Seipin accumulates and traps diacylglycerols and triglycerides in its ring-like structure

Pre-existing bilayer stresses modulate triglyceride accumulation in the ER versus lipid droplets

(2021) Valeria Zoni et al.   eLife

Membrane Curvature Catalyzes Lipid Droplet Assembly

(2020) Alexandre Santinho et al.   CURRENT BIOLOGY

Seipin and Nem1 establish discrete ER subdomains to initiate yeast lipid droplet biogenesis

(2020) Vineet Choudhary et al.   JOURNAL OF CELL BIOLOGY

New friends for seipin — Implications of seipin partner proteins in the life cycle of lipid droplets

(2020) Maria Bohnert   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Determinants of Endoplasmic Reticulum-to-Lipid Droplet Protein Targeting

(2020) Maria-Jesus Olarte et al.   DEVELOPMENTAL CELL

Nuclear lipid droplets form in the inner nuclear membrane in a seipin-independent manner

(2020) Kamil Sołtysik et al.   JOURNAL OF CELL BIOLOGY

Promethin Is a Conserved Seipin Partner Protein

(2019) Inês G. Castro et al.   Cells

Born this way – Biogenesis of lipid droplets from specialized ER subdomains

(2019) Niclas T. Nettebrock et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Membrane Asymmetry Imposes Directionality on Lipid Droplet Emergence from the ER

(2019) Aymeric Chorlay et al.   DEVELOPMENTAL CELL

Seipin Facilitates Triglyceride Flow to Lipid Droplet and Counteracts Droplet Ripening via Endoplasmic Reticulum Contact

(2019) Veijo T. Salo et al.   DEVELOPMENTAL CELL

Lipid Droplets in Disease

(2019) Paul Dalhaimer   Cells

LDAF1 and Seipin Form a Lipid Droplet Assembly Complex

(2019) Jeeyun Chung et al.   DEVELOPMENTAL CELL

Lipid droplet proteins and metabolic diseases

(2018) Shimeng Xu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Architecture of Lipid Droplets in Endoplasmic Reticulum Is Determined by Phospholipid Intrinsic Curvature

(2018) Vineet Choudhary et al.   CURRENT BIOLOGY

Seipin and the membrane-shaping protein Pex30 cooperate in organelle budding from the endoplasmic reticulum

(2018) Sihui Wang et al.   Nature Communications

Human SEIPIN Binds Anionic Phospholipids

(2018) Renhong Yan et al.   DEVELOPMENTAL CELL

Cryo–electron microscopy structure of the lipid droplet–formation protein seipin

(2018) Xuewu Sui et al.   JOURNAL OF CELL BIOLOGY

SPICA Force Field for Lipid Membranes: Domain Formation Induced by Cholesterol

(2018) Sangjae Seo et al.   Journal of Chemical Theory and Computation

Dynamics and functions of lipid droplets

(2018) James A. Olzmann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Identification of seipin-linked factors that act as determinants of a lipid droplet subpopulation

(2017) Michal Eisenberg-Bord et al.   JOURNAL OF CELL BIOLOGY

Regulation of lipid droplets by metabolically controlled Ldo isoforms

(2017) Vitor Teixeira et al.   JOURNAL OF CELL BIOLOGY

Lipid droplets and liver disease: from basic biology to clinical implications

(2017) Nina L. Gluchowski et al.   Nature Reviews Gastroenterology & Hepatology

The physics of lipid droplet nucleation, growth and budding

(2016) Abdou Rachid Thiam et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Seipin regulates ER–lipid droplet contacts and cargo delivery

(2016) Veijo T Salo et al.   EMBO JOURNAL

SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase

(2016) Martin Pagac et al.   Cell Reports

A mathematical model explains saturating axon guidance responses to molecular gradients

(2016) Huyen Nguyen et al.   eLife

Dysfunction of lipid metabolism in lipodystrophic Seipin-deficient mice

(2015) Mengyu Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Seipin is involved in the regulation of phosphatidic acid metabolism at a subdomain of the nuclear envelope in yeast

(2015) Heimo Wolinski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Dissecting seipin function: the localized accumulation of phosphatidic acid at ER/LD junctions in the absence of seipin is suppressed by Sei1pΔNterm only in combination with Ldb16p

(2015) Sungwon Han et al.   BMC CELL BIOLOGY

The seipin complex Fld1/Ldb16 stabilizes ER–lipid droplet contact sites

(2015) Alexandra Grippa et al.   JOURNAL OF CELL BIOLOGY

A conserved family of proteins facilitates nascent lipid droplet budding from the ER

(2015) Vineet Choudhary et al.   JOURNAL OF CELL BIOLOGY

Molecular dynamics simulations of cholesterol-rich membranes using a coarse-grained force field for cyclic alkanes

(2015) Christopher M. MacDermaid et al.   JOURNAL OF CHEMICAL PHYSICS

Lipid partitioning at the nuclear envelope controls membrane biogenesis

(2015) Antonio Daniel Barbosa et al.   MOLECULAR BIOLOGY OF THE CELL

Seipin performs dissectible functions in promoting lipid droplet biogenesis and regulating droplet morphology

(2015) Bethany R. Cartwright et al.   MOLECULAR BIOLOGY OF THE CELL

Biogenesis of the multifunctional lipid droplet: Lipids, proteins, and sites

(2014) Albert Pol et al.   JOURNAL OF CELL BIOLOGY

Lipid Droplets and Cellular Lipid Metabolism

(2012) Tobias C. Walther et al.   Annual Review of Biochemistry

Computer simulation studies of self-assembling macromolecules

(2012) Wataru Shinoda et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The yeast lipin orthologue Pah1p is important for biogenesis of lipid droplets

(2011) Oludotun Adeyo et al.   JOURNAL OF CELL BIOLOGY

Direct binding of triglyceride to fat storage-inducing transmembrane proteins 1 and 2 is important for lipid droplet formation

(2011) D. A. Gross et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Role for Phosphatidic Acid in the Formation of “Supersized” Lipid Droplets

(2011) Weihua Fei et al.   PLoS Genetics

Structure and assembly of pore-forming proteins

(2010) Ioan Iacovache et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Zwitterionic Lipid Assemblies: Molecular Dynamics Studies of Monolayers, Bilayers, and Vesicles Using a New Coarse Grain Force Field

(2010) Wataru Shinoda et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Triglyceride Blisters in Lipid Bilayers: Implications for Lipid Droplet Biogenesis and the Mobile Lipid Signal in Cancer Cell Membranes

(2010) Himanshu Khandelia et al.   PLoS One

Seipin deficiency alters fatty acid Δ9 desaturation and lipid droplet formation in Berardinelli-Seip congenital lipodystrophy

(2009) Emilie Boutet et al.   BIOCHIMIE

Diacylglycerol Enrichment of Endoplasmic Reticulum or Lipid Droplets Recruits Perilipin 3/TIP47 during Lipid Storage and Mobilization

(2009) James R. Skinner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast

(2008) Weihua Fei et al.   JOURNAL OF CELL BIOLOGY