) Francesca Moretti et al.   EMBO REPORTS

Long-chain acyl-CoA synthetase 1 interacts with key proteins that activate and direct fatty acids into niche hepatic pathways

(2018) Pamela A. Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites

(2018) Nikit Kumar et al.   JOURNAL OF CELL BIOLOGY

Phospholipid Remodeling in Physiology and Disease

(2018) Bo Wang et al.   Annual Review of Physiology

Dynamics and functions of lipid droplets

(2018) James A. Olzmann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Transglutaminase Type 2 Regulates ER-Mitochondria Contact Sites by Interacting with GRP75

(2018) Manuela D’Eletto et al.   Cell Reports

Lipid Droplets in Health and Disease

(2017) Gizem Onal et al.   Lipids in Health and Disease

The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation

(2017) Yan G. Zhao et al.   MOLECULAR CELL

Applying systems-level spectral imaging and analysis to reveal the organelle interactome

(2017) Alex M. Valm et al.   NATURE

Cytosolic lipolysis and lipophagy: two sides of the same coin

(2017) Rudolf Zechner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion

(2015) Xin Rong et al.   eLife

Fatty acid remodeling by LPCAT3 enriches arachidonate in phospholipid membranes and regulates triglyceride transport

(2015) Tomomi Hashidate-Yoshida et al.   eLife

Mitochondrial dynamics and mitochondrial quality control

(2015) Hong-Min Ni et al.   Redox Biology

Lipid droplet biogenesis

(2014) Florian Wilfling et al.   CURRENT OPINION IN CELL BIOLOGY

The Concentration of Phosphatidylethanolamine in Mitochondria Can Modulate ATP Production and Glucose Metabolism in Mice

(2014) J. N. van der Veen et al.   DIABETES

Phospholipid Synthesis and Transport in Mammalian Cells

(2014) Jean E. Vance   TRAFFIC

New advances in molecular mechanisms and emerging therapeutic targets in alcoholic liver diseases

(2014) Jessica A Williams et al.   WORLD JOURNAL OF GASTROENTEROLOGY

ER–mitochondria associations are regulated by the VAPB–PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43

(2014) Radu Stoica et al.   Nature Communications

Functions of autophagy in normal and diseased liver

(2013) Mark J. Czaja et al.   Autophagy

Autophagosomes form at ER–mitochondria contact sites

(2013) Maho Hamasaki et al.   NATURE

Mitophagy: mechanisms, pathophysiological roles, and analysis

(2012) Wen-Xing Ding et al.   BIOLOGICAL CHEMISTRY

Phosphatidylcholine Synthesis for Lipid Droplet Expansion Is Mediated by Localized Activation of CTP:Phosphocholine Cytidylyltransferase

(2011) Natalie Krahmer et al.   Cell Metabolism

Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets

(2011) Bin Gao et al.   GASTROENTEROLOGY

Cohen Syndrome-associated Protein, COH1, Is a Novel, Giant Golgi Matrix Protein Required for Golgi Integrity

(2011) Wenke Seifert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria

(2011) Hong Wang et al.   JOURNAL OF LIPID RESEARCH

ER Tubules Mark Sites of Mitochondrial Division

(2011) J. R. Friedman et al.   SCIENCE

Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis induction

(2010) Ryota Iwasawa et al.   EMBO JOURNAL

Phospholipid scramblase: An update

(2010) Edouard M. Bevers et al.   FEBS LETTERS

Mitochondrial calcium channels

(2010) Uta C. Hoppe   FEBS LETTERS

Impairedde NovoCholine Synthesis Explains Why PhosphatidylethanolamineN-Methyltransferase-deficient Mice Are Protected from Diet-induced Obesity

(2010) René L. Jacobs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lack of Phosphatidylethanolamine N -Methyltransferase Alters Plasma VLDL Phospholipids and Attenuates Atherosclerosis in Mice

(2009) Yang Zhao et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Lipid droplets interact with mitochondria using SNAP23

(2009) Sara Jägerström et al.   CELL BIOLOGY INTERNATIONAL

Elimination of the CDP-ethanolamine Pathway Disrupts Hepatic Lipid Homeostasis

(2009) Roberta Leonardi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of phosphatidylcholine biosynthesis in the regulation of lipoprotein homeostasis

(2008) Dennis E Vance   CURRENT OPINION IN LIPIDOLOGY

The Endoplasmic Reticulum Enzyme DGAT2 Is Found in Mitochondria-associated Membranes and Has a Mitochondrial Targeting Signal That Promotes Its Association with Mitochondria

(2008) Scot J. Stone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY